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Clinical Resources

Clinical practice guides for the management of sepsis were developed by the Surviving Sepsis Campaign (a collaboration of the Society of Critical Care Medicine and the European Society of Intensive Care Medicine). These guidelines were updated in 2016.

The Surviving Sepsis Campaign partnered with the Institute for Healthcare Improvement (IHI) to create bundles to help frontline providers implement the guidelines.

Bundles for Implementing Sepsis Guidelines

What's a bundle?

A bundle is a short, straightforward set of evidence-based practices intended to improve patient outcomes. Bundles were developed by the Institute for Healthcare Improvement to help health care providers more reliably deliver the best possible care for patients.

Learn more about bundles.

Education and Training

Printed Information

See the Getting Ahead of Sepsis section for patient and clinician information including

  • Factsheets
  • Brochures
  • Infographics
  • Videos

Healthcare Professional Continuing Education

CDC, in collaboration with various clinical partners, presents the webinar series, Tune in to Safe Healthcare, focusing on a variety of infection control and prevention topics. Webinars are offered free of cost and provide an opportunity to earn continuing education.

  • Sepsis Standard Work: Improving Compliance with Early Recognition and Management of Perinatal Sepsis
  • Empowering Nurses for Early Sepsis Recognition
  • Advances in Sepsis: Protecting Patients Throughout the Lifespan

Infection Control Guidelines

See the Infection Control Guideline Library

Medical Bibliography


Selected textbook and journal articles on sepsis.

  • Angus, DC, van der Poll, T. Severe Sepsis and Septic Shock. N Engl J Med 2013;369:840-51.
  • Ely E, Goyotte RE. Chapter 46. Sepsis with Acute Organ Dysfunction. In: Hall JB, Schmidt GA, Wood LH. eds. Principles of Critical Care, 3e. New York, NY: McGraw-Hill; 2005.
  • Felner K, Smith RL. Chapter 138. Sepsis. In: McKean SC, Ross JJ, Dressler DD, Brotman DJ, Ginsberg JS. eds. Principles and Practice of Hospital Medicine. New York, NY: McGraw-Hill; 2012.
  • Jui J. Chapter 146. Septic Shock. In: Tintinalli JE, Stapczynski J, Ma O, Cline DM, Cydulka RK, Meckler GD, T. eds. Tintinalli’s Emergency Medicine: A Comprehensive Study Guide, 7e. New York, NY: McGraw-Hill; 2011.
  • Munford RS. Chapter 271. Severe Sepsis and Septic Shock. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson J, Loscalzo J. eds. Harrison’s Principles of Internal Medicine, 18e. New York, NY: McGraw-Hill; 2012.
  • Munford RS, Suffredini AF. Chapter 70. Sepsis, Severe Sepsis, and Septic Shock. In: Mandell GL, Bennett JE, Dolin R. eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. Philadelphia, PA: Elsevier; 2010
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