Mycoplasma genitalium Treatment and Care

How should healthcare providers treat Mycoplasma genitalium (Mgen)?

The recommended treatment for all cases of Mgen is sequential two-step therapy with doxycycline, followed by an additional agent (either moxifloxacin or azithromycin). For cases occurring in pregnancy, please consult the STD Clinical Consultation Network for treatment recommendations.

What if a patient with Mgen fails antibiotic treatment?

Healthcare providers with patients experiencing persistent symptoms after completing recommended treatment for Mgen can receive consultation for additional treatment options via the STD Clinical Consultation Network. National experts provide consults by phone and email within 1-5 business days, based on the provider’s requested timeline.

CDC is tracking cases of Mgen treatment failure nationally through the Mycoplasma genitalium Treatment Failure Registry. By reporting cases on this form, providers can help identify emerging antimicrobial-resistant strains of Mgen in the United States. This information will also help the CDC understand which treatments may be effective in cases of treatment failure. The registry does not collect personal identifying information about the patient.

Treatment Guidelines and Updates