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Registry of Toxic Effects of Chemical Substances (RTECS)

Methylamine, m-phenylenebis-

RTECS #

PF8970000

CAS #

1477-55-0

Updated

September 2013

Molecular Weight

136.22

Molecular Formula

C8H12N2

Synonyms

1,3-Benzenedimethanamine
1,3-Bis(aminomethyl)benzene
1,3-Bis-aminomethylbenzen (Czech)
m-Phenylenebis(methylamine)
MXDA
m-Xylene alpha,alpha'-diamine
m-Xylene alpha,alpha'-diamine (ACGIH)
m-Xylene-alpha,alpha'-diamine
m-Xylylendiamin (Czech)
m-Xylylenediamine

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 µg/24H severe85JCAE -,447,1986
skin /rabbit 750 µg/24H severe85JCAE -,447,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 700 ppm/1HEye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression
85INA8 5,638,1986
oral/rat lethal dose (50 percent kill): 930 mg/kg85INA8 5,638,1986
skin/rabbit lethal dose (50 percent kill): 2 gm/kg85INA8 5,638,1986

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 0.1 mg/m3 (skin)DTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 0.1 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 mg/m3;KZW 0.1 mg/m3, 2007
Occupational Exposure Limit-BELGIUMshort term exposure limit 0.1 mg/m3, Skin, MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 0.02 ppm (0.1 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDceiling concentration 0.1 mg/m3, skin, NOV2011
Occupational Exposure Limit-FRANCEVLE 0.1 mg/m3, FEB2006
Occupational Exposure Limit-ICELANDshort term exposure limit 0.02 ppm (0.1 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAceiling concentration 0.1 mg/m3, skin, 2006
Occupational Exposure Limit-MEXICOpeak 0.1 mg/m3 (skin), 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 0.1 mg/m3, skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit-SWITZERLANDMAK-week 0.1 mg/m3, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-C 0.1 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-XYLENE-alpha,alpha'-DIAMINE-airceiling concentration 0.1 mg/m3 (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84031; Number of Industries 3; Total Number of Facilities 43; Number of Occupations 4; Total Number of Employees Exposed 1005
National Occupational Hazard Survey 1974Hazard Code 84031; Number of Industries 1; Total Number of Facilities 5; Number of Occupations 2; Total Number of Employees Exposed 15

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULEFEREAC 47,27009,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #105
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