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Registry of Toxic Effects of Chemical Substances (RTECS)

Valeraldehyde

RTECS #

YV3600000

CAS #

110-62-3

Updated

December 2016

Molecular Weight

86.15

Molecular Formula

C5H10O

Synonyms

Amyl aldehyde
Butyl formal
n-Pentanal
n-Valeraldehyde
n-Valeraldehyde (ACGIH)
n-Valeric aldehyde
Pentanal
Valeral
Valerianic aldehyde
Valeric acid aldehyde
Valeric aldehyde
Valerylaldehyde

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H severeFCTXAV 17,919,1979
skin /guinea pig 100% severeFCTXAV 17,919,1979
skin /rabbit 500 mg/24H moderateFCTXAV 17,919,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellslung/hamster10 mmol/LMUTAEX 4,277,1989
Unscheduled DNA Synthesisliver/rat3 µmol/LMUREAV 323,121,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, lung tumor Inhibitor Concentration (20 percent kill): 1.7 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 334,111,2015
In Vitro/Human, lung tumor Inhibitor Concentration (10 percent kill): 1 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 334,111,2015
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 0.75 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 334,111,2015
In Vitro/Human, lung tumor Inhibitor Concentration Low: 0.75 mmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXCYAC 334,111,2015
inhalation/rat lethal concentration (50 percent kill): 14000 mg/m3/4HVCVGK* -,376,1984
inhalation/rat Lowest published lethal concentration: 4000 ppm/4HAIHAAP 30,470,1969
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Behavioral: Ataxia
NTIS** OTS0533619
intraperitoneal/rat lethal dose (50 percent kill): 400 mg/kgBehavioral: Muscle weakness

Behavioral: Ataxia
NTIS** OTS0533619
oral/mouse lethal dose (50 percent kill): 6.4 mg/kgVCVGK* -,376,1984
oral/rat lethal dose (50 percent kill): 5.66 mg/kgVCVGK* -,376,1984
oral/rat lethal dose (50 percent kill): 5660 µL/kgAIHAAP 30,470,1969
skin/guinea pig lethal dose (50 percent kill): 20 gm/kgFCTXAV 17,919,1979
skin/rabbit lethal dose (50 percent kill): 5 mL/kgSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0535072
subcutaneous/mouse lowest published lethal dose: 2 gm/kgAPFRAD 14,710,1956

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 199,203,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (176 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (175 mg/m3);KZW 100 ppm (350 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (179 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (175 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 30 ppm (110 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (175 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (175 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (175 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (175 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (176 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.3 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (176 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 50 ppm (175 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 175 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-VALERALDEHYDE-air10H time-weighted average 50 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code B0122; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 5; Total Number of Employees Exposed 1557; Total Number of Female Employees Exposed 276

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
NIOSH Analytical Method, 1994: Valeraldehyde, 2536
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
OSHA ANALYTICAL METHOD #85
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