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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-isopropoxy-

RTECS #

KL5075000

CAS #

109-59-1

Updated

July 2016

Molecular Weight

104.17

Molecular Formula

C5H12O2

Synonyms

2-Isopropoxyethanol
2-Isopropoxyethanol (ACGIH)
beta-Hydroxyethyl isopropyl ether
Dowanol eipat
Ethylene glycol isopropyl ether
Ethylene glycol, monoisopropyl ether
Isopropyl cellosolve
Isopropyl glycol
Isopropyl oxitol
Isopropylethylene glycol ether
Monoisopropyl ether of ethylene glycol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild85JCAE -,627,1986
skin /rabbit 20 mg/24H moderate85JCAE -,627,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 1930 ppm/7HBehavioral: Analgesia

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria
JIHTAB 25,157,1943
inhalation/rat lethal concentration (50 percent kill): 3100 mg/m3/4H85GMAT -,67,1982
intraperitoneal/mammal (species unspecified) lowest published toxic dose: 100 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)VCVGK* -,165,1984
intraperitoneal/mouse lethal dose (50 percent kill): 1860 mg/kg85GMAT -,67,1982
intraperitoneal/mouse lethal dose (50 percent kill): 1250 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Blood: Other hemolysis with or without anemia
VCVGK* -,165,1984
intraperitoneal/rabbit lethal dose (50 percent kill): 800 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Blood: Other hemolysis with or without anemia
VCVGK* -,165,1984
intraperitoneal/rat lethal dose (50 percent kill): 1250 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Blood: Other hemolysis with or without anemia
VCVGK* -,165,1984
intraperitoneal/rat lethal dose (50 percent kill): 800 mg/kg85GMAT -,67,1982
oral/mouse lethal dose (50 percent kill): 4900 mg/kg85GMAT -,67,1982
oral/rat lethal dose (50 percent kill): 5660 µL/kgAIHAAP 30,470,1969
skin/rabbit lethal dose (50 percent kill): 1600 µL/kgAIHAAP 30,470,1969
unreported route/mouse lethal dose (50 percent kill): 1250 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes
GISAAA 41(11),7,1976
unreported route/rat lethal dose (50 percent kill): 1250 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes
GISAAA 41(11),7,1976

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 200 ppm/6H/26W- intermittentCardiac: Changes in heart weight

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0556079
inhalation/guinea pig lowest published toxic concentration: 200 ppm/6H/26W- intermittentLiver: Liver function tests impaired

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0556079
inhalation/rabbit lowest published toxic concentration: 200 ppm/6H/26W- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Musculoskeletal: Other changes
NTIS** OTS0556079
inhalation/rat lowest published toxic concentration: 1000 mg/m3/4H/30D- intermittentKidney, Ureter, and Bladder: Other changes

Blood: Changes in cell count (unspecified)
VCVGK* -,165,1994
inhalation/rat lowest published toxic concentration: 30 mg/m3/90D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,165,1994
inhalation/rat lowest published toxic concentration: 1650 mg/m3/7H/5W- intermittentBlood: Changes in spleenJIHTAB 25,374,1943
inhalation/rat lowest published toxic concentration: 10 mg/m3/24H/13W- continuousEndocrine: Hypoglycemia

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 41(11),7,1976
inhalation/rat lowest published toxic concentration: 142 ppm/6H/4W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in spleen

Blood: Changes in erythrocyte (RBC) count
INHTE5 4,43,1992
inhalation/rat lowest published toxic concentration: 200 ppm/6H/26W- intermittentEndocrine: Changes in spleen weight

Blood: Other changes

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0556079
subcutaneous/rat lowest published toxic dose: 1562.55 mg/kg/4W- intermittentBlood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARTODN 82,125,2008

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 25 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWREPTED 58,252,2015

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 25 ppm (105 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (22 mg/m3);KZW 20 ppm (88 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 25 ppm (108 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (22 mg/m3), skin, MAY2011
Occupational Exposure Limit-FRANCEVME 25 ppm (105 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 5 ppm (22 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (22 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 25 ppm (105 mg/m3), 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 25 ppm (106 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 20 ppm (80 mg/m3), JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (45 mg/m3);short term exposure limit 20 ppm (90 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (22 mg/m3), KZG-week 40 ppm (176 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 44 mg/m3, Skin, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X7487; Number of Industries 1; Total Number of Facilities 32; Number of Occupations 5; Total Number of Employees Exposed 1357; Total Number of Female Employees Exposed 63

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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