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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethylene glycol

RTECS #

KW2975000

CAS #

107-21-1; 71767-64-1

Updated

July 2016

Molecular Weight

62.08

Molecular Formula

C2H6O2

Synonyms

1,2-Dihydroxyethane
1,2-Ethandiol
1,2-Ethanediol
Athylenglykol (German)
Dowtherm SR 1
Ethane-1,2-diol
Ethylene alcohol
Ethylene dihydrate
Ethylene glycol (ACGIH)
Ethylene glycol, aerosol
Glycol alcohol
Lutrol-9
M.E.G.
Macrogol 400 BPC
Monoethylene glycol
NCI-C00920
Norkool
Tescol
Ucar 17

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,205,1986
eye /rabbit 100 mg/1H mildNTIS** LMF-69
eye /rabbit 0.012 ppm/3DTXAPA9 16,646,1970
eye /rabbit 1440 mg/6H moderateBUYRAI 31,25,1977
eye /rat 0.012%/3DTXAPA9 16,646,1970
skin /rabbit 555 mg open irritation test mildUCDS** 7/21/1965

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/rat1200 mg/kgTGANAK 19,436,1985
DNA Damageovary/hamster50 gm/L/2H (+enzymatic activation step)FCTOD7 48,1905,2010
DNA inhibitionlymphocyte/human320 mmol/LPNASA6 79,1171,1982
micronucleus testovary/hamster50 gm/L/3H (+enzymatic activation step)FCTOD7 48,1905,2010
mutation in mammalian somatic cellslymphocyte/mouse100 mmol/LPAACA3 21,74,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 2500 mg/m3/6H (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
FAATDF 24,57,1995
inhalation/mouse 1000 mg/m3/6H (6-15D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Other effects on female

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
FAATDF 24,57,1995
inhalation/mouse 1000 mg/m3/6H (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Sex ratio
FAATDF 24,57,1995
inhalation/mouse 2100 mg/m3/6H (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
FAATDF 27,49,1995
inhalation/mouse 2100 mg/m3/6H (6-15D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 27,49,1995
oral/rabbit 28 gm/kg (6-19D pregnant)Reproductive: Other effects on femaleNTIS** PB91-211219
oral/mouse 88720 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
EVHPAZ 57,141,1984
oral/mouse 7500 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 81,113,1985
oral/mouse 7500 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 29(2),52A,1984
oral/mouse 84 gm/kg (1-21D preg/21D after birth)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
TOXID9 4,136,1984
oral/mouse 88720 mg/kg (7-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
EVHPAZ 57,141,1984
oral/mouse 15 gm/kg (6-15D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Other measures of fertility
NTIS** PB85-105385
oral/rat 50 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)
TXAPA9 81,113,1985
oral/rat 8580 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
CHYCDW 20,289,1986
oral/rat 12500 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 29(2),52A,1984
oral/rat 25 gm/kg (6-15D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** PB85-104594
oral/rat 51948 mg/kg (13W male)Reproductive: Paternal effects: Testes, epididymis, sperm ductWDZAEK 8,12,1994
oral/mouse 413 gm/kg (15W male/15W pre-3W after birth)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 81,100,1985
oral/mouse 413 gm/kg (15W male/15W pre-3W after birth)Reproductive: Effects on newborn: Delayed effectsTXAPA9 81,100,1985
oral/mouse 1.7 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB84241108
oral/mouse 1.7 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Central nervous systemNTIS** #PB84241108
oral/mouse 1.7 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary systemNTIS** #PB84241108
oral/mouse 7.5 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)NTIS** #PB85-105385
oral/mouse 7.5 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
NTIS** #PB85-105385
oral/mouse 29.75 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB84241108
oral/mouse 59.5 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility
NTIS** #PB84241108
oral/mouse 98 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)NTIS** #PB86177383
oral/mouse 294 gm/kg (15W prior to copulation)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB86177383
oral/mouse 15 gm/kg (6-15D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** #PB85-105385
oral/mouse 15 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathNTIS** #PB85-105385
oral/rat 18.8 gm/kg (6-20D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB88-204326/AS
oral/mouse 850 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB86177383
oral/mouse 850 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital systemNTIS** #PB86177383
oral/rat 25000 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
NTIS** #PB95-274528
oral/rabbit 28000 mg/kg (6-19D pregnant)Reproductive: Effects on fertility: Abortion

Reproductive: Effects on newborn: Stillbirth
NTIS** #PB91-211219
oral/rat 33750 mg/kg (6-20D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB88-204326/AS
oral/rat 33750 mg/kg (6-20D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** #PB88-204326/AS
unreported route/rat 50000 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVGK* -,140,1994
unreported route/mouse 7500 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVGK* -,140,1994
unreported route/rat 5000 mg/kg (multigenerations)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVGK* -,140,1994
unreported route/mouse 750 mg/kg (multigenerations)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
VCVGK* -,140,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
eye/rabbit lowest published toxic dose: 10 pphEye: Conjunctiva irritationVCVGK* -,141,1984
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 1706485 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 712350 µmol/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (50 percent kill): 1447621 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Chicken, neurons Inhibitor Concentration (10 percent kill): 591179 µmol/L/20HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 7,653,1993
In Vitro/Hamster, lung fibroblast Inhibitor Concentration (50 percent kill): 365 mmol/L/60HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,511,1993
In Vitro/Hamster, lung fibroblast Inhibitor Concentration (10 percent kill): 100 mmol/L/60HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,511,1993
In Vitro/Human, HeLa cell Inhibitor Concentration (50 percent kill): 415 mmol/L/60HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,511,1993
In Vitro/Human, HeLa cell Inhibitor Concentration (10 percent kill): 117.5 mmol/L/60HIn Vitro Toxicity Studies: Cell countingTIVIEQ 7,511,1993
In Vitro/Human, kidney Inhibitor Concentration Low: 100 µmol/L/6HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TXCYAC 290,82,2011
In Vitro/Human, kidney Inhibitor Concentration Low: 100 µmol/L/12HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Other assays
TXCYAC 290,82,2011
In Vitro/Human, kidney tumor Inhibitor Concentration (50 percent kill): 70800 mg/LIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 27,1347,2013
In Vitro/Human, liver Inhibitor Concentration (50 percent kill): 138 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Human, liver Inhibitor Concentration (10 percent kill): 70 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 83000 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
In Vitro/Human, neuroblastoma Inhibitor Concentration (50 percent kill): 51400 mg/LIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 27,1347,2013
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 42700 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1347,2013
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 440000 mg/L/1MIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,367,1992
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 290 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Mouse, fibroblast Inhibitor Concentration (10 percent kill): 83 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 20500 mg/L/48HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 27,1347,2013
In Vitro/paaInhibitor Concentration Low: 392 mmol/L/44HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,1416,2013
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 68300 mg/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1347,2013
In Vitro/Rat, liver Inhibitor Concentration (50 percent kill): 262 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Rat, liver Inhibitor Concentration (10 percent kill): 83 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 6,47,1992
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 93 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 96 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 35.5 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 169 gm/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (10 percent kill): 43.7 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,111,1993
In Vitro/Rat, lung Inhibitor Concentration (75 percent kill): 158 gm/L/24HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 7,111,1993
inhalation/human lowest published toxic concentration: 10000 mg/m3Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes
AGGHAR 5,1,1933
inhalation/human lowest published toxic concentration: 22 mg/m3Kidney, Ureter, and Bladder: ProteinuriaIAEHDW 69,255,1997
inhalation/mouse Lethal concentration: >200 mg/m3/2HGTPZAB 25(11),57,1981
inhalation/rabbit lowest published toxic concentration: 12 mg/m3Eye: Conjunctiva irritationVCVGK* -,141,1984
inhalation/rabbit lowest published toxic concentration: 4 mg/m3/2HBehavioral: Alteration of classical conditioningVCVGK* -,139,1984
inhalation/rat lowest published toxic concentration: 0.004 gm/m3/2HBehavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Hypermotility, diarrhea
TPKVAL 7,102,1965
inhalation/rat Lethal concentration: >200 mg/m3/4HGTPZAB 25(11),57,1981
intramuscular/rabbit lowest published lethal dose: 5500 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
JPETAB 41,387,1931
intramuscular/rabbit lowest published lethal dose: 5500 mg/kgVCVGK* -,139,1984
intramuscular/rat lowest published lethal dose: 3300 mg/kgVCVGK* -,139,1984
intramuscular/rat lowest published lethal dose: 3300 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory stimulation
JPETAB 41,387,1931
intraperitoneal/monkey lowest published lethal dose: 4000 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)VCVGK* -,140,1984
intraperitoneal/mouse lethal dose (50 percent kill): 5614 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Blood: Changes in spleen
FEPRA7 6,342,1947
intraperitoneal/mouse lethal dose (50 percent kill): 1700 mg/kgVCVGK* -,139,1984
intraperitoneal/rabbit lowest published lethal dose: 1000 mg/kgVCVGK* -,139,1984
intraperitoneal/rat lethal dose (50 percent kill): 5010 mg/kgKRKRDT 9,36,1981
intravenous/mouse lethal dose (50 percent kill): 300 mg/kgVCVGK* -,139,1984
intravenous/rabbit lowest published lethal dose: 5000 mg/kgVCVGK* -,139,1984
intravenous/rabbit lowest published lethal dose: 5 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
JPETAB 41,387,1931
intravenous/rat lowest published lethal dose: 2800 mg/kgVCVGK* -,139,1984
intravenous/rat lethal dose (50 percent kill): 3260 mg/kgKRKRDT 9,36,1981
ocular/rabbit lowest published toxic dose: 100 pphEye: Lacrimation

Eye: Conjunctiva irritation
TPKVAL 7,102,1965
oral/cat lethal dose (50 percent kill): 2000 mg/kgVCVGK* -,139,1984
oral/cat lethal dose (50 percent kill): 1650 mg/kgKidney, Ureter, and Bladder: Other changesRMVEAG 154,137,1978
oral/child lowest published toxic dose: 5500 mg/kgBehavioral: General anesthetic

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes
PGMJAO 52,598,1976
oral/Dog lethal dose (50 percent kill): 5500 mg/kgKidney, Ureter, and Bladder: Other changesRMVEAG 154,137,1978
oral/guinea pig lethal dose (50 percent kill): 6610 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/guinea pig lethal dose (50 percent kill): 6600 mg/kgVCVGK* -,139,1984
oral/human lowest published lethal dose: 786 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Gastrointestinal: Hypermotility, diarrhea
EJTXAZ 9,373,1976
oral/human lowest published lethal dose: 398 mg/kgBehavioral: Headache

Gastrointestinal: Nausea or vomiting

Liver: Other changes
SMEZA5 26(2),48,1983
oral/human lowest published lethal dose: 1.43 mL/kgAPLMAS 129,e81,2005
oral/man lowest published toxic dose: 24 gm/kgBrain and Coverings: Recordings from specific areas of CNS

Brain and Coverings: Other degenerative changes
JTCTDW 38,445,2000
oral/man lowest published toxic dose: 24 gm/kgBrain and Coverings: Other degenerative changes

Behavioral: Ataxia

Behavioral: Coma
JTCTDW 38,445,2000
oral/man lowest published toxic dose: 24 gm/kgBrain and Coverings: Recordings from specific areas of CNS

Eye: Mydriasis (pupilliary dilation)

Lung, Thorax, or Respiration: Other changes
JTCTDW 38,445,2000
oral/man lowest published toxic dose: 15 gm/kgPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Gastrointestinal: Ulceration or bleeding from small intestine

Kidney, Ureter, and Bladder: Renal function tests depressed
AEMED3 20,208,1991
oral/man lowest published toxic dose: 1195 mg/kgPeripheral Nerve and Sensation: Sensory change involving peripheral nerve

Kidney, Ureter, and Bladder: Renal function tests depressed
AEMED3 20,208,1991
oral/man lowest published toxic dose: 16 gm/kgBehavioral: Coma

Kidney, Ureter, and Bladder: Renal function tests depressed

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
HETOEA 9,317,1990
oral/mouse lethal dose (50 percent kill): 5500 mg/kgGISAAA 32(3),31,1967
oral/rat lethal dose (50 percent kill): 4700 mg/kgVCVGK* -,139,1984
oral/rat lowest published toxic dose: 1110 mg/kgBrain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVGK* -,139,1984
oral/rat lowest published toxic dose: 5000 mg/kgBrain and Coverings: Other degenerative changes

Behavioral: Tetany

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VCVGK* -,139,1984
oral/rat lowest published toxic dose: 1000 mg/kgBrain and Coverings: Increased intracranial pressure

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,139,1984
oral/rat lowest published toxic dose: 2 gm/kgKidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JTCTDW 46,402,2008
oral/rat lowest published toxic dose: 120 mg/kgBlood: Changes in bone marrow not included in aboveVCVGK* -,140,1984
skin/rabbit lethal dose (50 percent kill): 9530 µL/kg34ZIAG -,731,1969
subcutaneous/cat lowest published lethal dose: 2 gm/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Blood: Other changes
AGGHAR 5,1,1933
subcutaneous/cat lowest published lethal dose: 2000 mg/kgVCVGK* -,139,1984
subcutaneous/guinea pig lowest published lethal dose: 5000 mg/kgVCVGK* -,139,1984
subcutaneous/mouse lethal dose (50 percent kill): 2700 mg/kgVCVGK* -,139,1984
subcutaneous/mouse lowest published lethal dose: 2700 mg/kgBJIMAG 1,207,1944
subcutaneous/mouse lowest published toxic dose: 5000 mg/kgKidney, Ureter, and Bladder: Renal function tests depressedEKFAE9 55,21,1992
subcutaneous/rabbit lethal dose (50 percent kill): 19500 mg/kgVCVGK* -,139,1984
subcutaneous/rat lethal dose (50 percent kill): 2800 mg/kgNPIRI* 1,49,1974
subcutaneous/rat lowest published toxic dose: 3000 mg/kgKidney, Ureter, and Bladder: Renal function tests depressedEKFAE9 55,21,1992
unreported route/guinea pig lethal dose (50 percent kill): 11150 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
GISAAA 33(3),16,1968
unreported route/human lowest published lethal dose: 70 mg/kgCardiac: Change in rate

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes
VCVGK* -,140,1984
unreported route/man lowest published lethal dose: 1637 mg/kg85DCAI 2,73,1970
unreported route/mouse lethal dose (50 percent kill): 8050 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
GISAAA 33(3),16,1968
unreported route/rabbit lethal dose (50 percent kill): 5017 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
GISAAA 33(3),16,1968
unreported route/rat lethal dose (50 percent kill): 13 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Gastrointestinal: Nausea or vomiting
GISAAA 33(3),16,1968

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/cat lowest published toxic concentration: 500000 mg/m3/6H/5D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: General anesthetic
VCVGK* -,140,1994
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/7D- intermittentLung, Thorax, or Respiration: Respiratory depressionTPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/45D- intermittentBehavioral: Excitement

Liver: Liver function tests impaired
TPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/76D- intermittentBehavioral: AggressionTPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/106D- intermittentBehavioral: Somnolence (general depressed activity)TPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/122D- intermittentKidney, Ureter, and Bladder: Urine volume increasedTPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/61D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 0.003 gm/m3/183D- intermittentBrain and Coverings: Other degenerative changes

Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TPKVAL 7,102,1965
inhalation/guinea pig lowest published toxic concentration: 1 mg/m3/122D- intermittentEye: Conjunctiva irritation

Behavioral: Irritability

Lung, Thorax, or Respiration: Cough
VCVGK* -,140,1994
inhalation/guinea pig lowest published toxic concentration: 1 mg/m3/154D- intermittentVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
VCVGK* -,140,1994
inhalation/human lowest published toxic concentration: 140 mg/m3/30D- intermittentLung, Thorax, or Respiration: CoughVCVGK* -,140,1994
inhalation/mammal (species unspecified) lowest published toxic concentration: 20 mg/m3/5Y- intermittentCardiac: Other changes

Vascular: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,141,1994
inhalation/mammal (species unspecified) lowest published toxic concentration: 256 mg/m3/28D- intermittentLiver: Liver function tests impairedVCVGK* -,140,1994
inhalation/monkey lowest published toxic concentration: 500000 mg/m3/6H/5D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: General anesthetic
VCVGK* -,140,1994
inhalation/mouse lowest published toxic concentration: 0.003 gm/m3/61D- intermittentBehavioral: Aggression

Vascular: Other changes

Lung, Thorax, or Respiration: Respiratory stimulation
TPKVAL 7,102,1965
inhalation/mouse lowest published toxic concentration: 0.003 gm/m3/30D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 7,102,1965
inhalation/mouse lowest published toxic concentration: 0.003 gm/m3/122D- intermittentLung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 7,102,1965
inhalation/mouse lowest published toxic concentration: 10 mg/m3/122D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,140,1994
inhalation/mouse lowest published toxic concentration: 1 mg/m3/122D- intermittentEye: Conjunctiva irritation

Behavioral: Irritability

Lung, Thorax, or Respiration: Cough
VCVGK* -,140,1994
inhalation/mouse lowest published toxic concentration: 1 mg/m3/154D- intermittentVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
VCVGK* -,140,1994
inhalation/rabbit lowest published toxic concentration: 12 mg/m3/8H/90D- intermittentEye: Corneal damage

Eye: Other eye effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 16,646,1970
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/4W- intermittentEye: Conjunctiva irritation

Vascular: Other changes
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/153D- intermittentLung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/45D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/61D- intermittentBlood: Changes in bone marrow not included in above

Blood: Changes in other cell count (unspecified)
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 120 mg/m3/8D- intermittentEye: Corneal damageVCVGK* -,140,1994
inhalation/rat lowest published toxic concentration: 1 mg/m3/154D- intermittentVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Other changes

Liver: Other changes
VCVGK* -,140,1994
inhalation/rat lowest published toxic concentration: 1 mg/m3/122D- intermittentEye: Conjunctiva irritation

Behavioral: Irritability

Lung, Thorax, or Respiration: Cough
VCVGK* -,140,1994
inhalation/rat lowest published toxic concentration: 198 mg/m3/4H/122D- intermittentCardiac: Other changes

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,140,1994
inhalation/rat lowest published toxic concentration: 1 mg/m3/32W- intermittentLung, Thorax, or Respiration: Other changes

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/7D- intermittentBehavioral: Excitement

Vascular: Other changes
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/14D- intermittentEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory stimulation
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/61D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity)

Liver: Liver function tests impaired
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/76D- intermittentBehavioral: AggressionTPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/106D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 8400 µg/m3/24H/12W- continuousBrain and Coverings: Changes in brain weight

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 39(9),106,1974
inhalation/rat lowest published toxic concentration: 12 mg/m3/8H/90D- intermittentEye: Corneal damage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 16,646,1970
inhalation/rat lowest published toxic concentration: 0.003 gm/m3/228D- intermittentBrain and Coverings: Other degenerative changes

Vascular: Structural changes in vessels

Lung, Thorax, or Respiration: Emphysema
TPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/2W- intermittentBehavioral: AggressionTPKVAL 7,102,1965
inhalation/rat lowest published toxic concentration: 0.02 gm/m3/20D- intermittentBehavioral: Somnolence (general depressed activity)TPKVAL 7,102,1965
oral/monkey lowest published toxic dose: 5751 gm/kg/22W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)TXAPA9 15,624,1969
oral/mouse lowest published toxic dose: 88720 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEVHPAZ 57,141,1984
oral/mouse lowest published toxic dose: 1081 gm/kg/2Y- continuousLiver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
NTPTR* NTP-TR-413,1993
oral/mouse lowest published toxic dose: 546 gm/kg/13W- continuousLiver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-413,1993
oral/mouse lowest published toxic dose: 29.4 gm/kg/7D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTXAPA9 81,100,1985
oral/mouse lowest published toxic dose: 117.6 gm/kg/14D- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTXAPA9 81,100,1985
oral/mouse lowest published toxic dose: 82.3 gm/kg/14W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTXAPA9 81,100,1985
oral/mouse lowest published toxic dose: 15000 mg/kg/10D- continuousSkin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Liver: Changes in liver weight
NTIS** #PB85-105385
oral/mouse lowest published toxic dose: 294000 mg/kg/15W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB86177383
oral/rabbit lowest published toxic dose: 28000 mg/kg/14D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** #PB91-211219
oral/rat lowest published toxic dose: 25000 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB95-274528
oral/rat lowest published toxic dose: 10.9 gm/kg/7D- intermittentKidney, Ureter, and Bladder: Proteinuria

Nutritional and Gross Metabolic: Changes in: Ca

Nutritional and Gross Metabolic: Changes in: P
PHMREP 43,89,2001
oral/rat lowest published toxic dose: 33750 mg/kg/15D- intermittentKidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Maternal effects: Uterus, cervix, vagina
NTIS** #PB85-105385
oral/rat lowest published toxic dose: 18750 mg/kg/15D- intermittentKidney, Ureter, and Bladder: Other changesNTIS** #PB85-105385
oral/rat lowest published toxic dose: 14 mL/kg/2W- continuousLiver: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
JOUOD4 13,13,1991
oral/rat lowest published toxic dose: 438 gm/kg/2Y- continuousBehavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTXAV 3,229,1965
oral/rat lowest published toxic dose: 85230 mg/kg/90D- continuousKidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: P
DCTODJ 13,43,1990
oral/rat lowest published toxic dose: 12 mL/kg/6D- intermittentNutritional and Gross Metabolic: Changes in: Ca

Nutritional and Gross Metabolic: Changes in: P

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TXAPA9 39,543,1977
oral/rat lowest published toxic dose: 26150 mg/kg/10D- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
DCTODJ 13,43,1990
oral/rat lowest published toxic dose: 21 mL/kg/28D- continuousKidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
JOETD7 140,234,2012
oral/rat lowest published toxic dose: 21 gm/kg/28D- continuousKidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Changes in: Ca
JOETD7 144,160,2012
oral/rat lowest published toxic dose: 18.2 gm/kg/1Y- continuousKidney, Ureter, and Bladder: Other changes in urine compositionTXAPA9 228,165,2008
oral/rat lowest published toxic dose: 109.5 gm/kg/1Y- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type field

Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Urine volume increased
TXAPA9 228,165,2008
oral/rat lowest published toxic dose: 146 gm/kg/1Y- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 228,165,2008
oral/rat lowest published toxic dose: 42 mg/kg/8W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
TOXID9 -,103,2009
oral/rat lowest published toxic dose: 5.25 gm/kg/1W- continuousKidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition
FCTOD7 48,1013,2010
oral/rat lowest published toxic dose: 21 gm/kg/4W- continuousKidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Changes in: Ca
FCTOD7 48,1013,2010
oral/rat lowest published toxic dose: 15.75 gm/kg/3W- continuousKidney, Ureter, and Bladder: Other changesTXCYAC 290,82,2011
unreported route/rat lowest published toxic dose: 9.1 mg/kg/26W- intermittentReproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
VCVGK* -,141,1994

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-ceiling concentration 100 mg/m3 (aerosol)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWAJMEAZ 38,409,1965
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWREPTED 8,99,1994
TOXICOLOGY REVIEWMUREAV 566,21,2004
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWJEMME* 15,653,1997
TOXICOLOGY REVIEWARTODN 78,671,2004
TOXICOLOGY REVIEWAINCM* 7,63,2006
TOXICOLOGY REVIEWENTOX* -,287,2005
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWFSINDR 155,179,2005
TOXICOLOGY REVIEWHUTOX* -,623,1996
TOXICOLOGY REVIEWAIRMJ* 18,114,1999
TOXICOLOGY REVIEWFESTAS 90,911,2008
TOXICOLOGY REVIEWREPTED 34,298,2012
TOXICOLOGY REVIEWFCTOD7 55,596,2013
TOXICOLOGY REVIEWREPTED 58,252,2015

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,308,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 mg/m3 (particulate)DTLWS* 3,19,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3 (aerosol), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 20 ppm (52 mg/m3), short term exposure limit 40 ppm (104 mg/m3) (vapor), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (26 mg/m3);KZW 20 ppm (52 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 20 ppm (52 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 40 ppm (104 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 mg/m3 (aerosol), MAY2011
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (26 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 52 mg/m3 (20 ppm);short term exposure limit 104 mg/m3 (40 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (50 mg/m3), short term exposure limit 40 ppm (100 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 20 ppm (52 mg/m3), VLE 40 ppm (104 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (26 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 52 mg/m3, short term exposure limit 104 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (26 mg/m3), aerosol, NOV2011
Occupational Exposure Limit-KOREAceiling concentration 50 ppm (125 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (125 mg/m3) (vapor), 2004
Occupational Exposure Limit-MEXICOpeak 100 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 50 ppm (127 mg/m3) (vapour and mist), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (63 mg/m3), JAN1999
Occupational Exposure Limit-PERUshort term exposure limit 39 ppm (100 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 15 mg/m3, MAC(short term exposure limit) 50 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (25 mg/m3);short term exposure limit 20 ppm (50 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (26 mg/m3), KZG-week 20 ppm (52 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3 (drops), 2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 52 mg/m3 (fume), 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3 (particulate), skin, OCT2007
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 20 ppm (52 mg/m3);short term exposure limit 40 ppm (104 mg/m3) (vapor), skin, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 32385; Number of Industries 340; Total Number of Facilities 102395; Number of Occupations 214; Total Number of Employees Exposed 1511087; Total Number of Female Employees Exposed 446607
National Occupational Hazard Survey 1974Hazard Code 32385; Number of Industries 308; Total Number of Facilities 69314; Number of Occupations 174; Total Number of Employees Exposed 743782

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101108/AS)
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9100;8EHQ-0892-9252
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse
NIOSH Analytical Method, 1994: Ethylene glycol, 5500
NIOSH Analytical Method, 1996: Glycols, 5523
On EPA IRIS database
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