Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, iodo-

RTECS #

PA9450000

CAS #

74-88-4

Updated

June 2017

Molecular Weight

141.94

Molecular Formula

CH3I

Synonyms

Halon 10001
Iodometano (Italian)
Iodomethane
Iodure de methyle (French)
Jod-methan (German)
Joodmethaan (Dutch)
Methyl iodide
Methyl iodide (ACGIH:OSHA)
Methyljodid (German)
Methyljodide (Dutch)
Metylu jodek (Polish)
Monoioduro di metile (Italian)
RCRA waste number U138

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeNTIS** OTS0570629
skin /human 1 gm/10M mildBJIMAG 7,122,1950
skin /rabbit 500 mg severeNTIS** OTS0570629
skin /rat 1 gm/30M mildBJIMAG 7,122,1950

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damage/Escherichia coli1 µmol/LARTODN 46,277,1980
DNA repair/Escherichia coli10 µg/discJJIND8 62,873,1979
gene conversion and mitotic recombination/Saccharomyes cerevisiae1000 ppmJJIND8 62,901,1979
morphological transformembryo/hamster1 mg/LIJCNAW 19,642,1977
mutation in mammalian somatic cellsovary/hamster2 mg/LMUREAV 136,137,1984
mutation in mammalian somatic cellslymphocyte/mouse3600 µg/LENMUDM 7,523,1985
mutation in microorganismslymphocyte/mouse50 mg/L/4H (+enzymatic activation step)MUREAV 59,61,1979
mutation in microorganisms/Salmonella typhimurium2 µL/plate (+/-enzymatic activation step)JJIND8 62,873,1979
mutation in microorganisms/Escherichia coli20 µmol/L (-enzymatic activation step)ARTODN 46,277,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit 20 ppm (6-28D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTOXID9 44,50,2005

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 44 mg/kg/8W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 35,1411,1975
subcutaneous/rat lowest published toxic dose: 50 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors

Tumorigenic: Tumors at site of application
ZEKBAI 74,241,1970

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 5 gm/m3/57M-continuousBJIMAG 7,122,1950
inhalation/mouse lethal concentration (50 percent kill): 5000 mg/m3/57MVCVGH* -,603,1990
inhalation/rat lethal concentration (50 percent kill): 1300 mg/m3/4HVCVGH* -,603,1990
inhalation/rat lowest published toxic concentration: 200 ppm/2HOlfaction: Ulcerated nasal septum

Olfaction: Other olfaction effects
TOXID9 60,150,2001
intraperitoneal/guinea pig lethal dose (50 percent kill): 51 mg/kg85GMAT -,84,1982
intraperitoneal/mouse lethal dose (50 percent kill): 172 mg/kg85GMAT -,84,1982
intraperitoneal/rat lethal dose (50 percent kill): 101 mg/kg85GMAT -,84,1982
oral/rabbit lowest published lethal dose: 70 mg/kg38MKAJ 2B,3447,1981
oral/rat lethal dose (50 percent kill): 76 mg/kgBIJOAK 98,38,1966
skin/guinea pig lethal dose (50 percent kill): 800 mg/kgKODAK* 21MAY1971
skin/rabbit lowest published lethal dose: 794 mg/kgLung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes

Blood: Hemorrhage
NTIS** OTS0570629
subcutaneous/mouse lethal dose (50 percent kill): 110 mg/kgTXAPA9 4,354,1962
subcutaneous/rat lethal dose (50 percent kill): 110 mg/kgZEKBAI 74,241,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 100 mg/m3/5H/16W- intermittentBlood: Changes in other cell count (unspecified)

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGH* -,604,1990
inhalation/rat lowest published toxic concentration: 25 ppm/6H/2D- intermittentLiver: Other changes

Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 44,49,2005

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppm (skin)DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 41,213,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1503,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 41,213,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1503,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1503,1999
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 763,294,2015
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 ppm (28 mg/m3) (skin)DTLVS* 3,166,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (12 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit-AUSTRIATRK-TMW 0.3 ppm (2 mg/m3);KZW 1.2 ppm (8 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (12 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (5.6 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 2 ppm (12 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (12 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (6 mg/m3), carc, skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (10 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 2 ppm (10 mg/m3);short term exposure limit 5 ppm (30 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (12 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (11,6 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 10 mg/m3, MAC(short term exposure limit) 30 mg/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 1 ppm (6 mg/m3);short term exposure limit 5 ppm (30 mg/m3), Skin, Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.3 ppm (2 mg/m3), carc 2, skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2 ppm (12 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 ppm (28 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 ppm (28 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 ppm (28 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 ppm (28 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL IODIDE-air10H Carcinogen time-weighted average 2 ppm (Sk) (1.7 ppm LOQ)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M0422; Number of Industries 2; Total Number of Facilities 34; Number of Occupations 6; Total Number of Employees Exposed 2182; Total Number of Female Employees Exposed 440
National Occupational Hazard Survey 1974Hazard Code M0422; Number of Industries 2; Total Number of Facilities 26; Number of Occupations 4; Total Number of Employees Exposed 413

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: L5178Y cells in vitro-TK test; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl iodide, 1014
NIOSH CURRENT INTELLIGENCE BULLETIN 43, 1984
On EPA IRIS database
TOP