Phenol, p-methoxy-

RTECS #

SL7700000

CAS #

150-76-5
See: NMAM or OSHA Methods

Updated

June 2017

Molecular Weight

124.15

Molecular Formula

C₇H₈O₂

Synonyms

4-Hydroxyanisole
4-Methoxyphenol
4-Methoxyphenol (ACGIH)
Hydroquinone monomethyl ether
Hydroxyanisole
Leucobasal
Leucodine B
Mechinolum
Mequinol
Mono methyl ether hydroquinone
Novo-Dermoquinona
P-Guaiacol
p-Hydroxyanisole
p-Hydroxymethoxybenzene
p-Methoxyphenol
PMF (antioxidant)
USAF AN-7

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
skin /rabbit	6 gm/12D- intermittent	mild	JIHTAB 31,79,1949
skin /rabbit	10%		VCVGK* -,299,1994

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	/hamster	250 µmol/L	MUREAV 608,28,2006
Cytogenetic Analysis	ovary/hamster	250 µmol/L	MUREAV 608,28,2006
DNA inhibition	lymphocyte/human	25 µmol/L	RCOCB8 54,133,1986

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
skin/rat	4440 mg/kg (6D preg-20D after birth)	Reproductive: Other effects on female Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Behavioral	HPV261 -,-,2003

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
intraperitoneal/mouse	lethal dose (50 percent kill): 250 mg/kg		NTIS** AD691-490
intraperitoneal/mouse	lowest published toxic dose: 200 mg/kg	Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases	CBINA8 142,317,2003
oral/rat	lethal dose (50 percent kill): 1600 mg/kg		VCVGK* -,299,1994
Tank with water/Zebrafish	lowest published toxic concentration: 2 mg/L/48H	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases Biochemical: Metabolism (intermediary): Other	JOETD7 154,240,2014

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/Dog	lowest published toxic dose: 33.6 gm/kg/4W- intermittent	Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV082 -,-,2002
oral/mouse	lowest published toxic dose: 7508 ng/kg/12D- intermittent	Liver: Other changes Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)	BJCAAI 45,935,1982
oral/rabbit	lowest published toxic dose: 105 gm/kg/5W- intermittent	Blood: Changes in erythrocyte (RBC) count Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV082 -,-,2002
oral/rat	lowest published toxic dose: 0.735 mg/kg/7W- continuous	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	VCVGK* -,299,1994
oral/rat	lowest published toxic dose: 18375 mg/kg/7W- intermittent	Kidney, Ureter, and Bladder: Other changes in urine composition Endocrine: Differential effect of sex or castration on observed toxicity Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV082 -,-,2002

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 5 mg/m³	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		JACTDZ 4(5),31,1985
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 672,10,2009
TOXICOLOGY REVIEW		MUREAV 672,17,2009
TOXICOLOGY REVIEW		MUREAV 750,1,2012
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		MUREAV 802,1,2016

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 5 mg/m³, JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 mg/m³;KZW 10 mg/m³, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 5 mg/m³, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 5 mg/m³, MAY2011
Occupational Exposure Limit-FRANCE	VME 5 mg/m³, FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 5 mg/m³, NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 5 mg/m³, 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 5 mg/m³, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 5 mg/m³, JAN1999
Occupational Exposure Limit-PERU	time-weighted average 5 mg/m³, JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 0.5 mg/m³, JUN2003
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 5 mg/m³, 2003

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4-METHOXYPHENOL-air	10H time-weighted average 5 mg/m³	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code X3672; Number of Industries 136; Total Number of Facilities 9805; Number of Occupations 89; Total Number of Employees Exposed 250087; Total Number of Female Employees Exposed 49763

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8789;8EHQ-0892-8802
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8825
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health