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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethylene, 1,2-dichloro-

RTECS #

KV9360000

CAS #

540-59-0

Updated

September 2013

Molecular Weight

96.94

Molecular Formula

C2H2Cl2

Synonyms

1,2-Dichlor-aethen (German)
1,2-Dichloroethene
1,2-Dichloroethylene (ACGIH:OSHA)
1,2-Dichloroethylene, sym-
Acetylene dichloride (OSHA)
cis-, trans-1,2-Dichloroethene
Dichloro-1,2-ethylene (French)
Dioform
NCI-C56031
sym-1,2-Dichloroethylene
sym-Dichloroethylene

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 100 mg/24H moderate85JCAE -,105,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagelymphocyte/human2 mmol/LMUREAV 371,185,1996
micronucleus testlymphocyte/human20 mmol/LMUREAV 371,185,1996
sex chromosome loss and nondisjunction/Aspergillus nidulans750 ppmMUREAV 266,117,1992

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat Lowest published lethal concentration: 50000 mg/m3Behavioral: Excitement

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
VCVGH* -,437,1990
inhalation/frog Lowest published lethal concentration: 117 mg/m3/1HPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory depression
AISFAR 15,1,1937
inhalation/mouse lethal concentration (50 percent kill): 21700 ppm/6HVCVGH* -,437,1990
intraperitoneal/mouse lethal dose (50 percent kill): 2 gm/kgEJTXAZ 7,247,1974
oral/mouse lethal dose (50 percent kill): 2122 mg/kgVCVGH* -,437,1990
oral/rat lethal dose (50 percent kill): 770 mg/kgVCVGH* -,437,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 9 mg/kg/90D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
VCVGH* -,437,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 200 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 200 ppm (790 mg/m3)DTLVS* 3,80,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 200 ppm (793 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 200 ppm (805 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (790 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 200 ppm (800 mg/m3), short term exposure limit 250 ppm (1000 mg/m3), NOV2011
Occupational Exposure Limit-GERMANYMAK 200 ppm (800 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 790 mg/m3, short term exposure limit 3160 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (790 mg/m3), NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 150 ppm (590 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 200 ppm (790 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 200 ppm (790 mg/m3);short term exposure limit 250 ppm (1000 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 200 ppm (793 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 100 ppm (395 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 200 ppm (793 mg/m3); short term exposure limit 250 ppm (991 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 50 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 150 ppm, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 200 ppm (790 mg/m3), KZG-week 400 ppm (1580 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 790 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 200 ppm (790 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 200 ppm (790 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 200 ppm (806 mg/m3);short term exposure limit 250 ppm (1010 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 200 ppm (790 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 200 ppm (790 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 200 ppm (790 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 200 ppm (790 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,2-DICHLOROETHYLENE-air10H time-weighted average 200 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 03350; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 7; Total Number of Employees Exposed 216; Total Number of Female Employees Exposed 10
National Occupational Hazard Survey 1974Hazard Code 03350; Number of Industries 5; Total Number of Facilities 896; Number of Occupations 6; Total Number of Employees Exposed 4673

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121081/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
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