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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Heptanone

RTECS #

MJ5075000

CAS #

110-43-0

Updated

July 2015

Molecular Weight

114.21

Molecular Formula

C7H14O

Synonyms

Amyl-methyl-cetone (French)
Ketone, methyl pentyl
Methyl n-amyl ketone
Methyl n-amyl ketone (ACGIH:OSHA)
Methyl pentyl ketone
Methyl-amyl-cetone (French)
n-Amyl methyl ketone

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 14 mg/24H open irritation test mildAIHAAP 23,95,1962

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 400 ppm (28D prior to copulation/1-19D pregnant)Reproductive: Other effects on femaleHPV275 -,-,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, skin Inhibitor Concentration Low: 60 µL/well/10MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1476,2013
inhalation/guinea pig lowest published toxic concentration: 7000 mg/m3/4HLung, Thorax, or Respiration: CoughVCVGK* -,429,1994
inhalation/guinea pig lowest published toxic concentration: 9300 mg/m3/4HBehavioral: General anestheticVCVGK* -,429,1994
inhalation/guinea pig Lowest published lethal concentration: 22400 mg/m3/4HVCVGK* -,429,1994
inhalation/rat Lowest published lethal concentration: 4000 ppm/4HAIHAAP 23,95,1962
inhalation/rat Lowest published lethal concentration: 4169 ppm/4HBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
HPV048 -,-,2001
intraperitoneal/mouse lethal dose (50 percent kill): 400 mg/kg38MKAJ 2C,4757,1982
intraperitoneal/rat lethal dose (50 percent kill): 800 mg/kg38MKAJ 2C,4757,1982
oral/mouse lethal dose (50 percent kill): 730 mg/kgENTOX* -,506,2005
oral/rat lethal dose (50 percent kill): 1600 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
HPV048 -,-,2001
oral/rat lethal dose (50 percent kill): 1670 mg/kgUCDS** 8/11/1958
skin/rabbit lethal dose (50 percent kill): 12600 µL/kgAIHAAP 23,95,1962

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 400 ppm/34D- intermittentBehavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV048 -,-,2001
oral/rat lowest published toxic dose: 45500 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in bladder weight
FCTXAV 10,625,1972
oral/rat lowest published toxic dose: 9100 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight
HPV048 -,-,2001
oral/rat lowest published toxic dose: 45500 mg/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in kidney weight
HPV048 -,-,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 50 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,506,2005

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (465 mg/m3)DTLVS* 3,157,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (233 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (237 mg/m3);KZW 100 ppm (473 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (238 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 100 ppm (475 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (238 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 238 mg/m3 (50 ppm);short term exposure limit 475 mg/m3 (100 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (240 mg/m3), short term exposure limit 75 ppm (360 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (238 mg/m3), VLE 100 ppm (475 mg/m3), Skin, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 238 mg/m3, short term exposure limit 476 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (238 mg/m3), short term exposure limit 100 ppm (475 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 50 ppm (235 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (235 mg/m3);short term exposure limit 100 ppm (465 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 50 ppm (233 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (115 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 50 ppm (233 mg/m3); short term exposure limit 100 ppm (467 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 25 ppm (120 mg/m3);short term exposure limit 50 ppm (250 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 50 ppm (235 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 233 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 50 ppm (237 mg/m3);short term exposure limit 100 ppm (475 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (465 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (465 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (465 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (465 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL AMYL KETONE-air10H time-weighted average 100 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 36340; Number of Industries 62; Total Number of Facilities 5080; Number of Occupations 47; Total Number of Employees Exposed 78196; Total Number of Female Employees Exposed 17866
National Occupational Hazard Survey 1974Hazard Code 36340; Number of Industries 10; Total Number of Facilities 489; Number of Occupations 8; Total Number of Employees Exposed 3345

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301
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