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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Naphthylamine, N-phenyl-

RTECS #

QM4550000

CAS #

135-88-6

Updated

October 2017

Molecular Weight

219.30

Molecular Formula

C16H13N

Synonyms

2-Anilinonaphthalene
2-Naphthylphenylamine
2-Phenylaminonaphthalene
Aceto PBN
AgeRite Powder
AK 1
AK 1 (stabilizer)
Antioxidant 116
Antioxidant D
Antioxidant PBN
beta-Naphthylphenylamine
Fenyl-beta-naftylamin (Czech)
N-(2-Naphthyl)aniline
Naftam 2
NCI-C02915
Neozon D
Neozone
Neozone D
N-Fenyl-2-aminonaftalen (Czech)
Nilox PbNa
Noclizer D
Nocrac D
Nonox D
N-Phenyl-2-naphthylamine
N-Phenyl-beta-naphthylamine
N-Phenyl-beta-naphthylamine (ACGIH)
PBNA
Phenyl-2-naphthylamine
Phenyl-beta-naphthylamine
Stabilizator AR
Stabilizer AR
Vulkanox PBN

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse360 mg/kg/18DGTPZAB 23(9),57,1979
morphological transformother cell types/human23100 µg/LITCSAF 17,719,1981
mutation in microorganisms/Salmonella typhimurium50 pph (+enzymatic activation step)CYGEDX 21(6),29,1987
specific locus testinhalation/mouse59.3 µmol/LMUREAV 608,29,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 18200 mg/kg (26W male)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
TPKVAL 12,86,1971

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse toxic dose: 264 gm/kg/99W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
SYSWAE 14,129,1981
oral/mouse toxic dose: 135 gm/kg/78W- intermittentTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTIS** PB223-159
oral/mouse toxic dose: 17280 mg/kg/9W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
CNREA8 44,3098,1984
oral/mouse lowest published toxic dose: 648900 mg/kg/103W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB88-216270/AS
oral/mouse lowest published toxic dose: 433 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-333,1988
oral/mouse lowest published toxic dose: 208 gm/kg/97W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
SYSWAE 14,129,1981
subcutaneous/mouse lowest published toxic dose: 464 mg/kgTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTIS** PB223-159

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 0.9 gm/m3/2HBrain and Coverings: Changes in circulation

Brain and Coverings: Other degenerative changes

Behavioral: Coma
TPKVAL 6,37,1964
oral/mouse lethal dose (50 percent kill): 1450 mg/kgBehavioral: Somnolence (general depressed activity)HYSAAV 31(1-3),183,1966
oral/rat lowest published toxic dose: 8000 mg/kgTPKVAL 12,86,1971
oral/rat lethal dose (50 percent kill): 8730 mg/kgBehavioral: Somnolence (general depressed activity)HYSAAV 31(1-3),183,1966
subcutaneous/mouse lowest published toxic dose: 1000 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: General anesthetic
TPKVAL 6,37,1964
subcutaneous/rat lowest published toxic dose: 1000 mg/kgLung, Thorax, or Respiration: Respiratory obstruction

Liver: Fatty liver degeneration

Biochemical: Metabolism (intermediary): Other
TPKVAL 6,37,1964
unreported route/rat lethal dose (50 percent kill): 8700 mg/kgBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes
TJSGA8 53,415,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 100 gm/m3/6D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTPKVAL 10,90,1968
inhalation/guinea pig lowest published toxic concentration: 100 gm/m3/12D- intermittentLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 6,37,1964
inhalation/rat lowest published toxic concentration: 0.9 gm/m3/10D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
TPKVAL 6,37,1964
oral/guinea pig lowest published toxic dose: 6000 mg/kg/40D- intermittentVascular: Other changes

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 6,37,1964
oral/mouse lowest published toxic dose: 437 gm/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-333,1988
oral/rabbit lowest published toxic dose: 5000 mg/kg/5D- intermittentKidney, Ureter, and Bladder: Proteinuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 6,37,1964
oral/rabbit lowest published toxic dose: 12000 mg/kg/3D- intermittentLiver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 6,37,1964
oral/rat lowest published toxic dose: 52 gm/kg/30D- intermittentLiver: Liver function tests impaired

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 31(2),25,1966
oral/rat lowest published toxic dose: 182 gm/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-333,1988
oral/rat lowest published toxic dose: 19 gm/kg/19D- intermittentKidney, Ureter, and Bladder: Proteinuria

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 12,86,1971
oral/rat lowest published toxic dose: 36400 mg/kg/1Y- intermittentLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Proteinuria
TPKVAL 12,86,1971
oral/rat lowest published toxic dose: 4000 mg/kg/4D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTPKVAL 12,86,1971
oral/rat lowest published toxic dose: 3650 mg/kg/0.5Y- continuousGastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition
TPKVAL 12,86,1971
oral/rat lowest published toxic dose: 54700 mg/kg/1.5Y- continuousKidney, Ureter, and Bladder: Urine volume decreased or anuriaTPKVAL 12,86,1971
oral/rat lowest published toxic dose: 3000 mg/kg/30D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Proteinuria
TPKVAL 12,86,1971
oral/rat lowest published toxic dose: 36500 mg/kg/1Y- continuousLung, Thorax, or Respiration: Changes in lung weightTPKVAL 12,86,1971
oral/rat lowest published toxic dose: 18200 mg/kg/0.5Y- continuousGastrointestinal: Necrotic changes

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 12,86,1971
subcutaneous/rat lowest published toxic dose: 30000 mg/kg/60W- intermittentSkin and Appendages: Tumors

Tumorigenic: Protects against induction of experimental tumors
VOONC* 37,60,1991

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Control as low as possibleDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 16,325,1978
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 16,325,1978
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,318,1987
TOXICOLOGY REVIEWTOLED5 134,39,2002
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 802,1,I2

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIACarcinogen, JUL2008
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.03 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENGroup B Carcinogen, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO N-PHENYL-beta-NAPHTHYLAMINE-airCarcinogen lowest concentrationNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 80313; Number of Industries 2; Total Number of Facilities 33; Number of Occupations 4; Total Number of Employees Exposed 1356; Total Number of Female Employees Exposed 41
National Occupational Hazard Survey 1974Hazard Code 80313; Number of Industries 15; Total Number of Facilities 751; Number of Occupations 32; Total Number of Employees Exposed 16148

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat
NIOSH CURRENT INTELLIGENCE BULLETIN 16, 1976
OSHA ANALYTICAL METHOD #96
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