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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-ethoxy-, acetate

RTECS #

KK8225000

CAS #

111-15-9

Updated

September 2013

Molecular Weight

132.18

Molecular Formula

C6H12O3

Synonyms

2-Aethoxy-aethylacetat (German)
2-Ethoxyethanol acetate
2-Ethoxyethanol, ester with acetic acid
2-Ethoxyethyl acetate
2-Ethoxyethyl acetate (ACGIH:OSHA)
2-Ethoxy-ethylacetaat (Dutch)
2-Ethoxyethylacetate
2-Ethoxyethyle, acetate de (French)
2-Ethoxyethylester kyseliny octove (Czech)
2-Etossietil-acetato (Italian)
Acetate de cellosolve (French)
Acetate de l'ether monoethylique de l'ethylene-glycol (French)
Acetate d'ethylglycol (French)
Acetato di cellosolve (Italian)
Acetic acid, 2-ethoxyethyl ester
Aethylenglykolaetheracetat (German)
beta-Ethoxyethyl acetate
Cellosolve acetate
Cellosolve acetate (OSHA)
Celosolvacetat (Czech)
CSAC
EGEEA
Ektasolve EE acetate solvent
Ethoxy acetate
Ethoxyethyl acetate
Ethyl cellosolve acetaat (Dutch)
Ethylene glycol ethyl ether acetate
Ethylene glycol monoethyl ether acetate
Ethylglycol acetate
Ethylglykolacetat (German)
Glycol ether EE acetate
Glycol monoethyl ether acetate
Octan etoksyetylu (Polish)
Oxytol acetate
Poly-Solv EE acetate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 40 mg moderateUCDS** 1/13/1967
skin /rabbit 490 mg open irritation test mildUCDS** 1/13/1967

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit 200 ppm/6H (6-18D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Urogenital system
UCRR** 09OCT1984
inhalation/rabbit 200 ppm/6H (6-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
UCRR** 09OCT1984
inhalation/rabbit 100 ppm/6H (6-18D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemUCRR** 09OCT1984
inhalation/rabbit 100 ppm/6H (6-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
EVHPAZ 57,33,1984
inhalation/rabbit 450 ppm/6H (6-18D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
NTIS** OTS0544004
inhalation/rat 600 ppm/7H (7-15D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathEPASR* 8EHQ-0682-0450
inhalation/rat 200 ppm/6H (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Respiratory system
FAATDF 10,20,1988
inhalation/rat 300 ppm/6H (6-15D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Urogenital system
UCRR** 09OCT1984
inhalation/rat 50 mg/kg/4H (1-19D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
FAVUAI 21,30,1989
inhalation/rat 50 ppm/6H (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemUCRR** 09OCT1984
oral/mouse 25 gm/kg (25D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductSAIGBL 21,29,1979
oral/mouse 100 gm/kg (25D male)Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glandsSAIGBL 21,29,1979
oral/mouse 0.93 gm/kg (multigenerations)Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Specific developmental abnormalities: Hepatobiliary system
NTIS** #PB86139565
oral/mouse 1.86 gm/kg (multigenerations)Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)NTIS** #PB86139565
oral/mouse 1.86 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary systemNTIS** #PB86139565
oral/mouse 441 gm/kg (21W prior to copulation)Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
NTIS** #PB86139565
oral/mouse 65.1 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB86139565
skin/rat 70 gm/kg (7-16D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
EVHPAZ 57,69,1984
skin/rat 70 gm/kg (7-16D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
EVHPAZ 57,69,1984

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lethal concentration (50 percent kill): >2000 ppm/4HKidney, Ureter, and Bladder: HematuriaTXAPA9 51,117,1979
inhalation/rat lethal concentration (50 percent kill): 12100 mg/m3/8HAIHAAP 20,364,1959
inhalation/rat lethal concentration (50 percent kill): >1500 ppm/8HIJTOFN 21,9,2002
intraperitoneal/mouse lethal dose (50 percent kill): 1420 mg/kgSCCUR* -,2,1961
oral/guinea pig lethal dose (50 percent kill): 1910 mg/kgBehavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/guinea pig lethal dose (50 percent kill): 1910 mg/kgBehavioral: General anestheticIJTOFN 21,9,2002
oral/rabbit lethal dose (50 percent kill): 1950 mg/kgEPASR* 8EHQ-0682-0450
oral/rat lethal dose (50 percent kill): 2700 mg/kgGISAAA 53(10),78,1988
oral/rat lethal dose (50 percent kill): 2900 mg/kgKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Hematuria
IJTOFN 21,9,2002
skin/guinea pig lethal dose (50 percent kill): >19460 mg/kgEPASR* 8EHQ-0682-0450
skin/rabbit lethal dose (50 percent kill): 10500 µL/kgUCDS** 1/13/1967
subcutaneous/mouse lowest published lethal dose: 5 gm/kgJPETAB 42,355,1931

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 84 gm/kg/4W- continuousBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB86139565
oral/mouse lowest published toxic dose: 441 gm/kg/21W- continuousReproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB86139565
oral/rat lowest published toxic dose: 7560 mg/kg/2W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
ARTODN 73,229,1999

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWCRTXB2 30,307,2000
TOXICOLOGY REVIEWIJTOFN 21,9,2002

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (540 mg/m3) (skin)DTLVS* 3,101,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 ppm (27 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (27 mg/m3);KZW 20 ppm (108 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (27 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (27 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 2 ppm (11 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 5 ppm (27 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 2 ppm (11 mg/m3), skin, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 27 mg/m3, short term exposure limit 108 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (27 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 5 ppm (27 mg/m3), skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (27 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 50 ppm (270 mg/m3);short term exposure limit 100 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 5 ppm (27 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (27 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (27 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 100 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 5 ppm (30 mg/m3);short term exposure limit 10 ppm (50 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (11 mg/m3), KZG-week 16 ppm (88 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 27 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 100 ppm (540 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 100 ppm (540 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 ppm (55 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (540 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (540 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (540 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (540 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EGEEA-air10H time-weighted average 0.5 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M4063; Number of Industries 149; Total Number of Facilities 16901; Number of Occupations 103; Total Number of Employees Exposed 265104; Total Number of Female Employees Exposed 51020
National Occupational Hazard Survey 1974Hazard Code M4063; Number of Industries 228; Total Number of Facilities 38895; Number of Occupations 127; Total Number of Employees Exposed 321063

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0693-9068
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450
On EPA IRIS database
OSHA ANALYTICAL METHOD #53
OSHA ANALYTICAL METHOD #79
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