Picolinic acid, 4-amino-3,5,6-trichloro-

RTECS #

TJ7525000

CAS #

1918-02-1
See: NMAM or OSHA Methods

Updated

October 2017

Molecular Weight

241.46

Molecular Formula

C₆H₃Cl₃N₂O₂

Synonyms

2-Pyridinecarboxylic acid, 4-amino-3,5,6-trichloro-
3,5,6-Trichloro-4-aminopicolinic acid
4-Amino-3,5,6-trichloro-2-picolinic acid
4-Amino-3,5,6-trichloropicolinic acid
4-Amino-3,5,6-trichlorpicolinsaeure (German)
Amdon
Amdon grazon
ATCP
Borolin
Grazon
K-Pin
NCI-C00237
Picloram
Picloram (ACGIH:OSHA)
Picloram, acid
Tordon

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
mutation in microorganisms	/Other microorganisms	200 µg/plate (-enzymatic activation step)	MUREAV 57,277,1978
mutation in microorganisms	/Saccharomyes cerevisiae	100 mg/L (-enzymatic activation step)	TGANAK 18,455,1984

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	5 gm/kg (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	FCTXAV 10,797,1972
oral/rat	7500 mg/kg (6-15D pregnant)	Reproductive: Specific developmental abnormalities: Urogenital system	FCTXAV 10,797,1972

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 340 gm/kg/80W- continuous	Tumorigenic: Neoplastic by RTECS criteria Endocrine: Tumors Endocrine: Thyroid tumors	JTEHD6 7,207,1981
oral/rat	toxic dose: 208 gm/kg/80W- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors	NCITR* NCI-TR-23,1978
oral/rat	toxic dose: 416 gm/kg/80W- continuous	Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors Endocrine: Tumors	NCITR* NCI-TR-23,1978
oral/rat	toxic dose: 417 gm/kg/80W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Endocrine: Tumors Endocrine: Thyroid tumors	JTEHD6 7,207,1981
oral/rat	lowest published toxic dose: 208 mg/kg/80W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Endocrine: Tumors Endocrine: Thyroid tumors	JTEHD6 7,207,1981

Acute Toxicity Data and References

Route/Organism	Dose	Reference
oral/duck	lethal dose (50 percent kill): >2 gm/kg	DOEAAH 35,25,1979
oral/rabbit	lethal dose (50 percent kill): 2 gm/kg	GUCHAZ 6,414,1973
oral/rat	lethal dose (50 percent kill): 4012 mg/kg	FEREAC 64,420,1999
skin/rabbit	lethal dose (50 percent kill): >4 gm/kg	WRPCA2 9,119,1970

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 2100 mg/kg/21D- intermittent	Liver: Changes in liver weight Endocrine: Changes in spleen weight	AECTCV 24,449,1993
oral/rat	lowest published toxic dose: 7 gm/kg/2W- continuous	Liver: Changes in liver weight	JTEHD6 20,367,1987
oral/rat	lowest published toxic dose: 27300 mg/kg/13W- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight	JTEHD6 20,367,1987
oral/rat	lowest published toxic dose: 10920 mg/kg/26W- continuous	Liver: Changes in liver weight	JTEHD6 20,367,1987
oral/rat	lowest published toxic dose: 73 gm/kg/1Y- continuous	Liver: Changes in liver weight	JTEHD6 20,367,1987

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 10 mg/m³	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Limited Evidence	IMEMDT 53,481,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Available Data	IMEMDT 53,481,1991
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 53,481,1991
TOXICOLOGY REVIEW		DTTIAF 80,485,1973
TOXICOLOGY REVIEW		MUTAEX 21,93,2006
TOXICOLOGY REVIEW		ENTOX* -,436,2005
TOXICOLOGY REVIEW		FEREAC 72,41913,2007
TOXICOLOGY REVIEW		TXAPA9 268,157,2013
TOXICOLOGY REVIEW		MUREAV 802,1,2016

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	RED Completed	RBREV* -,143,1998
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 mg/m³, JUL2008
Occupational Exposure Limit-BELGIUM	time-weighted average 10 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 10 mg/m³, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 10 mg/m³, short term exposure limit 20 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 10 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 10 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 10 mg/m³, short term exposure limit 20 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 mg/m³;short term exposure limit 20 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 mg/m³, JAN2002
Occupational Exposure Limit-PERU	time-weighted average 10 mg/m³, JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 2 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 10 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 10 mg/m³;short term exposure limit 20 mg/m³, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 15 mg/m³, total dust	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 5 mg/m³, respirable fraction	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Occupational Exposure Survey 1983	Hazard Code 83786; Number of Industries 1; Total Number of Facilities 45; Number of Occupations 2; Total Number of Employees Exposed 314
National Occupational Hazard Survey 1974	Hazard Code 83786; Number of Industries 1; Total Number of Facilities 12; Number of Occupations 1; Total Number of Employees Exposed 72

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);equivocal evidence:rat	NCITR* NCI-TR-23,1978
NCI Carcinogenesis Bioassay (feed);no evidence:mouse	NCITR* NCI-TR-23,1978
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health