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Registry of Toxic Effects of Chemical Substances (RTECS)

Methanamine, N,N-dimethyl-

RTECS #

PA0350000

CAS #

75-50-3

Updated

September 2013

Molecular Weight

59.13

Molecular Formula

C3H9N

Synonyms

Dimethylmethaneamine
N,N-Dimethylmethanamine
Trimethylamine
Trimethylamine (ACGIH)

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 4430 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Physical
CJPPA3 71,185,1993
intraperitoneal/mouse 2960 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)CJPPA3 71,185,1993

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 19 gm/m3TPKVAL 14,80,1975
inhalation/mouse lethal concentration (50 percent kill): 19 gm/m3Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GTPZAB 11(4),26,1967
inhalation/rat Lowest published lethal concentration: 3500 ppm/4HTOXID9 4,68,1984
intraperitoneal/mouse lethal dose (50 percent kill): 946 mg/kgYKKZAJ 97,1117,1977
intravenous/mouse lethal dose (50 percent kill): 90 mg/kgMPHEAE 16,529,1967
intravenous/rabbit lowest published lethal dose: 160 mg/kgCRSBAW 83,481,1920
oral/pig lowest published lethal dose: 1 gm/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Food intake (animal)
INHTE5 2,41,1990
oral/rat lethal dose (50 percent kill): 500 mg/kgINHTE5 2,41,1990
rectal/rabbit lowest published lethal dose: 800 mg/kgCRSBAW 83,481,1920
subcutaneous/frog lowest published lethal dose: 2 gm/kgCardiac: Pulse rate decreased with fall in BP

Cardiac: Other changes

Blood: Other changes
SAPHAO 10,201,1900
subcutaneous/rabbit lowest published lethal dose: 800 mg/kgCRSBAW 83,481,1920
unreported route/guinea pig lethal dose (50 percent kill): 315 mg/kgGISAAA 46(8),79,1981
unreported route/mouse lethal dose (50 percent kill): 460 mg/kgGISAAA 46(8),79,1981
unreported route/rabbit lethal dose (50 percent kill): 240 mg/kgGISAAA 46(8),79,1981
unreported route/rat lethal dose (50 percent kill): 535 mg/kgGISAAA 46(8),79,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 75 mg/m3/5H/30W- intermittentLung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Endocrine: Changes in adrenal weight

Blood: Changes in other cell count (unspecified)
GTPZAB 11(4),26,1967
inhalation/rat lowest published toxic concentration: 750 ppm/6H/2W- intermittentOlfaction: Other olfaction effects

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
INHTE5 2,41,1990
unreported route/rabbit lowest published toxic dose: 437 mg/kg/26W- intermittentBlood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 46(8),79,1981

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 15 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCHREAY 9,389,1931
TOXICOLOGY REVIEWMUREAV 741,32,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (24 mg/m3), short term exposure limit 15 ppm (36 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (12 mg/m3), short term exposure limit 15 ppm (37 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (12 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (12 mg/m3), short term exposure limit 15 ppm (37 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVLE 10 ppm (25 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 2 ppm (4.9 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 12.3 mg/m3, short term exposure limit 36.9 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (12 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (24 mg/m3), short term exposure limit 15 ppm (36 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (24 mg/m3), short term exposure limit 15 ppm (36 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (24 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (12 mg/m3); short term exposure limit 15 ppm (36 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (4.9 mg/m3), KZG-week 4 ppm (9.8 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIMETHYLAMINE-air10H time-weighted average 10 ppm;short term exposure limit 15 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 82039; Number of Industries 7; Total Number of Facilities 142; Number of Occupations 13; Total Number of Employees Exposed 5261; Total Number of Female Employees Exposed 2870
National Occupational Hazard Survey 1974Hazard Code 82039; Number of Industries 6; Total Number of Facilities 387; Number of Occupations 11; Total Number of Employees Exposed 3900

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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