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Laboratory Information

The Division of Tuberculosis Elimination (DTBE) Laboratory Branch (LB) provides services for the following tests on mycobacterial cultures. Any local health department, licensed physician's office, licensed laboratory or licensed health care facility may submit cultures for testing but they must be routed through either their state health department or other authorized facility.

Genotyping

State or local TB control programs

Two genotyping laboratories, one in Michigan and one in California, are under contract with CDC to provide genotyping services to TB programs in the United States. Three genotyping methods to identify TB strains:

  • Spoligotyping
  • Mycobacterial interspersed repetitive unit (MIRU) analysis
  • IS6110-based restriction fragment length polymorphism (RFLP) analysis

For more information, view the Guide to the Application of Genotyping to Tuberculosis Prevention and Control.

DTBE epidemiologic investigations and surveillance activities

  • The LB provides support for DTBE epidemiologic investigations and surveillance activities. TB genotyping results, when combined with epidemiologic data, help to distinguish TB patients who are involved in the same chain of recent transmission.

Drug susceptibility testing

The LB performs drug susceptibility testing for selected Mycobacterium species referred from state or other authorized health facilities. Cultures of mycobacteria are tested by the indirect proportion method with antituberculosis drugs incorporated into 7H10 agar plates.

Additional Resources

 
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    30329-4027 USA
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illustration of colorful DNA strand behind the text - Learn More CDC using whole genome sequencing to improve TB outbreak detection

  • Page last reviewed: December 17, 2014
  • Page last updated: December 19, 2014
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Centers for Disease Control and Prevention   1600 Clifton Rd. Atlanta, GA 30329-4027, USA
800-CDC-INFO (800-232-4636) TTY: (888) 232-6348 - Contact CDC-INFO