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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-butoxy-

RTECS #

KJ8575000

CAS #

111-76-2

Updated

July 2016

Molecular Weight

118.20

Molecular Formula

C6H14O2

Synonyms

2-Butossi-etanolo (Italian)
2-Butoxy-1-ethanol
2-Butoxy-aethanol (German)
2-Butoxyethanol
2-Butoxyethanol (ACGIH:OSHA)
3-Oxa-1-heptanol
BUCS
Butoksyetylowy alkohol (Polish)
Butoxyethanol
Butyl cellosolve
Butyl cellosolve (OSHA)
Butyl oxitol
Butylcelosolv (Czech)
Butylglycol (French,German)
Dowanol EB
Ektasolve EB
Ethylene glycol monobutyl ether
Ethylene glycol n-butyl ether
Ethylene glycol, monobutyl ether
Gafcol EB
Glycol butyl ether
Glycol ether EB
Glycol monobutyl ether
Jeffersol EB
Monobutyl ether of ethylene glycol
Monobutyl glycol ether
n-Butoxyethanol
O-Butyl ethylene glycol
Poly-Solv EB

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeAJOPAA 29,1363,1946
eye /rabbit 100 mg/24H moderate85JCAE -,629,1986
skin /rabbit 500 mg open irritation test mildUCDS**

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageunreported route/mouse3150 mg/kg/7DTOXID9 66,306,2002
mutation in microorganisms/Salmonella typhimurium19 µmol/plate (-enzymatic activation step)MUREAV 341,281,1995
Unscheduled DNA Synthesisunreported route/mouse1575 mg/kg/7DTOXID9 66,306,2002

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 483 mg/m3/6H (6-15D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
VCVGK* -,167,1994
inhalation/rabbit 483 mg/m3/6H (6-15D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
VCVGK* -,167,1994
inhalation/rat 200 ppm/6H (6-15D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
EVHPAZ 57,47,1984
inhalation/rat 25 ppm/6H (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemEVHPAZ 57,47,1984
inhalation/rat 12 mg/kg/4H (1-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FAVUAI 21,30,1989
inhalation/rat 200 ppm/6H (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** OTS0571237
inhalation/rabbit 200 ppm/6H (6-18D pregnant)Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
EVHPAZ 57,47,1984
inhalation/rabbit 100 ppm/6H (6-18D pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) systemEVHPAZ 57,47,1984
oral/mouse 9440 mg/kg (7-14D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)EVHPAZ 57,141,1984
oral/rat 6279 mg/kg (13W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)NTPTR* NIH-93-3349
oral/mouse 9440 mg/kg (7-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)EVHPAZ 57,141,1984
oral/mouse 7 gm/kg (8-14D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TCMUD8 7,55,1987
oral/mouse 9440 mg/kg (6-13D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)TCMUD8 7,29,1987
oral/mouse 25.2 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB85226827
oral/mouse 47.25 gm/kg (7D male/7D prior to copulation/21D pregnant)Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)NTIS** #PB85226827
oral/mouse 0.72 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB85226827
oral/mouse 0.72 gm/kg (multigenerations)Reproductive: Specific developmental abnormalities: Hepatobiliary systemNTIS** #PB85226827
oral/mouse 198.45 gm/kg (21W prior to copulation)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB85226827
oral/rat 600 mg/kg (9-11D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathNTIS** #PB89-165849

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 250 ppm/6H/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-484,2000
inhalation/mouse lowest published toxic concentration: 15600 mg/kg/104W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB#2000-105865
inhalation/mouse lowest published toxic concentration: 15600 mg/kg/104W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB#2000-105865
inhalation/rat lowest published toxic concentration: 3250 mg/kg/104W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Adrenal cortex tumors
NTIS** PB#2000-105865
inhalation/rat lowest published toxic concentration: 125 ppm/6H/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors
NTPTR* NTP-TR-484,2000

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Rabbit, ocular Inhibitor Concentration Low: 5 pph/5MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 25,1425,2011
In Vitro/Rat, embryo Inhibitor Concentration Low: 12.5 mmol/L/48HReproductive: Other effects to embryo or fetusTIVIEQ 7,777,1993
In Vitro/Rat, embryo Inhibitor Concentration Low: 25 mmol/L/48HReproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TIVIEQ 7,777,1993
In Vitro/Rat, embryo Inhibitor Concentration Low: 12.5 mmol/L/48HReproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Other developmental abnormalities
TIVIEQ 7,777,1993
inhalation/guinea pig Lethal concentration: >633 ppm/1HNTIS** OTS0572613
inhalation/human lowest published toxic concentration: 195 ppm/8HGastrointestinal: Nausea or vomitingAMIHAB 14,114,1956
inhalation/human lowest published toxic concentration: 100 ppmOlfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes
NPIRI* 1,50,1974
inhalation/human lowest published toxic concentration: 1500 mg/m3Eye: Conjunctiva irritation

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,166,1984
inhalation/mouse lethal concentration (50 percent kill): 3380 mg/m3/7HLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia
VCVGK* -,166,1984
inhalation/mouse lethal concentration (50 percent kill): 700 ppm/7HBehavioral: Analgesia

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Hematuria
JIHTAB 25,157,1943
inhalation/rat lethal concentration (50 percent kill): 450 ppm/4HBehavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 68,405,1983
inhalation/rat lethal concentration (50 percent kill): 2900 mg/m3/7HLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia
VCVGK* -,166,1984
inhalation/rat Lowest published lethal concentration: 1800 mg/m3/7HLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia
VCVGK* -,166,1984
intraperitoneal/mammal (species unspecified) lowest published toxic dose: 100 mg/kgEndocrine: Change in gonadotropinsVCVGK* -,166,1984
intraperitoneal/mouse lethal dose (50 percent kill): 536 mg/kgSCCUR* -,2,1961
intraperitoneal/rabbit lethal dose (50 percent kill): 220 mg/kg85GMAT -,67,1982
intraperitoneal/rat lethal dose (50 percent kill): 220 mg/kg85GMAT -,67,1982
intravenous/mouse lethal dose (50 percent kill): 1130 mg/kgAMIHAB 14,114,1956
intravenous/rabbit lethal dose (50 percent kill): 252 mg/kgAMIHAB 14,114,1956
intravenous/rat lethal dose (50 percent kill): 307 mg/kgAMIHAB 14,114,1956
oral/guinea pig lethal dose (50 percent kill): 1200 mg/kgBehavioral: General anesthetic

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
JIHTAB 23,259,1941
oral/human lowest published lethal dose: 143 mg/kgVCVGK* -,166,1984
oral/man lowest published toxic dose: 132 mg/kgBehavioral: Sleep

Kidney, Ureter, and Bladder: Hematuria

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
JTCTDW 41,57,2003
oral/mouse lethal dose (50 percent kill): 1167 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia
VCVGK* -,166,1984
oral/mouse lethal dose (50 percent kill): 1230 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair
AMIHAB 14,114,1956
oral/rabbit lethal dose (50 percent kill): 320 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia
VCVGK* -,166,1984
oral/rabbit lethal dose (50 percent kill): 300 mg/kgYKYUA6 32,1241,1981
oral/rat lethal dose (50 percent kill): 917 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other hemolysis with or without anemia
VCVGK* -,166,1984
oral/rat lethal dose (90 percent kill): 1500 mg/kgKidney, Ureter, and Bladder: Hematuria

Blood: Other changes
TXAPA9 225,102,2007
oral/rat lowest published lethal dose: 1500 mg/kgLung, Thorax, or Respiration: Changes in pulmonary vascular resistanceTOXID9 90,61,2006
oral/rat lethal dose (50 percent kill): 250 mg/kgENTOX* -,290,2005
oral/rat lowest published toxic dose: 500 mg/kgBlood: Other hemolysis with or without anemiaTOXID9 44,172,2005
oral/woman lowest published toxic dose: 600 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
HUTODJ 7,187,1988
oral/woman lowest published toxic dose: 7813 µL/kgBehavioral: Coma

Vascular: BP lowering not characterized in autonomic section

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
HUTODJ 8,243,1989
skin/guinea pig lethal dose (50 percent kill): 230 µL/kgTXAPA9 7,559,1965
skin/rabbit lethal dose (50 percent kill): 220 mg/kgDOWCC* MSD-46
skin/rabbit lowest published toxic dose: 0.56 mL/kg/1HBlood: Other hemolysis with or without anemia

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,167,1984
subcutaneous/mouse lowest published lethal dose: 500 mg/kgJPETAB 42,355,1931
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1500 mg/kgGISAAA 51(5),61,1986
unreported route/mouse lethal dose (50 percent kill): 1050 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes
GISAAA 41(11),7,1976
unreported route/rat lethal dose (50 percent kill): 917 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes
GISAAA 41(11),7,1976
unreported route/rat lowest published toxic dose: 250 mg/kgBlood: Change in clotting factorsTOXID9 44,172,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 415 ppm/7H/12W- intermittentBlood: Microcytosis with or without anemia

Kidney, Ureter, and Bladder: Other changes in urine composition
JIHTAB 25,409,1943
inhalation/Dog lowest published toxic concentration: 385 ppm/7H/28D- intermittentBlood: Other changes

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 14,114,1956
inhalation/Dog lowest published toxic concentration: 2000 mg/m3/7H/12W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVGK* -,167,1994
inhalation/guinea pig lowest published toxic concentration: 2500 mg/m3/8H/12D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,167,1994
inhalation/guinea pig lowest published toxic concentration: 376 ppm/7H/30D- intermittentLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHAB 14,114,1956
inhalation/monkey lowest published toxic concentration: 500 mg/m3/7H/12W- intermittentBlood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
VCVGK* -,167,1994
inhalation/mouse lowest published toxic concentration: 396 ppm/7H/30D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Hematuria

Blood: Other changes
AMIHAB 14,114,1956
inhalation/mouse lowest published toxic concentration: 401 ppm/7H/90D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Hematuria

Blood: Other changes
AMIHAB 14,114,1956
inhalation/rat lowest published toxic concentration: 1540 mg/m3/7H/5W- intermittentBlood: Changes in erythrocyte (RBC) countJIHTAB 25,374,1943
inhalation/rat lowest published toxic concentration: 432 ppm/7H/30D- intermittentKidney, Ureter, and Bladder: Hematuria

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 14,114,1956
inhalation/rat lowest published toxic concentration: 245 ppm/6H/9D- intermittentLiver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count
TXAPA9 68,405,1983
inhalation/rat lowest published toxic concentration: 10 mg/m3/24H/13W- continuousEndocrine: Hypoglycemia

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 41(11),7,1976
inhalation/rat lowest published toxic concentration: 421 mg/m3/13W- intermittentBlood: Other hemolysis with or without anemiaVCVGK* -,167,1994
inhalation/rat lowest published toxic concentration: 516 mg/m3/30D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,167,1994
inhalation/rat lowest published toxic concentration: 10 mg/m3/90D- continuousEndocrine: Hypoglycemia

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,167,1994
inhalation/rat lowest published toxic concentration: 900 mg/m3/4H/25D- intermittentBrain and Coverings: Increased intracranial pressure

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,167,1994
oral/mouse lowest published toxic dose: 198.45 gm/kg/21W- continuousRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** #PB85226827
oral/mouse lowest published toxic dose: 37.8 gm/kg/4W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** #PB85226827
oral/mouse lowest published toxic dose: 20.16 gm/kg/4W- continuousBehavioral: Fluid intakeNTIS** #PB85226827
oral/mouse lowest published toxic dose: 198.45 gm/kg/21W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB85226827
oral/mouse lowest published toxic dose: 198.45 gm/kg/21W- continuousKidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB85226827
oral/mouse lowest published toxic dose: 5180 mg/kg/2W- continuousEndocrine: Changes in thymus weightNTPTR* NIH-93-3349
oral/mouse lowest published toxic dose: 9440 mg/kg/8D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldEVHPAZ 57,141,1984
oral/mouse lowest published toxic dose: 5 gm/kg/10D- intermittentGastrointestinal: GastritisTXCYAC 180,257,2002
oral/mouse lowest published toxic dose: 2250 mg/kg/7D- intermittentLiver: Changes in liver weight

Blood: Other hemolysis with or without anemia

Blood: Changes in spleen
TOSCF2 70,252,2002
oral/mouse lowest published toxic dose: 51429 mg/kg/90D- intermittentLiver: Other changes

Blood: Other changes

Nutritional and Gross Metabolic: Conditioned vitamin deficiency
TOXID9 60,287,2001
oral/mouse lowest published toxic dose: 51429 mg/kg/90D- intermittentBiochemical: Metabolism (intermediary): OtherTOXID9 60,287,2001
oral/mouse lowest published toxic dose: 6300 mg/kg/7D- intermittentLiver: Other changesTOXID9 -,333,2009
oral/mouse lowest published toxic dose: 2250 mg/kg/7D- intermittentLiver: Other changes

Endocrine: Changes in spleen weight
TXCYAC 270,131,2010
oral/mouse lowest published toxic dose: 4500 mg/kg/7D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Other hemolysis with or without anemia
TXCYAC 270,131,2010
oral/rat lowest published toxic dose: 46.5 mg/kg/60D- continuousBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,167,1994
oral/rat lowest published toxic dose: 500 mg/kg/2D- intermittentBlood: Other changesARTODN 77,465,2003
oral/rat lowest published toxic dose: 500 mg/kg/4D- intermittentVascular: Thromobosis distant from injection site

Blood: Other hemolysis with or without anemia
ETPAEK 58,311,2007
oral/rat lowest published toxic dose: 3500 mg/kg/7D- intermittentBlood: Other changesTXAPA9 230,338,2008
oral/rat lowest published toxic dose: 1575 mg/kg/7D- intermittentLiver: Other changes

Blood: Other hemolysis with or without anemia

Blood: Changes in spleen
TOSCF2 70,252,2002
oral/rat lowest published toxic dose: 14000 mg/kg/4W- intermittentEndocrine: Changes in thymus weight

Blood: Changes in bone marrow not included in above

Related to Chronic Data: Changes in ovarian weight
VCVGK* -,166,1994
oral/rat lowest published toxic dose: 2170 mg/kg/4W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count
VCVGK* -,166,1994
oral/rat lowest published toxic dose: 13290 mg/kg/6W- intermittentLiver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
FAATDF 6,349,1986
oral/rat lowest published toxic dose: 139 gm/kg/90D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHAB 14,114,1956
oral/rat lowest published toxic dose: 9324 mg/m3/21D- continuousBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 16,830,1991
oral/rat lowest published toxic dose: 1500 mg/kg/12D- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Other changes

Blood: Changes in erythrocyte (RBC) count
TXAPA9 112,198,1992
oral/rat lowest published toxic dose: 300 mg/kg/3D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight
NTIS** #PB89-165849
oral/rat lowest published toxic dose: 300 mg/kg/3D- intermittentBlood: Normocytic anemia

Blood: Other hemolysis with or without anemia
NTIS** #PB89-165849
oral/rat lowest published toxic dose: 1000 mg/kg/4D- intermittentCardiac: Cardiomyopathy including infarction

Vascular: Thromobosis distant from injection site

Blood: Changes in bone marrow not included in above
TOXID9 72,30,2003
skin/mouse lowest published toxic dose: 6000 mg/kg/4D- continuousEndocrine: Changes in spleen weight

Blood: Changes in spleen
IJTOFN 20,383,2001
skin/mouse lowest published toxic dose: 2000 mg/kg/4D- continuousImmunological Including Allergic: Decrease in cellular immune responseIJTOFN 20,383,2001
skin/mouse lowest published toxic dose: 6 gm/kg/4D- intermittentEndocrine: Changes in spleen weight

Blood: Changes in spleen

Immunological Including Allergic: Decreased immune response
TOXID9 42,209,1998
skin/rabbit lowest published toxic dose: 6.3 mL/kg/2W- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,167,1994
skin/rabbit lowest published toxic dose: 4500 µL/kg/9D- intermittentLiver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count
NTIS** OTS0516797
skin/rat lowest published toxic dose: 17.5 mL/kg/10D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,167,1994
subcutaneous/rat lowest published toxic dose: 2955 mg/kg/4W- intermittentBlood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARTODN 82,125,2008
unreported route/rat lowest published toxic dose: 1000 mg/kg/4D- intermittentBlood: Change in clotting factors

Musculoskeletal: Other changes
TOXID9 44,172,2005
unreported route/rat lowest published toxic dose: 500 mg/kg/4D- intermittentBlood: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 90,341,2006
unreported route/rat lowest published toxic dose: 1000 mg/kg/4D- intermittentBlood: Other hemolysis with or without anemia

Blood: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 90,341,2006
unreported route/rat lowest published toxic dose: 750 mg/kg/3D- intermittentEye: Retinal changes pigmentary deposition, retinitis, other)

Eye: Changes in circulation
TOXID9 72,311,2003

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 20 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review: Group 3IMEMDT 88,400,2006
TOXICOLOGY REVIEWFAATDF 13,747,1989
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWENTOX* -,290,2005
TOXICOLOGY REVIEWENTOX* -,451,2005
TOXICOLOGY REVIEWIJTOFN 24,1,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWTOPADD 33,517,2005
TOXICOLOGY REVIEWJTEHD6 7,385,2004
TOXICOLOGY REVIEWREPTED 25,192,2008
TOXICOLOGY REVIEWMUREAV 566,49,2004
TOXICOLOGY REVIEWHUTOX* -,623,1996
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWTOLED5 180,100,2008
TOXICOLOGY REVIEWMUREAV 751,49,2012
TOXICOLOGY REVIEWTXAPA9 254,86,2011
TOXICOLOGY REVIEWTOLED5 199,203,2010
TOXICOLOGY REVIEWMUREAV 783,66,2015
TOXICOLOGY REVIEWREPTED 58,252,2015

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,241,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 50 ppm (240 mg/m3) (skin)DTLVS* 3,29,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 20 ppm (96.9 mg/m3), short term exposure limit 50 ppm (242 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 20 ppm (98 mg/m3);KZW 40 ppm (200 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 20 ppm (98 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 50 ppm (246 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 20 ppm (98 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 98 mg/m3 (20 ppm);short term exposure limit 246 mg/m3 (50 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 20 ppm (98 mg/m3), short term exposure limit 50 ppm (250 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (9.8 mg/m3), VLE 30 ppm (147.6 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 10 ppm (49 mg/m3), skin, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 98 mg/m3, short term exposure limit 246 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 20 ppm (100 mg/m3), short term exposure limit 50 ppm (246 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 25 ppm (120 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 26 ppm (120 mg/m3);short term exposure limit 75 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 25 ppm (121 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 20 ppm (97 mg/m3); short term exposure limit 50 ppm (242 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 360 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (50 mg/m3);short term exposure limit 20 ppm (100 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 ppm (49 mg/m3), KZG-week 20 ppm (98 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 100 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 50 ppm (240 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 50 ppm (240 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 25 ppm (123 mg/m3);short term exposure limit 50 ppm (246 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 50 ppm (240 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 50 ppm (240 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 50 ppm (240 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 50 ppm (240 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYLENE GLYCOL MONOBUTYL ETHER-air10H time-weighted average 5 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 29930; Number of Industries 402; Total Number of Facilities 130413; Number of Occupations 239; Total Number of Employees Exposed 2139297; Total Number of Female Employees Exposed 585932
National Occupational Hazard Survey 1974Hazard Code 29930; Number of Industries 398; Total Number of Facilities 141929; Number of Occupations 199; Total Number of Employees Exposed 1547951

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/102527/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse,rat
NIOSH Analytical Method, 1994: Alcohols IV, 1403
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Carcinogenisis Studies (inhalation):some evidence:mouse NTPTR* NTP-TR-484,2000
NTP Toxicity studies, RPT# TOX-26, October 2000
On EPA IRIS database
OSHA ANALYTICAL METHOD #83
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