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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Propenenitrile, 2-methyl-

RTECS #

UD1400000

CAS #

126-98-7

Updated

December 2015

Molecular Weight

67.10

Molecular Formula

C4H5N

Synonyms

2-Cyanopropene-1
2-Methylpropenenitrile
alpha-Methylacrylonitrile
Isopropene cyanide
Isopropenylnitrile
Methacrylonitrile
Methylacrylonitrile
Methylacrylonitrile (ACGIH)
RCRA waste number U152
USAF ST-40

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 mgJIHTAB 31,113,1949
eye /rabbit 500 mg/24H mild85JCAE -,901,1986
skin /rabbit 200 mg mildJIHTAB 31,113,1949
skin /rabbit 500 mg/24H mild85JCAE -,901,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 100 ppm/6H (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FAATDF 20,365,1993
oral/rat 150 mg/kg (10D pregnant)Reproductive: Other effects to embryo or fetusTXAPA9 163,149,2000
oral/rat 20 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB97-176390
oral/rat 20 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Behavioral
NTIS** #PB97-176390
oral/rat 350 mg/kg (1-7D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
BECTA6 48,696,1992

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lowest published lethal concentration: 52 ppm/7HBehavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Hypermotility, diarrhea
AIHAAP 29,202,1968
inhalation/guinea pig lethal concentration (50 percent kill): 88 ppm/4HBehavioral: Convulsions or effect on seizure thresholdAIHAAP 29,202,1968
inhalation/mouse lethal concentration (50 percent kill): 36 ppm/4HBehavioral: Convulsions or effect on seizure thresholdAIHAAP 29,202,1968
inhalation/rabbit lethal concentration (50 percent kill): 37 ppm/4HBehavioral: Convulsions or effect on seizure thresholdAIHAAP 29,202,1968
inhalation/rat lethal concentration (50 percent kill): 440 ppm/4HBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
HALRE* 10/1/1968
inhalation/rat lethal concentration (50 percent kill): 328 ppm/4HBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 29,202,1968
intraperitoneal/mouse lowest published lethal dose: 15 mg/kgJIHTAB 31,113,1949
oral/mouse lethal dose (50 percent kill): 17 mg/kgJUZIAG 94,664,1985
oral/mouse lowest published toxic dose: 3.15 mg/kgBlood: Other changesTOXID9 72,319,2003
oral/mouse lowest published lethal dose: 26 mg/kgLung, Thorax, or Respiration: Respiratory depressionTXAPA9 205,116,2005
oral/rabbit lethal dose (50 percent kill): 16 mg/kgGTPZAB 29(5),37,1985
oral/rat lethal dose (50 percent kill): 120 mg/kgGTPZAB 29(5),37,1985
oral/rat lowest published toxic dose: 50 mg/kgBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
DCTODJ 28,187,2005
oral/rat lowest published toxic dose: 50 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesDCTODJ 28,187,2005
oral/rat lowest published toxic dose: 100 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
DCTODJ 28,187,2005
oral/rat lowest published toxic dose: 60 mg/kgOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
TOXID9 60,404,2001
oral/rat lowest published toxic dose: 60 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)TOXID9 60,404,2001
oral/rat lowest published toxic dose: 60 mg/kgLung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
JJTHEC 65,523,2002
skin/rabbit lethal dose (50 percent kill): 12500 µg/kgNTIS** OTS0534646
skin/rat lethal dose (50 percent kill): 2080 mg/kgGTPZAB 29(5),37,1985

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 109 ppm/7H/91D- intermittentLiver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 29,202,1968
intramuscular/rat lowest published toxic dose: 2940 mg/kg/21W- intermittentLiver: Changes in liver weightNTIS** #PB97-176390
intramuscular/rat lowest published toxic dose: 294 mg/kg/21W- intermittentReproductive: Paternal effects: Testes, epididymis, sperm ductNTIS** #PB97-176390
oral/rat lowest published toxic dose: 420 mg/kg/7D- intermittentLiver: Other changes

Liver: Changes in liver weight
JJTHEC 65,523,2002
oral/rat lowest published toxic dose: 3150 mg/kg/21W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainARTODN 77,233,2003
oral/rat lowest published toxic dose: 14400 mg/kg/2Y- intermittentOlfaction: Change in olfactory nerve

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARTODN 77,233,2003
oral/rat lowest published toxic dose: 5400 mg/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** PB97-176390

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWFCTOD7 55,596,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (3 mg/m3) (skin)DTLWS* 3,22,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (2.7 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (2.7 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (3 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (2.8 mg/m3), short term exposure limit 2 ppm (5.5 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (3 mg/m3), Skin, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (3 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (3 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 ppm (3 mg/m3);short term exposure limit 2 ppm (6 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (2.7 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (2,7 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (3 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 3 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (2.8 mg/m3), skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLACRYLONITRILE-air10H time-weighted average 1 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X5279; Number of Industries 3; Total Number of Facilities 58; Number of Occupations 2; Total Number of Employees Exposed 213

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat
NTP Carcinogenesis studies; test completed (peer review), October 2000
NTP Toxicity studies, RPT# TOX-47, October 2000
On EPA IRIS database
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