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The seroepidemiology of chronic fatigue syndrome: a case-control study.
Mawle AC, Nisenbaum R, Dobbins JG, Gary HE, Stewart JA, Reyes M, Steele L, Schmid DS, Reeves WC.The seroepidemiology of chronic fatigue syndrome: a case-control study.
Clinical Infectious Diseases, vol. 21, pages 1386-1389, 1995.
Summary
Serum, saliva, urine, and stool specimens collected from CFS patients and matched healthy controls were analyzed to determine whether any association between infectious agents and CFS could be detected. The following infectious agents were tested for: retroviruses (HIV-1, HIV-2, HTLV-I, HTLV-II, pan-retrovirus reverse transcriptase activity), enteroviruses, arboviruses, Colorado tick fever virus, vesicular stomatitis virus, cytomegalovirus, human herpesvirus 6, varicella zoster virus, Epstein-Barr virus, parainfluenza viruses 1, 2, and 3, respiratory syncytial virus, coronavirus, hepatitis B, hepatitis C, measles, rubella, parvovirus, Rickettsia typhi, and Rickettsia rickettsiae, Ehrlichia chaffeensis, Bartonella henselae, Bartonella quintana, Bartonella elizabethae, Borellia burgdorferi, Candida albicans, and Chlamydia trachomatis. No evidence was found that any of these human pathogens increased the risk for developing CFS.
Abstract
We have performed serologic screening for a large number of infectious agents in 26 patients from Atlanta who had chronic fatigue syndrome (CFS), and in 50 controls matched by age, race, and sex. We did not find any agent associated with CFS. In addition, we did not find elevated levels of antibody to any of a wide range of agents examined. In particular, we did not find elevated titers to any herpesvirus, nor did we find evidence of enteroviral exposure in this group of patients.
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