Ether, diphenyl

RTECS #

KN8970000

CAS #

101-84-8
See: NMAM or OSHA Methods

Updated

December 2013

Molecular Weight

170.22

Molecular Formula

C₁₂H₁₀O

Synonyms

Benzene, 1,1'-oxybis- (9CI)
Benzene, phenoxy-
Biphenyl oxide
Chemcryl JK-EB
Diphenyl ether
Diphenyl oxide
Geranium crystals
Oxybisbenzene
Oxydiphenyl
Phenoxybenzene
Phenyl ether (ACGIH:OSHA)
Phenyl ether, fume
Phenyl oxide

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	10 ppm/140H		TXAPA9 33,78,1975
eye /rat	10 ppm/140H		TXAPA9 33,78,1975
skin /rabbit	500 mg/24H	mild	FCTXAV 12,707,1974

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	2000 mg/kg (6-15D pregnant)	Reproductive: Other effects on female	HPV217 -,-,2002

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lethal dose (50 percent kill): 2450 mg/kg	Behavioral: Food intake (animal) Behavioral: Muscle weakness Gastrointestinal: Other changes	NTIS** 0TS0518143
oral/rat	lethal dose (50 percent kill): 4000 mg/kg	Gastrointestinal: Other changes Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,303,1984
oral/rat	lethal dose (50 percent kill): 2450 mg/kg	Behavioral: Somnolence (general depressed activity) Gastrointestinal: Gastritis Liver: Other changes	HPV217 -,-,2002
skin/rabbit	lethal dose (50 percent kill): >7940 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Acute pulmonary edema	NTIS** 0TS0518143

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 150 mg/kg/5D- intermittent	Endocrine: Evidence of thyroid hypofunction Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOXID9 72,135,2003
oral/rat	lowest published toxic dose: 93 mg/kg/31D- intermittent	Endocrine: Evidence of thyroid hypofunction Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOXID9 72,135,2003
oral/rat	lowest published toxic dose: 930 mg/kg/31D- intermittent	Endocrine: Evidence of thyroid hypofunction Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Reproductive: Other effects on male	TOXID9 72,135,2003
oral/rat	lowest published toxic dose: 1860 mg/kg/31D- intermittent	Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands Related to Chronic Data: Changes in prostate weight	TOXID9 72,135,2003
oral/rat	lowest published toxic dose: 150 mg/kg/5D- intermittent	Liver: Liver function tests impaired Endocrine: Evidence of thyroid hypofunction Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	TOXID9 72,136,2003
oral/rat	lowest published toxic dose: 1200 mg/kg/20D- intermittent	Reproductive: Other effects on female	TOXID9 72,136,2003
oral/rat	lowest published toxic dose: 2000 mg/kg/10D- intermittent	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HPV217 -,-,2002
oral/rat	lowest published toxic dose: 5000 mg/kg/10D- intermittent	Behavioral: Food intake (animal) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	HPV217 -,-,2002
skin/rat	lowest published toxic dose: 27.3 gm/kg/6H/13W- intermittent	Liver: Changes in liver weight	FCTOD7 41,259,2003
skin/rat	lowest published toxic dose: 91 gm/kg/6H/13W- intermittent	Brain and Coverings: Changes in brain weight Kidney, Ureter, and Bladder: Changes in kidney weight	FCTOD7 41,259,2003
skin/rat	lowest published toxic dose: 9.1 gm/kg/6H/13W- intermittent	Skin: After systemic exposure: Dermatitis, other	FCTOD7 41,259,2003

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 1 ppm;short term exposure limit 2 ppm (vapor)	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUTAEX 25,335,2010

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 1 ppm (7 mg/m³) (vapor)	DTLVS* 3,205,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 1 ppm (7 mg/m³), short term exposure limit 2 ppm (14 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 1 ppm (7 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 1 ppm (7 mg/m³), (vapor), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 2 ppm (14 mg/m³) (vapor), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 1 ppm (7 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 1 ppm (7.1 mg/m³), short term exposure limit 3 ppm (21 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 1 ppm (7 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 1 ppm (7.1 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 1 ppm (7 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 1 ppm (7 mg/m³), short term exposure limit 2 ppm (14 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 1 ppm (7 mg/m³);short term exposure limit 2 ppm (14 mg/m³) (vapor), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 1 ppm (7 mg/m³), short term exposure limit 2 ppm (14 mg/m³) (vapour), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 1 ppm (7 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 1 ppm (7 mg/m³); short term exposure limit 2 ppm (14 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 7 mg/m³, MAC(short term exposure limit) 14 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 5 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 1 ppm (7 mg/m³), JAN2011
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 1 ppm (7 mg/m³), JAN1993
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 1 ppm (7.1 mg/m³) (vapor), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 1 ppm (7 mg/m³), vapor	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 1 ppm (7 mg/m³), vapor	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 1 ppm (7 mg/m³), vapor	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 1 ppm (7 mg/m³), vapor	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENYL ETHER, vapor-air	10H time-weighted average 1 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 57210; Number of Industries 62; Total Number of Facilities 7313; Number of Occupations 70; Total Number of Employees Exposed 90789; Total Number of Female Employees Exposed 33945
National Occupational Hazard Survey 1974	Hazard Code 57210; Number of Industries 17; Total Number of Facilities 561; Number of Occupations 33; Total Number of Employees Exposed 13791

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phenyl ether, 1617

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health