Triethylamine

RTECS #

YE0175000

CAS #

121-44-8
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

101.22

Molecular Formula

C₆H₁₅N

Synonyms

(Diethylamino)ethane
Ethanamine, N,N-diethyl-
N,N-Diethylethanamine
TEN
Triaethylamin (German)
Triethylamine (ACGIH:OSHA)
Trietilamina (Italian)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	365 mg open irritation test	mild	UCDS** 3/23/1970

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	inhalation/rat	1 mg/m³	GISAAA 36(11),9,1971

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 7.3 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
inhalation/guinea pig	Lowest published lethal concentration: 1000 ppm/4H		JIHTAB 30,2,1948
inhalation/human	lowest published toxic concentration: 12 mg/m³/11W- continuous	Eye: Visual field changes	IAEHDW 57,297,1986
inhalation/human	lowest published toxic concentration: 6500 µg/m³/4H	Eye: Visual field changes Eye: Corneal damage Eye: Other eye effects	OEMEEM 56,1,1999
inhalation/human	lowest published toxic concentration: 20 mg/m³/8H	Eye: Corneal damage	WDZAEK 4,45,1990
inhalation/mammal (species unspecified)	lowest published toxic concentration: 0.1 gm/m³	Eye: Lacrimation Eye: Conjunctiva irritation	TPKVAL 7,56,1965
inhalation/mammal (species unspecified)	lethal concentration (50 percent kill): 6 gm/m³		TPKVAL 14,80,1975
inhalation/mouse	lowest published toxic concentration: 0.5 gm/m³	Eye: Corneal damage	TPKVAL 7,56,1965
inhalation/mouse	Lowest published lethal concentration: 5 gm/m³	Lung, Thorax, or Respiration: Respiratory depression Liver: Fatty liver degeneration Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	TPKVAL 7,56,1965
inhalation/mouse	lethal concentration (50 percent kill): 6 gm/m³	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Other changes Liver: Fatty liver degeneration	TPKVAL 7,56,1965
inhalation/rat	Lowest published lethal concentration: 6 gm/m³	Vascular: Other changes Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Respiratory depression	TPKVAL 7,56,1965
inhalation/rat	lowest published toxic concentration: 0.2 gm/m³	Skin: After systemic exposure: Dermatitis, other	TPKVAL 7,56,1965
inhalation/rat	Lowest published lethal concentration: 1000 ppm/4H		AMIHBC 4,119,1951
intraperitoneal/mouse	lethal dose (50 percent kill): 405 mg/kg		YKKZAJ 97,1117,1977
intraperitoneal/rat	lowest published lethal dose: 75 mg/kg		FATOAO 31,238,1968
ocular/rabbit	lowest published toxic dose: 100 pph	Eye: Lacrimation Eye: Conjunctiva irritation	TPKVAL 7,56,1965
oral/mouse	lethal dose (50 percent kill): 546 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Excitement Behavioral: Muscle weakness	HYSAAV 30(7-9),351,1965
oral/rat	lethal dose (50 percent kill): 460 mg/kg		AMIHBC 4,119,1951
skin/rabbit	lethal dose (50 percent kill): 570 µL/kg		AMIHBC 4,119,1951

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 3 mg/m³/3H/26W- intermittent	Lung, Thorax, or Respiration: Other changes	WDZAEK 4,45,1990
inhalation/rabbit	lowest published toxic concentration: 420 mg/m³/7H/6W- intermittent	Cardiac: Other changes Lung, Thorax, or Respiration: Other changes Liver: Other changes	WDZAEK 4,45,1990
inhalation/rat	lowest published toxic concentration: 1 gm/m³/2W- intermittent	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi	TPKVAL 7,56,1965
inhalation/rat	lowest published toxic concentration: 0.05 gm/m³/0.5Y- intermittent	Liver: Other changes Blood: Changes in spleen Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TPKVAL 7,56,1965
inhalation/rat	lowest published toxic concentration: 0.05 gm/m³/30D- intermittent	Peripheral Nerve and Sensation: Recording from peripheral motor nerve Blood: Other changes	TPKVAL 7,56,1965
inhalation/rat	lowest published toxic concentration: 0.05 gm/m³/20D- intermittent	Behavioral: Alteration of classical conditioning	TPKVAL 7,56,1965
oral/rat	lowest published toxic dose: 4223 mg/kg/11W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	GISAAA 30(9),28,1965
oral/rat	lowest published toxic dose: 210 mg/kg/30W- intermittent	Brain and Coverings: Other degenerative changes	WDZAEK 4,45,1990

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 ppm;short term exposure limit 3 ppm (skin)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 25 ppm (100 mg/m³)	DTLVS* 3,268,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 2 ppm (8 mg/m³), short term exposure limit 4 ppm (17 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 2 ppm (8.4 mg/m³);KZW 3 ppm (12.6 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 ppm (4.2 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 3 ppm (12.6 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 ppm (4.1 mg/m³), skin, MAY2011
Occupational Exposure Limit-EC	time-weighted average 8.4 mg/m³ (2 ppm);short term exposure limit 12.6 mg/m³ (3 ppm), skin, JUN2000
Occupational Exposure Limit-FINLAND	short term exposure limit 1 ppm (4.2 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 2 ppm (8.4 mg/m³), VLE 3 ppm (12.6 mg/m³), Skin, FEB2006
Occupational Exposure Limit-GERMANY	MAK 1 ppm (4.2 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 8.4 mg/m³, short term exposure limit 12.6 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 2 ppm (8.4 mg/m³), short term exposure limit 3 ppm (12.6 mg/m³), skin, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 10 ppm (40 mg/m³), short term exposure limit 15 ppm (60 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 25 ppm (100 mg/m³);short term exposure limit 40 ppm (160 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 3 ppm (12 mg/m³), short term exposure limit 5 ppm (20 mg/m³), skin, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 10 ppm (40 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 1 ppm (4,1 mg/m³); short term exposure limit 3 ppm (12,4 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 10 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 1 ppm (4.2 mg/m³), KZG-week 2 ppm (8.4 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 20 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 25 ppm (100 mg/m³), JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 25 ppm (100 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 2 ppm (8 mg/m³);short term exposure limit 4 ppm (17 mg/m³), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 25 ppm (100 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 25 ppm (100 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 25 ppm (100 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 25 ppm (100 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code X6415; Number of Industries 1; Total Number of Facilities 5; Number of Occupations 1; Total Number of Employees Exposed 622; Total Number of Female Employees Exposed 55
National Occupational Exposure Survey 1983	Hazard Code 74175; Number of Industries 74; Total Number of Facilities 3153; Number of Occupations 52; Total Number of Employees Exposed 68091; Total Number of Female Employees Exposed 9701
National Occupational Hazard Survey 1974	Hazard Code 74175; Number of Industries 15; Total Number of Facilities 959; Number of Occupations 21; Total Number of Employees Exposed 10558

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health