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Registry of Toxic Effects of Chemical Substances (RTECS)

Triethylamine

RTECS #

YE0175000

CAS #

121-44-8

Updated

September 2013

Molecular Weight

101.22

Molecular Formula

C6H15N

Synonyms

(Diethylamino)ethane
Ethanamine, N,N-diethyl-
N,N-Diethylethanamine
TEN
Triaethylamin (German)
Triethylamine (ACGIH:OSHA)
Trietilamina (Italian)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 365 mg open irritation test mildUCDS** 3/23/1970

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisinhalation/rat1 mg/m3GISAAA 36(11),9,1971

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 7.3 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/guinea pig Lowest published lethal concentration: 1000 ppm/4HJIHTAB 30,2,1948
inhalation/human lowest published toxic concentration: 12 mg/m3/11W- continuousEye: Visual field changesIAEHDW 57,297,1986
inhalation/human lowest published toxic concentration: 6500 µg/m3/4HEye: Visual field changes

Eye: Corneal damage

Eye: Other eye effects
OEMEEM 56,1,1999
inhalation/human lowest published toxic concentration: 20 mg/m3/8HEye: Corneal damageWDZAEK 4,45,1990
inhalation/mammal (species unspecified) lowest published toxic concentration: 0.1 gm/m3Eye: Lacrimation

Eye: Conjunctiva irritation
TPKVAL 7,56,1965
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 6 gm/m3TPKVAL 14,80,1975
inhalation/mouse lowest published toxic concentration: 0.5 gm/m3Eye: Corneal damageTPKVAL 7,56,1965
inhalation/mouse Lowest published lethal concentration: 5 gm/m3Lung, Thorax, or Respiration: Respiratory depression

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 7,56,1965
inhalation/mouse lethal concentration (50 percent kill): 6 gm/m3Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Fatty liver degeneration
TPKVAL 7,56,1965
inhalation/rat Lowest published lethal concentration: 6 gm/m3Vascular: Other changes

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 7,56,1965
inhalation/rat lowest published toxic concentration: 0.2 gm/m3Skin: After systemic exposure: Dermatitis, otherTPKVAL 7,56,1965
inhalation/rat Lowest published lethal concentration: 1000 ppm/4HAMIHBC 4,119,1951
intraperitoneal/mouse lethal dose (50 percent kill): 405 mg/kgYKKZAJ 97,1117,1977
intraperitoneal/rat lowest published lethal dose: 75 mg/kgFATOAO 31,238,1968
ocular/rabbit lowest published toxic dose: 100 pphEye: Lacrimation

Eye: Conjunctiva irritation
TPKVAL 7,56,1965
oral/mouse lethal dose (50 percent kill): 546 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle weakness
HYSAAV 30(7-9),351,1965
oral/rat lethal dose (50 percent kill): 460 mg/kgAMIHBC 4,119,1951
skin/rabbit lethal dose (50 percent kill): 570 µL/kgAMIHBC 4,119,1951

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 3 mg/m3/3H/26W- intermittentLung, Thorax, or Respiration: Other changesWDZAEK 4,45,1990
inhalation/rabbit lowest published toxic concentration: 420 mg/m3/7H/6W- intermittentCardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
WDZAEK 4,45,1990
inhalation/rat lowest published toxic concentration: 1 gm/m3/2W- intermittentEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 7,56,1965
inhalation/rat lowest published toxic concentration: 0.05 gm/m3/0.5Y- intermittentLiver: Other changes

Blood: Changes in spleen

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TPKVAL 7,56,1965
inhalation/rat lowest published toxic concentration: 0.05 gm/m3/30D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Blood: Other changes
TPKVAL 7,56,1965
inhalation/rat lowest published toxic concentration: 0.05 gm/m3/20D- intermittentBehavioral: Alteration of classical conditioningTPKVAL 7,56,1965
oral/rat lowest published toxic dose: 4223 mg/kg/11W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainGISAAA 30(9),28,1965
oral/rat lowest published toxic dose: 210 mg/kg/30W- intermittentBrain and Coverings: Other degenerative changesWDZAEK 4,45,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppm;short term exposure limit 3 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 25 ppm (100 mg/m3)DTLVS* 3,268,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (8 mg/m3), short term exposure limit 4 ppm (17 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 ppm (8.4 mg/m3);KZW 3 ppm (12.6 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (4.2 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 3 ppm (12.6 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (4.1 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 8.4 mg/m3 (2 ppm);short term exposure limit 12.6 mg/m3 (3 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDshort term exposure limit 1 ppm (4.2 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (8.4 mg/m3), VLE 3 ppm (12.6 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 1 ppm (4.2 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 8.4 mg/m3, short term exposure limit 12.6 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (8.4 mg/m3), short term exposure limit 3 ppm (12.6 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (40 mg/m3), short term exposure limit 15 ppm (60 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 25 ppm (100 mg/m3);short term exposure limit 40 ppm (160 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 3 ppm (12 mg/m3), short term exposure limit 5 ppm (20 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (4,1 mg/m3); short term exposure limit 3 ppm (12,4 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (4.2 mg/m3), KZG-week 2 ppm (8.4 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 20 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 25 ppm (100 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 25 ppm (100 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2 ppm (8 mg/m3);short term exposure limit 4 ppm (17 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 25 ppm (100 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 25 ppm (100 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 25 ppm (100 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 25 ppm (100 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X6415; Number of Industries 1; Total Number of Facilities 5; Number of Occupations 1; Total Number of Employees Exposed 622; Total Number of Female Employees Exposed 55
National Occupational Exposure Survey 1983Hazard Code 74175; Number of Industries 74; Total Number of Facilities 3153; Number of Occupations 52; Total Number of Employees Exposed 68091; Total Number of Female Employees Exposed 9701
National Occupational Hazard Survey 1974Hazard Code 74175; Number of Industries 15; Total Number of Facilities 959; Number of Occupations 21; Total Number of Employees Exposed 10558

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000
On EPA IRIS database
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