Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridyl) ester
RTECS #
TF6300000
CAS #
Updated
March 2019
Molecular Weight
350.59
Molecular Formula
C9H11Cl3NO3PS
Synonyms
2-Pyridinol, 3,5,6-trichloro-, O-ester with O,O-diethyl phosphorothioate
Analytical grade chlorpyrifos
Brodan
Chlorpyrifos
Chlorpyrifos (ACGIH)
Chlorpyrifos-ethyl
Chlorpyriphos
Chlorpyriphos-ethyl
Detmol U.A.
Dowco 179
Dursban
Dursban F
ENT 27311
Ethion, dry
Lorsban
Lorsban 4E
Lorsban 50SL
O,O-Diaethyl-O-3,5,6-trichlor-2-pyridylmonothiophosphat (German)
O,O-Diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioate
O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate
OMS-0971
Piridane
Pyrinex
Stipend
Zidil
Analytical grade chlorpyrifos
Brodan
Chlorpyrifos
Chlorpyrifos (ACGIH)
Chlorpyrifos-ethyl
Chlorpyriphos
Chlorpyriphos-ethyl
Detmol U.A.
Dowco 179
Dursban
Dursban F
ENT 27311
Ethion, dry
Lorsban
Lorsban 4E
Lorsban 50SL
O,O-Diaethyl-O-3,5,6-trichlor-2-pyridylmonothiophosphat (German)
O,O-Diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioate
O,O-Diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate
OMS-0971
Piridane
Pyrinex
Stipend
Zidil
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| Cytogenetic Analysis | other cell types/mouse | 500 µg/L | MUREAV 279,165,1992 |
| Cytogenetic Analysis | sperm/human | 500 µmol/L/1H | REPTED 25,455,2008 |
| DNA Damage | sperm/human | 4.302 mmol/L/1H | REPTED 25,455,2008 |
| DNA Damage | multiple/other fish | 68 µg/L/1D | FCTOD7 47,650,2009 |
| DNA Damage | other cell types/human | 1 µmol/L/1H | TOXID9 -,223,2009 |
| DNA Damage | oral/mouse | 0.28 mg/kg | MUREAV 516,139,2002 |
| DNA Damage | liver/human | 10 µmol/L | TOXID9 -,73,2008 |
| DNA Damage | multiple/non-mammalian species | 0.08 mg/L/96H | MUREAV 680,2,2009 |
| DNA Damage | intramuscular/rat | 50 mg/kg | EMMUEG 49,426,2008 |
| DNA Damage | intramuscular/rat | 100.8 mg/kg/90D- intermittent | EMMUEG 49,426,2008 |
| DNA Damage | lymphocyte/rat | 0.01 mg/L/2H | MUREAV 761,10,2014 |
| DNA Damage | lymphocyte/rat | 0.01 mg/L/4H | MUREAV 761,10,2014 |
| DNA Damage | subcutaneous/rat | 70 mg/kg/7D | NRTXDN 45,22,2014 |
| DNA Damage | lymphocyte/human | 0.000623 mg/L/24H | FCTOD7 96,90,2016 |
| DNA Damage | lymphocyte/human | 0.016 mg/L/4H | FCTOD7 96,90,2016 |
| DNA Damage | other cell types/human | 0.0262 mg/L/4H | FCTOD7 96,90,2016 |
| DNA inhibition | other cell types/human | 3 µmol/L/1H | TXAPA9 206,17,2005 |
| micronucleus test | lymphocyte/human | 0.0262 mg/L/4H | FCTOD7 96,90,2016 |
| micronucleus test | lymphocyte/human | 0.000623 mg/L/24H | FCTOD7 96,90,2016 |
| micronucleus test | other cell types/human | 0.016 mg/L/4H | FCTOD7 96,90,2016 |
| micronucleus test | multiple/non-mammalian species | 0.16 mg/L/96H | MUREAV 680,2,2009 |
| micronucleus test | multiple/other fish | 68 µg/L/3D-continuous | FCTOD7 47,650,2009 |
| micronucleus test | multiple/other fish | 102 µg/L/1D | FCTOD7 47,650,2009 |
| sex chromosome loss and nondisjunction | oral/Drosophila melanogaster | 50 ppb | ENMUDM 5,835,1983 |
| sister chromatid exchange | lymphocyte/human | 2 mg/L | MUREAV 102,89,1982 |
| sister chromatid exchange | other cell types/mouse | 1 mg/L | MUREAV 279,165,1992 |
| specific locus test | oral/Drosophila melanogaster | 50 ppb | MUREAV 279,15,1992 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/rat | 210 µg/kg (1-7D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | VHTODE 34,498,1992 |
| intraperitoneal/rat | 4500 µg/kg (7-21D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | VHTODE 34,498,1992 |
| intraperitoneal/mouse | 80 mg/kg (1D prior to copulation) | Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) | REPTED 17,401,2003 |
| intraperitoneal/mouse | 40 mg/kg (10D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | REPTED 20,267,2005 |
| intraperitoneal/mouse | 80 mg/kg (10D pregnant) | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system | REPTED 20,267,2005 |
| oral/rat | 45 mg/kg (6-20D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic | TOXID9 60,240,2001 |
| oral/rat | 75 mg/kg (6-20D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | TOXID9 66,131,2002 |
| oral/rat | 8 mg/kg (14D preg-7D after birth) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) Reproductive: Specific developmental abnormalities: Hepatobiliary system | TOXID9 66,138,2002 |
| oral/rat | 5 mg/kg (14-18D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TOXID9 66,130,2002 |
| oral/rat | 50 mg/kg (14D pregnant) | Reproductive: Other effects on female Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | ARTODN 76,30,2002 |
| oral/mouse | 6 mg/kg (multigenerations) | Reproductive: Specific developmental abnormalities: Endocrine system | REPTED 22,263,2006 |
| oral/mouse | 24 mg/kg (15-18D pregnant) | Reproductive: Specific developmental abnormalities: Endocrine system | REPTED 22,263,2006 |
| oral/mouse | 12 mg/kg (15-18D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | TOSCF2 93,105,2006 |
| oral/rat | 252 mg/kg (1-21D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | JTSCDR 31,521,2006 |
| oral/rat | 315 mg/kg (1-21D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | JTSCDR 31,521,2006 |
| oral/rat | 180 mg/kg (6-15D pregnant) | Reproductive: Other effects on female Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | INJPD2 39,145,2007 |
| oral/rat | 45 mg/kg (6-20D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic | TOSCF2 77,83,2004 |
| oral/rat | 250 mg/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | REPTED 17,203,2003 |
| oral/rat | 250 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Hepatobiliary system | REPTED 17,203,2003 |
| oral/rat | 250 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Eye, ear | REPTED 17,203,2003 |
| oral/rat | 150 mg/kg (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | REPTED 17,203,2003 |
| oral/rat | 25 mg/kg (14-18D pregnant) | Reproductive: Other effects on female | TOSCF2 52,92,1999 |
| oral/rat | 135 mg/kg (6-22D preg/10D after birth) | Reproductive: Other effects on female Reproductive: Effects on newborn: Biochemical and metabolic | TOSCF2 53,438,2000 |
| oral/mouse | 250 mg/kg (6-15D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TXAPA9 54,31,1980 |
| oral/rabbit | 12180 mg/kg (6-19D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | FEREAC 60,7509,1995 |
| oral/pigeon | 35 mg/kg (7D prior to copulation) | Reproductive: Effects on fertility: Other measures of fertility Reproductive: Other effects to embryo or fetus Reproductive: Effects on newborn: Other neonatal measures or effects | TOXID9 -,14,2008 |
| oral/rat | 787.5 mg/kg (7D preg-21D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Other postnatal measures or effects | NETEEC 30,125,2008 |
| oral/mouse | 18 mg/kg (15D preg-14D after birth) | Reproductive: Effects on newborn: Behavioral | NETEEC 32,234,2010 |
| oral/rat | 225 mg/kg (30D male) | Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) | TIHEEC 23,439,2007 |
| oral/mouse | 246 µg/kg (multigeneration) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Physical Reproductive: Effects on newborn: Biochemical and metabolic | TXCYAC 308,74,2013 |
| oral/mouse | 246 µg/kg (multigeneration) | Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) | TXCYAC 308,74,2013 |
| oral/mouse | 24 mg/kg (14-17D pregnant) | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Delayed effects | NETEEC 46,32,2014 |
| oral/rat | 3.7 mg/kg (7-22D preg/21D after birth) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | FCTOD7 99,135,2017 |
| oral/rat | 29 mg/kg (1D preg-7D after birth) | Reproductive: Effects on newborn: Behavioral | FCTOD7 113,66,2018 |
| oral/rat | 43 mg/kg (1D preg-21D after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | FCTOD7 113,66,2018 |
| skin/rat | 30 mg/kg (18D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Central nervous system | JTEHD6 63,173,2001 |
| skin/rat | 1.6 mg/kg (5-20D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) | TOXID9 72,127,2003 |
| skin/rat | 17 mg/kg (4-20D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Delayed effects | ARTODN 80,620,2006 |
| skin/rat | 1.7 mg/kg (4-20D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Delayed effects | TOXID9 78,274,2004 |
| skin/rat | 1.7 mg/kg (4-20D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Delayed effects | ARTODN 78,467,2004 |
| skin/rat | 17 mg/kg (4-20D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | TOXID9 90,295,2006 |
| subcutaneous/mouse | 180 mg/kg (6-17D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TERPM* -,394,2006 |
| subcutaneous/rat | 4 mg/kg (9-12D pregnant) | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Delayed effects | NETEEC 26,95,2004 |
| subcutaneous/rat | 20 mg/kg (17-20D pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TOXID9 66,130,2002 |
| subcutaneous/rat | 200 mL/kg (12D pregnant) | Reproductive: Other effects on female Reproductive: Specific developmental abnormalities: Central nervous system | JTEHD6 44,189,1995 |
| subcutaneous/rat | 50 mg/kg (12-19D pregnant) | Reproductive: Other effects on female Reproductive: Other effects to embryo or fetus | PBBHAU 53,771,1996 |
| subcutaneous/rat | 200 mg/kg (12-19D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | PBBHAU 53,771,1996 |
| subcutaneous/guinea pig | 250 mg/kg (53-63D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral | NRTXDN 56,17,2016 |
| subcutaneous/guinea pig | 100 mg/kg (50-60D prior to copulation) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral | NETOX* 48,9,2015 |
| subcutaneous/rat | 4 mg/kg (15-18D pregnant) | Reproductive: Other developmental abnormalities Reproductive: Effects on newborn: Other postnatal measures or effects | NETEEC 37,23,2013 |
| subcutaneous/mouse | 24 mg/kg (6-17D pregnant) | Reproductive: Specific developmental abnormalities: Central nervous system | TXAPA9 245,310,2010 |
| subcutaneous/mouse | 100 mg/kg (9-18D pregnant) | Reproductive: Other developmental abnormalities | NETEEC 32,498,2010 |
| subcutaneous/mouse | 144 mg/kg (6-17D pregnant) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | NETEEC 32,504,2010 |
| subcutaneous/mouse | 20 mg/kg (17-20D pregnant) | Reproductive: Specific developmental abnormalities: Endocrine system | REPTED 29,74,2010 |
| subcutaneous/mouse | 4 mg/kg (17-20D pregnant) | Reproductive: Effects on newborn: Behavioral | REPTED 29,74,2010 |
| subcutaneous/mouse | 15 mg/kg (17-20 D pregnant) | Reproductive: Effects on newborn: Behavioral | TOXID9 12,466,2008 |
| subcutaneous/rat | 4 mg/kg (17-20D pregnant) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Drug dependence | NETEEC 24,733,2002 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 25 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Apoptosis in vitro | NRTXDN 42,58,2014 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | NRTXDN 42,58,2014 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration (50 percent kill): 126 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 26,406,2012 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration (50 percent kill): 9.2 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc. | TIVIEQ 26,406,2012 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 100 µmol/L/18H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 26,406,2012 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 10 µmol/L/48H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 26,406,2012 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 10 µmol/L/24H | In Vitro Toxicity Studies: Apoptosis in vitro Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TIVIEQ 26,406,2012 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 10 µmol/L/72H | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. | TIVIEQ 26,406,2012 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration (50 percent kill): 73.6 µmol/L/4H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TIVIEQ 32,190,2016 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration (50 percent kill): 0.15 µmol/L/24H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TIVIEQ 32,190,2016 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration (50 percent kill): 4.5 µmol/L/24H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TIVIEQ 32,190,2016 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 0.1 µmol/L/24H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TIVIEQ 32,190,2016 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 1 µmol/L/24H | Biochemical: Effect on specific coenzyme: Proportion of isoenzymes | TIVIEQ 32,190,2016 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 40,88,2017 |
| In Vitro/Human, embryonic cells | Inhibitor Concentration Low: 10 µmol/L/19H | In Vitro Toxicity Studies: Apoptosis in vitro | TXAPA9 329,26,2017 |
| In Vitro/Human, liver | Inhibitor Concentration Low: 10 µmol/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 26,718,2012 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 0.016 µg/mL/24H | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. | FCTOD7 96,90,2016 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 6 µmol/L/72H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 25,2074,2011 |
| In Vitro/Human, liver tumor | Inhibitor Concentration Low: 2 µmol/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 25,2074,2011 |
| In Vitro/Human, lymphocyte | Inhibitor Concentration Low: 0.000623 µg/mL/4H | In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc. In Vitro Toxicity Studies: Apoptosis in vitro In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. | FCTOD7 96,90,2016 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 40 µmol/L/48H | In Vitro Toxicity Studies: Other assays | FCTOD7 103,246,2017 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration (50 percent kill): 100 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 218,235,2013 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Apoptosis in vitro | TOLED5 218,235,2013 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Apoptosis in vitro | TXAPA9 268,55,2013 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 50 µmol/L/12H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TXAPA9 268,55,2013 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 100 µmol/L/3H | In Vitro Toxicity Studies: Cell differentiation | TXAPA9 278,159,2014 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 100 µmol/L/24H | Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | TXAPA9 278,159,2014 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 50 µmol/L/6H | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TXAPA9 278,159,2014 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 25 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 334,72,2015 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 50 µmol/L/12H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Apoptosis in vitro | TXCYAC 334,72,2015 |
| In Vitro/Human, neuroblastoma | Inhibitor Concentration Low: 50 µmol/L/24H | Biochemical: Metabolism (intermediary): Effect on mitochondrial function | TXCYAC 334,72,2015 |
| In Vitro/iag | Inhibitor Concentration Low: 25 µmol/L/6H | In Vitro Toxicity Studies: Other assays | NRTXDN 51,145,2015 |
| In Vitro/iag | Inhibitor Concentration Low: 50 µmol/L/3H | In Vitro Toxicity Studies: Other assays | NRTXDN 51,145,2015 |
| In Vitro/iag | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. In Vitro Toxicity Studies: Apoptosis in vitro | NRTXDN 51,145,2015 |
| In Vitro/jrd | Inhibitor Concentration Low: 0.05 µmol/L/10D | In Vitro Toxicity Studies: Cell growth: Colony formation | TOLED5 213,184,2012 |
| In Vitro/jrd | Inhibitor Concentration Low: 0.05 µmol/L/24H | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. | TOLED5 213,184,2012 |
| In Vitro/jrd | Inhibitor Concentration Low: 50 µmol/L/96H | In Vitro Toxicity Studies: Cell counting | TOLED5 213,184,2012 |
| In Vitro/jrd | Inhibitor Concentration Low: 100 µmol/L | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 213,184,2012 |
| In Vitro/maa | Inhibitor Concentration Low: 25 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | NRTXDN 60,54,2017 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (20 percent kill): 390 µmol/L/12H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 217,14,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (20 percent kill): 48 µmol/L/3D | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 217,14,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): >1000 µmol/L/12H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 217,14,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 340 µmol/L/3D | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 217,14,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (80 percent kill): >1000 µmol/L/12H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 217,14,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (80 percent kill): >400 µmol/L/3D | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 217,14,2013 |
| In Vitro/Mouse, leukemia cells | Inhibitor Concentration Low: 100 µmol/L/24H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. In Vitro Toxicity Studies: Apoptosis in vitro In Vitro Toxicity Studies: Other assays | TXAPA9 263,148,2012 |
| In Vitro/Mouse, leukemia cells | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXAPA9 263,148,2012 |
| In Vitro/Mouse, leukemia cells | Inhibitor Concentration Low: 100 µmol/L/12H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TXAPA9 263,148,2012 |
| In Vitro/Mouse, liver | Inhibitor Concentration Low: 1 µmol/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 26,718,2012 |
| In Vitro/Mouse, neuroblastom | Inhibitor Concentration Low: 1 µmol/L/8H | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. | TXAPA9 308,20,2016 |
| In Vitro/mtb | Inhibitor Concentration Low: 50 µmol/L/72H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | CBINA8 259,368,2016 |
| In Vitro/mtb | Inhibitor Concentration (50 percent kill): 0.044 mmol/L/48H | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. | TXCYAC 314,135,2013 |
| In Vitro/mtb | Inhibitor Concentration (50 percent kill): 0.057 mmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 314,135,2013 |
| In Vitro/mtb | Inhibitor Concentration (50 percent kill): 0.13 mmol/L/72H | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. | TXCYAC 314,135,2013 |
| In Vitro/mtb | Inhibitor Concentration (50 percent kill): 0.12 mmol/L/72H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TXCYAC 314,135,2013 |
| In Vitro/mtb | Inhibitor Concentration (50 percent kill): 0.18 mmol/L/72H | In Vitro Toxicity Studies: Cell differentiation | TXCYAC 314,135,2013 |
| In Vitro/mtb | Inhibitor Concentration Low: 10 µmol/L/12H | In Vitro Toxicity Studies: Cell differentiation | TOLED5 217,14,2013 |
| In Vitro/mtb | Inhibitor Concentration Low: 20 µmol/L/3D | In Vitro Toxicity Studies: Cell differentiation | TOLED5 217,14,2013 |
| In Vitro/mtb | Inhibitor Concentration (50 percent kill): 35 µmol/L/3D | In Vitro Toxicity Studies: Other assays | TOLED5 217,14,2013 |
| In Vitro/mtb | Inhibitor Concentration (20 percent kill): 200 µmol/L/12H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 217,14,2013 |
| In Vitro/mtb | Inhibitor Concentration (20 percent kill): 20 µmol/L/3D | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 217,14,2013 |
| In Vitro/mtb | Inhibitor Concentration (50 percent kill): 610 µmol/L/12H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 217,14,2013 |
| In Vitro/mtb | Inhibitor Concentration (50 percent kill): 140 µmol/L/3D | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 217,14,2013 |
| In Vitro/mtb | Inhibitor Concentration (80 percent kill): 970 µmol/L/12H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 217,14,2013 |
| In Vitro/mtb | Inhibitor Concentration (80 percent kill): 250 µmol/L/3D | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TOLED5 217,14,2013 |
| In Vitro/Rat, embryonic cells | Inhibitor Concentration Low: 10 µmol/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | NRTXDN ,111,2017 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 29 µmol/L/5D | In Vitro Toxicity Studies: Cell morphology: overgrowth of cell appendixes etc. | TXAPA9 325,25,2017 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 10 µmol/L/6D | In Vitro Toxicity Studies: Cell differentiation In Vitro Toxicity Studies: Cell protein synthesis | NETEEC 34,505,2012 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 30 µmol/L/24H | In Vitro Toxicity Studies: Other assays | NETEEC 34,232,2012 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration (50 percent kill): 0.431 µmol/L/20M | In Vitro Toxicity Studies: Other assays | NRTXDN 43,110,2014 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 50 µmol/L/24H | In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. | TXAPA9 256,281,2011 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 50 µmol/L/4D | In Vitro Toxicity Studies: Cell counting In Vitro Toxicity Studies: Other assays | TXAPA9 256,281,2011 |
| In Vitro/Rat, endocrine tumor | Inhibitor Concentration Low: 50 µmol/L/6D | In Vitro Toxicity Studies: Cell counting In Vitro Toxicity Studies: Cell differentiation | TXAPA9 256,281,2011 |
| In Vitro/Rat, liver | Inhibitor Concentration Low: 20 µmol/L/8H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | TXAPA9 337,67,2017 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration Low: 80 µmol/L/48H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 32,181,2016 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration Low: 5 µmol/L/48H | Biochemical: Metabolism (intermediary): Lipids including transport | TIVIEQ 32,181,2016 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration Low: 20 µmol/L/16H | Biochemical: Metabolism (intermediary): Lipids including transport | TIVIEQ 32,181,2016 |
| In Vitro/Rat, liver tumor | Inhibitor Concentration Low: 20 µmol/L/24H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | TIVIEQ 32,181,2016 |
| In Vitro/Rat, neurons | Inhibitor Concentration (50 percent kill): 21 µmol/L/20M | In Vitro Toxicity Studies: Other assays | NETOX* 48,152,2015 |
| In Vitro/Rat, neurons | Inhibitor Concentration Low: 40 µmol/L/1H | In Vitro Toxicity Studies: Other assays | NRTXDN 44,204,2014 |
| inhalation/rat | lethal concentration (50 percent kill): >0.2 gm/m3/4H | ENTOX* -,583,2005 | |
| intraperitoneal/mouse | lowest published toxic dose: 30 mg/kg | Brain and Coverings: Other degenerative changes Behavioral: Change in motor activity (specific assay) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TXAPA9 211,78,2006 |
| intraperitoneal/mouse | lowest published toxic dose: 10 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | TXAPA9 205,149,2005 |
| intraperitoneal/mouse | lethal dose (50 percent kill): 192 mg/kg | TXAPA9 65,144,1982 | |
| intraperitoneal/mouse | lowest published toxic dose: 30 mg/kg | Brain and Coverings: Other degenerative changes | TOLED5 135,89,2002 |
| intraperitoneal/mouse | lowest published toxic dose: 30 mg/kg | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | TXAPA9 224,98,2007 |
| intraperitoneal/mouse | lowest published toxic dose: 100 mg/kg | Brain and Coverings: Other degenerative changes Behavioral: Tremor | TXAPA9 227,42,2008 |
| intraperitoneal/non-mammalian species | lowest published toxic dose: 2 mg/kg | Blood: Changes in spleen Blood: Changes in leukocyte (WBC) count Immunological Including Allergic: Increase in cellular immune response | TOXID9 78,321,2004 |
| intraperitoneal/non-mammalian species | lowest published toxic dose: 50 mg/kg | Kidney, Ureter, and Bladder: Other changes Immunological Including Allergic: Decreased immune response Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 78,321,2004 |
| intraperitoneal/rat | lowest published toxic dose: 15 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,312,2002 |
| multiple/man | lowest published toxic concentration: 45 pph/15M | Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Gastrointestinal: Nausea or vomiting | JTCTDW 41,883,2003 |
| oral/chicken | lethal dose (50 percent kill): 18.14 mg/kg | TOLED5 174,110,2007 | |
| oral/chicken | lowest published toxic dose: 5 mg/kg | Eye: Lacrimation Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold | TOLED5 174,110,2007 |
| oral/chicken | lowest published toxic dose: 2 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning | TOLED5 174,110,2007 |
| oral/chicken | lowest published toxic dose: 150 mg/kg | Behavioral: Ataxia | ARTODN 76,367,2002 |
| oral/chicken | lethal dose (50 percent kill): 25400 µg/kg | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Somnolence (general depressed activity) Behavioral: Convulsions or effect on seizure threshold | TXAPA9 11,49,1967 |
| oral/Dog | lowest published toxic dose: 1 mg/kg | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,311,2002 |
| oral/duck | lethal dose (50 percent kill): 76 mg/kg | TXAPA9 20,57,1971 | |
| oral/guinea pig | lethal dose (50 percent kill): 504 mg/kg | FMCHA2 -,C74,1991 | |
| oral/guinea pig | lowest published lethal dose: 299 mg/kg | RTOPDW 35,105,2002 | |
| oral/human | lowest published toxic dose: 2 mg/kg | Endocrine: Differential effect of sex or castration on observed toxicity Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TOSCF2 66,34,2002 |
| oral/man | lowest published toxic dose: 1.71 mL/kg | Behavioral: Muscle weakness Vascular: BP lowering not characterized in autonomic section Lung, Thorax, or Respiration: Respiratory depression | VHTODE 43,34,2001 |
| oral/man | lowest published toxic dose: 300 mg/kg | Peripheral Nerve and Sensation: Paresthesia Behavioral: Muscle weakness Behavioral: Coma | ARTODN 59,176,1986 |
| oral/mouse | lowest published toxic dose: 10 mg/kg | Liver: Liver function tests impaired Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | FCTOD7 46,797,2008 |
| oral/mouse | lowest published toxic dose: 25 mg/kg | Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Fasciculations Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 234,90,2007 |
| oral/mouse | lethal dose (50 percent kill): 60 mg/kg | TXCYAC 234,90,2007 | |
| oral/mouse | lethal dose (50 percent kill): 75 mg/kg | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXCYAC 234,90,2007 |
| oral/mouse | lowest published toxic dose: 5 mg/kg/24H | Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 288,429,2015 |
| oral/mouse | lowest published toxic dose: 0.1 mg/kg/20M | Behavioral: Change in psychophysiological tests | TXAPA9 288,429,2015 |
| oral/mouse | lowest published toxic dose: 2 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TXAPA9 337,67,2017 |
| oral/pigeon | lowest published toxic dose: 3 mg/kg | Behavioral: Alteration of classical conditioning | TOXID9 -,270,2009 |
| oral/pigeon | lowest published toxic dose: 1 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 -,270,2009 |
| oral/pigeon | lethal dose (50 percent kill): 10 mg/kg | ASTTA8 (680),157,1979 | |
| oral/quail | lethal dose (50 percent kill): 13300 µg/kg | ASTTA8 (680),157,1979 | |
| oral/rabbit | lowest published lethal dose: 1000 mg/kg | RTOPDW 35,105,2002 | |
| oral/rabbit | lethal dose (50 percent kill): 1 gm/kg | ENTOX* -,583,2005 | |
| oral/rat | lowest published toxic dose: 2.4 mg/kg | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOVEFN (3),15,1993 |
| oral/rat | lowest published lethal dose: 8 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 210,142,2006 |
| oral/rat | lowest published toxic dose: 3 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TXCYAC 217,1,2006 |
| oral/rat | lowest published toxic dose: 30 mg/kg | Gastrointestinal: Changes in structure or function of salivary glands Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TXCYAC 217,1,2006 |
| oral/rat | lowest published lethal dose: 10 mg/kg | Peripheral Nerve and Sensation: Fasciculations Gastrointestinal: Hypermotility, diarrhea | TXCYAC 220,13,2006 |
| oral/rat | lowest published toxic dose: 1 mg/kg | Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 220,13,2006 |
| oral/rat | lowest published toxic dose: 60 mg/kg | Peripheral Nerve and Sensation: Fasciculations Gastrointestinal: Hypermotility, diarrhea | TXAPA9 205,31,2005 |
| oral/rat | lowest published toxic dose: 2 mg/kg | Brain and Coverings: Other degenerative changes Behavioral: Somnolence (general depressed activity) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 210,142,2006 |
| oral/rat | lethal dose (10 percent kill): 136 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 60,241,2001 |
| oral/rat | lowest published toxic dose: 15 mg/kg | Brain and Coverings: Other degenerative changes Blood: Other changes Nutritional and Gross Metabolic: Body temperature decrease | TOXID9 60,246,2001 |
| oral/rat | lowest published toxic dose: 1 mg/kg | Behavioral: Change in motor activity (specific assay) | TOXID9 60,246,2001 |
| oral/rat | lowest published toxic dose: 10 mg/kg | Brain and Coverings: Changes in surface EEG | TOXID9 60,246,2001 |
| oral/rat | lowest published toxic dose: 1.5 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,312,2002 |
| oral/rat | lethal dose (40 percent kill): 80 mg/kg | TOXID9 66,313,2002 | |
| oral/rat | lowest published lethal dose: 69 mg/kg | RTOPDW 35,105,2002 | |
| oral/rat | lowest published toxic dose: 30 mg/kg | Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Body temperature decrease | TOXID9 66,35,2002 |
| oral/rat | lowest published toxic dose: 50 mg/kg | Behavioral: Tremor Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | ARTODN 76,30,2002 |
| oral/rat | lowest published toxic dose: 1.5 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOSCF2 77,63,2004 |
| oral/rat | lowest published lethal dose: 8 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,308,2003 |
| oral/rat | lowest published toxic dose: 10 mg/kg | Nutritional and Gross Metabolic: Body temperature decrease | TOXID9 72,308,2003 |
| oral/rat | lowest published toxic dose: 5 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,309,2003 |
| oral/rat | lowest published toxic dose: 10 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TOSCF2 66,34,2002 |
| oral/rat | lowest published toxic dose: 23.5 mg/kg | Brain and Coverings: Other degenerative changes Autonomic Nervous System: Other (direct) parasympathomimetic Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NRTXDN 22,39,2001 |
| oral/rat | lowest published toxic dose: 25 mg/kg | Behavioral: Change in psychophysiological tests | TXCYAC 146,1,2000 |
| oral/rat | lowest published toxic dose: 1 mg/kg | Nutritional and Gross Metabolic: Body temperature increase | TXCYAC 177,215,2002 |
| oral/rat | lethal dose (50 percent kill): 82 mg/kg | TXAPA9 14,515,1969 | |
| oral/rat | lowest published toxic dose: 30 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Metabolism (intermediary): Other | NRTXDN 30,377,2009 |
| oral/rat | lowest published toxic dose: 30 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TOXID9 -,337,2009 |
| oral/rat | lowest published toxic dose: 10 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins | ARTODN 83,319,2009 |
| oral/rat | lowest published toxic dose: 35 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TOXID9 -,117,2009 |
| oral/rat | lowest published toxic dose: 0.1 mg/kg | Brain and Coverings: Other degenerative changes | TXAPA9 248,144,2010 |
| oral/rat | lowest published toxic dose: 68 mg/kg | Peripheral Nerve and Sensation: Fasciculations Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 238,157,2007 |
| oral/rat | lowest published toxic dose: 7.5 mg/kg | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 238,157,2007 |
| oral/rat | lowest published toxic dose: 15 mg/kg | Peripheral Nerve and Sensation: Fasciculations | TXCYAC 238,157,2007 |
| oral/rat | lowest published lethal dose: 50 mg/kg | Behavioral: Sleep Behavioral: Tremor | TXCYAC 237,145,2007 |
| oral/rat | lowest published toxic dose: 5 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Eye: Miosis (pupilliary constriction) | TOSCF2 92,235,2006 |
| oral/rat | lowest published toxic dose: 20 mg/kg | Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOSCF2 92,235,2006 |
| oral/rat | lowest published toxic dose: 25 mg/kg | Cardiac: Pulse rate increased without fall in BP Vascular: BP elevation not characterized in autonomic section Nutritional and Gross Metabolic: Body temperature decrease | BCLPT* 96,503,2005 |
| oral/wild bird | lethal dose (50 percent kill): 5 mg/kg | TXAPA9 21,315,1972 | |
| oral/woman | lowest published toxic dose: 0.33 mL/kg | Peripheral Nerve and Sensation: Flaccid paralysis with appropriate anesthesia Eye: Miosis (pupilliary constriction) Gastrointestinal: Hypermotility, diarrhea | TOLED5 159,235,2005 |
| oral/woman | lowest published toxic dose: 3 mL/kg | Peripheral Nerve and Sensation: Recording from peripheral motor nerve Behavioral: Rigidity (includes catalepsy) Gastrointestinal: Nausea or vomiting | JTCTDW 43,877,2005 |
| skin/mouse | lowest published toxic dose: 100 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOLED5 151,219,2004 |
| skin/mouse | lethal dose (50 percent kill): 120 mg/kg | YKYUA6 38,745,1987 | |
| skin/mouse | lowest published toxic dose: 100 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase | TXAPA9 255,214,2011 |
| skin/rabbit | lethal dose (50 percent kill): 2000 mg/kg | USXXAM #6193990 | |
| skin/rat | lethal dose (50 percent kill): 202 mg/kg | TXAPA9 14,515,1969 | |
| skin/rat | lowest published toxic dose: 30 mg/kg | Brain and Coverings: Other degenerative changes Liver: Other changes Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) | JTEHD6 63,173,2001 |
| subcutaneous/guinea pig | lowest published lethal dose: 100 mg/kg | JEENAI 60,733,1967 | |
| subcutaneous/guinea pig | lowest published toxic dose: 390 mg/kg | Brain and Coverings: Other degenerative changes Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 60,242,2001 |
| subcutaneous/guinea pig | lowest published toxic dose: 300 mg/kg | Brain and Coverings: Other degenerative changes Behavioral: Change in psychophysiological tests | NRTXDN 36,42,2013 |
| subcutaneous/mouse | lowest published toxic dose: 150 mg/kg | Behavioral: Tremor | TXAPA9 256,324,2011 |
| subcutaneous/mouse | lowest published toxic dose: 300 mg/kg | Behavioral: Tremor Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 256,324,2011 |
| subcutaneous/mouse | lowest published toxic dose: 0.5 mg/kg | Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 -,441,2009 |
| subcutaneous/rat | lowest published toxic dose: 250 mg/kg | Behavioral: Alteration of classical conditioning | NRTXDN 30,1025,2009 |
| subcutaneous/rat | lowest published toxic dose: 250 mg/kg | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NRTXDN 32,836,2011 |
| subcutaneous/rat | lowest published toxic dose: 250 mg/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NRTXDN 28,541,2007 |
| subcutaneous/rat | lowest published toxic dose: 250 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | TOLED5 176,162,2008 |
| subcutaneous/rat | lowest published toxic dose: 60 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | JTEHF8 67,431,2004 |
| subcutaneous/rat | lowest published toxic dose: 60 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 219,136,2007 |
| subcutaneous/rat | lowest published toxic dose: 250 mg/kg | Behavioral: Change in motor activity (specific assay) Behavioral: Change in psychophysiological tests Biochemical: Metabolism (intermediary): Other | NRTXDN 40,57,2014 |
| subcutaneous/rat | lowest published toxic dose: 250 mg/kg | Behavioral: Change in psychophysiological tests Biochemical: Metabolism (intermediary): Other Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | TOLED5 216,73,2013 |
| subcutaneous/rat | lowest published toxic dose: 2.5 mg/kg | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | JPETAB 305,375,2003 |
| subcutaneous/rat | lowest published toxic dose: 60 mg/kg | Behavioral: Change in motor activity (specific assay) | TOXID9 66,316,2002 |
| subcutaneous/rat | lowest published toxic dose: 84 mg/kg | Brain and Coverings: Other degenerative changes Behavioral: Change in motor activity (specific assay) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 216,150,2006 |
| subcutaneous/rat | lowest published toxic dose: 84 mg/kg | Brain and Coverings: Recordings from specific areas of CNS Nutritional and Gross Metabolic: Body temperature decrease Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 90,301,2006 |
| subcutaneous/rat | lowest published toxic dose: 13.5 mg/kg | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 25,599,2003 |
| subcutaneous/rat | lowest published toxic dose: 45 mg/kg | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | NETEEC 25,599,2003 |
| subcutaneous/rat | lowest published toxic dose: 166 mg/kg | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 26,305,2004 |
| subcutaneous/rat | lowest published toxic dose: 60 mg/kg | Brain and Coverings: Other degenerative changes | TOXID9 72,305,2003 |
| subcutaneous/rat | lowest published toxic dose: 280 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | NRTXDN 50,20,2015 |
| subcutaneous/rat | lowest published toxic dose: 280 mg/kg | Behavioral: Tremor Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | TXAPA9 272,608,2013 |
| Tank with water/Alga | toxic concentration: 2.4 mg/L/24H | Aquatic organism effects: Growth retardation Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | ETOPFR 45,179,2016 |
| Tank with water/Carp | lowest published toxic concentration: 1.13 µg/L/40 D | Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases | FCTOD7 62,148,2013 |
| Tank with water/Carp | lowest published toxic concentration: 11.3 µg/L/40 D | Kidney, Ureter, and Bladder: Other changes Blood: Changes in spleen Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | FCTOD7 62,148,2013 |
| Tank with water/Carp | lowest published toxic concentration: 0.04 mg/L/10D | Blood: Changes in erythrocyte (RBC) count Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | FCTOD7 50,2703 ,2012 |
| Tank with water/Shrimp | lethal concentration (50 percent kill): 0.063 µg/L/96H | EESADV 73,360,2010 | |
| Tank with water/Zebrafish | lowest published toxic concentration: 1.39 µmol/L 144H | Blood: Other changes Musculoskeletal: Other changes | REPTED 33,142,2012 |
| Tank with water/Zebrafish | lowest published toxic concentration: 0.02 mmol/L 144H | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | REPTED 33,142,2012 |
| Tank with water/Zebrafish | Lowest published lethal concentration: 3 µmol/L/5D | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NETEEC 33,735,2011 |
| Tank with water/Zebrafish | lowest published toxic concentration: 300 nmol/L/66H | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 33,735,2011 |
| Tank with water/Zebrafish | lowest published toxic concentration: 300 nmol/L/5D | Behavioral: Change in motor activity (specific assay) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 33,735,2011 |
| Tank with water/Zebrafish | lowest published toxic concentration: 100 µg/L/3D | Behavioral: Alteration of classical conditioning | NETEEC 33,742,2011 |
| Tank with water/Zebrafish | lowest published toxic concentration: 100 µg/L/5D | Behavioral: Alteration of classical conditioning Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | NETEEC 33,742,2011 |
| Tank with water/Zebrafish | lowest published toxic concentration: 3.51 µg/L/7D | Reproductive: Other developmental abnormalities Reproductive: Effects on newborn: Behavioral | NETEEC 34,458,2012 |
| Tank with water/Zebrafish | lowest published toxic concentration: 0.1 µmol/L/3D | Reproductive: Effects on newborn: Behavioral Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETOX* 49,50,2015 |
| Tank with water/Zebrafish | toxic concentration: 0.3 µmol/L/5D | Behavioral: Change in motor activity (specific assay) | NRTXDN 66,221,2018 |
| unreported route/mammal (species unspecified) | lethal dose (50 percent kill): 163 mg/kg | JAFCAU 27,712,1979 | |
| unreported route/rat | lethal dose (50 percent kill): 150 mg/kg | 30ZDA9 -,339,1971 | |
| unreported route/rat | lowest published toxic dose: 1 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other | TOXID9 44,197,2005 |
| unreported route/rat | lowest published toxic dose: 279 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 60,241,2001 |
| unreported route/rat | lowest published toxic dose: 279 mg/kg | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Other | TOXID9 60,241,2001 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intramuscular/rat | lowest published toxic dose: 300 mg/kg/3D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | PCBPBS 88,191,2007 |
| intraperitoneal/rat | lowest published toxic dose: 5 mg/kg/5D- intermittent | Behavioral: Alteration of classical conditioning Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | NRTXDN 50,149,2015 |
| multiple/non-mammalian species | lowest published toxic dose: 101.67 mg/m3/6D- continuous | Behavioral: Alteration of classical conditioning Behavioral: Alteration of operant conditioning | NETEEC 31,242,2009 |
| oral/chicken | lowest published toxic dose: 28 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOLED5 174,110,2007 |
| oral/chicken | lowest published toxic dose: 980 mg/kg/2W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXAPA9 11,49,1967 |
| oral/Dog | lowest published toxic dose: 2190 mg/kg/2Y- continuous | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | FCTXAV 12,47,1974 |
| oral/Dog | lowest published toxic dose: 2190 mg/kg/2Y- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | RTOPDW 35,105,2002 |
| oral/Dog | lowest published toxic dose: 7 mg/kg/1W- continuous | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,311,2002 |
| oral/Dog | lowest published toxic dose: 84 mg/kg/6W- continuous | Cardiac: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,311,2002 |
| oral/Dog | lowest published toxic dose: 8.4 mg/kg/4W- continuous | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,312,2002 |
| oral/Dog | lowest published toxic dose: 365 mg/kg/1Y- continuous | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 60,322,2001 |
| oral/Dog | lowest published toxic dose: 8.7 mg/kg/4W- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | RTOPDW 47,240,2007 |
| oral/Dog | lowest published toxic dose: 4.2 mg/kg/1W- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | RTOPDW 47,240,2007 |
| oral/Dog | lowest published toxic dose: 21 mg/kg/6W- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | RTOPDW 47,240,2007 |
| oral/mouse | lowest published toxic dose: 24 mg/kg/4D- intermittent | Endocrine: Evidence of thyroid hypofunction | REPTED 22,263,2006 |
| oral/mouse | lowest published toxic dose: 639 mg/kg/10W- intermittent | Blood: Luekopenia Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | JTSCDR 32,111,2007 |
| oral/mouse | lowest published toxic dose: 447.3 mg/kg/7W- intermittent | Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | JTSCDR 32,111,2007 |
| oral/mouse | lowest published toxic dose: 125 mg/kg/5D- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXCYAC 234,90,2007 |
| oral/mouse | lowest published toxic dose: 93.6 mg/kg/30D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 234,90,2007 |
| oral/mouse | lowest published toxic dose: 31.25 mg/kg/5D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 234,90,2007 |
| oral/mouse | lowest published toxic dose: 15.6 mg/kg/5D- intermittent | Liver: Other changes Endocrine: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TXCYAC 234,90,2007 |
| oral/mouse | lowest published toxic dose: 15 mg/kg/15D- intermittent | Reproductive: Effects on newborn: Other postnatal measures or effects Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | FCTOD7 118,42,2018 |
| oral/mouse | lowest published toxic dose: 15 mg/kg/15D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | FCTOD7 118,42,2018 |
| oral/mouse | lowest published toxic dose: 20 mg/kg/10D- intermittent | Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | FCTOD7 118,821,2018 |
| oral/mouse | lowest published toxic dose: 20 mg/kg/10D- intermittent | Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 118,821,2018 |
| oral/mouse | lowest published toxic dose: 42 mg/kg/7D- intermittent | Liver: Multiple effects Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | FCTOD7 58,177,2013 |
| oral/mouse | lowest published toxic dose: 105 mg/kg/4W- continuous | Behavioral: Alteration of operant conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | FCTOD7 92,224,2016 |
| oral/mouse | lowest published toxic dose: 200 mg/kg/4W- intermittent | Behavioral: Change in psychophysiological tests Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases Biochemical: Metabolism (intermediary): Other | FCTOD7 72,289,2014 |
| oral/mouse | lowest published toxic dose: 39.6 mg/kg/30D- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | FCTOD7 41,767,2003 |
| oral/mouse | lowest published toxic dose: 79.2 mg/kg/60D- continuous | Blood: Normocytic anemia Blood: Luekopenia | FCTOD7 41,767,2003 |
| oral/rabbit | lowest published toxic dose: 1960 mg/kg/13D- intermittent | Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | FEREAC 60,7509,1995 |
| oral/rat | lowest published toxic dose: 75 mg/kg/5D- intermittent | Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | REPTED 17,203,2003 |
| oral/rat | lowest published toxic dose: 75 mg/kg/5D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | REPTED 17,203,2003 |
| oral/rat | lowest published toxic dose: 1820 mg/kg/1Y- continuous | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,309,2003 |
| oral/rat | lowest published toxic dose: 9 mg/kg/5D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOSCF2 76,400,2003 |
| oral/rat | lowest published toxic dose: 12 mg/kg/4D- intermittent | Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOSCF2 77,63,2004 |
| oral/rat | lowest published toxic dose: 4.2 mg/kg/28D- continuous | Endocrine: Changes in thyroid weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | FCTOD7 42,1269,2004 |
| oral/rat | lowest published toxic dose: 4.2 mg/kg/28D- continuous | Blood: Other changes | FCTOD7 42,1269,2004 |
| oral/rat | lowest published toxic dose: 119 mg/kg/17D- intermittent | Nutritional and Gross Metabolic: Body temperature increase | TXCYAC 177,215,2002 |
| oral/rat | lowest published toxic dose: 210 mg/kg/2W- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TOSCF2 55,124,2000 |
| oral/rat | lowest published toxic dose: 60 mg/kg/4W- intermittent | Eye: Miosis (pupilliary constriction) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 22,237,2000 |
| oral/rat | lowest published toxic dose: 200 mg/kg/4W- intermittent | Behavioral: Tremor Behavioral: Alteration of operant conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 22,237,2000 |
| oral/rat | lowest published toxic dose: 50 mg/kg/5D- intermittent | Eye: Miosis (pupilliary constriction) Gastrointestinal: Changes in structure or function of salivary glands Nutritional and Gross Metabolic: Body temperature increase | NETEEC 22,237,2000 |
| oral/rat | lowest published toxic dose: 50 mg/kg/3D- intermittent | Behavioral: Alteration of operant conditioning Behavioral: Change in motor activity (specific assay) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 23,33,2001 |
| oral/rat | lowest published toxic dose: 730 mg/kg/2Y- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | FCTXAV 12,47,1974 |
| oral/rat | lowest published toxic dose: 21840 µg/kg/28D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | ESKHA5 (106),48,1988 |
| oral/rat | lowest published toxic dose: 800 mg/kg/8W- intermittent | Eye: Miosis (pupilliary constriction) Behavioral: Somnolence (general depressed activity) Behavioral: Tremor | TOXID9 36(1 Pt2),345,1997 |
| oral/rat | lowest published toxic dose: 57 mg/kg/12D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOSCF2 59,260,2001 |
| oral/rat | lowest published toxic dose: 111 mg/kg/21D- intermittent | Behavioral: Change in motor activity (specific assay) | TOSCF2 59,260,2001 |
| oral/rat | lowest published toxic dose: 18 mg/kg/6D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOSCF2 59,260,2001 |
| oral/rat | lowest published toxic dose: 213 mg/kg/24W- intermittent | Behavioral: Change in motor activity (specific assay) Nutritional and Gross Metabolic: Body temperature decrease Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | TXCYAC 177,215,2002 |
| oral/rat | lowest published toxic dose: 127.5 mg/kg/24W- intermittent | Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation | TXCYAC 177,215,2002 |
| oral/rat | lowest published toxic dose: 15 mg/kg/15D- intermittent | Nutritional and Gross Metabolic: Body temperature increase | TXCYAC 177,215,2002 |
| oral/rat | lowest published toxic dose: 270 mg/kg/1Y- intermittent | Eye: Retinal changes pigmentary deposition, retinitis, other) | TOXID9 60,245,2001 |
| oral/rat | lowest published toxic dose: 80 mg/kg/20D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins | TOXID9 90,295,2006 |
| oral/rat | lowest published toxic dose: 14 mg/kg/14D- intermittent | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,313,2002 |
| oral/rat | lowest published toxic dose: 42 mg/kg/14D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,313,2002 |
| oral/rat | lowest published toxic dose: 364 mg/kg/1Y- intermittent | Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,313,2002 |
| oral/rat | lowest published toxic dose: 1820 mg/kg/1Y- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Change in psychophysiological tests Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,313,2002 |
| oral/rat | lowest published toxic dose: 21 mg/kg/21D- intermittent | Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 44,198,2005 |
| oral/rat | lowest published toxic dose: 66 mg/kg/11D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins Biochemical: Metabolism (intermediary): Other | TOXID9 44,199,2005 |
| oral/rat | lowest published toxic dose: 21 mg/kg/21D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 44,199,2005 |
| oral/rat | lowest published toxic dose: 79.5 mg/kg/21D- intermittent | Biochemical: Metabolism (intermediary): Other | TOXID9 44,199,2005 |
| oral/rat | lowest published toxic dose: 4.5 mg/kg/6D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,131,2002 |
| oral/rat | lowest published toxic dose: 8 mg/kg/16D- intermittent | Brain and Coverings: Other degenerative changes Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | TOXID9 66,138,2002 |
| oral/rat | lowest published toxic dose: 45 mg/kg/9D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | RTOPDW 35,105,2002 |
| oral/rat | lowest published toxic dose: 53 mg/kg/21D- intermittent | Behavioral: Alteration of operant conditioning Endocrine: Differential effect of sex or castration on observed toxicity Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 78,273,2004 |
| oral/rat | lowest published toxic dose: 120 mg/kg/24D- intermittent | Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TOXID9 78,276,2004 |
| oral/rat | lowest published toxic dose: 42 mg/kg/31D- intermittent | Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 1,113,2001 |
| oral/rat | lowest published toxic dose: 126 mg/kg/31D- intermittent | Biochemical: Metabolism (intermediary): Other | TOXID9 1,113,2001 |
| oral/rat | lowest published toxic dose: 30 mg/kg/5D- intermittent | Behavioral: Change in motor activity (specific assay) | TOXID9 1,113,2001 |
| oral/rat | lowest published toxic dose: 30 mg/kg/5D- intermittent | Behavioral: Excitement | TOXID9 1,113,2001 |
| oral/rat | lowest published toxic dose: 26 mg/kg/17D- intermittent | Behavioral: Alteration of classical conditioning | TOXID9 1,113,2001 |
| oral/rat | lowest published toxic dose: 3.5 mg/kg/7D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes Biochemical: Metabolism (intermediary): Other | NRTXDN 43,82,2014 |
| oral/rat | lowest published toxic dose: 225 mg/kg/30D- intermittent | Reproductive: Paternal effects: Testes, epididymis, sperm duct | TIHEEC 23,439,2007 |
| oral/rat | lowest published toxic dose: 375 mg/kg/30D- intermittent | Endocrine: Androgenic Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Related to Chronic Data: Changes in testicular weight | TIHEEC 23,439,2007 |
| oral/rat | lowest published toxic dose: 103.6 mg/kg/21D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | NETEEC 31,98,2009 |
| oral/rat | lowest published toxic dose: 151.2 mg/kg/4W- intermittent | Liver: Multiple effects Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | FCTOD7 55,549,2013 |
| oral/rat | lowest published toxic dose: 151.2 mg/kg/4W- intermittent | Lung, Thorax, or Respiration: Emphysema Lung, Thorax, or Respiration: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | FCTOD7 48,1714,2010 |
| oral/rat | lowest published toxic dose: 1261.4 mg/kg/17W- intermittent | Blood: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 48,3477,2010 |
| oral/rat | lowest published toxic dose: 153 mg/kg/90D- intermittent | Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 103,246,2017 |
| oral/rat | lowest published toxic dose: 1350 mg/kg/90D- intermittent | Behavioral: Tremor Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | FCTOD7 103,246,2017 |
| oral/rat | lowest published toxic dose: 1350 mg/kg/90D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins | FCTOD7 103,246,2017 |
| oral/rat | lowest published toxic dose: 140 mg/kg/4W- continuous | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Brain and Coverings: Other degenerative changes | TXCYAC 308,41,2013 |
| oral/rat | lowest published toxic dose: 735 mg/kg/21W- continuous | Behavioral: Alteration of operant conditioning | TXCYAC 308,41,2013 |
| oral/rat | lowest published toxic dose: 28 mg/kg/4W- intermittent | Behavioral: Change in motor activity (specific assay) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 34,442,2012 |
| oral/rat | lowest published toxic dose: 140 mg/kg/4W- intermittent | Behavioral: Change in psychophysiological tests | NETEEC 34,442,2012 |
| oral/rat | lowest published toxic dose: 900 mg/kg/26W- continuous | Behavioral: Alteration of classical conditioning | NRTXDN 53,85,2016 |
| oral/rat | lowest published toxic dose: 3.5 mg/kg/7D- intermittent | Behavioral: Antianxiety Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases | NRTXDN 59,183,2017 |
| oral/rat | lowest published toxic dose: 1350 mg/kg/90D- intermittent | Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea Liver: Other changes | TXCYAC 384,50,2017 |
| oral/rat | lowest published toxic dose: 5.5 mg/kg/11D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | RTOPDW 63,209,2012 |
| oral/rat | lowest published toxic dose: 18.9 mg/kg/9W- intermittent | Endocrine: Other changes Biochemical: Metabolism (intermediary): Lipids including transport | FCTOD7 111,144,2018 |
| oral/rat | lowest published toxic dose: 18 mg/kg/6D- intermittent | Brain and Coverings: Other degenerative changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOSCF2 92,500,2006 |
| oral/rat | lowest published toxic dose: 9 mg/kg/6D- intermittent | Brain and Coverings: Other degenerative changes | TOSCF2 92,500,2006 |
| oral/rat | lowest published toxic dose: 378 mg/kg/8W- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOLED5 169,26,2007 |
| oral/rat | lowest published toxic dose: 180 mg/kg/9D- intermittent | Liver: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Metabolism (intermediary): Lipids including transport | INJPD2 39,145,2007 |
| oral/rat | lowest published toxic dose: 315 mg/kg/21D- intermittent | Olfaction: Other olfaction effects Eye: Hemorrhage Behavioral: Tremor | JTSCDR 31,521,2006 |
| oral/rat | lowest published toxic dose: 105 mg/kg/7D- intermittent | Behavioral: Food intake (animal) | JTSCDR 31,521,2006 |
| oral/rat | lowest published toxic dose: 252 mg/kg/21D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JTSCDR 31,521,2006 |
| oral/rat | lowest published toxic dose: 378 mg/kg/8W- intermittent | Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | TOLED5 163,235,2006 |
| oral/rat | lowest published toxic dose: 450 mg/kg/15D- intermittent | Liver: Liver function tests impaired Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects | PCBPBS 89,118,2007 |
| oral/rat | lowest published toxic dose: 35 mg/kg/7D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TOXID9 -,117,2009 |
| oral/rat | lowest published toxic dose: 30 mg/kg/15D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases | TOXID9 -,118,2009 |
| oral/rat | lowest published toxic dose: 35 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 -,37,2009 |
| oral/rat | lowest published toxic dose: 5.6 mg/kg/8W- intermittent | FCTOD7 62,732,2013 | |
| skin/rat | lowest published toxic dose: 3 mg/kg/30D- intermittent | Behavioral: Change in psychophysiological tests | ARTODN 77,452,2003 |
| skin/rat | lowest published toxic dose: 30 mg/kg/30D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Change in psychophysiological tests Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 66,314,2002 |
| skin/rat | lowest published toxic dose: 26 mg/kg/13D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | TOXID9 72,89,2003 |
| subcutaneous/mouse | lowest published toxic dose: 300 mg/kg/2W- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | NRTXDN 23,537,2002 |
| subcutaneous/mouse | lowest published toxic dose: 4.5 mg/kg/2W- intermittent | Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites | TOXID9 60,238,2001 |
| subcutaneous/mouse | lowest published toxic dose: 300 mg/kg/2W- intermittent | Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum | TOXID9 60,238,2001 |
| subcutaneous/mouse | lowest published toxic dose: 75 mg/kg/2W- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 60,242,2001 |
| subcutaneous/mouse | lowest published toxic dose: 120 mg/kg/12D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TERPM* -,394,2006 |
| subcutaneous/mouse | lowest published toxic dose: 4 mg/kg/4D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOSCF2 93,105,2006 |
| subcutaneous/mouse | lowest published toxic dose: 12 mg/kg/4D- intermittent | Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOSCF2 93,105,2006 |
| subcutaneous/mouse | lowest published toxic dose: 12 mg/kg/4D- intermittent | Behavioral: Change in motor activity (specific assay) Behavioral: Aggression Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOSCF2 93,105,2006 |
| subcutaneous/mouse | lowest published toxic dose: 4 mg/kg/4D- intermittent | Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOSCF2 93,105,2006 |
| subcutaneous/mouse | lowest published toxic dose: 120 mg/kg/12D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXAPA9 245,310,2010 |
| subcutaneous/mouse | lowest published toxic dose: 48 mg/kg/12D- intermittent | Brain and Coverings: Other degenerative changes | TXAPA9 245,310,2010 |
| subcutaneous/rat | lowest published toxic dose: 12 mg/kg/4D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 287,137,2011 |
| subcutaneous/rat | lowest published toxic dose: 20 mg/kg/2D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TXCYAC 287,137,2011 |
| subcutaneous/rat | lowest published toxic dose: 270 mg/kg/29D- intermittent | Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 34,1,2012 |
| subcutaneous/rat | lowest published toxic dose: 150 mg/kg/29D- intermittent | Behavioral: Alteration of classical conditioning | NETEEC 34,1,2012 |
| subcutaneous/rat | lowest published toxic dose: 54 mg/kg/3D- intermittent | Behavioral: Alteration of operant conditioning | NETEEC 32,415,2010 |
| subcutaneous/rat | lowest published toxic dose: 54 mg/kg/5D- intermittent | Behavioral: Alteration of operant conditioning | NETEEC 32,415,2010 |
| subcutaneous/rat | lowest published toxic dose: 252 mg/kg/14D- intermittent | Behavioral: Alteration of operant conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 32,415,2010 |
| subcutaneous/rat | lowest published toxic dose: 270 mg/kg/30D- intermittent | Behavioral: Alteration of operant conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 32,415,2010 |
| subcutaneous/rat | lowest published toxic dose: 70 mg/kg/7D- intermittent | Behavioral: Antianxiety Behavioral: Alteration of classical conditioning | NRTXDN 32,355,2011 |
| subcutaneous/rat | lowest published toxic dose: 70 mg/kg/7D- intermittent | Brain and Coverings: Changes in surface EEG | NRTXDN 45,22,2014 |
| subcutaneous/rat | lowest published toxic dose: 7 mg/kg/7D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes | NRTXDN 45,22,2014 |
| subcutaneous/rat | lowest published toxic dose: 4 mg/kg/4D- intermittent | Brain and Coverings: Other degenerative changes | NETEEC 37,23,2013 |
| subcutaneous/rat | lowest published toxic dose: 120 mg/kg/35D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOPADD 33,378,2005 |
| subcutaneous/rat | lowest published toxic dose: 35 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 -,37,2009 |
| subcutaneous/rat | lowest published toxic dose: 120 mg/kg/42D- intermittent | Brain and Coverings: Other degenerative changes Peripheral Nerve and Sensation: Structural change in nerve or sheath | TOXID9 -,443,2009 |
| subcutaneous/rat | lowest published toxic dose: 270 mg/kg/30D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | JPETAB 322,1117,2007 |
| subcutaneous/rat | lowest published toxic dose: 150 mg/kg/30D- intermittent | Behavioral: Alteration of classical conditioning Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase | JPETAB 322,1117,2007 |
| subcutaneous/rat | lowest published toxic dose: 37.5 mg/kg/30D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase | JPETAB 322,1117,2007 |
| subcutaneous/rat | lowest published toxic dose: 10 mg/kg/7D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Reactivates cholinesterase | JPETAB 322,1117,2007 |
| subcutaneous/rat | lowest published toxic dose: 21 mg/kg/9D- intermittent | Brain and Coverings: Other degenerative changes Behavioral: Alteration of classical conditioning Biochemical: Metabolism (intermediary): Other | TOXID9 60,241,2001 |
| subcutaneous/rat | lowest published toxic dose: 250 mg/kg/10D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | JPETAB 305,375,2003 |
| subcutaneous/rat | lowest published toxic dose: 300 mg/kg/6D- intermittent | Behavioral: Tremor Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Hypermotility, diarrhea | JPETAB 305,375,2003 |
| subcutaneous/rat | lowest published toxic dose: 10 mg/kg/4D- intermittent | Behavioral: Change in psychophysiological tests | JPETAB 305,375,2003 |
| subcutaneous/rat | lowest published toxic dose: 20 mg/kg/4D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 195,203,2004 |
| subcutaneous/rat | lowest published toxic dose: 20 mg/kg/4D- intermittent | Brain and Coverings: Other degenerative changes Endocrine: Differential effect of sex or castration on observed toxicity Biochemical: Metabolism (intermediary): Other proteins | TXAPA9 203,132,2005 |
| subcutaneous/rat | lowest published toxic dose: 20 mg/kg/4D- intermittent | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 66,130,2002 |
| subcutaneous/rat | lowest published toxic dose: 20 mg/kg/4D- intermittent | Behavioral: Change in motor activity (specific assay) Behavioral: Alteration of classical conditioning Behavioral: Alteration of operant conditioning | TOXID9 1,114,2001 |
| subcutaneous/rat | lowest published toxic dose: 250 mg/kg/7D- intermittent | Behavioral: Alteration of operant conditioning Behavioral: Change in motor activity (specific assay) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | NETEEC 23,33,2001 |
| subcutaneous/rat | lowest published toxic dose: 21 mg/kg/7D- intermittent | Behavioral: Change in psychophysiological tests | TXAPA9 174,89,2001 |
| subcutaneous/rat | lowest published toxic dose: 0.6 mg/kg/5D- intermittent | Behavioral: Change in psychophysiological tests | TXAPA9 174,89,2001 |
| subcutaneous/rat | lowest published toxic dose: 120 mg/kg/42D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,305,2003 |
| subcutaneous/rat | lowest published toxic dose: 120 mg/kg/1H/4W- intermittent | Brain and Coverings: Other degenerative changes Blood: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | ARTODN 75,480,2001 |
| subcutaneous/rat | lowest published toxic dose: 160 mg/kg/16D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase Biochemical: Metabolism (intermediary): Other | PBBHAU 46,219,1993 |
| subcutaneous/rat | lowest published toxic dose: 42 mg/kg/14D- intermittent | NETOX* 47,17,2015 | |
| unreported route/rat | lowest published toxic dose: 4 mg/kg/4D- intermittent | Behavioral: Alteration of classical conditioning | TOXID9 44,197,2005 |
| unreported route/rat | lowest published toxic dose: 4 mg/kg/4D- intermittent | Brain and Coverings: Recordings from specific areas of CNS | TOXID9 72,124,2003 |
| unreported route/rat | lowest published toxic dose: 10.5 mg/kg/7D- intermittent | Brain and Coverings: Other degenerative changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | TOXID9 72,309,2003 |
| unreported route/rat | lowest published toxic dose: 15 mg/kg/5D- intermittent | Brain and Coverings: Other degenerative changes | TOXID9 72,309,2003 |
| unreported route/rat | lowest published toxic dose: 4 mg/kg/4D- intermittent | Brain and Coverings: Other degenerative changes | TOXID9 66,130,2002 |
| unreported route/rat | lowest published toxic dose: 20 mg/kg/4D- intermittent | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases | TOXID9 60,241,2001 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 0.1 mg/m3 (inhal, vapor, skin) | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | RREVAH 50,1,1974 | |
| TOXICOLOGY REVIEW | RREVAH 46,1,1973 | |
| TOXICOLOGY REVIEW | RREVAH 63,1,1976 | |
| TOXICOLOGY REVIEW | MUREAV 539,77,2003 | |
| TOXICOLOGY REVIEW | TOLED5 127,101,2002 | |
| TOXICOLOGY REVIEW | TOLED5 127,29,2002 | |
| TOXICOLOGY REVIEW | PPTHFJ 42,55,2005 | |
| TOXICOLOGY REVIEW | REPTED 22,196,2006 | |
| TOXICOLOGY REVIEW | REPTED 22,164,2006 | |
| TOXICOLOGY REVIEW | MUTAEX 21,93,2006 | |
| TOXICOLOGY REVIEW | APHRER 40,1040,2006 | |
| TOXICOLOGY REVIEW | NETOX* 26,573,2005 | |
| TOXICOLOGY REVIEW | CCATAR 366,1,2006 | |
| TOXICOLOGY REVIEW | ENTOX* -,583,2005 | |
| TOXICOLOGY REVIEW | MUREAV 627,10,2007 | |
| TOXICOLOGY REVIEW | ENTOX* -,306,2005 | |
| TOXICOLOGY REVIEW | ENTOX* -,308,2005 | |
| TOXICOLOGY REVIEW | REPTED 23,260,2007 | |
| TOXICOLOGY REVIEW | FEREAC 72,44439,2007 | |
| TOXICOLOGY REVIEW | REPTED 26,1,2008 | |
| TOXICOLOGY REVIEW | JTPAE7 19,1,2006 | |
| TOXICOLOGY REVIEW | HUTOX* -,541,1996 | |
| TOXICOLOGY REVIEW | HTOPA* 1,501,2002 | |
| TOXICOLOGY REVIEW | MUREAV 681,3,2009 | |
| TOXICOLOGY REVIEW | TPHSDY 29,322,2008 | |
| TOXICOLOGY REVIEW | FCTOD7 46,813,2008 | |
| TOXICOLOGY REVIEW | MUREAV 674,3,2009 | |
| TOXICOLOGY REVIEW | FEREAC 73,53732,2008 | |
| TOXICOLOGY REVIEW | REPTED 26,13,2008 | |
| TOXICOLOGY REVIEW | HETOEA 26,321,2007 | |
| TOXICOLOGY REVIEW | FCTOD7 47,2906,2009 | |
| TOXICOLOGY REVIEW | MUTAEX 26,19,2011 | |
| TOXICOLOGY REVIEW | TOLED5 190,107,2009 | |
| TOXICOLOGY REVIEW | REPTED 31,297,2011 | |
| TOXICOLOGY REVIEW | NRTXDN 31,562,2010 | |
| TOXICOLOGY REVIEW | MUREAV 721,27,2011 | |
| TOXICOLOGY REVIEW | REPTED 38,1,2013 | |
| TOXICOLOGY REVIEW | NRTXDN 33,575,2012 | |
| TOXICOLOGY REVIEW | NETOX* 33,911,2012 | |
| TOXICOLOGY REVIEW | TXAPA9 258,309,2012 | |
| TOXICOLOGY REVIEW | MUREAV 760,1,2014 | |
| TOXICOLOGY REVIEW | NETEEC 33,608,2011 | |
| TOXICOLOGY REVIEW | TOLED5 198,297,2010 | |
| TOXICOLOGY REVIEW | TOLED5 208,16,2012 | |
| TOXICOLOGY REVIEW | TOLED5 209,86,2012 | |
| TOXICOLOGY REVIEW | NRTXDN 39,158,2013 | |
| TOXICOLOGY REVIEW | NRTXDN 33,1420,2012 | |
| TOXICOLOGY REVIEW | NRTXDN 33,1473,2012 | |
| TOXICOLOGY REVIEW | TOLED5 208,16,2011 | |
| TOXICOLOGY REVIEW | TXCYAC 307,24,2013 | |
| TOXICOLOGY REVIEW | TXCYAC 307,46,2013 | |
| TOXICOLOGY REVIEW | TXCYAC 307,89,2013 | |
| TOXICOLOGY REVIEW | TXCYAC 307,115,2013 | |
| TOXICOLOGY REVIEW | TXCYAC 307,123,2013 | |
| TOXICOLOGY REVIEW | TXCYAC 307,136,2013 | |
| TOXICOLOGY REVIEW | TOLED5 230,85,2014 | |
| TOXICOLOGY REVIEW | TOLED5 230,104,2014 | |
| TOXICOLOGY REVIEW | TOLED5 230,146,2014 | |
| TOXICOLOGY REVIEW | TOLED5 230,434,2014 | |
| TOXICOLOGY REVIEW | MUREAV 767,67,2016 | |
| TOXICOLOGY REVIEW | NETEEC 36,17,2013 | |
| TOXICOLOGY REVIEW | NETEEC 44,30,2014 | |
| TOXICOLOGY REVIEW | TXAPA9 268,157,2013 | |
| TOXICOLOGY REVIEW | FCTOD7 86,298,2015 | |
| TOXICOLOGY REVIEW | NETEEC 52,25,2015 | |
| TOXICOLOGY REVIEW | NETEEC 52,68,2015 | |
| TOXICOLOGY REVIEW | NETEEC 52,78,2015 | |
| TOXICOLOGY REVIEW | NETEEC 52,88,2015 | |
| TOXICOLOGY REVIEW | FCTOD7 105,456,2017 | |
| TOXICOLOGY REVIEW | FCTOD7 108,365,2017 | |
| TOXICOLOGY REVIEW | REPTED 81,147,2018 | |
| TOXICOLOGY REVIEW | VETODR ,197,2018 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION | FEREAC 54,7740,1989 | |
| Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES | Supported | RBREV* -,99,1998 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 0.2 mg/m3, JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 0.2 mg/m3;KZW 0.4 mg/m3, skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 0.1 mg/m3 (vapor, aerosol), Skin, MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 0.2 mg/m3, skin, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 0.2 mg/m3, Skin, FEB2006 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 0.2 mg/m3, skin, NOV2011 | |
| Occupational Exposure Limit-KOREA | time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, skin, 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 0.2 mg/m3;short term exposure limit 0.6 mg/m3 (skin), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 0.2 mg/m3, skin, JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 0.2 mg/m3, JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 0.2 mg/m3, JUL2005 | |
| Occupational Exposure Limit-POLAND | time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, JAN1999 | |
| Occupational Exposure Limit-SWITZERLAND | MAK-week 0.2 mg/m3, inhal, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.2 mg/m3, Skin, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.2 mg/m3;short term exposure limit 0.6 mg/m3, skin, OCT2007 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORPYRIFOS-air | 10H time-weighted average 0.2 mg/m3;short term exposure limit 0.6 mg/m3 (Sk) | NIOSH* DHHS #95-121,1995 |
| National Occupational Exposure Survey 1983 | Hazard Code M4463; Number of Industries 4; Total Number of Facilities 1276; Number of Occupations 3; Total Number of Employees Exposed 11404; Total Number of Female Employees Exposed 842 | |
| National Occupational Hazard Survey 1974 | Hazard Code M4463; Number of Industries 1; Total Number of Facilities 753; Number of Occupations 3; Total Number of Employees Exposed 22523 | |
| National Occupational Hazard Survey 1974 | Hazard Code T0714; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 7 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health