Phthalic acid, bis(2-ethylhexyl) ester

RTECS #

TI0350000

CAS #

117-81-7
See: NMAM or OSHA Methods

Updated

March 2019

Molecular Weight

390.62

Molecular Formula

C₂₄H₃₈O₄

Synonyms

1,2-Benzenedicarboxylic acid, bis(2-ethylhexyl) ester
2-Ethylhexyl phthalate
Bis(2-ethylhexyl)-1,2-benzenedicarboxylate
Bis-(2-ethylhexyl)ester kyseliny ftalove (Czech)
Bis(2-ethylhexyl)phthalate
Bisoflex 81
Bisoflex DOP
Compound 889
DEHP
Di-(2-ehylhexyl) phthalate
Di(2-ethylhexyl)orthophthalate
Di-(2-ethylhexyl)phthalate
Di(2-ethylhexyl)phthalate
Di-2-ethylhexyl phthalate
Diethylhexyl phthalate
Dioctyl phthalate
Di-sec-octyl phthalate (ACGIH:OSHA)
Ergoplast FDO
Ethylhexyl phthalate
Eviplast 80
Eviplast 81
Fleximel
Flexol DOP
Flexol Plasticizer DOP
Good-rite GP 264
Hatcol DOP
Hercoflex 260
Jayflex DOP
Kodaflex DOP
Mollan O
NCI-C52733
Nuoplaz DOP
Octoil
Palatinol AH
Phthalic acid dioctyl ester
Pittsburgh PX-138
Platinol AH
Platinol DOP
RC Plasticizer DOP
RCRA waste number U028
Reomol D 79P
Reomol DOP
Sicol 150
Staflex DOP
Truflex DOP
Vestinol AH
Vinicizer 80
Witcizer 312

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	500 mg	mild	AJOPAA 29,1363,1946
eye /rabbit	500 mg/24H	mild	85JCAE -,389,1986
skin /rabbit	500 mg/24H	mild	85JCAE -,389,1986

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	leukocyte/human	6 mg/L	JPMSAE 65,1648,1976
Cytogenetic Analysis	oral/hamster	7500 mg/kg	EVHPAZ 45,119,1982
DNA Damage	oral/rat	14 gm/kg/14D- intermittent	FCTOD7 42,107,2004
DNA Damage	other cell types/mouse	3 mmol/L/24H	TXAPA9 248,52,2010
DNA Damage	oral/rat	1000 mg/kg	MUREAV 751,73,2013
DNA Damage	testis/mouse	3 mmol/L	TOLED5 196S,S163,2010
Dominant Lethal Test	intraperitoneal/mouse	12780 mg/kg	TXAPA9 29,35,1974
Dominant Lethal Test	subcutaneous/mouse	2970 mg/kg/10D- intermittent	JTEHD6 16,71,1985
gene conversion and mitotic recombination	/Saccharomyes cerevisiae	5 gm/L	PMRSDJ 5,217,1985
morphological transform	oral/hamster	750 mg/kg	EVHPAZ 45,119,1982
morphological transform	embryo/hamster	4 mg/L	PMRSDJ 5,665,1985
morphological transform	embryo/hamster	2.5 mg/L/7D	MUREAV 698,6,2010
morphological transform	fibroblast/mouse	0.01 pph/21D (-enzymatic activation step)	EMMUEG 35,300,2000
mutation in microorganisms	/Saccharomyes cerevisiae	4905 mg/L/16H	MUTAEX 20,105,2004
mutation in microorganisms	lymphocyte/mouse	40 mg/L (+enzymatic activation step)	PMRSDJ 5,569,1985
mutation in microorganisms	/Saccharomyes cerevisiae	1541 mg/L (+/-enzymatic activation step)	PMRSDJ 5,271,1985
mutation in microorganisms	/Salmonella typhimurium	5 mg/plate (-enzymatic activation step)	EVHPAZ 45,119,1982
other mutation test systems	oral/mouse	1 gm/kg	MUREAV 343,157,1995
other mutation test systems	intraperitoneal/mouse	2000 mg/kg	MUREAV 747,164,2012
other mutation test systems	oral/rat	0.72 gm/kg/4W- intermittent	MUREAV 834,51,2018
phage inhibition capacity	/Escherichia coli	50 µg/well	MUREAV 260,349,1991
sex chromosome loss and nondisjunction	liver/hamster	50 mg/L	PMRSDJ 5,397,1985
sister chromatid exchange	ovary/hamster	25 mg/L	SCIEAS 236,933,1987
sister chromatid exchange	lymphocyte/human	50 µmol/L	MUREAV 211,77,1989
specific locus test	oral/Drosophila melanogaster	200 mmol/L/48H	MUREAV 222,359,1989
sperm morphology	oral/rat	1 pph/60D-continuous	EVHPAZ 65,343,1986
sperm morphology	oral/rat	15 gm/kg/30D- intermittent	FCTOD7 90,64,2016
Unscheduled DNA Synthesis	oral/mouse	202 gm/kg/40W-continuous	TXAPA9 96,494,1988
Unscheduled DNA Synthesis	liver/rat	500 µmol/L	PMRSDJ 5,371,1985
Unscheduled DNA Synthesis	oral/rat	670 mg/kg	PAACA3 27,148,1986

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/rat	6 mL/kg (3-9D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	EVHPAZ 3,91,1973
intraperitoneal/rat	2 mL/kg (3D pregnant)	Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	EVHPAZ 3,91,1973
intraperitoneal/rat	2 mL/kg (6D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	EVHPAZ 3,91,1973
intraperitoneal/rat	4 mL/kg (3-6D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	EVHPAZ 3,91,1973
intraperitoneal/rat	6 gm/kg (3-9D pregnant)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	JDSCAE 55,696,1972
intraperitoneal/rat	10 gm/kg (5-15D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Other developmental abnormalities	JPMSAE 61,51,1972
intraperitoneal/rat	5 gm/kg (5-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	JPMSAE 61,51,1972
intraperitoneal/rat	1 gm/kg (10D male)	Reproductive: Other effects on male	TXAPA9 62,121,1982
intraperitoneal/rat	6 gm/kg (3-9D pregnant)	Reproductive: Maternal effects: Parturition Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	EVHPAZ 3,91,1973
intraperitoneal/mouse	30 gm/kg (5D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	EVHPAZ 65,255,1986
intraperitoneal/mouse	25560 mg/kg (1D male)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	EVHPAZ 3,81,1973
intraperitoneal/mouse	12780 mg/kg (1D male)	Reproductive: Effects on embryo or fetus: Fetal death	EVHPAZ 3,81,1973
intraperitoneal/mouse	12780 µg/kg (1D male)	Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	TXAPA9 29,35,1974
intraperitoneal/mouse	24 gm/kg (7-9D pregnant)	Reproductive: Effects on fertility: Abortion	ARTODN 56,263,1985
intravenous/mouse	50 mg/kg (1D prior to copulation)	Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)	NTIS** PB250-102
intravenous/mouse	350 mg/kg (7D male)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	NTIS** PB250-102
intravenous/mouse	15 mg/kg (3-5D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	NTIS** PB250-102
intravenous/mouse	5 mg/kg (8D pregnant)	Reproductive: Effects on fertility: Other measures of fertility	NTIS** PB250-102
oral/guinea pig	20 gm/kg (10D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	EVHPAZ 45,77,1982
oral/mammal (species unspecified)	20 gm/kg (10D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	EVHPAZ 45,77,1982
oral/mammal (species unspecified)	509 gm/kg (60W male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXCYAC 6,341,1976
oral/mouse	8400 mg/kg (1-21D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	ENVRAL 22,245,1980
oral/mouse	49.2 mg/kg (7D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TOLED5 4,113,1979
oral/mouse	98.4 mg/kg (7D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death	TOLED5 4,113,1979
oral/mouse	984.6 mg/kg (7D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system	TOLED5 4,113,1979
oral/rat	72000 mg/kg (60D male)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	EVHPAZ 65,343,1986
oral/rat	66000 mg/kg (14D prior to copulation/0-7D pregnant)	Reproductive: Maternal effects: Menstrual cycle changes or disorders Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)	JTSCDR 34,SP111,2009
oral/mouse	1 mg/kg (multigeneration)	Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects Reproductive: Effects on newborn: Delayed effects	TOLED5 189,40,2009
oral/rat	1290 mg/kg (1-22D preg/21D after birth)	Reproductive: Specific developmental abnormalities: Central nervous system	NRTXDN 31,747,2010
oral/rat	1110 mg/kg (1D preg-15D after birth)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system	NRTXDN 33,78,2012
oral/mouse	4701 mg/kg (28D male/4W pre-2D after birth)	Reproductive: Effects on newborn: Other postnatal measures or effects	TXCYAC 289,1,2011
oral/mouse	9768 mg/kg (28D male/4W pre-3W pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on fertility: Other measures of fertility	TXCYAC 289,1,2011
oral/rat	10.75 mg/kg (0D preg-21D after birth)	Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Delayed effects	TOLED5 212,212,2012
oral/mouse	74 mg/kg (4W male/4W pre-18D pregnant)	Reproductive: Other developmental abnormalities	TXCYAC 309,52,2013
oral/mouse	3440 mg/kg (multigeneration)	Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Delayed effects	TOLED5 228,235,2014
oral/rat	5700 mg/kg (14-22D pregnant)	Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Other postnatal measures or effects Reproductive: Effects on newborn: Delayed effects	TXAPA9 266,95,2013
oral/mouse	9000 mg/kg (13D preg-21D after birth)	Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system	TXAPA9 274,402,2013
oral/mouse	22 mg/kg (1-12D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Other developmental abnormalities	TXAPA9 307,123,2016
oral/mouse	2.1 mg/kg (0-21D preg/21D after birth)	Reproductive: Effects on newborn: Germ cell effects (in offspring)	TXAPA9 322,113,2017
oral/mouse	8 mg/kg (6-13D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system	TOLED5 259,69,2016
oral/mouse	78880 mg/kg (6-13D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	TCMUD8 7,29,1987
oral/mouse	4200 mg/kg (21D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	OKEHDW 15,129,1977
oral/mouse	1 gm/kg (7D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Specific developmental abnormalities: Musculoskeletal system	EVHPAZ 45,71,1982
oral/mouse	2040 mg/kg (1-17D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetal death	NTIS** PB85-105674
oral/mouse	2040 mg/kg (1-17D pregnant)	Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system	TJADAB 27,84A,1983
oral/rat	7140 mg/kg (1-21D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TXAPA9 26,253,1973
oral/rat	35 mg/kg (14D prior to copulation)	Reproductive: Maternal effects: Ovaries, fallopian tubes	FCTXAV 15,389,1977
oral/rat	6 gm/kg (3D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	ARTODN 59,290,1986
oral/rat	17200 mg/kg (multigenerations)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	NEZAAQ 31,507,1976
oral/rat	10 gm/kg (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other effects to embryo or fetus Reproductive: Specific developmental abnormalities: Hepatobiliary system	IJEBA6 27,885,1989
oral/rat	9766 mg/kg (12D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system Reproductive: Specific developmental abnormalities: Urogenital system	TJADAB 35,41,1987
oral/rat	137 mL/kg (1-22D preg/21D after birth)	Reproductive: Effects on newborn: Physical	FCTOD7 36,963,1998
oral/mouse	1.6 gm/kg (17D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	NTIS** #PB88204300
oral/mouse	1.6 gm/kg (17D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #PB88204300
oral/mouse	2.04 gm/kg (1-17D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Other effects to embryo or fetus	NTIS** #PB85-105674
oral/mouse	2.04 gm/kg (1-17D pregnant)	Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Other developmental abnormalities	NTIS** #PB85-105674
oral/rat	10 gm/kg (1-20D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	NTIS** #PB85-105658
oral/rat	11.46 gm/kg (20D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	NTIS** #87119046
oral/rat	20 gm/kg (1-20D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Other developmental abnormalities	NTIS** #PB85-105658
oral/rat	6260 mg/kg (20D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	NTIS** #87119046
oral/rat	9.6 gm/kg (8D preg-17D after birth)	Reproductive: Specific developmental abnormalities: Urogenital system	TOXID9 72,283,2003
oral/rat	3.2 gm/kg (multigeneration)	Reproductive: Specific developmental abnormalities: Urogenital system	TOXID9 72,283,2003
oral/rat	352 mg/kg (multigeneration)	Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Endocrine system	TOXID9 72,283,2003
oral/rat	1 gm/kg (12-21D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system	BIREBV 65,1252,2001
oral/rat	30.8 gm/kg (3-22D preg/21D after birth)	Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	EVHPAZ 109,229,2001
oral/rat	61.5 gm/kg (3-22D preg/21D after birth)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Germ cell effects (in offspring)	EVHPAZ 109,229,2001
oral/rat	123 gm/kg (3-22D preg/21D after birth)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	EVHPAZ 109,229,2001
oral/mouse	1.6 gm/kg (33D male/33D prior to copulation/22D pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	FCTOD7 40,1499,2002
oral/mouse	15 gm/kg (33D male/33D pre-4D after birth)	Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Behavioral	FCTOD7 40,1499,2002
oral/mouse	27 gm/kg (33D male/33D pre-4W after birth)	Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)	FCTOD7 40,1499,2002
oral/mouse	0.06 mg/kg (multigeneration)	Reproductive: Effects on newborn: Delayed effects	FCTOD7 40,1499,2002
oral/mouse	1692 mg/kg (4W prior to copulation/1-19D pregnant)	Reproductive: Effects on newborn: Sex ratio	FCTOD7 41,1429,2003
oral/mouse	1008 mg/kg (4W male)	Reproductive: Effects on newborn: Sex ratio	FCTOD7 41,1429,2003
oral/mouse	2.7 gm/kg (4W male/ 4W pre-19D pregnant)	Reproductive: Effects on newborn: Sex ratio	FCTOD7 41,1429,2003
oral/rat	4500 mg/kg (7-21D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system	REPTED 17,475,2003
oral/rat	5000 mg/kg (14-18D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TOXID9 72(Suppl 1),272,2003
oral/rat	4500 mg/kg (7-21D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system	REPTED 18,53,2004
oral/rat	11.3 gm/kg (7-21D pregnant)	Reproductive: Other developmental abnormalities	REPTED 18,53,2004
oral/rat	418 mg/kg (4W male/4W prior to copulation/0-3W pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	TXAPA9 197,231,2004
oral/rat	2 gm/kg (4W male/4W prior to copulation/0-3W pregnant)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TXAPA9 197,231,2004
oral/rat	2090 mg/kg (multigeneration)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)	TXAPA9 197,231,2004
oral/rat	3300 mg/kg (8-18D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system	TOXID9 44,355,2005
oral/rat	6750 mg/kg (8-16D pregnant)	Reproductive: Specific developmental abnormalities: Urogenital system	TOXID9 44,355,2005
oral/mouse	109.2 gm/kg (13W male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Other effects on male	TOXID9 78,353,2004
oral/rat	500 mg/kg (14-18D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system	TOXID9 78,282,2004
oral/rat	28.5 mg/kg (1-19D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Central nervous system	TOXID9 90,74,2006
oral/rat	2500 mg/kg (14-18D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Delayed effects	TOXID9 90,316,2006
oral/rat	570 mg/kg (6D preg-21D after birth)	Reproductive: Effects on newborn: Germ cell effects (in offspring)	TOXID9 228,85,2006
oral/rat	190 mg/kg (6D preg-21D after birth)	Reproductive: Specific developmental abnormalities: Urogenital system	TOXID9 228,85,2006
oral/rat	1.71 mg/kg (6D preg-21D after birth)	Reproductive: Effects on newborn: Biochemical and metabolic	TOXID9 228,85,2006
oral/rat	15390 mg/kg (6D preg-21D after birth)	Reproductive: Effects on newborn: Delayed effects	TOXID9 229,114,2007
oral/rat	1500 mg/kg (7-21D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TXCYAC 223,144,2006
oral/rat	2295 mg/kg (6D preg-1D after birth)	Reproductive: Effects on newborn: Other neonatal measures or effects	TXCYAC 225,64,2006
oral/rat	2.3 mg/kg (6D preg-1D after birth)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TXCYAC 225,64,2006
oral/rat	11745 mg/kg (6D preg-13D after birth)	Reproductive: Effects on newborn: Physical	TXCYAC 225,64,2006
oral/rat	190 mg/kg (6D preg-21D after birth)	Reproductive: Effects on newborn: Other postnatal measures or effects	TXCYAC 225,64,2006
oral/rat	8000 mg/kg (7-14D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	JTSCDR 30,175,2005
oral/rat	3000 mg/kg (7-18D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	JTSCDR 30,175,2005
oral/rat	12000 mg/kg (7-18D pregnant)	Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Effects on newborn: Other postnatal measures or effects	JTSCDR 30,175,2005
oral/rat	5000 mg/kg (7-16D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	JTSCDR 30,175,2005
oral/rat	30000 mg/kg (0-19D pregnant)	Reproductive: Other effects to embryo or fetus Reproductive: Specific developmental abnormalities: Central nervous system	ARTODN 81,57,2007
oral/rat	570 mg/kg (6-22D preg/21D after birth)	Reproductive: Effects on newborn: Physical	TOSCF2 91,247,2006
oral/rat	0.765 mg/kg (6-22D pregnant)	Reproductive: Effects on newborn: Other neonatal measures or effects	TOSCF2 91,247,2006
oral/rat	2295 mg/kg (6-22D pregnant)	Reproductive: Effects on newborn: Physical	TOSCF2 91,247,2006
oral/rat	46.17 mg/kg (6-22D preg/21D after birth)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	TOSCF2 91,247,2006
oral/rat	21.5 gm/kg (1-22D preg/21D after birth)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	HETOEA 25,297,2006
oral/rat	21.5 gm/kg (1-22D preg/21D after birth)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on newborn: Behavioral	HETOEA 25,297,2006
oral/rat	4300 mg/kg (1-22D preg/21D after birth)	Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	HETOEA 25,297,2006
oral/rat	585 mg/kg (6-22D preg/22D after birth)	Reproductive: Effects on newborn: Physical	NSAPCC 372(Suppl 1),100,2006
oral/rat	5265 mg/kg (6-22D preg/22D after birth)	Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Other postnatal measures or effects	NSAPCC 372(Suppl 1),100,2006
oral/rat	15390 mg/kg (6-22D preg/21D after birth)	Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Other postnatal measures or effects	NSAPCC 372(Suppl 1),100,2006
oral/rat	2430 mg/kg (6-22D preg/1D after birth)	Reproductive: Effects on newborn: Other postnatal measures or effects	NSAPCC 372(Suppl 1),100,2006
oral/rat	190 mg/kg (6-22D preg/21D after birth)	Reproductive: Specific developmental abnormalities: Urogenital system	NSAPCC 372(Suppl 1),100,2006
oral/rat	570 mg/kg (6-22D preg/21D after birth)	Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Physical	NSAPCC 372(Suppl 1),100,2006
oral/rat	3750 mg/kg (14-18D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on newborn: Physical	TOLED5 170,177,2007
oral/rat	3750 mg/kg (14-18D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Physical	TOLED5 170,177,2007
oral/rat	4800 mg/kg (6-21D pregnant)	Reproductive: Effects on newborn: Physical	TERP2* -,367,2005
subcutaneous/mouse	2970 mg/kg (3D male)	Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on embryo or fetus: Fetal death	JTEHD6 16,71,1985
subcutaneous/mouse	19722 mg/kg (3D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	JTEHD6 26,39,1989
subcutaneous/mouse	1972 mg/kg (3D male)	Reproductive: Other effects on male	JTEHD6 26,39,1989
subcutaneous/mouse	9861 mg/kg (3D prior to copulation)	Reproductive: Other effects on female	JTEHD6 26,39,1989
unreported route/rat	2500 mg/kg (14-18D pregnant)	Reproductive: Other effects to embryo or fetus Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Specific developmental abnormalities: Urogenital system	TOXID9 -,10,2008
unreported route/rat	1375 mg/kg (14D preg-3D after birth)	Reproductive: Effects on newborn: Behavioral	TOXID9 -,37,2009
unreported route/rat	41250 mg/kg (14D preg-3D after birth)	Reproductive: Specific developmental abnormalities: Urogenital system	TOXID9 60,225,2001

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
oral/mouse	lowest published toxic dose: 260 gm/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NTPTR* NTP-TR-217,1982
oral/mouse	toxic dose: 519 gm/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NTPTR* NTP-TR-217,1982
oral/mouse	toxic dose: 120 gm/kg/24W- continuous	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Liver: Tumors	CRNGDP 4,1021,1983
oral/mouse	toxic dose: 262 gm/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	EVHPAZ 65,271,1986
oral/mouse	lowest published toxic dose: 98.5 mg/kg	Tumorigenic: Equivocal tumorigenic agent by RTECS criteria	TOSCF2 58,377,2000
oral/mouse	lowest published toxic dose: 519120 mg/kg/103W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NTIS** PB82-184011
oral/mouse	lowest published toxic dose: 259560 mg/kg/103W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NTIS** PB82-184011
oral/mouse	lowest published toxic dose: 32760 mg/kg/26W- intermittent	Tumorigenic: Neoplastic by RTECS criteria Liver: Tumors	JTPAE7 29,458,2001
oral/rat	lowest published toxic dose: 519120 mg/kg/103W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NTIS** PB82-184011
oral/rat	lowest published toxic dose: 432600 mg/kg/103W- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	NTIS** PB82-184011
oral/rat	lowest published toxic dose: 216 gm/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Endocrine: Tumors	NTPTR* NTP-TR-217,1982
oral/rat	toxic dose: 438 gm/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	CALEDQ 38,15,1987
oral/rat	toxic dose: 91 gm/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	TOSCF2 50,195,1999
oral/rat	lowest published toxic dose: 430.8 gm/kg/78W- continuous	Tumorigenic: Neoplastic by RTECS criteria Gastrointestinal: Tumors	TOSCF2 55,433,2000
oral/rat	toxic dose: 524 gm/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors	EVHPAZ 65,271,1986
oral/rat	toxic dose: 433 gm/kg/2Y- continuous	Tumorigenic: Carcinogenic by RTECS criteria Liver: Tumors Reproductive: Tumorigenic effects: Testicular tumors	NTPTR* NTP-TR-217,1982

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, embryonic cells	Inhibitor Concentration (50 percent kill): >500 µmol/L/24H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.	TIVIEQ 38,41,2017
In Vitro/Human, embryonic cells	Inhibitor Concentration (50 percent kill): >500 µmol/L/24H	In Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)	TIVIEQ 38,41,2017
In Vitro/Human, endocrine tumor	Inhibitor Concentration Low: 1 mg/L/48H	Endocrine: Estrogenic	TOLED5 217,50,2013
In Vitro/Human, endocrine tumor	Inhibitor Concentration (50 percent kill): 0.28 µmol/L/24H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TXAPA9 268,309,2013
In Vitro/Human, fibroblast	Inhibitor Concentration Low: 1 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 65,105,2014
In Vitro/Human, kidney	Inhibitor Concentration (20 percent kill): >100 µmol/L/2H	In Vitro Toxicity Studies: Cell metabolic activity: Alamar Blue assay etc.	TIVIEQ 40,66,2017
In Vitro/Human, kidney	Inhibitor Concentration (20 percent kill): >100 µmol/L/2H	Endocrine: Other changes	TIVIEQ 40,66,2017
In Vitro/Human, leukemia cells	Inhibitor Concentration (50 percent kill): 250 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 25,2010,2011
In Vitro/Human, leukemia cells	Inhibitor Concentration (50 percent kill): 234 µmol/L/48H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 25,2010,2011
In Vitro/Human, leukemia cells	Inhibitor Concentration (50 percent kill): 100 µmol/L/72H	In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.	TIVIEQ 25,2010,2011
In Vitro/Human, leukemia cells	Inhibitor Concentration Low: 234 µmol/L/48H	In Vitro Toxicity Studies: Apoptosis in vitro In Vitro Toxicity Studies: Other assays Biochemical: Metabolism (intermediary): Effect on mitochondrial function	TIVIEQ 25,2010,2011
In Vitro/Human, liver	Inhibitor Concentration Low: 62.5 µmol/L/48H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 59,325,2013
In Vitro/Human, liver	Inhibitor Concentration Low: 125 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 59,325,2013
In Vitro/Human, liver	Inhibitor Concentration Low: 62.5 µmol/L/12H	In Vitro Toxicity Studies: Other assays	FCTOD7 59,325,2013
In Vitro/Human, liver	Inhibitor Concentration Low: 62.5 µmol/L/24H	In Vitro Toxicity Studies: Other assays	FCTOD7 59,325,2013
In Vitro/Human, neuroblastoma	Inhibitor Concentration Low: 10 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TXAPA9 280,190,2014
In Vitro/Human, neuroblastoma	Inhibitor Concentration Low: 10 µmol/L/48H	In Vitro Toxicity Studies: Apoptosis in vitro	TXAPA9 280,190,2014
In Vitro/Human, skin	Inhibitor Concentration Low: 1 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	FCTOD7 65,105,2014
In Vitro/Human, skin	Inhibitor Concentration (50 percent kill): >100 µmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 30,281,2015
In Vitro/Human, skin	Inhibitor Concentration Low: 10 µmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 30,281,2015
In Vitro/Human, skin	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. In Vitro Toxicity Studies: Apoptosis in vitro In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.	TIVIEQ 30,281,2015
In Vitro/Human, skin	Inhibitor Concentration Low: 100 µmol/L/4H	In Vitro Toxicity Studies: Other assays	TIVIEQ 30,281,2015
In Vitro/jrc	Inhibitor Concentration Low: 10 µmol/L/3W	In Vitro Toxicity Studies: Other assays	TXAPA9 248,111,2010
In Vitro/jrd	Inhibitor Concentration Low: 10 mg/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Apoptosis in vitro	TOLED5 217,50,2013
In Vitro/jrd	Inhibitor Concentration Low: 1 µmol/L/24H	Endocrine: Other changes	TOLED5 232,376,2015
In Vitro/jrd	Inhibitor Concentration Low: >50 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TOLED5 232,376,2015
In Vitro/jti	Inhibitor Concentration Low: 3 mmol/L/24H	In Vitro Toxicity Studies: Other assays	FCTOD7 49,1565,2011
In Vitro/mkc	Inhibitor Concentration Low: 10 mg/L/96H	In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc.	TXAPA9 284,42,2015
In Vitro/mkc	Inhibitor Concentration Low: 1 mg/L/48H	Endocrine: Androgenic Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TXAPA9 284,42,2015
In Vitro/mkc	Inhibitor Concentration Low: 1 mg/L/72H	Endocrine: Estrogenic	TXAPA9 284,42,2015
In Vitro/Monkey, kidney	Inhibitor Concentration (50 percent kill): >100 µmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 30,281,2015
In Vitro/Monkey, kidney	Inhibitor Concentration Low: 10 µmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 30,281,2015
In Vitro/Monkey, kidney	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. In Vitro Toxicity Studies: Other assays	TIVIEQ 30,281,2015
In Vitro/Mouse, fibroblast	Inhibitor Concentration (50 percent kill): 600 µmol/L/24H	In Vitro Toxicity Studies: Cell growth: Colony formation	TIVIEQ 1,49,1987
In Vitro/Mouse, neuroblastom	Inhibitor Concentration Low: 40 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Apoptosis in vitro In Vitro Toxicity Studies: Other assays	TOLED5 206,245,2011
In Vitro/Mouse, neuroblastom	Inhibitor Concentration Low: 40 µmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TOLED5 206,245,2011
In Vitro/Mouse, neuroblastom	Inhibitor Concentration Low: 40 µmol/L/48H	In Vitro Toxicity Studies: Apoptosis in vitro	TOLED5 206,245,2011
In Vitro/Mouse, neuroblastom	Inhibitor Concentration Low: 40 µmol/L/48H	In Vitro Toxicity Studies: Other assays	TOLED5 206,245,2011
In Vitro/Mouse, neuroblastom	Inhibitor Concentration Low: 40 µmol/L/24H	In Vitro Toxicity Studies: Other assays	TOLED5 206,245,2011
In Vitro/mtd	Inhibitor Concentration Low: 10 mg/L/24H	In Vitro Toxicity Studies: Other assays Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases	TXAPA9 258,288,2012
In Vitro/mtd	Inhibitor Concentration Low: 1 mg/L/96H	In Vitro Toxicity Studies: Other assays	TXAPA9 258,288,2012
In Vitro/mti	Inhibitor Concentration Low: 0.001 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TXAPA9 248,52,2010
In Vitro/mti	Inhibitor Concentration Low: 3 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases In Vitro Toxicity Studies: Other assays	TXAPA9 248,52,2010
In Vitro/mti	Inhibitor Concentration (50 percent kill): 3 mmol/L/24H	In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.	TXAPA9 248,52,2010
In Vitro/mti	Inhibitor Concentration Low: 3 mmol/L	In Vitro Toxicity Studies: Cell Viability (cell death), unspecified assay	TOLED5 196S,S163,2010
In Vitro/mti	Inhibitor Concentration Low: 3 mmol/L	In Vitro Toxicity Studies: Other assays	TOLED5 196S,S163,2010
In Vitro/mtj	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Apoptosis in vitro	ETOPFR 44,18,2016
In Vitro/Non-mammalian species, liver	Inhibitor Concentration Low: 0.05 nmol/L/4D	In Vitro Toxicity Studies: Other assays	TIVIEQ 27,84,2013
In Vitro/nta	Inhibitor Concentration Low: 1 mg/L/96H	Biochemical: Metabolism (intermediary): Lipids including transport Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TOLED5 217,50,2013
In Vitro/pqa	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Cell differentiation In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Other assays	TIVIEQ 27,250,2013
In Vitro/pqa	Inhibitor Concentration Low: 10 µmol/L/24H	In Vitro Toxicity Studies: Cell differentiation	TIVIEQ 27,250,2013
In Vitro/Rat, myocard	Inhibitor Concentration Low: 1 mg/L/72H	In Vitro Toxicity Studies: Membrane currents	TXCYAC 279,54,2011
In Vitro/Rat, myocard	Inhibitor Concentration Low: 50 mg/L/72H	In Vitro Toxicity Studies: Membrane currents In Vitro Toxicity Studies: Other assays Nutritional and Gross Metabolic: Changes in: Ca	TXCYAC 279,54,2011
In Vitro/Rat, neurons	Inhibitor Concentration Low: 10 µmol/L/48H	In Vitro Toxicity Studies: Apoptosis in vitro	TXAPA9 280,190,2014
In Vitro/Rat, testis	Inhibitor Concentration Low: 100 µmol/L/8H	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TIVIEQ 36,210,2016
In Vitro/Rat, testis	Inhibitor Concentration Low: 100 µmol/L/24H	In Vitro Toxicity Studies: Other assays	TIVIEQ 36,210,2016
inhalation/mouse	lowest published toxic concentration: 300 mg/m³/50M	Lung, Thorax, or Respiration: Respiratory depression	TXCYAC 235,119,2007
inhalation/rat	lowest published toxic concentration: 100 mg/m³	Behavioral: Alteration of classical conditioning	TPKVAL 15,123,1979
inhalation/rat	lowest published toxic concentration: 10 mg/m³	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Respiratory depression	TPKVAL 15,123,1979
intraperitoneal/mouse	lowest published lethal dose: 14000 mg/kg		MUREAV 747,164,2012
intraperitoneal/mouse	lowest published toxic dose: 100 mg/kg	Liver: Other changes	TOLED5 177,20,2008
intraperitoneal/mouse	lethal dose (50 percent kill): 14 gm/kg	Vascular: BP lowering not characterized in autonomic section Behavioral: Excitement	JPMSAE 55,158,1966
intraperitoneal/rabbit	Lethal dose: >31 mL/kg		AMIHAB 13,259,1956
intraperitoneal/rat	lowest published toxic dose: 2 mL/kg	Reproductive: Maternal effects: Parturition	EVHPAZ 3,91,1973
intraperitoneal/rat	lethal dose (50 percent kill): 30700 mg/kg		JIHTAB 27,130,1945
intratracheal/rat	lowest published lethal dose: 30 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Blood: Hemorrhage	TPKVAL 2,59,1961
intravenous/mouse	lethal dose (50 percent kill): 1060 mg/kg		NTIS** PB250-102
intravenous/rat	lethal dose (50 percent kill): 250 mg/kg	Lung, Thorax, or Respiration: Other changes	TXAPA9 45,230,1978
oral/guinea pig	lethal dose (50 percent kill): 26 gm/kg		IMEMDT 29,269,1982
oral/man	lowest published toxic dose: 143 mg/kg	Gastrointestinal: Other changes	JIHTAB 27,130,1945
oral/monkey	lowest published toxic dose: 100 mg/kg	Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOXID9 72(Suppl 1),384,2003
oral/mouse	lowest published toxic dose: 40 mg/kg	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXCYAC 194,35,2003
oral/mouse	lethal dose (50 percent kill): 1500 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Gastrointestinal: Necrotic changes	TPKVAL 2,59,1961
oral/mouse	lowest published toxic dose: 984.6 mg/kg	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOLED5 4,113,1979
oral/mouse	lethal dose (50 percent kill): 29.5 gm/kg		TOLED5 4,113,1979
oral/mouse	lowest published toxic dose: 1150 mg/kg	Liver: Other changes	TOXID9 -,217,2009
oral/rabbit	lethal dose (50 percent kill): 34 gm/kg		EVHPAZ 4,3,1973
oral/rat	lethal dose (50 percent kill): 30 gm/kg		NPIRI* 2,32,1975
oral/rat	lowest published toxic dose: 2000 mg/kg	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Biochemical: Metabolism (intermediary): Other	TXAPA9 200,103,2004
oral/rat	lowest published toxic dose: 2000 mg/kg	Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Metabolism (intermediary): Other	TOXID9 1,72,2001
oral/rat	lowest published toxic dose: 2000 mg/kg	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TOLED5 173,107,2007
oral/rat	lowest published toxic dose: 1000 mg/kg	Biochemical: Metabolism (intermediary): Other proteins	MUREAV 751,73,2013
skin/guinea pig	lethal dose (50 percent kill): 10 gm/kg		EVHPAZ 4,3,1973
skin/mouse	lowest published toxic dose: 220 gm/kg	Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	JOETD7 115,25,2008
skin/mouse	lowest published lethal dose: 4 gm/kg	Skin and Appendages: Other glands	GISAAA 45(6),35,1980
skin/rabbit	lethal dose (50 percent kill): 25 gm/kg		JIHTAB 27,130,1945
skin/rat	lowest published lethal dose: 4 gm/kg	Skin and Appendages: Other glands	GISAAA 45(6),35,1980
unreported route/guinea pig	lethal dose (50 percent kill): 40500 mg/kg		GTPZAB 32(7),52,1988
unreported route/mouse	lethal dose (50 percent kill): 7 gm/kg		GTPZAB 32(7),52,1988
unreported route/rat	lethal dose (50 percent kill): 47 gm/kg		GTPZAB 32(7),52,1988

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 13 mg/m³/14W- intermittent	Lung, Thorax, or Respiration: Other changes Immunological Including Allergic: Increase in humoral response Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TXCYAC 235,119,2007
inhalation/rat	lowest published toxic concentration: 25 mg/m³/6H/24D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOSCF2 93,164,2006
inhalation/rat	lowest published toxic concentration: 5 mg/m³/6H/8D- intermittent	Reproductive: Other effects on female	TOSCF2 93,164,2006
inhalation/rat	lowest published toxic concentration: 25 mg/m³/6H/63D- intermittent	Reproductive: Maternal effects: Menstrual cycle changes or disorders	TOSCF2 93,164,2006
inhalation/rat	lowest published toxic concentration: 25 mg/m³/6H/20D- intermittent	Endocrine: Change in LH Endocrine: Estrogenic Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOSCF2 93,164,2006
inhalation/rat	lowest published toxic concentration: 5 mg/m³/6H/20D- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOSCF2 93,164,2006
inhalation/rat	lowest published toxic concentration: 25 mg/m³/63D- intermittent	Endocrine: Effect on menstrual cycle Reproductive: Maternal effects: Uterus, cervix, vagina Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	TOXID9 90,24,2006
inhalation/rat	lowest published toxic concentration: 940 mg/m³/6H/4W- intermittent	Lung, Thorax, or Respiration: Changes in lung weight Liver: Changes in liver weight Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	FCTOD7 30,915,1992
intramuscular/rat	lowest published toxic dose: 8400 mg/kg/1W- continuous	Nutritional and Gross Metabolic: Changes in: Other metals Biochemical: Metabolism (intermediary): Lipids including transport Related to Chronic Data: Changes in testicular weight	TOLED5 23,67,1984
intraperitoneal/mouse	lowest published toxic dose: 11111.2 µg/kg/8D- intermittent	Immunological Including Allergic: Increase in humoral response	TOLED5 170,223,2007
intraperitoneal/mouse	lowest published toxic dose: 10500 mg/kg/6W- intermittent	Gastrointestinal: Peritonitis Related to Chronic Data: Changes in testicular weight	JPMSAE 55,158,1966
intraperitoneal/rat	lowest published toxic dose: 9 mg/kg/11D- intermittent	Liver: Other changes Nutritional and Gross Metabolic: Conditioned vitamin deficiency Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	IJEBA6 36,264,1998
intraperitoneal/rat	lowest published toxic dose: 15 mL/kg/10D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	ENVRAL 12,131,1976
intraperitoneal/rat	lowest published toxic dose: 15 mL/kg/10D- intermittent	Reproductive: Maternal effects: Ovaries, fallopian tubes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	ENVRAL 12,131,1976
intraperitoneal/rat	lowest published toxic dose: 6 mL/kg/7D- intermittent	Reproductive: Maternal effects: Parturition Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	EVHPAZ 3,91,1973
intraperitoneal/rat	lowest published toxic dose: 4 mg/kg/3D- intermittent	Reproductive: Maternal effects: Parturition Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	EVHPAZ 3,91,1973
intraperitoneal/rat	lowest published toxic dose: 6.25 gm/kg/5D- intermittent	Endocrine: Androgenic	BECTA6 21,65,1979
intraperitoneal/rat	lowest published toxic dose: 24500 mg/kg/49D- intermittent	Liver: Changes in liver weight	FCTOD7 103,157,2017
intraperitoneal/rat	lowest published toxic dose: 52500 mg/kg/15W- intermittent	Liver: Changes in liver weight Tumorigenic: Facilitates action of known carcinogens	FCTOD7 103,157,2017
intravenous/rat	lowest published toxic dose: 6300 mg/kg/21D- intermittent	Liver: Changes in liver weight Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight	IJTOFN 22,159,2003
intravenous/rat	lowest published toxic dose: 12600 mg/kg/21D- intermittent	Blood: Changes in spleen Skin: After systemic exposure: Dermatitis, irritative Nutritional and Gross Metabolic: Weight loss or decreased weight gain	IJTOFN 22,159,2003
intravenous/rat	lowest published toxic dose: 3000 mg/kg/11D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	EVHPAZ 65,237,1986
oral/domestic bird	lowest published toxic dose: 384 mg/kg/30D- continuous	Nutritional and Gross Metabolic: Other changes Biochemical: Metabolism (intermediary): Lipids including transport	BECTA6 25,345,1980
oral/guinea pig	lowest published toxic dose: 30 gm/kg/15D- intermittent	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TOLED5 40,209,1988
oral/hamster	lowest published toxic dose: 14 gm/kg/14D- intermittent	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TXAPA9 72,46,1984
oral/mammal (species unspecified)	lowest published toxic dose: 509 gm/kg/60W- continuous	Liver: Other changes Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXCYAC 6,341,1976
oral/monkey	lowest published toxic dose: 227500 mg/kg/13W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	ENVRAL 78,43,1998
oral/monkey	lowest published toxic dose: 42 gm/kg/60W- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOXID9 72,384,2003
oral/monkey	lowest published toxic dose: 221.7 gm/kg/454D- intermittent	Liver: Other changes	TXAPA9 197,229,2004
oral/monkey	lowest published toxic dose: 227500 mg/kg/65W- intermittent	Endocrine: Estrogenic Related to Chronic Data: Changes in ovarian weight Related to Chronic Data: Changes in uterine weight	JTEHF8 69,1651,2006
oral/monkey	lowest published toxic dose: 227500 mg/kg/65W- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	JTEHF8 69,1651,2006
oral/monkey	lowest published toxic dose: 28000 mg/kg/28D- intermittent	Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Effect on mitochondrial function	JTPAE7 21,73,2008
oral/mouse	lowest published toxic dose: 13671.7 mg/kg/2W- intermittent	Liver: Multiple effects Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	ARTODN 81,219,2007
oral/mouse	lowest published toxic dose: 6072 mg/kg/46D- continuous	Liver: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Lipids including transport	TXCYAC 289,1,2011
oral/mouse	lowest published toxic dose: 2737 mg/kg/46D- continuous	Liver: Other changes	TXCYAC 289,1,2011
oral/mouse	lowest published toxic dose: 420 mg/kg/14D- intermittent	Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Other	FCTOD7 71,272,2014
oral/mouse	lowest published toxic dose: 460 mg/kg/46D- continuous	Biochemical: Metabolism (intermediary): Lipids including transport Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TXCYAC 309,52,2013
oral/mouse	lowest published toxic dose: 840 µg/kg/28D- intermittent	Immunological Including Allergic: Uncharacterized (multiple organ involvement)	TXCYAC 324,88,2014
oral/mouse	lowest published toxic dose: 24000 mg/kg/10D- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	BCPCA6 36,4221,1987
oral/mouse	lowest published toxic dose: 28000 mg/kg/14D- intermittent	Liver: Changes in liver weight Endocrine: Other changes Reproductive: Maternal effects: Menstrual cycle changes or disorders	TOXID9 60,297,2001
oral/mouse	lowest published toxic dose: 24 mg/kg/48D- intermittent	Liver: Changes in liver weight Endocrine: Changes in adrenal weight Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	TOXID9 60,297,2001
oral/mouse	lowest published toxic dose: 15120 mg/kg/3W- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Other proteins	TXCYAC 204,109,2004
oral/mouse	lowest published toxic dose: 7000 mg/kg/7D- intermittent	Liver: Changes in liver weight Biochemical: Metabolism (intermediary): Other proteins	TXCYAC 207,149,2005
oral/mouse	lowest published toxic dose: 109.2 gm/kg/13W- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Other proteins	TOXID9 78,353,2004
oral/mouse	lowest published toxic dose: 2.52 gm/kg/7D- continuous	Liver: Other changes Liver: Changes in liver weight	EVHPAZ 110,363,2002
oral/mouse	lowest published toxic dose: 10.08 gm/kg/28D- continuous	Liver: Other changes Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	EVHPAZ 110,363,2002
oral/mouse	lowest published toxic dose: 7 gm/kg/1W- intermittent	Liver: Changes in liver weight	TXCYAC 191,211,2003
oral/mouse	lowest published toxic dose: 323 mg/kg/17D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #87119046
oral/mouse	lowest published toxic dose: 1440 mg/kg/12D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #PB85-105674
oral/mouse	lowest published toxic dose: 2040 mg/kg/17D- continuous	Liver: Changes in liver weight	NTIS** #PB85-105674
oral/mouse	lowest published toxic dose: 4250 mg/kg/17D- continuous	Behavioral: Sleep Skin and Appendages: Other: Hair	NTIS** #PB85-105674
oral/mouse	lowest published toxic dose: 6720 mg/kg/14D- continuous	Gastrointestinal: Changes in structure or function of salivary glands Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	BCPCA6 62,249,2001
oral/mouse	lowest published toxic dose: 921.7 gm/kg/104W- continuous	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOSCF2 58,377,2000
oral/mouse	lowest published toxic dose: 1061.6 gm/kg/104W- continuous	Kidney, Ureter, and Bladder: Changes in kidney weight Liver: Changes in liver weight Related to Chronic Data: Changes in uterine weight	TOSCF2 58,377,2000
oral/mouse	lowest published toxic dose: 212.7 gm/kg/104W- continuous	Brain and Coverings: Changes in brain weight Kidney, Ureter, and Bladder: Changes in kidney weight Related to Chronic Data: Changes in testicular weight	TOSCF2 58,377,2000
oral/mouse	lowest published toxic dose: 691.3 gm/kg/78W- continuous	Liver: Other changes Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOSCF2 58,377,2000
oral/mouse	lowest published toxic dose: 796.2 gm/kg/78W- continuous	Liver: Other changes Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation	TOSCF2 58,377,2000
oral/mouse	lowest published toxic dose: 193.4 gm/kg/78W- continuous	Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli	TOSCF2 58,377,2000
oral/mouse	lowest published toxic dose: 30 gm/kg/15D- intermittent	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	TOLED5 40,209,1988
oral/mouse	lowest published toxic dose: 33852 mg/kg/13W- continuous	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-217,1982
oral/mouse	lowest published toxic dose: 403 gm/kg/40W- continuous	Liver: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Other changes	TXAPA9 96,494,1988
oral/mouse	lowest published toxic dose: 213 gm/kg/2Y- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0559217
oral/mouse	lowest published toxic dose: 60480 mg/kg/12W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTPAE7 29,458,2001
oral/mouse	lowest published toxic dose: 32760 mg/kg/26W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	JTPAE7 29,458,2001
oral/mouse	lowest published toxic dose: 32760 mg/kg/26W- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight Reproductive: Paternal effects: Testes, epididymis, sperm duct	JTPAE7 29,458,2001
oral/mouse	lowest published toxic dose: 131040 mg/kg/26W- intermittent	Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	JTPAE7 29,458,2001
oral/mouse	lowest published toxic dose: 131040 mg/kg/26W- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTPAE7 29,458,2001
oral/mouse	lowest published toxic dose: 131040 mg/kg/26W- intermittent	Liver: Other changes Reproductive: Paternal effects: Testes, epididymis, sperm duct	JTPAE7 29,458,2001
oral/pig	lowest published toxic dose: 3600 mg/kg/4W- intermittent	Endocrine: Other changes	REPTED 21,160,2006
oral/rabbit	lowest published toxic dose: 840 mg/kg/28D- continuous	Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport	LPDSAP 13,673,1978
oral/rabbit	lowest published toxic dose: 30 gm/kg/15D- intermittent	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TOLED5 40,209,1988
oral/rat	lowest published toxic dose: 42 gm/kg/28D- continuous	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	NTIS** OTS0530399
oral/rat	lowest published toxic dose: 1500 mg/kg/30D- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Related to Chronic Data: Changes in testicular weight	VHTODE 37,310,1995
oral/rat	lowest published toxic dose: 139 gm/kg/2Y- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	AMIHBC 8,219,1953
oral/rat	lowest published toxic dose: 17500 mg/kg/7D- intermittent	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Related to Chronic Data: Changes in testicular weight	TXAPA9 61,205,1981
oral/rat	lowest published toxic dose: 59388 mg/kg/6W- continuous	Kidney, Ureter, and Bladder: Changes in bladder weight Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTXAV 15,389,1977
oral/rat	lowest published toxic dose: 168 gm/kg/17W- continuous	Blood: Other changes Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain	FCTXAV 15,389,1977
oral/rat	lowest published toxic dose: 19796 mg/kg/12W- continuous	Liver: Changes in liver weight Skin and Appendages: Other: Hair Related to Chronic Data: Changes in testicular weight	FCTXAV 15,389,1977
oral/rat	lowest published toxic dose: 25200 mg/kg/21D- continuous	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases	TXAPA9 77,116,1985
oral/rat	lowest published toxic dose: 14 gm/kg/14D- intermittent	Liver: Other changes Liver: Changes in liver weight	TOLED5 66,317,1993
oral/rat	lowest published toxic dose: 8400 mg/kg/14D- continuous	Liver: Changes in liver weight Endocrine: Evidence of thyroid hyperfunction Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOLED5 121,35,2001
oral/rat	lowest published toxic dose: 5.52 gm/kg/7D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TOSCF2 55,433,2000
oral/rat	lowest published toxic dose: 143.6 gm/kg/182D- continuous	Blood: Other changes Blood: Changes in erythrocyte (RBC) count	TOSCF2 55,433,2000
oral/rat	lowest published toxic dose: 287.2 gm/kg/364D- continuous	Blood: Normocytic anemia Biochemical: Metabolism (intermediary): Other	TOSCF2 55,433,2000
oral/rat	lowest published toxic dose: 170.8 gm/kg/182D- continuous	Blood: Normocytic anemia Blood: Other changes Biochemical: Metabolism (intermediary): Other	TOSCF2 55,433,2000
oral/rat	lowest published toxic dose: 26.7 gm/kg/182D- continuous	Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation	TOSCF2 55,433,2000
oral/rat	lowest published toxic dose: 4.2 gm/kg/104W- continuous	Kidney, Ureter, and Bladder: Other changes	TOSCF2 55,433,2000
oral/rat	lowest published toxic dose: 21.04 gm/kg/104W- continuous	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	TOSCF2 55,433,2000
oral/rat	lowest published toxic dose: 106.7 gm/kg/104W- continuous	Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	TOSCF2 55,433,2000
oral/rat	lowest published toxic dose: 132.3 gm/kg/104W- continuous	Liver: Changes in liver weight	TOSCF2 55,433,2000
oral/rat	lowest published toxic dose: 683.2 gm/kg/104W- continuous	Kidney, Ureter, and Bladder: Changes in kidney weight	TOSCF2 55,433,2000
oral/rat	lowest published toxic dose: 12000 mg/kg/10D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands Related to Chronic Data: Changes in prostate weight	ATSUDG 4,452,1980
oral/rat	lowest published toxic dose: 42000 mg/kg/21D- continuous	Liver: Fatty liver degeneration	EVHPAZ 70,195,1986
oral/rat	lowest published toxic dose: 1050 mg/kg/21D- continuous	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Effect on specific coenzyme: CoA	EVHPAZ 70,195,1986
oral/rat	lowest published toxic dose: 21000 mg/kg/21D- continuous	Liver: Other changes	EVHPAZ 70,195,1986
oral/rat	lowest published toxic dose: 1050 mg/kg/21D- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes	EVHPAZ 70,195,1986
oral/rat	lowest published toxic dose: 4200 mg/kg/21D- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases Biochemical: Effect on specific coenzyme: CoA	EVHPAZ 70,195,1986
oral/rat	lowest published toxic dose: 54800 mg/kg/274D- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases	EVHPAZ 70,195,1986
oral/rat	lowest published toxic dose: 21000 mg/kg/21D- continuous	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases	EVHPAZ 70,195,1986
oral/rat	lowest published toxic dose: 10153 mg/kg/13D- continuous	Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases	EVHPAZ 70,195,1986
oral/rat	lowest published toxic dose: 1338 mg/kg/3D- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases	EVHPAZ 70,195,1986
oral/rat	lowest published toxic dose: 3600 mg/kg/3D- continuous	Endocrine: Evidence of thyroid hypofunction Blood: Other changes	EVHPAZ 70,195,1986
oral/rat	lowest published toxic dose: 12600 mg/kg/21D- continuous	Endocrine: Evidence of thyroid hypofunction Blood: Other changes	EVHPAZ 70,195,1986
oral/rat	lowest published toxic dose: 28 gm/kg/14D- intermittent	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	ENVRAL 36,160,1985
oral/rat	lowest published toxic dose: 36000 mg/kg/12D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXAPA9 128,216,1994
oral/rat	lowest published toxic dose: 16000 mg/kg/8D- intermittent	Endocrine: Effect on menstrual cycle	TXAPA9 128,216,1994
oral/rat	lowest published toxic dose: 6000 mg/kg/3D- intermittent	Endocrine: Change in LH Endocrine: Change in gonadotropins Reproductive: Maternal effects: Ovaries, fallopian tubes	TXAPA9 128,216,1994
oral/rat	lowest published toxic dose: 10000 mg/kg/5D- intermittent	Endocrine: Other changes	TXAPA9 128,216,1994
oral/rat	lowest published toxic dose: 28000 mg/kg/10D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct	EVHPAZ 65,237,1986
oral/rat	lowest published toxic dose: 23800 mg/kg/14D- continuous	Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight	EVHPAZ 65,237,1986
oral/rat	lowest published toxic dose: 1000 mg/kg/5D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	TXAPA9 95,104,1988
oral/rat	lowest published toxic dose: 2500 mg/kg/5D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	TXAPA9 95,104,1988
oral/rat	lowest published toxic dose: 5000 mg/kg/5D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	TXAPA9 95,104,1988
oral/rat	lowest published toxic dose: 5000 mg/kg/5D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Related to Chronic Data: Changes in testicular weight	TXAPA9 95,104,1988
oral/rat	lowest published toxic dose: 10000 mg/kg/5D- intermittent	Related to Chronic Data: Changes in testicular weight	TXAPA9 95,104,1988
oral/rat	lowest published toxic dose: 5000 mg/kg/5D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXAPA9 95,104,1988
oral/rat	lowest published toxic dose: 12600 mg/kg/6W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	EVHPAZ 65,343,1986
oral/rat	lowest published toxic dose: 8400 mg/kg/1W- continuous	Behavioral: Food intake (animal)	EVHPAZ 65,343,1986
oral/rat	lowest published toxic dose: 72000 mg/kg/60D- continuous	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight	EVHPAZ 65,343,1986
oral/rat	lowest published toxic dose: 18000 mg/kg/60D- continuous	Liver: Changes in liver weight	EVHPAZ 65,343,1986
oral/rat	lowest published toxic dose: 1050 mg/kg/2W- continuous	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	EVHPAZ 65,343,1986
oral/rat	lowest published toxic dose: 28000 mg/kg/10D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in prostate weight Related to Chronic Data: Changes in testicular weight	EVHPAZ 65,229,1986
oral/rat	lowest published toxic dose: 28000 mg/kg/10D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in prostate weight	EVHPAZ 65,229,1986
oral/rat	lowest published toxic dose: 840 mg/kg/7D- continuous	Liver: Changes in liver weight Endocrine: Evidence of thyroid hyperfunction Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	ATSUDG 12,85,1988
oral/rat	lowest published toxic dose: 6000 mg/kg/3D- intermittent	Endocrine: Change in gonadotropins Reproductive: Maternal effects: Ovaries, fallopian tubes Reproductive: Maternal effects: Menstrual cycle changes or disorders	TXAPA9 128,216,1994
oral/rat	lowest published toxic dose: 2.52 gm/kg/7D- continuous	Liver: Other changes Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	EVHPAZ 110,363,2002
oral/rat	lowest published toxic dose: 2.1 gm/kg/7D- continuous	Liver: Changes in liver weight Endocrine: Changes in thyroid weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	EVHPAZ 110,363,2002
oral/rat	lowest published toxic dose: 10.08 gm/kg/28D- continuous	Liver: Other changes Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	EVHPAZ 110,363,2002
oral/rat	lowest published toxic dose: 8.4 gm/kg/28D- continuous	Liver: Changes in liver weight Endocrine: Changes in thyroid weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)	EVHPAZ 110,363,2002
oral/rat	lowest published toxic dose: 6260 mg/kg/20D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #87119046
oral/rat	lowest published toxic dose: 11460 mg/kg/20D- continuous	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #87119046
oral/rat	lowest published toxic dose: 5040 mg/kg/4W- continuous	Liver: Other changes Endocrine: Estrogenic Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	IJCNAW 58,736,1994
oral/rat	lowest published toxic dose: 10080 mg/kg/8W- continuous	Liver: Other changes Endocrine: Estrogenic Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	IJCNAW 58,736,1994
oral/rat	lowest published toxic dose: 20160 mg/kg/16W- continuous	Liver: Other changes Endocrine: Estrogenic	IJCNAW 58,736,1994
oral/rat	lowest published toxic dose: 2000 mg/kg/4D- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** #PB85-105658
oral/rat	lowest published toxic dose: 5000 mg/kg/20D- continuous	Behavioral: Food intake (animal) Liver: Changes in liver weight Skin and Appendages: Other: Hair	NTIS** #PB85-105658
oral/rat	lowest published toxic dose: 8400 mg/kg/1W- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	PHTOEH 65,265,1989
oral/rat	lowest published toxic dose: 8400 mg/kg/1W- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Lipids including transport	TOLED5 76,63,1995
oral/rat	lowest published toxic dose: 700 mg/kg/14D- intermittent	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases	FCTOD7 42,107,2004
oral/rat	lowest published toxic dose: 2800 mg/kg/14D- intermittent	Liver: Changes in liver weight Endocrine: Changes in adrenal weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	FCTOD7 42,107,2004
oral/rat	lowest published toxic dose: 38304 mg/kg/21D- continuous	Endocrine: Evidence of thyroid hyperfunction	REPTED 16,709,2002
oral/rat	lowest published toxic dose: 38304 mg/kg/21D- continuous	Liver: Hepatitis (hepatocellular necrosis), zonal Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	REPTED 16,709,2002
oral/rat	lowest published toxic dose: 18240 mg/kg/10D- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases	REPTED 16,709,2002
oral/rat	lowest published toxic dose: 134.4 gm/kg/28D- continuous	Liver: Other changes	TOXID9 72,235,2003
oral/rat	lowest published toxic dose: 8000 mg/kg/8D- intermittent	Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	EVHPAZ 111,139,2003
oral/rat	lowest published toxic dose: 9000 mg/kg/9D- intermittent	Endocrine: Estrogenic Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	EVHPAZ 111,139,2003
oral/rat	lowest published toxic dose: 6836 mg/kg/2W- intermittent	Liver: Other changes	TXAPA9 197,229,2004
oral/rat	lowest published toxic dose: 140 mg/kg/14D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Metabolism (intermediary): Other	BIREBV 65,1252,2001
oral/rat	lowest published toxic dose: 280 mg/kg/28D- intermittent	Endocrine: Change in gonadotropins Endocrine: Androgenic	BIREBV 65,1252,2001
oral/rat	lowest published toxic dose: 13500 mg/kg/18D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	EVHPAZ 109,229,2001
oral/rat	lowest published toxic dose: 6 gm/kg/3D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Nutritional and Gross Metabolic: Changes in: Other metals	TXCYAC 171,105,2002
oral/rat	lowest published toxic dose: 14 gm/kg/7D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Nutritional and Gross Metabolic: Changes in: Other metals Related to Chronic Data: Changes in testicular weight	TXCYAC 171,105,2002
oral/rat	lowest published toxic dose: 1250 mg/kg/28D- continuous	Liver: Liver function tests impaired	TXAPA9 197,231,2004
oral/rat	lowest published toxic dose: 1000 mg/kg/10D- intermittent	Liver: Changes in liver weight	TXCYAC 208,115,2005
oral/rat	lowest published toxic dose: 2000 mg/kg/10D- intermittent	Liver: Changes in liver weight Related to Chronic Data: Changes in prostate weight	TXCYAC 208,115,2005
oral/rat	lowest published toxic dose: 8.4 gm/kg/28D- continuous	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Metabolism (intermediary): Lipids including transport	LPDSAP 13,673,1978
oral/rat	lowest published toxic dose: 12600 mg/kg/5W- intermittent	Liver: Changes in liver weight	REPTED 21,253,2006
oral/rat	lowest published toxic dose: 52500 mg/kg/5W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	REPTED 21,253,2006
oral/rat	lowest published toxic dose: 4 gm/kg/2D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	REPTED 22,77,2006
oral/rat	lowest published toxic dose: 4 gm/kg/2D- intermittent	Related to Chronic Data: Changes in testicular weight	REPTED 22,77,2006
oral/rat	lowest published toxic dose: 14 gm/kg/7D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	REPTED 22,77,2006
oral/rat	lowest published toxic dose: 500 mg/kg/5D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases	ARTODN 77,446,2003
oral/rat	lowest published toxic dose: 5000 mg/kg/5D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Related to Chronic Data: Changes in testicular weight	ARTODN 77,446,2003
oral/rat	lowest published toxic dose: 28000 mg/kg/14D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	TOXID9 1,72,2001
oral/rat	lowest published toxic dose: 9350.32 mg/kg/4W- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight	REPTED 22,411,2006
oral/rat	lowest published toxic dose: 45594.08 mg/kg/4W- intermittent	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	REPTED 22,411,2006
oral/rat	lowest published toxic dose: 14000 mg/kg/4W- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	TERP2* -,310,2004
oral/rat	lowest published toxic dose: 6300 mg/kg/21D- intermittent	Liver: Changes in liver weight Reproductive: Paternal effects: Testes, epididymis, sperm duct Related to Chronic Data: Changes in testicular weight	IJTOFN 22,159,2003
oral/rat	lowest published toxic dose: 11400 mg/kg/19D- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight Skin and Appendages: Other: Hair Nutritional and Gross Metabolic: Weight loss or decreased weight gain	IJTOFN 22,159,2003
oral/rat	lowest published toxic dose: 3000 mg/kg/3D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	IJTOFN 22,159,2003
oral/rat	lowest published toxic dose: 8000 mg/kg/8D- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTSCDR 30,175,2005
oral/rat	lowest published toxic dose: 1.71 mg/kg/38D- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight	TOSCF2 91,247,2006
oral/rat	lowest published toxic dose: 15390 mg/kg/38D- intermittent	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in kidney weight	TOSCF2 91,247,2006
oral/rat	lowest published toxic dose: 15 gm/kg/30D- intermittent	Related to Chronic Data: Changes in testicular weight Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	FCTOD7 90,64,2016
oral/rat	lowest published toxic dose: 5.25 mg/kg/15W- intermittent	Liver: Other changes	TXAPA9 316,17,2017
oral/rat	lowest published toxic dose: 70 mg/kg/7D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXCYAC 306,9,2013
oral/rat	lowest published toxic dose: 210 mg/kg/21D- intermittent	Endocrine: Change in LH	TOLED5 215,84,2012
oral/rat	lowest published toxic dose: 350 mg/kg/35D- intermittent	Endocrine: Other changes	TOLED5 215,84,2012
oral/rat	lowest published toxic dose: 350 mg/kg/14D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TOLED5 215,84,2012
oral/rat	lowest published toxic dose: 13671.7 mg/kg/2W- intermittent	Liver: Multiple effects Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	ARTODN 81,219,2007
oral/rat	lowest published toxic dose: 6300 mg/kg/7D- continuous	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	TOLED5 173,107,2007
oral/rat	lowest published toxic dose: 85085 mg/kg/13W- continuous	Liver: Changes in liver weight	MOCAE8 42,9,2005
oral/rat	lowest published toxic dose: 60480 mg/kg/12W- continuous	Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases	TOLED5 178,110,2008
oral/rat	lowest published toxic dose: 4200 mg/kg/2W- intermittent	Liver: Other changes Reproductive: Maternal effects: Menstrual cycle changes or disorders	JTSCDR 34,SP111,2009
oral/rat	lowest published toxic dose: 84000 mg/kg/4W- intermittent	Reproductive: Maternal effects: Menstrual cycle changes or disorders Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in ovarian weight	JTSCDR 34,SP111,2009
oral/rat	lowest published toxic dose: 14000 mg/kg/2W- intermittent	Liver: Other changes Liver: Changes in liver weight Reproductive: Maternal effects: Ovaries, fallopian tubes	JTSCDR 34,SP111,2009
oral/rat	lowest published toxic dose: 42000 mg/kg/2W- intermittent	Liver: Changes in liver weight Endocrine: Other changes Endocrine: Changes in pituitary weight	JTSCDR 34,SP111,2009
oral/rat	lowest published toxic dose: 8400 mg/kg/4W- intermittent	Liver: Other changes Liver: Changes in liver weight Reproductive: Maternal effects: Ovaries, fallopian tubes	JTSCDR 34,SP111,2009
oral/rat	lowest published toxic dose: 22000 mg/kg/22D- intermittent	Reproductive: Maternal effects: Menstrual cycle changes or disorders Nutritional and Gross Metabolic: Weight loss or decreased weight gain	JTSCDR 34,SP111,2009
oral/rat	lowest published toxic dose: 28000 mg/kg/4W- intermittent	Gastrointestinal: Changes in structure or function of salivary glands Liver: Changes in liver weight Reproductive: Maternal effects: Ovaries, fallopian tubes	JTSCDR 34,SP111,2009
oral/rat	lowest published toxic dose: 300 mg/kg/30D- intermittent	Endocrine: Androgenic Musculoskeletal: Other changes Biochemical: Metabolism (intermediary): Other carbohydrates	TXAPA9 257,155,2011
oral/rat	lowest published toxic dose: 3000 mg/kg/30D- intermittent	Endocrine: Other changes Musculoskeletal: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase	TXAPA9 257,155,2011
oral/rat	lowest published toxic dose: 2800 mg/kg/28D- intermittent	Endocrine: Hyperglycemia	TXAPA9 257,155,2011
skin/mouse	lowest published toxic dose: 30000 mg/kg/15D- intermittent	Liver: Changes in liver weight	TXCYAC 244,231,2008
subcutaneous/mouse	lowest published toxic dose: 3 mg/kg/3D- intermittent	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Related to Chronic Data: Changes in testicular weight	JTEHD6 26,39,1989
unreported route/mouse	lowest published toxic dose: 2300 mg/kg/2D- intermittent	Liver: Other changes Biochemical: Metabolism (intermediary): Other	TOXID9 60,205,2001
unreported route/mouse	lowest published toxic dose: 3450 mg/kg/3D- intermittent	Liver: Other changes Liver: Changes in liver weight	TXCYAC 213,223,2005
unreported route/rat	lowest published toxic dose: 18900 mg/kg/21D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands Related to Chronic Data: Changes in prostate weight	TOXID9 44,281,2005
unreported route/rat	lowest published toxic dose: 18900 mg/kg/21D- intermittent	Related to Chronic Data: Changes in testicular weight	TOXID9 44,281,2005
unreported route/rat	lowest published toxic dose: 18900 mg/kg/21D- intermittent	Endocrine: Other changes Endocrine: Changes in adrenal weight	TOXID9 44,281,2005

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 mg/m³	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 101,260,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 101,260,2013
TOXICOLOGY REVIEW		EVHPAZ 3,73,1973
TOXICOLOGY REVIEW		RREVAH 54,1,1975
TOXICOLOGY REVIEW		JJOMDZ 15,808,1973
TOXICOLOGY REVIEW		CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW		ESKHA5 (93),1,1975
TOXICOLOGY REVIEW		TXAPA9 45,1,1978
TOXICOLOGY REVIEW		JTEHD6 9,141,1982
TOXICOLOGY REVIEW		JJATDK 8,75,1988
TOXICOLOGY REVIEW		FAATDF 13,747,1989
TOXICOLOGY REVIEW		REPTED 16,679,2002
TOXICOLOGY REVIEW		MUREAV 543,201,2003
TOXICOLOGY REVIEW		MUREAV 567,227,2004
TOXICOLOGY REVIEW		TXAPA9 197,178,2004
TOXICOLOGY REVIEW		BPCEM* 16,105,2002
TOXICOLOGY REVIEW		ENTOX* -,733,2005
TOXICOLOGY REVIEW		CRTXB2 36,695,2006
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		BCLPT* 96,131,2005
TOXICOLOGY REVIEW		MUREAV 658,124,2008
TOXICOLOGY REVIEW		REPTED 25,192,2008
TOXICOLOGY REVIEW		REPTED 22,291,2006
TOXICOLOGY REVIEW		MUREAV 654,114,2008
TOXICOLOGY REVIEW		JTPAE7 17,69,2004
TOXICOLOGY REVIEW		JTPAE7 20,197,2007
TOXICOLOGY REVIEW		HUTOX* -,649,1996
TOXICOLOGY REVIEW		MUREAV 672,10,2009
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		RTOPDW 53,90,2009
TOXICOLOGY REVIEW		JTSCDR 34,SP1,2009
TOXICOLOGY REVIEW		MUREAV 590,1,2005
TOXICOLOGY REVIEW		MUREAV 682,94,2009
TOXICOLOGY REVIEW		FESTAS 90,911,2008
TOXICOLOGY REVIEW		MUREAV 705,165,2010
TOXICOLOGY REVIEW		MUREAV 705,184,2010
TOXICOLOGY REVIEW		REPTED 31,327,2011
TOXICOLOGY REVIEW		REPTED 31,363,2011
TOXICOLOGY REVIEW		MUREAV 653,99,2008
TOXICOLOGY REVIEW		MUREAV 728,107,2011
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		TXCYAC 285,83,2011
TOXICOLOGY REVIEW		MUREAV 750,141,2012
TOXICOLOGY REVIEW		MUREAV 751,82,2012
TOXICOLOGY REVIEW		REPTED 38,1,2013
TOXICOLOGY REVIEW		REPTED 34,298,2012
TOXICOLOGY REVIEW		TXAPA9 254,86,2011
TOXICOLOGY REVIEW		MUREAV 764-765,46,2014
TOXICOLOGY REVIEW		MUREAV 764-765,36,2014
TOXICOLOGY REVIEW		TOLED5 201,152,2011
TOXICOLOGY REVIEW		TOLED5 202,36,2011
TOXICOLOGY REVIEW		REPTED 49,117,2014
TOXICOLOGY REVIEW		NRTXDN 41,112,2014
TOXICOLOGY REVIEW		TXCYAC 307,35,2013
TOXICOLOGY REVIEW		TXCYAC 311,41,2013
TOXICOLOGY REVIEW		MUREAV 786-788,14,2015
TOXICOLOGY REVIEW		TXAPA9 261,227,2012
TOXICOLOGY REVIEW		MUREAV 767,67,2016
TOXICOLOGY REVIEW		MUREAV 795,7,2016
TOXICOLOGY REVIEW		NETOX* 48,21,2015
TOXICOLOGY REVIEW		FCTOD7 86,298,2015
TOXICOLOGY REVIEW		NETEEC 52,25,2015
TOXICOLOGY REVIEW		NRTXDN 55,92,2016
TOXICOLOGY REVIEW		JOETD7 176,135,2015
TOXICOLOGY REVIEW		REPTED 65,76,2016
TOXICOLOGY REVIEW		REPTED 54,141,2015
TOXICOLOGY REVIEW		EMMUEG 57,579,2016
TOXICOLOGY REVIEW		TOLED5 265,106,2017
TOXICOLOGY REVIEW		ENVIN* 94,758,2016
TOXICOLOGY REVIEW		MUREAV 832-833,7,2018
TOXICOLOGY REVIEW		REPTED 81,140,2018
TOXICOLOGY REVIEW		REPTED 81,147,2018
TOXICOLOGY REVIEW		RTOPDW 61,251,2011
TOXICOLOGY REVIEW		SFDRA* 38,523,2016

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION		FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Cancelled	RBREV* -,270,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 5 mg/m³	DTLVS* 3,96,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 5 mg/m³, short term exposure limit 10 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 mg/m³;KZW 50 mg/m³, inhal, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 5 mg/m³, short term exposure limit 10 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 3 mg/m³, MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 5 mg/m³, short term exposure limit 10 mg/m³, NOV2011
Occupational Exposure Limit-FRANCE	VME 5 mg/m³, FEB2006
Occupational Exposure Limit-GERMANY	MAK 10 mg/m³, 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 10 mg/m³, short term exposure limit 40 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 3 mg/m³, carc, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 5 mg/m³, 2B carc, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 5 mg/m³, short term exposure limit 10 mg/m³, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 5 mg/m³;short term exposure limit 10 mg/m³, 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 mg/m³; short term exposure limit 10 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 3 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 5 mg/m³, JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 1 mg/m³, MAC(short term exposure limit) 5 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 3 mg/m³;short term exposure limit 5 mg/m³, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 mg/m³, inhal, JAN2011
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 5 mg/m³, JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 5 mg/m³;short term exposure limit 10 mg/m³, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 5 mg/m³	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 5 mg/m³	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 5 mg/m³	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 5 mg/m³	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DEHP-air	10H Carcinogen time-weighted average 5 mg/m³;short term exposure limit 10 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code M0347; Number of Industries 164; Total Number of Facilities 19879; Number of Occupations 116; Total Number of Employees Exposed 340800; Total Number of Female Employees Exposed 106918
National Occupational Hazard Survey 1974	Hazard Code M0347; Number of Industries 222; Total Number of Facilities 33723; Number of Occupations 126; Total Number of Employees Exposed 332356

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182400/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Rodent dominant lethal
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9120
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:mouse,rat
NIOSH Analytical Method, 1994: Di(2-ethylhexyl) phthalate, 5020
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #104

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health