Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Picolinic acid, 4-amino-3,5,6-trichloro-

RTECS #

TJ7525000

CAS #

1918-02-1

Updated

October 2017

Molecular Weight

241.46

Molecular Formula

C6H3Cl3N2O2

Synonyms

2-Pyridinecarboxylic acid, 4-amino-3,5,6-trichloro-
3,5,6-Trichloro-4-aminopicolinic acid
4-Amino-3,5,6-trichloro-2-picolinic acid
4-Amino-3,5,6-trichloropicolinic acid
4-Amino-3,5,6-trichlorpicolinsaeure (German)
Amdon
Amdon grazon
ATCP
Borolin
Grazon
K-Pin
NCI-C00237
Picloram
Picloram (ACGIH:OSHA)
Picloram, acid
Tordon

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Other microorganisms200 µg/plate (-enzymatic activation step)MUREAV 57,277,1978
mutation in microorganisms/Saccharomyes cerevisiae100 mg/L (-enzymatic activation step)TGANAK 18,455,1984

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 5 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemFCTXAV 10,797,1972
oral/rat 7500 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemFCTXAV 10,797,1972

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 340 gm/kg/80W- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors
JTEHD6 7,207,1981
oral/rat toxic dose: 208 gm/kg/80W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-23,1978
oral/rat toxic dose: 416 gm/kg/80W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Endocrine: Tumors
NCITR* NCI-TR-23,1978
oral/rat toxic dose: 417 gm/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors
JTEHD6 7,207,1981
oral/rat lowest published toxic dose: 208 mg/kg/80W- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors

Endocrine: Thyroid tumors
JTEHD6 7,207,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/duck lethal dose (50 percent kill): >2 gm/kgDOEAAH 35,25,1979
oral/rabbit lethal dose (50 percent kill): 2 gm/kgGUCHAZ 6,414,1973
oral/rat lethal dose (50 percent kill): 4012 mg/kgFEREAC 64,420,1999
skin/rabbit lethal dose (50 percent kill): >4 gm/kgWRPCA2 9,119,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2100 mg/kg/21D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight
AECTCV 24,449,1993
oral/rat lowest published toxic dose: 7 gm/kg/2W- continuousLiver: Changes in liver weightJTEHD6 20,367,1987
oral/rat lowest published toxic dose: 27300 mg/kg/13W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
JTEHD6 20,367,1987
oral/rat lowest published toxic dose: 10920 mg/kg/26W- continuousLiver: Changes in liver weightJTEHD6 20,367,1987
oral/rat lowest published toxic dose: 73 gm/kg/1Y- continuousLiver: Changes in liver weightJTEHD6 20,367,1987

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 53,481,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human No Available DataIMEMDT 53,481,1991
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 53,481,1991
TOXICOLOGY REVIEWDTTIAF 80,485,1973
TOXICOLOGY REVIEWMUTAEX 21,93,2006
TOXICOLOGY REVIEWENTOX* -,436,2005
TOXICOLOGY REVIEWFEREAC 72,41913,2007
TOXICOLOGY REVIEWTXAPA9 268,157,2013
TOXICOLOGY REVIEWMUREAV 802,1,I2

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESRED CompletedRBREV* -,143,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 10 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83786; Number of Industries 1; Total Number of Facilities 45; Number of Occupations 2; Total Number of Employees Exposed 314
National Occupational Hazard Survey 1974Hazard Code 83786; Number of Industries 1; Total Number of Facilities 12; Number of Occupations 1; Total Number of Employees Exposed 72

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);equivocal evidence:ratNCITR* NCI-TR-23,1978
NCI Carcinogenesis Bioassay (feed);no evidence:mouseNCITR* NCI-TR-23,1978
On EPA IRIS database
TOP