Ethanol, 2-butoxy-, acetate

RTECS #

KJ8925000

CAS #

112-07-2
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

160.24

Molecular Formula

C₈H₁₆O₃

Synonyms

2-Butoxyethanol acetate
2-Butoxyethyl acetate
2-Butoxyethylester kyseliny octove (Czech)
Acetic acid, 2-butoxyethyl ester
Butyl cellosolve acetate
Butylcelosolvacetat (Czech)
Butylglycol acetate
Ektasolve EB acetate
Ethylene glycol monobutyl ether acetate
Glycol monobutyl ether acetate

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	500 mg/24H	mild	85JCAE -,713,1986
skin /rabbit	500 mg open irritation test	mild	UCDS** 1/31/1966

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, melanoma	Inhibitor Concentration (50 percent kill): 3042.8 mg/L/48H	In Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.	FCTOD7 50,2084,2012
oral/mouse	lethal dose (50 percent kill): 3200 mg/kg		KODAK* 21MAY1971
oral/rat	lethal dose (50 percent kill): 2400 mg/kg	Kidney, Ureter, and Bladder: Hematuria Kidney, Ureter, and Bladder: Other changes in urine composition	TXAPA9 51,117,1979
skin/guinea pig	lowest published lethal dose: 5 mL/kg		KODAK* 21MAY1971
skin/rabbit	lethal dose (50 percent kill): 1500 mg/kg	Kidney, Ureter, and Bladder: Hematuria Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Normocytic anemia	TXAPA9 51,117,1979

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 4060 mg/kg/2W- continuous	Kidney, Ureter, and Bladder: Other changes in urine composition Kidney, Ureter, and Bladder: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases	ARTODN 73,229,1999

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 20 ppm	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Confirmed animal carcinogen	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-AUSTRALIA	time-weighted average 20 ppm (133 mg/m³), short term exposure limit 50 ppm (333 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 20 ppm (133 mg/m³);KZW 40 ppm (270 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 20 ppm (133 mg/m³), MAR2002
Occupational Exposure Limit-BELGIUM	short term exposure limit 50 ppm (333 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 20 ppm (130 mg/m³), skin, MAY2011
Occupational Exposure Limit-EC	time-weighted average 133 mg/m³ (20 ppm);short term exposure limit 333 mg/m³ (50 ppm), skin, JUN2000
Occupational Exposure Limit-FINLAND	time-weighted average 20 ppm (130 mg/m³), short term exposure limit 50 ppm (330 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 2 ppm (13.3 mg/m³), VLE 30 ppm (199.8 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 10 ppm (66 mg/m³), skin, 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 133 mg/m³, short term exposure limit 333 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 20 ppm (133 mg/m³), short term exposure limit 50 ppm (333 mg/m³), skin, NOV2011
Occupational Exposure Limit-PERU	time-weighted average 20 ppm (131 mg/m³); short term exposure limit 50 ppm, JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 100 mg/m³, JAN1999
Occupational Exposure Limit-SWEDEN	time-weighted average 10 ppm (70 mg/m³);short term exposure limit 20 ppm (140 mg/m³), Skin, JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 10 ppm (66 mg/m³), KZG-week 20 ppm (132 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 135 mg/m³, Skin, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 20 ppm (133 mg/m³);short term exposure limit 50 ppm (332 mg/m³), skin, OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EGBEA-air	10H time-weighted average 5 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 81350; Number of Industries 116; Total Number of Facilities 15329; Number of Occupations 70; Total Number of Employees Exposed 150893; Total Number of Female Employees Exposed 38379
National Occupational Hazard Survey 1974	Hazard Code 81350; Number of Industries 50; Total Number of Facilities 4676; Number of Occupations 41; Total Number of Employees Exposed 36527

Status in Federal Agencies

Organization	Reference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/102527/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #83

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health