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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, chlorodifluoro-

RTECS #

PA6390000

CAS #

75-45-6

Updated

September 2013

Molecular Weight

86.47

Molecular Formula

CHClF2

Synonyms

Algeon 22
Algofrene 22
Algofrene type 6
Arcton 22
Arcton 4
CFC 22
Chlorodifluoromethane (ACGIH)
Daiflon 22
Difluorochloromethane
Difluoromonochloromethane
Dymel 22
Electro-CF 22
Eskimon 22
F 22
Flugene 22
Fluorocarbon-22
Forane 22
Freon 22
Frigen 22
Genetron 22
Haltron 22
HFA-22
Isceon 22
Isotron 22
Khaladon 22
Monochlorodifluoromethane
Propellant 22
R 22 (refrigerant)
R-22
Racon 22
Refrigerant R 22
Ucon 22

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium33 pph/24H-continuous (+/-enzymatic activation step)TOLED5 2,1,1978

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 50000 ppm/5H (56D male)Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsFAATDF 1,266,1981
inhalation/rat 5 ppm (6-15D pregnant)Reproductive: Specific developmental abnormalities: Eye, earNTIS** OTS0520838
inhalation/rat 50000 ppm/6H (6-15D pregnant)Reproductive: Specific developmental abnormalities: Eye, earNTIS** OTS0545682

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lowest published lethal concentration: 70 pphLung, Thorax, or Respiration: Other changesTXAPA9 2,363,1960
inhalation/guinea pig Lowest published lethal concentration: 30 pph/2HBehavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
ZAARAM 21,149,1971
inhalation/guinea pig lowest published toxic concentration: 584000 mg/m3/55MBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
VCVGH* -,618,1990
inhalation/guinea pig lowest published toxic concentration: 1380000 mg/m3/2HBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
VCVGH* -,618,1990
inhalation/guinea pig Lowest published lethal concentration: 1800000 mg/m3/18MVCVGH* -,618,1990
inhalation/mouse lethal concentration (50 percent kill): 1000000 mg/m3/2HVCVGH* -,618,1990
inhalation/mouse lethal concentration (50 percent kill): 1020000 mg/m3/30MVCVGH* -,618,1990
inhalation/mouse lethal concentration (50 percent kill): 1380 gm/m3/2HBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis
TLSMA6 75,241,1963
inhalation/rabbit Lowest published lethal concentration: 1100000 mg/m3/30MVCVGH* -,618,1990
inhalation/rabbit Lowest published lethal concentration: 1530000 mg/m3/20MVCVGH* -,618,1990
inhalation/rat lethal concentration (50 percent kill): 35 pph/15MBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
HUTODJ 1,239,1982
oral/rat Lethal dose: >43200 µg/kgGISAAA 48(8),69,1983

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 50 gm/m3/6H/43W- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Behavioral: Alteration of classical conditioning
TLSMA6 75,231,1963
oral/rat lowest published toxic dose: 2457 mg/kg/26W- intermittentBrain and Coverings: Other degenerative changes

Blood: Changes in other cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 48(8),69,1983

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1000 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 41,237,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 71,1339,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 41,237,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 71,1339,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1339,1999
TOXICOLOGY REVIEWFAZMAE 18,365,1974
TOXICOLOGY REVIEWNYSJAM 74,1939,1974
TOXICOLOGY REVIEWENTOX* -,384,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHUTOX* -,683,1996
TOXICOLOGY REVIEWHUTOX* -,577,1996

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1000 ppm (3540 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 500 ppm (1800 mg/m3);KZW 1000 ppm (3600 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1000 ppm (3600 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 500 ppm (1770 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 3600 mg/m3 (1000 ppm), JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 1000 ppm (3600 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1000 ppm (3600 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 500 ppm (1800 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 3600 mg/m3, short term exposure limit 14400 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 500 ppm (1770 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 1000 ppm (3500 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 1000 ppm (3500 mg/m3), short term exposure limit 1250 ppm (4375 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1000 ppm (3500 mg/m3);short term exposure limit 1250 ppm, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1000 ppm (3540 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 500 ppm (1750 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1000 ppm (3537 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 3000 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 500 ppm (1800 mg/m3);short term exposure limit 750 ppm (2500 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 500 ppm (1800 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 3600 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1000 ppm (3590 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORODIFLUOROMETHANE-airtime-weighted average 1000 ppm;short term exposure limit 1250 ppmNIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code 80048; Number of Industries 78; Total Number of Facilities 12513; Number of Occupations 57; Total Number of Employees Exposed 157080; Total Number of Female Employees Exposed 12185
National Occupational Hazard Survey 1974Hazard Code 80048; Number of Industries 76; Total Number of Facilities 7420; Number of Occupations 44; Total Number of Employees Exposed 56234

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9099;8EHQ-0892-9107
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9108;8EHQ-0892-9117
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9118
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Chlorodifluoromethane, 1018
On EPA IRIS database
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