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Registry of Toxic Effects of Chemical Substances (RTECS)

Phthalic acid, dimethyl ester

RTECS #

TI1575000

CAS #

131-11-3; 64441-70-9

Updated

October 2015

Molecular Weight

194.20

Molecular Formula

C10H10O4

Synonyms

1,2-Benzenedicarboxylic acid, dimethyl ester
Avolin
Dimethyl 1,2-benzenedicarboxylate
Dimethyl benzene-o-dicarboxylate
Dimethyl benzeneorthodicarboxylate
Dimethyl o-phthalate
Dimethyl phthalate (ACGIH:OSHA)
Dimethylester kyseliny ftalove (Czech)
Dimethylphthalate
DMF (insect repellent)
ENT 262
Fermine
Methyl phthalate
Mipax
NTM
o-Dimethyl phthalate
Palatinol M
Phthalate acid, dimethyl ester
Phthalic acid methyl ester
Phthalsaeuredimethylester (German)
RCRA waste number U102
Repeftal
Solvanom
Solvarone
Unimoll DM

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 119 mgJPETAB 82,377,1944

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisskin/rat25 gm/kg/4W- intermittentFATOAO 40,454,1977
mutation in microorganisms/Salmonella typhimurium200 µg/plate (+enzymatic activation step)JTEHD6 16,61,1985

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 338 mg/kg (5-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JPMSAE 61,51,1972
intraperitoneal/rat 338 mg/kg (5-15D pregnant)Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Other developmental abnormalities
JPMSAE 61,51,1972
intraperitoneal/rat 1125 mg/kg (5-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathJPMSAE 61,51,1972
intraperitoneal/rat 1500 mg/kg (3-9D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)JDSCAE 55,696,1972
intraperitoneal/rat 3 mL/kg (3-9D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)EVHPAZ 3,91,1973
oral/rat 35700 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleHPV349 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rat, neurons Inhibitor Concentration (50 percent kill): 7.87 µmol/L/10MIn Vitro Toxicity Studies: Other assaysNRTXDN 40,75,2014
inhalation/cat Lowest published lethal concentration: 9300 mg/m3/6.5H14CYAT 2,1905,1963
inhalation/rat lowest published toxic concentration: 10 mg/m3Peripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 15,123,1979
intraperitoneal/mouse lethal dose (50 percent kill): 1380 mg/kgIPSTB3 3,93,1976
intraperitoneal/rat lethal dose (50 percent kill): 3375 µL/kgJPMSAE 61,51,1972
intraperitoneal/rat lethal dose (50 percent kill): 30.7 gm/kgENTOX* -,422,2005
oral/chicken lethal dose (50 percent kill): 8500 µL/kgJPETAB 93,26,1948
oral/Dog Lethal dose: >1400 mg/kgEVHPAZ 3,61,1973
oral/guinea pig lethal dose (50 percent kill): 2400 µL/kgJPETAB 93,26,1948
oral/mouse lethal dose (50 percent kill): >30 gm/kgENTOX* -,422,2005
oral/mouse lethal dose (50 percent kill): 6800 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 24(3),25,1980
oral/rabbit lethal dose (50 percent kill): 4400 µL/kgJPETAB 93,26,1948
oral/rat lethal dose (50 percent kill): 6900 mg/kgHPV349 -,-,2001
oral/rat lethal dose (50 percent kill): 6800 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 24(3),25,1980
skin/guinea pig lethal dose (50 percent kill): >10 mL/kgJPETAB 93,26,1948
skin/rabbit lethal dose (50 percent kill): >20 mL/kg38MKAJ 2A,2343,1981
skin/rat lethal dose (50 percent kill): >4800 mg/kg85JFAN A154,1983
subcutaneous/mouse lowest published lethal dose: 6500 mg/kgLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
EDWU** -,-,1937
unreported route/guinea pig lethal dose (50 percent kill): 4800 mg/kgGTPZAB 32(7),52,1988
unreported route/mouse lethal dose (50 percent kill): 6800 mg/kgGTPZAB 32(7),52,1988
unreported route/rat lethal dose (50 percent kill): 9500 mg/kgGTPZAB 32(7),52,1988

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1840 µg/kg/4H/17W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
GISAAA 39(12),26,1974
intraperitoneal/rat lowest published toxic dose: 3 mL/kg/7D- intermittentReproductive: Maternal effects: Parturition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EVHPAZ 3,91,1973
oral/rat lowest published toxic dose: 36 gm/kg/10D- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB89164826/AS
oral/rat lowest published toxic dose: 2 gm/kg/10D- continuousBehavioral: Fluid intakeNTIS** #PB89164826/AS
oral/rat lowest published toxic dose: 8 gm/kg/10D- continuousBehavioral: Food intake (animal)NTIS** #PB89164826/AS
skin/human lowest published toxic dose: 1290 mg/kg/30D- intermittentBlood: Other changesTPKVAL 15,49,1979
skin/rabbit lowest published toxic dose: 360 gm/kg/90D- continuousLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli
HPV349 -,,2001
skin/rabbit lowest published toxic dose: 360 mL/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJPETAB 93,26,1948

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWEVHPAZ 3,73,1973
TOXICOLOGY REVIEWRREVAH 54,1,1975
TOXICOLOGY REVIEWEVHPAZ 4,3,1973
TOXICOLOGY REVIEWJACTDZ 4(3),267,1985
TOXICOLOGY REVIEWEMCPT* 2,137,2005
TOXICOLOGY REVIEWENTOX* -,422,2005
TOXICOLOGY REVIEWIJTOFN 24,1,2005
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWREPTED 34,298,2012
TOXICOLOGY REVIEWMUREAV 763,36,2014
TOXICOLOGY REVIEWNRTXDN 41,112,2014

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,270,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 mg/m3DTLVS* 3,91,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 3 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 5 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 3 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 mg/m3, JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 0.3 mg/m3, short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 3 mg/m3;short term exposure limit 5 mg/m3, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 mg/m3;short term exposure limit 10 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLPHTHALATE-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 59210; Number of Industries 56; Total Number of Facilities 6174; Number of Occupations 66; Total Number of Employees Exposed 57908; Total Number of Female Employees Exposed 16352
National Occupational Hazard Survey 1974Hazard Code 59210; Number of Industries 38; Total Number of Facilities 2879; Number of Occupations 58; Total Number of Employees Exposed 50231

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
OSHA ANALYTICAL METHOD #104
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