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Registry of Toxic Effects of Chemical Substances (RTECS)

Manganese

RTECS #

OO9275000

CAS #

7439-96-5

Updated

October 2017

Molecular Weight

54.94

Molecular Formula

Mn

Synonyms

Colloidal manganese
Magnacat
Mangan (Polish)
Mangan nitridovany (Czech)
Manganese (ACGIH:OSHA)
Tronamang

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild28ZPAK -,21,1972
skin /rabbit 500 mg/24H mild28ZPAK -,21,1972

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Dominant Lethal Testintraperitoneal/rat25 mg/kgVCVN5* -,413,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 0.71 mg/m3 (15-16D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicNRTXDN 27,395,2006
inhalation/rat 0.71 mg/m3 (multigeneration)Reproductive: Effects on newborn: Biochemical and metabolicNRTXDN 27,395,2006
oral/rat 90 mg/kg (18D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TOSCF2 92,516,2006
oral/rat 50 mg/kg (20D after birth)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
NRTXDN 23,635,2002
oral/mouse 322.5 mg/kg (43D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)REPTED 17,547,2003
oral/mouse 1290 mg/kg (43D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductREPTED 17,547,2003

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intramuscular/rat lowest published toxic dose: 400 mg/kg/1Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
NCIUS* PH43-64-886

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/man lowest published toxic concentration: 2300 µg/m3Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness
AIHAAP 27,454,1966
oral/rat lethal dose (50 percent kill): 9 gm/kg28ZPAK -,21,1972
Tank with water/Daphnia lethal concentration (50 percent kill): 5700 µg/L/48HTIVIEQ 31,125,1995

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 250 mg/m3/1Y- intermittentPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Irritability

Lung, Thorax, or Respiration: Other changes
VCVN5* -,413,1989
inhalation/human lowest published toxic concentration: 0.5 mg/m3/39W- intermittentBrain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Behavioral: Irritability
VCVN5* -,413,1989
inhalation/human lowest published toxic dose: >0.1 mg/kg/1Y- intermittentBehavioral: Change in motor activity (specific assay)TOXID9 -,144,2008
inhalation/man lowest published toxic concentration: 210 µg/m3/5Y- intermittentEndocrine: Other changesACLSCP 26,10,1996
inhalation/monkey lowest published toxic concentration: 0.3 mg/m3/5H/26W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Immunological Including Allergic: Decrease in cellular immune response
VCVN5* -,412,1989
inhalation/mouse lowest published toxic concentration: 0.7 mg/m3/24H/22W- continuousLung, Thorax, or Respiration: Fibrosis (interstitial)

Immunological Including Allergic: Decrease in cellular immune response
VCVN5* -,412,1989
inhalation/rat : 0.71 mg/m3/2H/10D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins
NRTXDN 27,395,2006
inhalation/rat lowest published toxic concentration: 0.7 mg/m3/24H/22W- continuousLung, Thorax, or Respiration: Fibrosis (interstitial)

Immunological Including Allergic: Decrease in cellular immune response
VCVN5* -,412,1989
inhalation/rat lowest published toxic concentration: 0.3 mg/m3/5H/26W- intermittentLung, Thorax, or Respiration: Fibrosis (interstitial)

Immunological Including Allergic: Decrease in cellular immune response
VCVN5* -,412,1989
inhalation/rat lowest published toxic concentration: 3709 mg/m3/6H/13W- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes
TOXID9 54,85,2000
intraperitoneal/rat lowest published toxic dose: 180 mg/kg/30D- intermittentBrain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Other metals
TOLED5 7,217,1981
intraperitoneal/rat lowest published toxic dose: 57.6 mg/kg/4W- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Change in psychophysiological tests
TOXID9 66,205,2002
intraperitoneal/rat lowest published toxic dose: 216 mg/kg/15W- intermittentBiochemical: Neurotransmitters or modulators (putative): Dopamine at other sitesTOXID9 44,122,2005
intraperitoneal/rat lowest published toxic dose: 144 mg/kg/5W- intermittentBehavioral: Alteration of classical conditioning

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TOXID9 44,122,2005
oral/rat : 5.25 mg/kg/21D- intermittentBehavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NETEEC 28,323,2006
oral/rat lowest published toxic dose: 185 mg/kg/37D- continuousNutritional and Gross Metabolic: Changes in: Fe

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
TOSCF2 92,516,2006
oral/rat lowest published toxic dose: 200 mg/kg/20D- intermittentReproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Behavioral
NRTXDN 23,645,2002
unreported route/rat lowest published toxic dose: 24 mg/kg/5W- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Ataxia

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
TOXID9 78,82,2004
unreported route/rat lowest published toxic dose: 72 mg/kg/5W- intermittentBehavioral: Change in motor activity (specific assay)TOXID9 78,82,2004

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.02 mg/m3 (resp),0.1 mg/m3 (inhal)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTRBMAV 33,85,1975
TOXICOLOGY REVIEWACLSCP 4,487,1974
TOXICOLOGY REVIEWADTEAS 5,51,1972
TOXICOLOGY REVIEWFOREAE 7,313,1942
TOXICOLOGY REVIEWKOTTAM 11,1300,1975
TOXICOLOGY REVIEW85DHAX Mn,1,1973
TOXICOLOGY REVIEWPEXTAR 12,102,1969
TOXICOLOGY REVIEWIMSUAI 24,1,1955
TOXICOLOGY REVIEWCREOH* 42,25,2002
TOXICOLOGY REVIEWBCPCA6 66,1,2003
TOXICOLOGY REVIEWTOLED5 134,17,2002
TOXICOLOGY REVIEWMUREAV 613,103,2006
TOXICOLOGY REVIEWNRTXDN 27,147,2006
TOXICOLOGY REVIEWNRTXDN 27,304,2006
TOXICOLOGY REVIEWNRTXDN 27,315,2006
TOXICOLOGY REVIEWNRTXDN 27,333,2006
TOXICOLOGY REVIEWNRTXDN 27,340,2006
TOXICOLOGY REVIEWNRTXDN 27,347,2006
TOXICOLOGY REVIEWNRTXDN 27,350,2006
TOXICOLOGY REVIEWNRTXDN 27,362,2006
TOXICOLOGY REVIEWNRTXDN 27,369,2006
TOXICOLOGY REVIEWNRTXDN 27,429,2006
TOXICOLOGY REVIEWMUREAV 613,76,2006
TOXICOLOGY REVIEWREPTED 23,260,2007
TOXICOLOGY REVIEWITODC* -,355,2004
TOXICOLOGY REVIEWHUTOX* -,515,1996
TOXICOLOGY REVIEWHTOPA* 1,595,2002
TOXICOLOGY REVIEWMUREAV 674,73,2009
TOXICOLOGY REVIEWMUREAV 674,137,2009
TOXICOLOGY REVIEWPTPAD4 113,229,2007
TOXICOLOGY REVIEWMUREAV 667,82,2009
TOXICOLOGY REVIEWNEUCL* 23,485,2005
TOXICOLOGY REVIEWNETEEC 32,16,2010
TOXICOLOGY REVIEWNTAPM* -,265,1995
TOXICOLOGY REVIEWNTAPM* -,617,1995
TOXICOLOGY REVIEWNTAPM* -,629,1995
TOXICOLOGY REVIEWNTAPM* -,689,1995
TOXICOLOGY REVIEWNTAPM* -,711,1995
TOXICOLOGY REVIEWNTAPM* -,727,1995
TOXICOLOGY REVIEWNTAPM* -,753,1995
TOXICOLOGY REVIEWNBREV* 15,333,1991
TOXICOLOGY REVIEWNRTXDN 31,555,2010
TOXICOLOGY REVIEWNRTXDN 33,178,2012
TOXICOLOGY REVIEWREPTED 34,298,2012
TOXICOLOGY REVIEWNRTXDN 43,36,2014
TOXICOLOGY REVIEWNRTXDN 44,314,2014
TOXICOLOGY REVIEWTXCYAC 313,3,2013
TOXICOLOGY REVIEWTXCYAC 323,78,2014
TOXICOLOGY REVIEWMUREAV 770,140,I2

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARDair-ceiling concentration 5 mg/m3DTLVS* 3,149,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg/m3 (dust), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3 (fume), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg(Mn)/m3 (fume), MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 0.2 mg/m3 (dust), MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3 (respirable), MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 0.1 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.2 mg/m3, inhal. dust, NOV2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg/m3, resp. dust, NOV2011
Occupational Exposure Limit-FRANCEVME 1 mg/m3 (fume), FEB2006
Occupational Exposure Limit-GERMANYMAK 0.02 mg(Mn)/m3 (resp), 0.2 mg(Mn)/m3 (inhal), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 5 mg/m3, short term exposure limit 20 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 1 mg/m3 (resp. dust), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.2 mg/m3, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 1 mg/m3, short term exposure limit 3 mg/m3 (fume), 2006
Occupational Exposure Limit-KOREAtime-weighted average 5 mg/m3 (dust), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(Mn)/m3, 2004
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg(Mn)/m3;short term exposure limit 3 mg(Mn)/m3, 2004
Occupational Exposure Limit-MEXICOtime-weighted average 0.2 mg/m3, 2004
Occupational Exposure Limit-MEXICOtime-weighted average 1 mg(Mn)/m3 (fume), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg/m3 (dust), JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 mg/m3; short term exposure limit 3 mg/m3 (fume), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0,2 mg/m3, JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 0.1 mg/m3, short term exposure limit 0.6 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.2 mg/m3, (total dust);time-weighted average 0.1 mg/m3, (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 5 mg/m3 (fume), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg/m3, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 5 mg(Mn)/m3, fumeCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 5 mg(Mn)/m3, fumeCFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 5 mg(Mn)/m3, fumeCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 5 mg(Mn)/m3, fumeCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MANGANESE COMPDS (as Mn)-airtime-weighted average 1 mg/m3;short term exposure limit 3 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X5920; Number of Industries 2; Total Number of Facilities 26; Number of Occupations 4; Total Number of Employees Exposed 305; Total Number of Female Employees Exposed 71
National Occupational Exposure Survey 1983Hazard Code X5992; Number of Industries 9; Total Number of Facilities 235; Number of Occupations 9; Total Number of Employees Exposed 4560; Total Number of Female Employees Exposed 12
National Occupational Exposure Survey 1983Hazard Code 44000; Number of Industries 316; Total Number of Facilities 66404; Number of Occupations 125; Total Number of Employees Exposed 756403; Total Number of Female Employees Exposed 15912
National Occupational Hazard Survey 1974Hazard Code 44000; Number of Industries 29; Total Number of Facilities 1963; Number of Occupations 53; Total Number of Employees Exposed 19787

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108025)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
NIOSH Analytical Method, 1994: Elements in blood or tissue, 8005
NIOSH Analytical Method, 1994: Metals in urine, 8310
On EPA IRIS database
OSHA ANALYTICAL METHOD #ID121
OSHA ANALYTICAL METHOD #ID-125G
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