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Registry of Toxic Effects of Chemical Substances (RTECS)

Ether, chloromethyl methyl

RTECS #

KN6650000

CAS #

107-30-2

Updated

April 2017

Molecular Weight

80.52

Molecular Formula

C2H5ClO

Synonyms

Chlordimethylether (Czech)
Chloromethyl methyl ether
Chloromethyl methyl ether (ACGIH:OSHA)
Chloromethyl methyl ether, technical grade
CMME
Dimethylchloroether
Ether methylique monochlore (French)
Ether, dimethyl chloro
Methoxychloromethane
Methylchloromethyl ether
Monochlorodimethyl ether
RCRA waste number U046

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionlymphocyte/human5 mL/LCALEDQ 13,213,1981
morphological transformembryo/hamster10 mg/LAETODY 1,241,1980

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lowest published toxic concentration: 1 ppm/6H/90DTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AEHLAU 30,70,1975
inhalation/hamster lowest published toxic concentration: 1 ppm/852D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV174 -,-,2003
inhalation/mouse lowest published toxic concentration: 2 ppm/21W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV174 -,-,2003
inhalation/mouse lowest published toxic concentration: 2 ppm/82D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AEHLAU 22,663,1971
inhalation/rat lowest published toxic concentration: 1 ppm/6H/72WTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Endocrine: Tumors
AEHLAU 30,70,1975
inhalation/rat lowest published toxic concentration: 1 ppm/852D- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV174 -,-,2003
subcutaneous/mouse lowest published toxic dose: 5 ml/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV174 -,-,2003
subcutaneous/mouse lowest published toxic dose: 312 mg/kg/26W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 46,143,1971
subcutaneous/mouse toxic dose: 852 mg/kg/71W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
JNCIAM 48,1431,1972
subcutaneous/mouse toxic dose: 125 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
TXAPA9 15,92,1969

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/hamster lethal concentration (50 percent kill): 65 ppm/7HLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage
AEHLAU 30,61,1975
inhalation/hamster lethal concentration (50 percent kill): 212.5 mg/m3/7HLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,278,1994
inhalation/mouse Lowest published lethal concentration: 330 mg/m3/2HVCVGK* -,278,1994
inhalation/mouse lethal concentration (50 percent kill): 1030 mg/m3/2H85GMAT -,89,1982
inhalation/rabbit lowest published toxic concentration: 9 mg/m3Lung, Thorax, or Respiration: CoughVCVGK* -,278,1994
inhalation/rabbit lowest published toxic concentration: 27 mg/m3Behavioral: Alteration of classical conditioningVCVGK* -,278,1994
inhalation/rat lethal concentration (50 percent kill): 55 ppm/7HLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage
AEHLAU 30,61,1975
inhalation/rat lethal concentration (50 percent kill): 179.8 mg/m3/7HLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
VCVGK* -,278,1994
inhalation/rat lethal concentration (50 percent kill): 55 ppm/7HLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Changes in lung weight
HPV174 -,-,2003
oral/rat lowest published lethal dose: 1000 mg/kgHPV174 -,-,2003
oral/rat lethal dose (50 percent kill): 223 mg/kgHPV174 -,-,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 6 mg/m3/130D- intermittentLung, Thorax, or Respiration: TumorsVCVGK* -,278,1994
inhalation/rabbit lowest published toxic concentration: 3 mg/m3/5H/90D- intermittentLung, Thorax, or Respiration: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,278,1994
inhalation/rat lowest published toxic concentration: 32.7 mg/m3/30D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,278,1994
inhalation/rat lowest published toxic concentration: 3.27 mg/m3/130W- continuousLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Skin and Appendages: Tumors
VCVGK* -,278,1994
inhalation/rat lowest published toxic concentration: 10 ppm/3D- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV174 -,-,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Control as low as possibleDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Suspected human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 4,239,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 4,239,1974
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 100F,306,2012
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 100F,306,2012
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMSUDL 7,131,1987
International Agency for Research on Cancer (IARC)Cancer Review:Group 1IMEMDT 100F,306,2012
TOXICOLOGY REVIEWEESADV 1,289,1977
TOXICOLOGY REVIEWMUREAV 566,21,2004
TOXICOLOGY REVIEWFCTOD7 44,1699,2006
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 733,39,2012
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIACarcinogen, JUL2008
Occupational Exposure Limit-JAPAN2A carc, MAY2012
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENGroup A Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLANDcarc 1, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)see Code of Federal Regulations (CFR) 29,1926.1108CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA)-cancer suspect agentCFRGBR 29,1910.1006,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROMETHYL METHYL ETHER-airCarcinogen use 29 Code of Federal Regulations (CFR) 1910.1006NIOSH* DHHS #92-100,1992

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
On EPA IRIS database
OSHA ANALYTICAL METHOD #10
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