Although diphtheria is now rarely reported in the United States, before a vaccine was available, the disease was one of the most common causes of illness and death among children. Since the introduction and widespread use of diphtheria vaccines beginning in the 1920s and 1930s and universal childhood immunization in the late 1940s, diphtheria has been well controlled in the United States.
The following case definition for diphtheria was revised by the Council of State and Territorial Epidemiologists (CSTE) and published in 2010.
Probable: In the absence of a more likely diagnosis, an upper respiratory tract illness with an adherent membrane of the nose, pharynx, tonsils, or larynx; and absence of laboratory confirmation; and lack of epidemiologic linkage to a laboratory-confirmed case of diphtheria.
Confirmed: An upper respiratory tract illness with an adherent membrane of the nose, pharynx, tonsils, or larynx; and any of the following: isolation of Corynebacterium diphtheriae from the nose or throat; or histopathologic diagnosis of diphtheria; or epidemiologic linkage to a laboratory-confirmed case of diphtheria.
Comment: Cutaneous diphtheria should not be reported. Respiratory disease caused by nontoxigenic C. diphtheriae should be reported as diphtheria. All diphtheria isolates, regardless of association with disease, should be sent to the Diphtheria Laboratory, National Center for Immunization and Respiratory Diseases (NCIRD), CDC.
Reporting to CDC
Suspected diphtheria cases should be reported promptly by telephone to the CDC Emergency Operations Center (770-488-7100) so that diphtheria antitoxin can be obtained for the patient. An FDA-licensed diphtheria antitoxin product is no longer available commercially in the United States. However, diphtheria antitoxin is available from CDC under an Investigational New Drug (IND) protocol, additional epidemiologic and clinical data are needed as requirements under the IND.
The healthcare provider should notify the state health department promptly so that an epidemiologic investigation can be initiated. Reports of probable and confirmed cases should be forwarded by the state health department to the National Notifiable Disease Surveillance System (NNDSS). Reporting should not be delayed because of incomplete information or lack of laboratory confirmation.
Images and logos on this website which are trademarked/copyrighted or used with permission of the trademark/copyright or logo holder are not in the public domain. These images and logos have been licensed for or used with permission in the materials provided on this website. The materials in the form presented on this website may be used without seeking further permission. Any other use of trademarked/copyrighted images or logos requires permission from the trademark/copyright holder...more
This graphic notice means that you are leaving an HHS Web site. For more information, please see the Exit Notification and Disclaimer policy.