Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Propyl alcohol

RTECS #

UH8225000

CAS #

71-23-8

Updated

October 2017

Molecular Weight

60.11

Molecular Formula

C3H8O

Synonyms

1-Hydroxypropane
1-Propanol
1-Propyl alcohol
Alcool propilico (Italian)
Alcool propylique (French)
Ethyl carbinol
n-Propanol
n-Propyl alcohol
n-Propyl alcohol (ACGIH:OSHA)
n-Propyl alkohol (German)
Optal
Osmosol Extra
Propan-1-ol
Propanol
Propanol-1
Propanole (German)
Propanolen (Dutch)
Propanoli (Italian)
Propylic alcohol
Propylowy alkohol (Polish)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,191,1986
skin /human 100%/47H mildCODEDG 39,240,1998
skin /human 100%/24H mildCODEDG 68,192,1988
skin /rabbit 500 mg open irritation test mildUCDS** 6/28/1972

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Escherichia coli4 pph (-enzymatic activation step)ABMGAJ 23,843,1969
sex chromosome loss and nondisjunction/Aspergillus nidulans18000 ppmMUREAV 215,187,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 7000 ppm/7H (6W male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)NTOTDY 7,779,1985
inhalation/rat 7000 ppm/7H (1-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FCTOD7 26,247,1988
inhalation/rat 10000 ppm/7H (1-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FCTOD7 26,247,1988

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 50 gm/kg/81W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia
ARGEAR 45,19,1975
subcutaneous/rat lowest published toxic dose: 6 gm/kg/95W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia
ARGEAR 45,19,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 220 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Rat, myocard Inhibitor Concentration Low: 150 mmol/L/6HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 26,849,2012
inhalation/mouse lethal concentration (50 percent kill): 48000 mg/m3Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes
VCVGK* -,96,1984
inhalation/mouse lethal concentration (50 percent kill): 48 gm/m3GTPZAB 18(3),48,1974
inhalation/rat Lowest published lethal concentration: 4000 ppm/4HAMIHBC 10,61,1954
inhalation/rat Lowest published lethal concentration: 9800 mg/m3/4HBehavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes
VCVGK* -,96,1984
intraperitoneal/guinea pig lethal dose (50 percent kill): 1208 mg/kgEVHPAZ 61,321,1985
intraperitoneal/hamster lethal dose (50 percent kill): 2338 mg/kgEVHPAZ 61,321,1985
intraperitoneal/mouse lethal dose (50 percent kill): 3125 mg/kgEVHPAZ 61,321,1985
intraperitoneal/rabbit lethal dose (50 percent kill): 515 mg/kgEVHPAZ 61,321,1985
intraperitoneal/rat lethal dose (50 percent kill): 2164 mg/kgEVHPAZ 61,321,1985
intravenous/cat lowest published lethal dose: 4008 mg/kgJPETAB 16,1,1920
intravenous/mouse lethal dose (50 percent kill): 697 mg/kgEVHPAZ 61,321,1985
intravenous/rabbit lethal dose (50 percent kill): 483 mg/kgEVHPAZ 61,321,1985
intravenous/rat lethal dose (50 percent kill): 590 mg/kgEVHPAZ 61,321,1985
oral/Dog lowest published lethal dose: 3 gm/kgGastrointestinal: Other changes

Blood: Hemorrhage
COREAF 81,192,1875
oral/mouse lethal dose (50 percent kill): 6800 mg/kgPSDTAP 9,276,1968
oral/mouse lowest published lethal dose: 140 mg/kgBehavioral: General anestheticVCVGK* -,96,1984
oral/rabbit lowest published lethal dose: 3500 mg/kgBehavioral: General anestheticVCVGK* -,96,1984
oral/rabbit lethal dose (50 percent kill): 2825 mg/kgIMSUAI 41,31,1972
oral/rat lethal dose (50 percent kill): 1870 mg/kgAMIHBC 10,61,1954
oral/rat lethal dose (50 percent kill): 2200 mg/kgBehavioral: General anestheticVCVGK* -,96,1984
oral/woman lowest published lethal dose: 5700 mg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Other changes
ATXKA8 16,84,1956
skin/rabbit lethal dose (50 percent kill): 5040 mg/kgAMIHBC 10,61,1954
subcutaneous/Dog lowest published lethal dose: 4 gm/kgGastrointestinal: Other changes

Blood: Hemorrhage
COREAF 81,192,1875
subcutaneous/mammal (species unspecified) lowest published lethal dose: 5 gm/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes
ATXKA8 16,84,1956
subcutaneous/mouse lethal dose (50 percent kill): 4700 mg/kgTXAPA9 18,185,1971
subcutaneous/rabbit lowest published lethal dose: 3 gm/kgBDBU** -,-,1930
unreported route/rabbit lowest published lethal dose: 4500 mg/kgTHMOAM 6,327,1892

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 20 mg/m3/24H/90D- continuousBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Liver: Multiple effects
VCVGK* -,98,1994
oral/rat lowest published toxic dose: 7 mL/kg/7D- intermittentLiver: Other changes

Biochemical: Effect on specific coenzyme: B vitamins including folate
JDGRAX 10(1-2),25,1978

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 100 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 140-141,53,2003
TOXICOLOGY REVIEWREPTED 32,142,2011
TOXICOLOGY REVIEWREPTED 58,252,2015

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,290,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 200 ppm (490 mg/m3)DTLVS* 3,217,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 200 ppm (492 mg/m3), short term exposure limit 250 ppm (614 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 200 ppm (500 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 200 ppm (499 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 250 ppm (623 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (500 mg/m3), skin, MAY2011
Occupational Exposure Limit-FRANCEVME 200 ppm (500 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (500 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 200 ppm (500 mg/m3), short term exposure limit 250 ppm (625 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 200 ppm (500 mg/m3);short term exposure limit 250 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 200 ppm (492 mg/m3), short term exposure limit 250 ppm (614 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 100 ppm (245 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 200 ppm (491 mg/m3); short term exposure limit 250 ppm (614 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 200 mg/m3, MAC(short term exposure limit) 600 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 150 ppm (350 mg/m3);short term exposure limit 250 ppm (600 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 200 ppm (500 mg/m3), skin, JAN2011
Occupational Exposure Limit-TURKEYtime-weighted average 200 ppm (500 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 200 ppm (500 mg/m3);short term exposure limit 250 ppm (625 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 200 ppm (500 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 200 ppm (500 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 200 ppm (500 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 200 ppm (500 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYL ALCOHOL-airtime-weighted average 200 ppm (Sk);short term exposure limit 250 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M0256; Number of Industries 130; Total Number of Facilities 17036; Number of Occupations 99; Total Number of Employees Exposed 226129; Total Number of Female Employees Exposed 84196
National Occupational Hazard Survey 1974Hazard Code M0256; Number of Industries 151; Total Number of Facilities 18176; Number of Occupations 103; Total Number of Employees Exposed 122603

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols II, 1401
TOP