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Registry of Toxic Effects of Chemical Substances (RTECS)

3-Heptanone, 5-methyl-

RTECS #

MJ7350000

CAS #

541-85-5

Updated

September 2013

Molecular Weight

128.24

Molecular Formula

C8H16O

Synonyms

2-Methylbutyl ethyl ketone
3-Methyl-5-heptanone
5-Methyl-3-heptanone (OSHA)
Ethyl 2-methylbutyl ketone
Ethyl amyl ketone
Ethyl amyl ketone (ACGIH)
Ethyl sec-amyl ketone (OSHA)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg mildSCCUR* -,6,1961

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 3484 ppm/4HSCCUR* -,6,1961
inhalation/rat Lowest published lethal concentration: 3484 ppm/8HSCCUR* -,6,1961
oral/guinea pig lethal dose (50 percent kill): 2500 mg/kgBCPCA6 16,631,1967
oral/mouse lethal dose (50 percent kill): 3800 mg/kgSCCUR* -,6,1961
oral/rat lethal dose (50 percent kill): 3500 mg/kgSCCUR* -,6,1961
skin/rabbit lethal dose (50 percent kill): >16 gm/kgSHELL* MSDS 540-1

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 25 ppm (130 mg/m3)DTLVS* 3,104,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (53 mg/m3), short term exposure limit 20 ppm (107 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (53 mg/m3);KZW 20 ppm (107 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (53 mg/m3), short term exposure limit 20 ppm (107 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (53 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 53 mg/m3 (10 ppm);short term exposure limit 107 mg/m3 (20 ppm), JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (53 mg/m3), short term exposure limit 20 ppm (110 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 10 ppm (53 mg/m3), VLE 20 ppm (107 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (53 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 53 mg/m3, short term exposure limit 106 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (53 mg/m3), short term exposure limit 20 ppm (107 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 25 ppm (130 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 25 ppm (130 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 25 ppm (131 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 25 ppm (131 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 25 ppm (130 mg/m3);short term exposure limit 50 ppm (250 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (53 mg/m3), KZG-week 20 ppm (106 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 133 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 ppm (53 mg/m3);short term exposure limit 20 ppm (107 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 25 ppm (130 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 25 ppm (130 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 25 ppm (130 mg/m3)CFRGBR 29,1910.1000,1994

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL AMYL KETONE-air10H time-weighted average 25 ppmNIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974Hazard Code 83448; Number of Industries 26; Total Number of Facilities 1523; Number of Occupations 22; Total Number of Employees Exposed 19792

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301
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