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Registry of Toxic Effects of Chemical Substances (RTECS)

Ethanol, 2-amino-

RTECS #

KJ5775000

CAS #

141-43-5

Updated

July 2016

Molecular Weight

61.10

Molecular Formula

C2H7NO

Synonyms

2-Aminoaethanol (German)
2-Aminoetanolo (Italian)
2-Aminoethanol (OSHA)
2-Hydroxyethylamine
Aethanolamin (German)
beta-Aminoethyl alcohol
beta-Ethanolamine
beta-Hydroxyethylamine
Colamine
Etanolamina (Italian)
Ethanolamine
Ethanolamine (ACGIH:OSHA)
Ethylolamine
Glycinol
Kolamin (Czech)
Monoaethanolamin (German)
Monoethanolamine
Olamine
Thiofaco M-50
USAF EK-1597

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg severeAJOPAA 29,1363,1946
skin /mammal (species unspecified) 5%TPKVAL 4,81,1962
skin /rabbit 505 mg open irritation test moderateUCDS** 1/13/1972

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human100 µmol/LBZARAZ 39,422,1986
sister chromatid exchangelymphocyte/human1 mmol/LCYGEDX 21(6),29,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TCMUD8 6,403,1986
oral/rat 500 mg/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemTCMUD8 6,403,1986
oral/rat 4500 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleFAATDF 40,158,1997
skin/rat 2250 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleFAATDF 31,117,1996

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 8.7 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Human, skin Inhibitor Concentration Low: 0.08 mL/well/1HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 28,616,2014
In Vitro/Rabbit, ocular Inhibitor Concentration Low: 5 pph/5MIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,1855,2013
inhalation/cat lowest published toxic concentration: 0.1 gm/m3Behavioral: Alteration of classical conditioning

Behavioral: Alteration of operant conditioning
TPKVAL 4,81,1962
inhalation/cat Lethal concentration: >2420 mg/m3/2HGTPZAB 23(9),55,1979
inhalation/mouse Lethal concentration: >2420 mg/m3/2HGTPZAB 23(9),55,1979
intramuscular/rat lethal dose (50 percent kill): 1750 mg/kgGTPZAB 23(9),55,1979
intraperitoneal/mouse lethal dose (50 percent kill): 50 mg/kgUSXXAM #6582498
intraperitoneal/rat lethal dose (50 percent kill): 67 mg/kgTOVEFN (5),45,1994
intravenous/rat lethal dose (50 percent kill): 225 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
KBMEAL (4),44,1968
ocular/rabbit lowest published toxic dose: 100 pphEye: Miosis (pupilliary constriction)

Eye: Conjunctiva irritation

Eye: Corneal damage
TPKVAL 4,81,1962
oral/guinea pig lethal dose (50 percent kill): 620 mg/kgEVSSAV 2,289,1968
oral/mammal (species unspecified) lowest published lethal dose: 1400 mg/kgNTIS** OTS0520710
oral/mouse lethal dose (50 percent kill): 700 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
TPKVAL 4,81,1962
oral/mouse lowest published lethal dose: 500 mg/kgLiver: Fatty liver degeneration

Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 4,81,1962
oral/rabbit lethal dose (50 percent kill): 1 gm/kgGTPZAB 23(9),55,1979
oral/rat lethal dose (50 percent kill): 1720 mg/kgTXAPA9 42,417,1977
skin/rabbit lethal dose (50 percent kill): 1 mL/kgUCDS** 1/13/1972
subcutaneous/rat lethal dose (50 percent kill): 1500 mg/kgGTPZAB 23(9),55,1979

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 102 ppm/24H/30D- continuousBehavioral: Somnolence (general depressed activity)

Skin: After systemic exposure: Dermatitis, irritative

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 21,374,1960
inhalation/guinea pig lowest published toxic concentration: 75 ppm/24H/24D- continuousBehavioral: Somnolence (general depressed activity)

Skin: After systemic exposure: Dermatitis, irritative

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 21,374,1960
inhalation/rat lowest published toxic concentration: 0.3 gm/m3/0.5Y- intermittentLung, Thorax, or Respiration: Respiratory depression

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Proteinuria
TPKVAL 4,81,1962
inhalation/rat lowest published toxic concentration: 66 ppm/24H/30D- continuousBehavioral: Somnolence (general depressed activity)

Skin: After systemic exposure: Dermatitis, irritative

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 21,374,1960
inhalation/rat lowest published toxic concentration: 300 mg/m3/5H/26W- intermittentKidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 23(9),55,1979
oral/rat lowest published toxic dose: 115 gm/kg/90D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0516797
oral/rat lowest published toxic dose: 105 mg/kg/30W- intermittentLiver: Liver function tests impaired

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 29(2),9,1964

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 3 ppm;short term exposure limit 6 ppmDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,266,2005
TOXICOLOGY REVIEWTXAPA9 243,239,2010
TOXICOLOGY REVIEWFCTOD7 55,596,2013
TOXICOLOGY REVIEWREPTED 58,252,2015

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,308,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 3 ppm (6 mg/m3)DTLVS* 3,100,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 3 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 3 ppm (7.5 mg/m3), short term exposure limit 6 ppm (15 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 ppm (2.5 mg/m3);KZW 3 ppm (7.6 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (2.5 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 3 ppm (7.6 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (2.5 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 2.5 mg/m3 (1 ppm);short term exposure limit 7.6 mg/m3 (3 ppm), skin, FEB2006
Occupational Exposure Limit-FINLANDtime-weighted average 1 ppm (2.5 mg/m3), short term exposure limit 3 ppm (7.6 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 3 ppm (8 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 2 ppm (5.1 mg/m3), skin, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (2.5 mg/m3), short term exposure limit 3 ppm (7.6 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 3 ppm (7.5 mg/m3), MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 3 ppm (8 mg/m3), short term exposure limit 6 ppm (15 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 3 ppm (8 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 3 ppm (7.5 mg/m3); short term exposure limit 6 ppm (15 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 3 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 3 ppm (7.5 mg/m3); short term exposure limit 6 ppm (15 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 3 mg/m3, short term exposure limit 10 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 3 ppm (8 mg/m3);short term exposure limit 6 ppm (15 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (5 mg/m3), KZG-week 4 ppm (10 mg/m3), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 2.5 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 3 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (2.5 mg/m3);short term exposure limit 3 ppm (7.6 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 3 ppm (6 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 3 ppm (6 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 3 ppm (6 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 3 ppm (6 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHANOLAMINE-air10H time-weighted average 3 ppm;short term exposure limit 6 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 04980; Number of Industries 274; Total Number of Facilities 56219; Number of Occupations 190; Total Number of Employees Exposed 1163087; Total Number of Female Employees Exposed 328648
National Occupational Hazard Survey 1974Hazard Code 04980; Number of Industries 201; Total Number of Facilities 33147; Number of Occupations 144; Total Number of Employees Exposed 499260

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Aminoethanol compounds I, 2007; compounds II, 3509
NIOSH Analytical Method, 1996: Aminoethanol compounds II, 3509
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