Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

s-Triazine, 2-chloro-4-ethylamino-6-isopropylamino-

RTECS #

XY5600000

CAS #

1912-24-9; 11121-31-6; 12040-45-8; 12797-72-7; 39400-72-1; 69771-31-9; 93616-39-8

Updated

October 2017

Molecular Weight

215.72

Molecular Formula

C8H14ClN5

Synonyms

1,3,5-Triazine-2,4-diamine, 6-chloro-N-ethyl-N'-(1-methylethyl)- (9CI)
1-Chloro-3-ethylamino-5-isopropylamino-2,4,6-triazine
1-Chloro-3-ethylamino-5-isopropylamino-s-triazine
2-Aethylamino-4-chlor-6-isopropylamino-1,3,5-triazin (German)
2-Aethylamino-4-isopropylamino-6-chlor-1,3,5-triazin (German)
2-Chloro-4-(2-propylamino)-6-ethylamino-s-triazine
2-Chloro-4-ethylamineisopropylamine-s-triazine
2-Chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine
2-Chloro-4-ethylamino-6-isopropylamino-s-triazine
6-Chloro-N-ethyl-N'-(1-methylethyl)-1,3,5-triazine-2,4-diamine
6-Chloro-N-ethyl-N9-(1-methylethyl)-1,3,5-triazine-2,4-diamine
A 361
Aatram 20G
Aatrex
Aatrex 4L
Aatrex 80W
Aatrex nine-O
Aktikon
Aktikon PK
Aktinit A
Aktinit PK
Aneldazin
Argezin
Atrataf
Atrazin
Atrazine
Atrazine (ACGIH)
Azoprim
Ceasin 50
Cekuzina-T
Chromozin
Cyazin
G 30027
Geigy 30,027
Gesaprim
Herbatoxol
Hungazin
Hungazin PK
Oleogesaprim
Primatol A
Radazin
Technical atrazine
Technical grade atrazine
Triazine A 1294
Vectal
Vectal SC
Weedex A
Wonuk
Zeapos
Zeazin
Zeazine
Zeopos

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /mammal (species unspecified) 100 mg severeVRDEA5 (5),133,1977
eye /rabbit 6320 µg severeCIGET* -,-,1977
skin /mammal (species unspecified) 500 mg mildVRDEA5 (5),133,1977
skin /rabbit 38 mg open irritation test mildCIGET* -,-,1977

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human1 mg/LMUREAV 281,295,1992
Cytogenetic Analysisoral/mouse72 mg/kg/30D-continuousEMMUEG 19,77,1992
Cytogenetic Analysisoral/hamster5.0 µmol/LMUREAV 608,28,2006
DNA Damageintraperitoneal/mouse500 mg/kgMUREAV 493,1,2001
DNA Damageoral/rat2100 mg/kg/7DMUREAV 654,145,2008
DNA Damagemultiple/other fish6.25 µg/L/72H-continuousPCBPBS 90,42,2008
DNA Damagemultiple/other fish5 µg/L/2D- intermittentFCTOD7 49,1431,2011
DNA Damageoral/rat875 mg/kgMUREAV 209,145,1988
DNA Damagelymphocyte/human100 mg/LMUREAV 344,41,1995
Dominant Lethal Testparenteral/Drosophila melanogaster556 µmol/LJTEHD6 3,691,1977
Dominant Lethal Testoral/Drosophila melanogaster100 ppmJTEHD6 3,691,1977
Dominant Lethal Testoral/mouse1500 mg/kgMUREAV 74,77,1980
gene conversion and mitotic recombination/Aspergillus nidulans6 mmol/LMUREAV 74,77,1980
host-mediated assayEscherichia coli/mouse100 mg/kgMUREAV 74,77,1980
host-mediated assayEscherichia coli/rat100 mg/kgCECED9 6388,328,1980
micronucleus testmultiple/other fish5 µg/L/2D- intermittentFCTOD7 49,1431,2011
micronucleus testoral/rat2100 mg/kg/7DMUREAV 654,145,2008
micronucleus testoral/rat2100 mg/kgMUREAV 654,145,2008
micronucleus testmultiple/other fish6.25 µg/L/72H-continuousPCBPBS 90,42,2008
mutation in microorganisms/Aspergillus nidulans6 mmol/L (+enzymatic activation step)MUREAV 74,77,1980
mutation in microorganismslung/hamster3 mmol/L (+enzymatic activation step)MUREAV 74,77,1980
mutation in microorganisms/Schizosaccharomyces pombe6 mmol/L (+enzymatic activation step)MUREAV 74,77,1980
other mutation test systemsoral/mouse216 mg/kg/90D-continuousEMMUEG 19,77,1992
sex chromosome loss and nondisjunction/Neurospora crassa10 mg/LMUREAV 167,35,1986
sex chromosome loss and nondisjunctionoral/Drosophila melanogaster100 ppmJTEHD6 3,691,1977
specific locus testoral/Drosophila melanogaster5 mmol/LMUREAV 280,291,1992
sperm morphologysperm/human100 µmol/L/1HREPTED 22,508,2006
Unscheduled DNA Synthesisfibroblast/human3 mmol/LMUREAV 74,77,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 1028 mg/kg (60D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
JJATDK 20,61,2000
oral/rat 1000 mg/kg (6-10D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 15,61,2000
oral/rat 1000 mg/kg (11-15D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
REPTED 15,61,2000
oral/rat 500 mg/kg (6-10D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
REPTED 15,61,2000
oral/rat 600 mg/kg (8-10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)REPTED 15,61,2000
oral/rat 1000 mg/kg (6-10D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)REPTED 15,61,2000
oral/rat 35 mg/kg (10D preg-23D after birth)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial systemTOXID9 72,120,2003
oral/rat 200 mg/kg (6-10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TOXID9 72,77,2003
oral/rat 1260 mg/kg (10-22D preg/23D after birth)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic
TOSCF2 76,366,2003
oral/rat 500 mg/kg (15-19D pregnant)Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TXAPA9 195,23,2004
oral/rat 300 mg/kg (17-19D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TOXID9 44,230,2005
oral/rat 700 mg/kg (13-19D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TOXID9 44,230,2005
oral/rat 7 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JTEHD6 24,307,1988
oral/rat 700 mg/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JTEHD6 24,307,1988
oral/rat 720 mg/kg (10D prior to copulation)Reproductive: Other effects on female

Reproductive: Effects on newborn: Behavioral
APHHDU 83,79,1995
oral/rat 300 mg/kg (15-17D pregnant)Reproductive: Specific developmental abnormalities: Skin and skin appendagesTOXID9 78,218,2004
oral/rat 300 mg/kg (17-19D pregnant)Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Effects on newborn: Delayed effects
TOXID9 78,218,2004
oral/rat 700 mg/kg (13-19D pregnant)Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Effects on newborn: Delayed effects
TOXID9 78,218,2004
oral/rat 500 mg/kg (15-19D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 66,371,2002
oral/rat 500 mg/kg (15-19D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTOXID9 66,373,2002
oral/rabbit 975 mg/kg (7-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JTEHD6 24,307,1988
oral/rabbit 975 mg/kg (7-19D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemJTEHD6 24,307,1988
oral/rat 125 mg/kg (5D after birth)Reproductive: Specific developmental abnormalities: Urogenital systemTOSCF2 52,68,1999
oral/mouse 29 mg/kg (14-21D preg/1-21D after birth)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Behavioral
REPTED 22,263,2006
oral/rat 500 mg/kg (15-19D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Physical
TXAPA9 218,238,2007
oral/rat 500 mg/kg (15-19D pregnant)Reproductive: Effects on newborn: Delayed effectsTXAPA9 218,238,2007
oral/mouse 2900 µg/kg (14-21D preg/21D after birth)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities
TXCYAC 279,19,2011
oral/mouse 29 µg/kg (14-21D preg/21D after birth)Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Other developmental abnormalities
TXCYAC 279,19,2011
oral/mouse 123 µg/kg (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Biochemical and metabolic
TXCYAC 308,74,2013
oral/mouse 123 µg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)TXCYAC 308,74,2013
subcutaneous/mouse 616000 µg/kg (10D preg-10D after birth)Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TXAPA9 214,69,2006
subcutaneous/rat 2400 mg/kg (3-9D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)BECTA6 9,301,1973
subcutaneous/rat 6 gm/kg (3-9D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathBECTA6 9,301,1973
subcutaneous/mouse 418 mg/kg (6-14D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
NTIS** PB223-160
subcutaneous/mouse 588 mg/kg (10-21D preg/9D after birth)Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Delayed effects
TOXID9 78,10,2004
unreported route/rat 125 mg/kg (5D after birth)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 78,116,2004
unreported route/rat 500 mg/kg (15-19D pregnant)Reproductive: Effects on newborn: Other neonatal measures or effectsTOXID9 60,391,2001
unreported route/rat 875 mg/kg (14-20D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TOXID9 90,190,2006

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 9000 mg/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB223-159
oral/rat lowest published toxic dose: 36.5 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors
HBPTO* 2,1514,2001
oral/rat lowest published toxic dose: 33775 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Reproductive: Tumorigenic effects: Uterine tumors
NEOLA4 37,533,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, embryonic cells Inhibitor Concentration Low: 1 mmol/L/24HIn Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.TIVIEQ 27,995,2013
In Vitro/Human, embryonic cells Inhibitor Concentration Low: 10 pmol/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,995,2013
In Vitro/Human, endocrine tumor Inhibitor Concentration Low: 5 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,107,2012
In Vitro/Human, endocrine tumor Inhibitor Concentration (50 percent kill): 3.3 µmol/L/24HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TXAPA9 268,309,2013
In Vitro/Human, liver tumor Inhibitor Concentration Low: 50 µmol/L/48HIn Vitro Toxicity Studies: Other assaysTIVIEQ 28,156,2014
In Vitro/jvxInhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,107,2012
In Vitro/Mouse, liver Inhibitor Concentration Low: 10 µmol/L/48HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,718,2012
In Vitro/mpdInhibitor Concentration (50 percent kill): 672.8 µmol/L/4HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 76,61,2015
In Vitro/mpdInhibitor Concentration (50 percent kill): 457.1 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 76,61,2015
In Vitro/mpdInhibitor Concentration (50 percent kill): 1 µmol/L/24HImmunological Including Allergic: Decrease in cellular immune response

In Vitro Toxicity Studies: Apoptosis in vitro
FCTOD7 76,61,2015
In Vitro/ntaInhibitor Concentration Low: 0.03 µg/LIn Vitro Toxicity Studies: Other assaysFCTOD7 98,25,2016
In Vitro/Rat, endocrine tumor Inhibitor Concentration (50 percent kill): 5 µmol/L/6HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterasesTXAPA9 265,19,2012
In Vitro/Rat, endocrine tumor Inhibitor Concentration Low: 10 µmol/LEndocrine: Other changesTXAPA9 265,19,2012
In Vitro/Rat, testis Inhibitor Concentration Low: 10 µmol/L/2HEndocrine: Androgenic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
TXAPA9 265,19,2012
In Vitro/Rat, testis Inhibitor Concentration Low: 10 µmol/L/24HIn Vitro Toxicity Studies: Other assaysTIVIEQ 26,107,2012
In Vitro/Rat, testis Inhibitor Concentration Low: 232 µmol/L/6HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,700,2013
In Vitro/Rat, testis Inhibitor Concentration Low: 25 mg/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 25,1588,2011
In Vitro/Rat, testis Inhibitor Concentration Low: 50 mg/L/72HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.

In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.
TIVIEQ 25,1588,2011
inhalation/rat lethal concentration (50 percent kill): 700 mg/kgENTOX* -,188,2005
inhalation/rat lethal concentration (50 percent kill): 5200 mg/m3/4HFMCHA2 -,C29,1991
intraperitoneal/mouse lethal dose (50 percent kill): 626 mg/kgPESTD5 17,351,1976
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgEndocrine: Other changes

Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response
TOXID9 72,172,2003
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgImmunological Including Allergic: Decrease in humoral immune responseTOXID9 60,24,2001
intraperitoneal/rat lowest published toxic dose: 100 mg/kgCardiac: Arrythmias (indlucing changes in conduction)TOXID9 90,304,2006
intraperitoneal/rat lowest published toxic dose: 300 mg/kgLiver: Other changesETOPFR 12,1,2002
intraperitoneal/rat lowest published toxic dose: 100 mg/kgBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumTOXID9 44,400,2005
intraperitoneal/rat lethal dose (50 percent kill): 235 mg/kgPESTD5 17,351,1976
oral/hamster lethal dose (50 percent kill): 1 gm/kgTXAPA9 48,A192,1979
oral/mouse lethal dose (50 percent kill): 850 mg/kg85GMAT -,36,1982
oral/mouse lowest published toxic dose: 875 mg/kgEndocrine: Changes in thymus weight

Blood: Changes in spleen
TOXID9 72(Suppl 1),329,2003
oral/mouse lowest published toxic dose: 8.75 mg/kgImmunological Including Allergic: Decrease in cellular immune responseTOXID9 72(Suppl 1),329,2003
oral/rabbit lethal dose (50 percent kill): 750 mg/kgENTOX* -,188,2005
oral/rat lowest published toxic dose: 75 mg/kgEndocrine: Adrenal cortex hyperplasia

Endocrine: Other changes
TOXID9 -,18,2008
oral/rat lowest published toxic dose: 75 mg/kgEndocrine: Change in LH

Endocrine: Other changes
TOXID9 -,30,2009
oral/rat lethal dose (50 percent kill): 2 gm/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
ENTOX* -,188,2005
oral/rat lowest published toxic dose: 300 mg/kgLiver: Tumors

Tumorigenic: Facilitates action of known carcinogens
TOSCF2 53,297,2000
oral/rat lowest published toxic dose: 40 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 72,77,2003
oral/rat lethal dose (50 percent kill): 672 mg/kgFAATDF 7,299,1986
oral/rat lowest published toxic dose: 200 mg/kgEndocrine: Androgenic

Endocrine: Estrogenic

Biochemical: Metabolism (intermediary): Other
TOXID9 78,117,2004
oral/rat lowest published toxic dose: 5 mg/kgEndocrine: Other changesNETEEC 34,295,2012
oral/rat lowest published toxic dose: 200 mg/kgTaste: Change in functionNETEEC 34,295,2012
oral/rat lowest published toxic dose: 50 mg/kgBehavioral: Food intake (animal)NETEEC 34,295,2012
skin/rabbit lethal dose (50 percent kill): 7500 mg/kg28ZEAL 5,15,1976
skin/rat lethal dose (50 percent kill): >12500 mg/kgGISAAA 55(7),87,1990
skin/rat lethal dose (50 percent kill): 3 gm/kgBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
ENTOX* -,188,2005
Tank with water/Carp lowest published toxic concentration: 4.28 µg/L/40 DKidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
FCTOD7 62,148,2013
Tank with water/Carp lowest published toxic concentration: 42.8 µg/L/40 DKidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 62,148,2013
Tank with water/other fish lowest published toxic concentration: 0.17 mg/L/21DLiver: Other changesTIVIEQ 31,217,1995
Tank with water/Zebrafish lowest published toxic concentration: 3 µg/L/28 DBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effectsFCTOD7 61,82,2013
Tank with water/Zebrafish lowest published toxic concentration: 90 µg/L/28 DAquatic organism effects: Growth retardation

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
FCTOD7 61,82,2013
Tank with water/Zebrafish lowest published toxic concentration: 1000 µg/L/14DBehavioral: Change in psychophysiological tests

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
NETEEC 44,62,2014
Tank with water/Zebrafish lowest published toxic concentration: 3 µg/L/3DReproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Delayed effects
TXCYAC 333,156,2015
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1400 mg/kgGISAAA 44(6),81,1979

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 10 mg/m3/26W- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
KHZDAN 12,114,1969
intraperitoneal/rat lowest published toxic dose: 30 mg/kg/3D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
ETOPFR 12,1,2002
intraperitoneal/rat lowest published toxic dose: 360 mg/kg/23D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJAPTO* 20,61,2000
intraperitoneal/rat lowest published toxic dose: 1020 mg/kg/60D- intermittentEndocrine: Changes in pituitary weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Related to Chronic Data: Changes in prostate weight
JAPTO* 20,61,2000
intraperitoneal/rat lowest published toxic dose: 600 mg/kg/2W- intermittentBehavioral: Change in motor activity (specific assay)

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NRTXDN 34,82,2013
intraperitoneal/rat lowest published toxic dose: 2040 mg/kg/60D- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductJAPTO* 20,61,2000
oral/Dog lowest published toxic dose: 9100 mg/kg/52W- intermittentCardiac: Other changesHBPTO* 2,1512,2001
oral/Dog lowest published toxic dose: 9125 mg/kg/1Y- continuousCardiac: Changes in coronary arteries

Cardiac: Pulse rate increased without fall in BP

Cardiac: Other changes
NTIS** OTS0543210
oral/mouse lowest published toxic dose: 350 mg/kg/14D- intermittentEndocrine: Changes in spleen weightTXCYAC 209,15,2005
oral/mouse lowest published toxic dose: 3500 mg/kg/14D- intermittentEndocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 209,15,2005
oral/mouse lowest published toxic dose: 7000 mg/kg/14D- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 209,15,2005
oral/mouse lowest published toxic dose: 2100 mg/kg/21D- intermittentLiver: Changes in liver weightAECTCV 24,449,1993
oral/mouse lowest published toxic dose: 20.8 gm/kg/78W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1514,2001
oral/mouse lowest published toxic dose: 1750 mg/kg/14D- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine in striatumTOXID9 44,400,2005
oral/mouse lowest published toxic dose: 109.2 mg/kg/26W- intermittentBiochemical: Metabolism (intermediary): Other

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
TOXID9 90,304,2006
oral/mouse lowest published toxic dose: 7000 mg/kg/14D- intermittentBlood: Changes in erythrocyte (RBC) count

Immunological Including Allergic: Increase in cellular immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* IMM-94003
oral/mouse lowest published toxic dose: 3500 mg/kg/14D- intermittentBehavioral: Alteration of classical conditioning

Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
NTPTR* IMM-94003
oral/mouse lowest published toxic dose: 3500 mg/kg/14D- intermittentBlood: Changes in spleenNTPTR* IMM-94003
oral/mouse lowest published toxic dose: 4000 mg/kg/8D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* IMM-94002
oral/mouse lowest published toxic dose: 7500 mg/kg/15D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thymus weight
NTPTR* IMM-94002
oral/mouse lowest published toxic dose: 7500 mg/kg/15D- intermittentBlood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count

Immunological Including Allergic: Decrease in cellular immune response
NTPTR* IMM-94002
oral/mouse lowest published toxic dose: 7500 mg/kg/15D- intermittentImmunological Including Allergic: Increase in humoral responseNTPTR* IMM-94002
oral/mouse lowest published toxic dose: 375 mg/kg/15D- intermittentBlood: Changes in other cell count (unspecified)NTPTR* IMM-94002
oral/mouse lowest published toxic dose: 1250 mg/kg/10D- intermittentBehavioral: Change in psychophysiological tests

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NETEEC 39,26,2013
oral/mouse lowest published toxic dose: 50 mg/kg/10D- intermittentBiochemical: Metabolism (intermediary): OtherTXCYAC 326,130,2014
oral/mouse lowest published toxic dose: 14000 µg/kg/20W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 225,392,2014
oral/mouse lowest published toxic dose: 1125 mg/kg/9D- intermittentBehavioral: Change in psychophysiological testsNETEEC 39,26,2013
oral/mouse lowest published toxic dose: 500 mg/kg/4D- intermittentBehavioral: Change in motor activity (specific assay)NETEEC 39,26,2013
oral/pig lowest published toxic dose: 38 mg/kg/19D- intermittentEndocrine: Change in LH

Endocrine: Effect on menstrual cycle
TOLED5 85,9,1996
oral/pig lowest published toxic dose: 20 mg/kg/20D- continuousEndocrine: Change in LH

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXAPA9 197,351,2004
oral/rat lowest published toxic dose: 800 mg/kg/4D- intermittentEndocrine: Estrogenic

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Metabolism (intermediary): Other
TOXID9 78,117,2004
oral/rat lowest published toxic dose: 6 gm/kg/30D- intermittentEndocrine: Other changes

Related to Chronic Data: Changes in prostate weight
TOXID9 54,366,2000
oral/rat lowest published toxic dose: 33572 mg/kg/22W- intermittentLiver: Other changes

Blood: Pigmented or nucleated red blood cells

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
KHZDAN 12,114,1969
oral/rat lowest published toxic dose: 2800 mg/kg/14D- intermittentKidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes
BECTA6 36,325,1986
oral/rat lowest published toxic dose: 900 mg/kg/9D- intermittentReproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight
RTOPDW 35,468,2002
oral/rat lowest published toxic dose: 750 mg/kg/25D- intermittentReproductive: Maternal effects: Uterus, cervix, vaginaRTOPDW 35,468,2002
oral/rat lowest published toxic dose: 800 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTXCYAC 195,177,2004
oral/rat lowest published toxic dose: 4200 mg/kg/7D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
JJATDK 7,373,1987
oral/rat lowest published toxic dose: 14.6 gm/kg/2Y- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1514,2001
oral/rat lowest published toxic dose: 150 mg/kg/3D- intermittentEndocrine: AndrogenicREPTED 16,275,2002
oral/rat lowest published toxic dose: 1350 mg/kg/27D- intermittentEndocrine: AndrogenicREPTED 16,275,2002
oral/rat lowest published toxic dose: 420 mg/kg/7D- intermittentEndocrine: AndrogenicJSTBBK 33,141,1989
oral/rat lowest published toxic dose: 300 mg/kg/3D- intermittentBlood: Changes in leukocyte (WBC) countHBPTO* 1,777,2001
oral/rat lowest published toxic dose: 1440 mg/kg/6D- intermittentEndocrine: Evidence of thyroid hypofunctionBESCE5 9,60,1996
oral/rat lowest published toxic dose: 318.5 mg/kg/13W- continuousEndocrine: EstrogenicJTEHD6 43,169,1994
oral/rat lowest published toxic dose: 5460 mg/kg/39W- continuousEndocrine: Other changesJTEHD6 43,169,1994
oral/rat lowest published toxic dose: 910 mg/kg/13W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainJTEHD6 43,169,1994
oral/rat lowest published toxic dose: 14700 mg/kg/105W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJTEHD6 43,169,1994
oral/rat lowest published toxic dose: 105 mg/kg/30D- continuousEndocrine: Effect on menstrual cycleJTEHD6 43,169,1994
oral/rat lowest published toxic dose: 315 mg/kg/90D- continuousEndocrine: EstrogenicJTEHD6 43,169,1994
oral/rat lowest published toxic dose: 800 mg/kg/40W- continuousEndocrine: Change in gonadotropinsJTEHD6 43,169,1994
oral/rat lowest published toxic dose: 14700 mg/kg/105W- continuousEndocrine: TumorsJTEHD6 43,169,1994
oral/rat lowest published toxic dose: 7280 mg/kg/52W- continuousEndocrine: TumorsJTEHD6 43,169,1994
oral/rat lowest published toxic dose: 1500 mg/kg/5D- intermittentEndocrine: Change in LHTOXID9 72,133,2003
oral/rat lowest published toxic dose: 1572.2 mg/kg/2W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainFCTOD7 41,1811,2003
oral/rat lowest published toxic dose: 18.87 gm/kg/24W- continuousBehavioral: Food intake (animal)

Brain and Coverings: Changes in brain weight

Related to Chronic Data: Changes in testicular weight
FCTOD7 41,1811,2003
oral/rat lowest published toxic dose: 3825 mg/kg/21D- intermittentReproductive: Maternal effects: Menstrual cycle changes or disordersREPTED 10,257,1996
oral/rat lowest published toxic dose: 250 mg/kg/5D- intermittentEndocrine: Other changesTOSCF2 52,68,1999
oral/rat lowest published toxic dose: 4200 mg/kg/21D- intermittentEndocrine: Estrogenic

Endocrine: Differential effect of sex or castration on observed toxicity

Biochemical: Metabolism (intermediary): Other
TOXID9 78,117,2004
oral/rat lowest published toxic dose: 18.75 mg/kg/3D- intermittentEndocrine: Change in LHTOXID9 44,353,2005
oral/rat lowest published toxic dose: 225 mg/kg/3D- intermittentEndocrine: Other changesTOXID9 44,353,2005
oral/rat lowest published toxic dose: 910 mg/kg/0.5Y- continuousBiochemical: Neurotransmitters or modulators (putative): Dopamine at other sitesTOXID9 78,277,2004
oral/rat lowest published toxic dose: 1820 mg/kg/0.5Y- continuousBehavioral: Change in motor activity (specific assay)

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
TOXID9 78,277,2004
oral/rat lowest published toxic dose: 3150 mg/kg/21D- intermittentEndocrine: Change in LH

Endocrine: Other changes
TOSCF2 53,297,2000
oral/rat lowest published toxic dose: 1575 mg/kg/21D- intermittentEndocrine: Change in LHTOSCF2 53,297,2000
oral/rat lowest published toxic dose: 900 mg/kg/3D- intermittentReproductive: Maternal effects: OogenesisTOSCF2 53,297,2000
oral/rat lowest published toxic dose: 125 mg/kg/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainREPTED 15,61,2000
oral/rat lowest published toxic dose: 600 mg/kg/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldREPTED 15,61,2000
oral/rat lowest published toxic dose: 300 mg/kg/3D- intermittentBehavioral: Alteration of classical conditioningTOXID9 44,230,2005
oral/rat lowest published toxic dose: 3640 mg/kg/0.5Y- continuousEndocrine: Change in LHTOXID9 60,321,2001
oral/rat lowest published toxic dose: 50 mg/kg/4D- intermittentEndocrine: Adrenal cortex hyperplasiaTOXID9 -,18,2008
oral/rat lowest published toxic dose: 400 mg/kg/8D- intermittentReproductive: Maternal effects: Ovaries, fallopian tubes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 58,135,2000
oral/rat lowest published toxic dose: 800 mg/kg/8D- intermittentEndocrine: Change in LH

Endocrine: Other changes

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
TOSCF2 58,135,2000
oral/rat lowest published toxic dose: 800 mg/kg/8D- intermittentReproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOSCF2 58,135,2000
oral/rat lowest published toxic dose: 1600 mg/kg/8D- intermittentEndocrine: EstrogenicTOSCF2 58,135,2000
oral/rat lowest published toxic dose: 150 mg/kg/3D- intermittentEndocrine: Estrogenic

Endocrine: Other changes
TOXID9 -,121,2009
oral/rat lowest published toxic dose: 420 mg/kg/2W- intermittentEye: LacrimationJTSCDR 34,SP147,2009
oral/rat lowest published toxic dose: 4200 mg/kg/2W- intermittentReproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Menstrual cycle changes or disorders

Related to Chronic Data: Changes in ovarian weight
JTSCDR 34,SP147,2009
oral/rat lowest published toxic dose: 840 mg/kg/4W- intermittentEye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Reproductive: Maternal effects: Menstrual cycle changes or disorders
JTSCDR 34,SP147,2009
oral/rat lowest published toxic dose: 8400 mg/kg/4W- intermittentReproductive: Maternal effects: Menstrual cycle changes or disorders

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight
JTSCDR 34,SP147,2009
oral/rat lowest published toxic dose: 2440 mg/kg/244D- continuousBehavioral: Change in motor activity (specific assay)NETEEC 33,263,2011
oral/rat lowest published toxic dose: 150 mg/kg/3D- intermittentEndocrine: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
HBPTO* 1,738,2001
oral/rat lowest published toxic dose: 2970 mg/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHBPTO* 2,1512,2001
oral/rat lowest published toxic dose: 1400 mg/kg/14D- intermittentEndocrine: Estrogenic

Endocrine: Effect on menstrual cycle

Blood: Other changes
JTEHD6 43,155,1994
oral/rat lowest published toxic dose: 4200 mg/kg/14D- intermittentEndocrine: Other changes

Blood: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina
JTEHD6 43,155,1994
oral/rat lowest published toxic dose: 600 mg/kg/2D- intermittentReproductive: Maternal effects: Uterus, cervix, vagina

Tumorigenic: Cells (cultured) transformed
JTEHF8 43,183,1994
oral/rat lowest published toxic dose: 300 mg/kg/4D- intermittentEndocrine: Adrenal cortex hyperplasia

Endocrine: Other changes
TOXID9 -,18,2008
oral/rat lowest published toxic dose: 400 mg/kg/4D- intermittentEndocrine: Change in LH

Endocrine: Change in gonadotropins

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 -,271,2008
oral/rat lowest published toxic dose: 800 mg/kg/4D- intermittentEndocrine: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 12,471,2008
oral/rat lowest published toxic dose: 98 mg/kg/4W- continuousEndocrine: Effect on menstrual cycleJTEHD6 43,169,1994
oral/rat lowest published toxic dose: 7280 mg/kg/52W- continuousSkin and Appendages: Other: BreastJTEHD6 43,169,1994
oral/rat lowest published toxic dose: 4200 mg/kg/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJTEHD6 43,155,1994
oral/rat lowest published toxic dose: 1400 mg/kg/14D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight
JTEHD6 43,155,1994
oral/rat lowest published toxic dose: 3350 mg/kg/335D- continuousBehavioral: Alteration of classical conditioningNETEEC 33,263,2011
oral/rat lowest published toxic dose: 3650 mg/kg/1Y- continuousBehavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NETEEC 33,263,2011
oral/rat lowest published toxic dose: 3650 mg/kg/365D- continuousBehavioral: Change in motor activity (specific assay)

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NETEEC 40,59,2013
oral/rat lowest published toxic dose: 145600 mg/kg/104W- continuousEndocrine: Tumors

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)
HBPTO* 1,738,2001
skin/rabbit lowest published toxic dose: 25 gm/kg/25D- continuousBlood: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0555001
subcutaneous/rat lowest published toxic dose: 45 mg/kg/3W- intermittentGastrointestinal: Other changes

Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other
LIFSAK 69,901,2001
unreported route/rat lowest published toxic dose: 1500 mg/kg/5D- intermittentEndocrine: Change in LH

Endocrine: Estrogenic
TOXID9 66,339,2002
unreported route/rat lowest published toxic dose: 1575 mg/kg/21D- continuousEndocrine: Estrogenic

Endocrine: Other changes

Reproductive: Maternal effects: Menstrual cycle changes or disorders
HBPTO* 1,738,2001
unreported route/rat lowest published toxic dose: 840 mg/kg/7D- continuousEndocrine: Effect on menstrual cycleHBPTO* 1,738,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 53,441,1991
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 73,59,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 53,441,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 73,59,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 73,59,1999
TOXICOLOGY REVIEWCNDQA8 10(3),43,1975
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWMUREAV 613,17,2006
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,188,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWMUREAV 658,124,2008
TOXICOLOGY REVIEWJTEHD6 7,1,2004
TOXICOLOGY REVIEWREPTED 23,337,2007
TOXICOLOGY REVIEWMUREAV 544,305,2003
TOXICOLOGY REVIEWFEREAC 72,32570,2007
TOXICOLOGY REVIEWFEREAC 72,53449,2007
TOXICOLOGY REVIEWJTPAE7 17,69,2004
TOXICOLOGY REVIEWREPTED 26,1,2008
TOXICOLOGY REVIEWITODC* -,355,2004
TOXICOLOGY REVIEWHUTOX* -,551,1996
TOXICOLOGY REVIEWMUREAV 672,10,2009
TOXICOLOGY REVIEWMUREAV 672,17,2009
TOXICOLOGY REVIEWHTOPA* 1,501,2002
TOXICOLOGY REVIEWJTSCDR 34,SP1,2009
TOXICOLOGY REVIEWFEREAC 73,37850,2008
TOXICOLOGY REVIEWFESTAS 90,911,2008
TOXICOLOGY REVIEWMUTAEX 26,19,2011
TOXICOLOGY REVIEWMUTAEX 26,223,2011
TOXICOLOGY REVIEWREPTED 31,337,2011
TOXICOLOGY REVIEWREPTED 31,327,2011
TOXICOLOGY REVIEWREPTED 38,1,2013
TOXICOLOGY REVIEWMUTAEX 23,207,2008
TOXICOLOGY REVIEWMUREAV 763,36,2014
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWTOLED5 201,152,2011
TOXICOLOGY REVIEWTOLED5 202,36,2011
TOXICOLOGY REVIEWMUTAEX 30,89,2014
TOXICOLOGY REVIEWTXCYAC 307,42,2013
TOXICOLOGY REVIEWTXCYAC 307,123,2013
TOXICOLOGY REVIEWTXCYAC 307,136,2013
TOXICOLOGY REVIEWTOLED5 230,146,2014
TOXICOLOGY REVIEWTXAPA9 268,157,2013
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,87,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 mg/m3, inhal, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 mg/m3, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 5 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 2 mg/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 2 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 2 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ATRAZINE-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 18420; Number of Industries 1; Total Number of Facilities 44; Number of Occupations 9; Total Number of Employees Exposed 1001; Total Number of Female Employees Exposed 123
National Occupational Hazard Survey 1974Hazard Code 18420; Number of Industries 1; Total Number of Facilities 165; Number of Occupations 2; Total Number of Employees Exposed 331

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB2004/100001)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-reversion; S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8894
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
TOP