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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, trichloronitro-

RTECS #

PB6300000

CAS #

76-06-2

Updated

December 2015

Molecular Weight

164.37

Molecular Formula

CCl3NO2

Synonyms

Acquinite
Chloorpikrine (Dutch)
Chloroform, nitro-
Chloropicrin
Chloropicrin (ACGIH:OSHA)
Chloropicrine (French)
Chlorpikrin (German)
Cloropicrina (Italian)
Dojyopicrin
Dolochlor
G 25
KLOP
Larvacide
Microlysin
NCI-C00533
Nitrochloroform
Nitrotrichloromethane (OSHA)
Pic-Clor
Picfume
Picride
Profume A
PS
Trichloornitromethaan (Dutch)
Trichlornitromethan (German)
Trichloronitromethane
Tri-clor
Tricloro-nitro-metano (Italian)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium50 µg/plate (-enzymatic activation step)MUREAV 116,185,1983
mutation in microorganisms/Escherichia coli50 µg/plate (+enzymatic activation step)SAIGBL 29,34,1987
other mutation test systems/Escherichia coli300 µg/LMUREAV 348,147,1995
sister chromatid exchangelymphocyte/human8 mg/LTCMUD8 10,21,1990

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 26 gm/kg/78W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NCITR* NCI-TR-65,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, lung fibroblast Inhibitor Concentration Low: 16 µmol/L/6HIn Vitro Toxicity Studies: Other assaysTIVIEQ 28,209,2014
In Vitro/Human, lung tumor Inhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Apoptosis in vitro
TOLED5 226,236,2014
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 112 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TOLED5 226,236,2014
In Vitro/jdaInhibitor Concentration Low: 50 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.

In Vitro Toxicity Studies: Other assays
TOLED5 211,239,2012
inhalation/cat Lowest published lethal concentration: 800 mg/m3/20MBehavioral: Food intake (animal)

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
ZGEMAZ 106,296,1939
inhalation/Dog Lowest published lethal concentration: 0.5 gm/m3/30MCardiac: Cardiomyopathy including infarction

Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory obstruction
TPKVAL 3,103,1961
inhalation/guinea pig Lowest published lethal concentration: 0.5 gm/m3/30MBrain and Coverings: Changes in circulation

Behavioral: Ataxia

Behavioral: Tetany
TPKVAL 3,103,1961
inhalation/guinea pig Lowest published lethal concentration: 800 mg/m3/20MLung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea
ZGEMAZ 106,296,1939
inhalation/human lowest published toxic concentration: 2 mg/m3Eye: Lacrimation

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
ZGEMAZ 106,296,1939
inhalation/human Lowest published lethal concentration: 2000 mg/m3/10M34ZIAG -,169,1969
inhalation/mouse lethal concentration (50 percent kill): 66 mg/m3/4HEye: Increased intraocular pressure

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation
SAIGBL 15,406,1973
inhalation/mouse Lowest published lethal concentration: 0.15 gm/m3/15MSkin: After systemic exposure: Dermatitis, otherTPKVAL 3,103,1961
inhalation/mouse lowest published toxic concentration: 0.99 ppm/30MBlood: HemorrhageTOXID9 60,426,2001
inhalation/rabbit lethal concentration (50 percent kill): 800 mg/m3/20MFMCHA2 -,C72,1991
inhalation/rat lethal concentration (50 percent kill): 14400 ppb/4HLung, Thorax, or Respiration: Other changesNNGADV 16,63,1991
inhalation/rat lethal concentration (50 percent kill): 18.9 ppm/4HOlfaction: Change in sensation of smell

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
TOXID9 60,426,2001
inhalation/rat lowest published toxic concentration: 10.5 ppm/4HGastrointestinal: Nausea or vomitingTOXID9 60,426,2001
inhalation/rat lowest published toxic concentration: 10.5 ppm/4HLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 60,426,2001
inhalation/rat Lowest published lethal concentration: 18 ppm/4HOlfaction: Other olfaction effects

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 60,426,2001
inhalation/rat Lowest published lethal concentration: 23.5 ppm/4HOlfaction: Change in sensation of smell

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
TOXID9 60,426,2001
intraperitoneal/mouse lethal dose (50 percent kill): 25 mg/kgENTOX* -,571,2005
intravenous/guinea pig lethal dose (50 percent kill): 4200 µg/kgLung, Thorax, or Respiration: Acute pulmonary edemaAIPTAK 114,146,1958
oral/rat lethal dose (50 percent kill): 250 mg/kgDOWCC* -,-,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 400 mg/kg/10D- intermittentEndocrine: Changes in thymus weight

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 17,125,1994
oral/rat lowest published toxic dose: 2880 mg/kg/90D- intermittentGastrointestinal: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 17,125,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWENTOX* -,571,2005
TOXICOLOGY REVIEWMUREAV 636,242,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESSupportedRBREV* -,98,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.1 ppm (0.7 mg/m3)DTLVS* 3,54,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 ppm (0.67 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.1 ppm (0.7 mg/m3);KZW 0.2 ppm (1.4 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 ppm (0.68 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 ppm (0.7 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 ppm (0.7 mg/m3), short term exposure limit 0.3 ppm (2.1 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 ppm (0.7 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 0.1 ppm (0.68 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 0.1 ppm (0.7 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 ppm (0.67 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.1 ppm (0.7 mg/m3), short term exposure limit 0.3 ppm (2 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.1 ppm (0.7 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 ppm (0.67 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.1 ppm (0.7 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,1 ppm (0,7 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDceiling concentration 0.1 ppm (0.7 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.7 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.1 ppm (0.7 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.1 ppm (0.7 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.1 ppm (0.68 mg/m3);short term exposure limit 0.3 ppm (2.1 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.1 ppm (0.7 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.1 ppm (0.7 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.1 ppm (0.7 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.1 ppm (0.7 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROPICRIN-air10H time-weighted average 0.1 ppmNIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code M0419; Number of Industries 3; Total Number of Facilities 484; Number of Occupations 8; Total Number of Employees Exposed 4843; Total Number of Female Employees Exposed 939

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (gavage);inadequate studies:ratNCITR* NCI-TR-65,1978
NCI Carcinogenesis Bioassay (gavage);no evidence:mouseNCITR* NCI-TR-65,1978
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