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Registry of Toxic Effects of Chemical Substances (RTECS)

Methacrylic acid

RTECS #

OZ2975000

CAS #

79-41-4

Updated

December 2015

Molecular Weight

86.10

Molecular Formula

C4H6O2

Synonyms

2-Methylpropenoic acid
2-Propenoic acid, 2-methyl- (9CI)
Acrylic acid, 2-methyl-
alpha-Methylacrylic acid
Kyselina methakrylova (Czech)
Methacrylic acid (ACGIH)
No Lift Nails Primer
Propionic acid, 2-methylene-

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adduct/Escherichia coli50 µmol/LMUREAV 89,95,1981

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 170 mg/m3Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
TOVEFN (4),23,2000
inhalation/rat lowest published toxic concentration: 120 mg/m3Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
TOVEFN (4),23,2000
intraperitoneal/mouse lethal dose (50 percent kill): 48 mg/kgJPMSAE 62,778,1973
intravenous/Dog lowest published lethal dose: 95200 nL/kgJPMSAE 63,376,1974
oral/child lowest published toxic dose: 250 µL/kgLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Gastrointestinal: Nausea or vomiting

Skin: After systemic exposure: Dermatitis, other
PEDIAU 102,979,1998
oral/mouse lethal dose (50 percent kill): 1250 mg/kgGTPZAB 25(11),57,1981
oral/rabbit lethal dose (50 percent kill): 1200 mg/kgGISAAA 38(8),13,1973
oral/rat lethal dose (50 percent kill): 1060 mg/kgTOVEFN (4),23,2000
skin/guinea pig lethal dose (50 percent kill): 1 gm/kg38MKAJ 2C,4953,1982
skin/rabbit lethal dose (50 percent kill): 500 mg/kg85INA8 5,362,1986
unreported route/mouse lethal dose (50 percent kill): 1250 mg/kgGISAAA 49(10),64,1984
unreported route/rat lethal dose (50 percent kill): 1600 mg/kgGISAAA 49(10),64,1984

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 221 mg/m3/24H/17W- continuousBehavioral: Alteration of classical conditioningGISAAA 46(5),10,1981
inhalation/rat lowest published toxic concentration: 221 mg/m3/24H/17W- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: DehydrogenasesGISAAA 46(5),10,1981
oral/rabbit lowest published toxic dose: 910 mg/kg/26W- intermittentLiver: Liver function tests impaired

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
GISAAA 38(8),13,1973
oral/rat lowest published toxic dose: 910 mg/kg/26W- intermittentBehavioral: Alteration of classical conditioningGISAAA 38(8),13,1973

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 20 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWEVHPAZ 11,141,1975
TOXICOLOGY REVIEWIJTOFN 24,33,2005
TOXICOLOGY REVIEWHPCQA4 38,527,2007
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWDERCL* 27,289,2009
TOXICOLOGY REVIEWFCTOD7 55,596,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 20 ppm (70 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (70 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 20 ppm (71 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 20 ppm (70 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (71 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 20 ppm (70 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 5 ppm (18 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 20 ppm (70 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 2 ppm, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 20 ppm (70 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 20 ppm (70 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 20 ppm (70 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 20 ppm (70 mg/m3);short term exposure limit 30 ppm (100 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (18 mg/m3), KZG-week 10 ppm (36 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 70 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 20 ppm (72 mg/m3);short term exposure limit 40 ppm (143 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHACRYLIC ACID-air10H time-weighted average 20 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M3304; Number of Industries 109; Total Number of Facilities 10110; Number of Occupations 75; Total Number of Employees Exposed 145414; Total Number of Female Employees Exposed 46453
National Occupational Hazard Survey 1974Hazard Code M3304; Number of Industries 12; Total Number of Facilities 1529; Number of Occupations 31; Total Number of Employees Exposed 18977

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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