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Chicago Antimicrobial Resistance and Infection Prevention Epicenter (C-PIE)

Rush University Medical Center

Chicago Antimicrobial Resistance and Infection Prevention Epicenter (C-PIE)

First Funded: 2006

Overview: Researchers from the Cook County Health and Hospitals System (CCHHS) and Rush University Medical Center (RUMC) are collaborating to form the Chicago Antimicrobial Resistance and Infection Prevention Epicenter (C-PIE). The Epicenter has developed a clinical data warehouse using data from the electronic health records from affiliated hospitals, laboratories, and ambulatory clinics. The data warehouse is being used to monitor the prevalence of antimicrobial-resistant bacteria, to track healthcare-associated bloodstream infections, and to assess antibiotic use. Innovations developed for the C-PIE data warehouse are being leveraged for a Chicago citywide effort to implement electronic laboratory reporting of communicable diseases and are helping to provide mechanisms for automated surveillance for key modules in CDC's National Healthcare Safety Network (NHSN). The data warehouse also will facilitate rapid detection and automated surveillance of infectious diseases as part of the Epicenter's quality improvement initiatives. Additional information about the Epicenter or Epicenter-related projects.

Research Study Areas: Antimicrobial benchmarking and prescribing improvement; reducing the bio-burden of nosocomial pathogens through source control; developing and enhancing electronic surveillance for a broad range of healthcare-associated events and infections; and evaluating the effectiveness of state-mandated screening for methicillin-resistant Staphylococcus aureus (MRSA).

Research Projects Led by C-PIE—Examples: Related to antimicrobial benchmarking and prescribing improvement, the Epicenter is measuring the variability and appropriateness of antimicrobial utilization in multiple ICUs in several Epicenter facilities. To reduce the bio-burden of nosocomial pathogens, the Epicenter is lowering the risk of BSIs and of antimicrobial resistant pathogens, including MRSA and vancomycin-resistant enterococci (VRE), through patient cleansing. The electronic surveillance of central vascular catheter BSIs is an ongoing local project that includes collaboration among Chicago (CCHHS and RUMC), Ohio (Ohio State University), and St. Louis (Washington University) Epicenters. The Chicago Epicenter is collaborating with the Illinois and Chicago Departments of Public Health to evaluate the effect of state-mandated MRSA screening on the prevalence of MRSA among patients hospitalized in ICUs in acute care hospitals throughout Chicago.

Principal Investigator
Robert A. Weinstein, MD
Interim Chairman, Department of Medicine
Stroger (Cook County) Hospital, CCHHS
The C. Anderson Hedberg, MD,
Professor of Medicine, Rush Medical College


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