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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Hexanone, 5-methyl-

RTECS #

MP3850000

CAS #

110-12-3

Updated

September 2013

Molecular Weight

114.21

Molecular Formula

C7H14O

Synonyms

2-Methyl-5-hexanone
5-Methyl-2-hexanone
Isoamyl methyl ketone
Isopentyl methyl ketone
Ketone, methyl isoamyl
Methyl isoamyl ketone
Methyl isoamyl ketone (ACGIH:OSHA)
Methyl isopentyl ketone
MIAK

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL/24H mildNTIS** OTS0535379

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 3813 ppm/6HCardiac: Other changes

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0535379
inhalation/rat lethal concentration (50 percent kill): 17806 mg/m3/6HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
HPV049 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 800 mg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0535379
intraperitoneal/rat lowest published lethal dose: 400 mg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0535379
oral/mouse lethal dose (50 percent kill): 2542 mg/kgTOLED5 30,13,1986
oral/rat lethal dose (50 percent kill): 5657 mg/kgBehavioral: Tremor

Behavioral: Ataxia
HPV049 -,-,2001
oral/rat lethal dose (50 percent kill): 3200 mg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0535379
skin/guinea pig Lethal dose: >20 mL/kgCardiac: Other changes

Lung, Thorax, or Respiration: Other changes
NTIS** OTS0535379
skin/rabbit lethal dose (50 percent kill): 10 mL/kgUCDS** 8/7/1963

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1000 ppm/6H/16D- intermittentLiver: Changes in liver weightFAATDF 6,498,1986
inhalation/rat lowest published toxic concentration: 1000 ppm/6H/96D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
FAATDF 6,498,1986
inhalation/rat lowest published toxic concentration: 1000 ppm/96D- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
HPV049 -,-,2001
inhalation/rat lowest published toxic concentration: 2000 ppm/96D- intermittentBehavioral: Somnolence (general depressed activity)

Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
HPV049 -,-,2001
oral/rat lowest published toxic dose: 130000 mg/kg/13W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV049 -,-,2001
oral/rat lowest published toxic dose: 130000 mg/kg/13W- intermittentLiver: Other changesHPV275 -,-,2003
oral/rat lowest published toxic dose: 30 gm/kg/3W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0571116
oral/rat lowest published toxic dose: 130 gm/kg/13W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
NTIS** OTS0571116

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 20 ppm;short term exposure limit 50 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (475 mg/m3)DTLWS* 3,22,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (234 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (95 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 20 ppm (95 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 20 ppm (95 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 95 mg/m3 (20 ppm), JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (95 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 20 ppm (95 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (47 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 230 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 20 ppm (95 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (240 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 100 ppm (475 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (234 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 50 ppm, JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 25 ppm (120 mg/m3);short term exposure limit 50 ppm (250 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (94 mg/m3), KZG-week 40 ppm (188 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 233 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 20 ppm (95 mg/m3);short term exposure limit 100 ppm (475 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (475 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (475 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (475 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ISOAMYL KETONE-air10H time-weighted average 50 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M0430; Number of Industries 17; Total Number of Facilities 1132; Number of Occupations 22; Total Number of Employees Exposed 18834; Total Number of Female Employees Exposed 4071
National Occupational Hazard Survey 1974Hazard Code M0430; Number of Industries 44; Total Number of Facilities 3003; Number of Occupations 36; Total Number of Employees Exposed 25307

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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