Clinical Resources

Clinical practice guides for the management of sepsis were developed by the Surviving Sepsis Campaign (SSC)external icon (a collaboration of the Society of Critical Care Medicine and the European Society of Intensive Care Medicine). These guidelines were updated in 2016.

The Surviving Sepsis Campaign partnered with the Institute for Healthcare Improvement (IHI) to create bundles to help frontline providers implement the guidelines.

Clinical Guidelines

International Guidelines for Management of Severe Sepsis and Septic Shock: 2016external icon (Surviving Sepsis Campaign)

Bundles for Implementing Sepsis Guidelines

What's a bundle?

A bundle is a short, straightforward set of evidence-based practices intended to improve patient outcomes. Bundles were developed by the Institute for Healthcare Improvement to help health care providers more reliably deliver the best possible care for patients.

Learn more about bundlesexternal icon.

Patient Information

See the Get Ahead of Sepsis section for patient and clinician information including

  • Factsheets
  • Brochures
  • Infographics
  • Videos

Infection Control Guidelines

See the Infection Control Guideline Library

Medical Bibliography

Selected textbook and journal articles on sepsis.

  • Angus, DC, van der Poll, T. Severe Sepsis and Septic Shockexternal iconN Engl J Med 2013;369:840-51.
  • Ely E, Goyotte RE. Chapter 46. Sepsis with Acute Organ Dysfunctionexternal icon. In: Hall JB, Schmidt GA, Wood LH. eds. Principles of Critical Care, 3e. New York, NY: McGraw-Hill; 2005.
  • Felner K, Smith RL. Chapter 138. Sepsisexternal icon. In: McKean SC, Ross JJ, Dressler DD, Brotman DJ, Ginsberg JS. eds. Principles and Practice of Hospital Medicine. New York, NY: McGraw-Hill; 2012.
  • Jui J. Chapter 146. Septic Shockexternal icon. In: Tintinalli JE, Stapczynski J, Ma O, Cline DM, Cydulka RK, Meckler GD, T. eds. Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 7e. New York, NY: McGraw-Hill; 2011.
  • Munford RS, Suffredini AF. Chapter 70. Sepsis, Severe Sepsis, and Septic Shock. In: Mandell GL, Bennett JE, Dolin R. eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. Philadelphia, PA: Elsevier; 2010