CAS No. 67-66-3
Chloroform (CHCl3) is a colorless liquid that quickly evaporates into gas. It can harm the eyes, skin, liver, kidneys, and nervous system. Chloroform can be toxic if inhaled or swallowed. Exposure to chloroform may also cause cancer. Workers may be harmed from exposure to chloroform. The level of exposure depends upon the dose, duration, and work being done.
Chloroform is used in many industries. It is released from pulp and paper mills, hazardous waste sites, chlorinated water, and certain landfills. Chloroform is used in some refrigerants, solvents, and chemical manufacturing. Some examples of workers at risk of being exposed to chloroform include the following:
- Workers involved in paper manufacture or recycle industries
- Service employees exposed to some air conditioner refrigerants
- Equipment operators working at sanitary landfills
- Workers who work in water treatment plants
NIOSH recommends that employers use Hierarchy of Controls to prevent injuries. If you work in an industry that uses chloroform, please read chemical labels and the accompanying Safety Data Sheets for hazard information. Visit NIOSH’s page on Managing Chemical Safety in the Workplace to learn more about controlling chemical workplace exposures.
The following resources provide information about occupational exposure to chloroform. Useful search terms for chloroform include “methane trichloride” and “trichloromethane.”
The NIOSH Pocket Guide to Chemical Hazards (NPG) helps workers, employers, and occupational health professionals recognize and control workplace chemical hazards.
The NIOSH Manual of Analytical Methods (NMAM) is a collection of methods for sampling and analysis of contaminants in workplace air, and in the blood and urine of workers who are occupationally exposed.
- NIOSHTIC-2 search results on chloroform—NIOSHTIC-2 is a searchable database of worker safety and health publications, documents, grant reports, and journal articles supported in whole or in part by NIOSH.
- Immediately Dangerous to Life or Health Concentrations (IDLH) Value Profile: Chloroform—NIOSH reviews relevant scientific data and researches methods for developing IDLH values.
- NIOSH Worker Health Study Summaries—NIOSH conducts research to prevent illnesses and injuries in the workplace. The NIOSH Worker Notification Program notifies workers and other stakeholders about the findings of these research studies.
- NIOSH Criteria for a Recommended Standard: Occupational Exposure to Chloroform—DHHS (NIOSH) Publication No. 75-114. This report increases awareness and recommends work practices to reduce exposures.
- NIOSH Revised Recommended Chloroform Standard
- Occupational Health Guideline for Chloroform—This guideline is intended as a source of information for employees, employers, and those in the health professions who need more information on exposure to chloroform.
- Hydrocarbons, Halogenated No. 1009—Sampling and measurement from NMAM, fourth edition
- ATSDR ToxFAQs for Chloroform
- ATSDR Toxic Substance Portal: Chloroform
- ATSDR Toxicological Profile for Chloroform
- EPA Acute Exposure Guideline Levels (AEGLs): Chloroformexternal icon
- EPA Chemistry Dashboard: Chloroformexternal icon
- EPA Hazard Summary: Chloroformexternal icon
- EPA Integrated Risk Information System (IRIS): Chloroformexternal icon
- IARC Monographs Vol. 73: Chloroformexternal icon
- NLM Haz-Map: Chloroformexternal icon
- NLM TOXNET: Chloroformexternal icon
- NTP Report on Carcinogens, Fourteenth Editionexternal icon
- OSHA Hazard Communicationexternal icon
- OSHA Health and Safety Topics: Waste Anesthetic Gasesexternal icon
- OSHA Sampling and Analytical Method: Chloroformexternal icon
- New Jersey Hazardous Substance Fact Sheets: Chloroformexternal icon
- European Chemicals Agency (ECHA): Chloroformexternal icon
- Gestis Substance Databaseexternal icon
- International Chemical Safety Card: Chloroformexternal icon
- IPCS INCHEM Health and Safety Guide No. 87: Chloroformexternal icon
- IPCS INCHEM Poison Information Monograph No. 121: Chloroformexternal icon
- OECD Global Portal to Information on Chemical Substances external icon
- WHO CICAD No. 58: Chloroformexternal icon