CDC recommends routine pneumococcal vaccination for all children aged <2 years and older adults aged ≥65 years. CDC also recommends clinicians vaccinate older children and adults who are at increased risk for pneumococcal disease. See Pneumococcal Vaccination: Information for Healthcare Professionals for information on all pneumococcal vaccine recommendations by vaccine, age, and indication.


In general, CDC does not recommend chemoprophylaxis for close contacts of patients with pneumococcal disease. Secondary cases of invasive pneumococcal infection are uncommon.

The American Academy of Pediatrics typically recommends daily antimicrobial prophylaxis with oral penicillin V for children with functional or anatomic asplenia, especially those with sickle-cell disease. In general, clinicians should consider antimicrobial prophylaxis (in addition to immunization) for all children with asplenia younger than 5 years of age and for at least 1 year after splenectomy.


American Academy of Pediatrics. Antimicrobial therapy for treatment and prophylaxis. In: Kimberlin DW, Brady MT, Jackson MA, Long SS, eds. Red Book: 2018 Report of the Committee on Infectious Diseases, 31st ed. Elk Grove Village, IL; 2018.

Related Links
Expert Commentary

CDC, Medscape from WebMD

CDC-Medscape video: Updated Pneumococcal Vaccine Recommendations for Older Adults

CDC Commentary – Updated Recommendations for PCV13 Use in Older Adultsexternal icon

Running Time: 5:08 mins
Date Released: 01/31/2020

Learn about considerations for this new shared clinical decision-making recommendation.

Page last reviewed: September 1, 2020