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Registry of Toxic Effects of Chemical Substances (RTECS)

Dipropylene glycol, monomethyl ether

RTECS #

JM1575000

CAS #

34590-94-8; 12002-25-4; 12002-35-6; 83730-60-3; 104512-57-4; 112388-78-0

Updated

July 2016

Molecular Weight

148.23

Molecular Formula

C7H16O3

Synonyms

1-(1-Methyl-2-methoxyethoxy)-2-propanol
1-(2-Methoxyisopropoxy)-2-propanol
1,4-Dimethyl-3,6-dioxa-1-heptanol
Arcosolv
Dipropylene glycol methyl ether
Dipropylene glycol methyl ether (ACGIH:OSHA)
Dowanol DPM
Dowanol-50B
Kino-red
Methyl dipropanol
Oxybispropanol methyl ether
Ucar solvent 2LM

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 8 mg mildJTOTDO 2,229,1983/1984
eye /rabbit 500 mg/24H mild85JCAE -,633,1986
skin /rabbit 500 mg open irritation test mildUCDS** 11/15/1971

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 3000 mg/m3Behavioral: General anestheticVCVGK* -,175,1984
oral/Dog lethal dose (50 percent kill): 7500 mg/kgLung, Thorax, or Respiration: Other changesJPETAB 102,79,1951
oral/rat lethal dose (50 percent kill): 5400 µL/kgAMIHBC 9,509,1954
oral/rat lethal dose (50 percent kill): 5.5 mL/kgVCVGK* -,175,1984
skin/rabbit lethal dose (50 percent kill): 10 mL/kgAIHAAP 23,95,1962

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 2000 mg/m3/7H/26W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,175,1994
inhalation/monkey lowest published toxic concentration: 2000 mg/m3/7H/26W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,175,1994
inhalation/rabbit lowest published toxic concentration: 2000 mg/m3/7H/26W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,175,1994
inhalation/rat lowest published toxic concentration: 2000 mg/m3/7H/26W- intermittentBrain and Coverings: Other degenerative changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,175,1994
skin/rabbit lowest published toxic dose: 650 mL/kg/13W- intermittentBehavioral: General anesthetic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHBC 9,509,1954

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 100 ppm;short term exposure limit 150 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWENTOX* -,451,2005
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWREPTED 58,252,2015

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 100 ppm (600 mg/m3) (skin)DTLVS* 3,96,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 50 ppm (308 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (307 mg/m3);KZW 100 ppm (614 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 50 ppm (308 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 50 ppm (300 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 308 mg/m3 (50 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (310 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 50 ppm (308 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 50 ppm (310 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 308 mg/m3, short term exposure limit 308 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 50 ppm (300 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 100 ppm (600 mg/m3), short term exposure limit 150 ppm (900 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 100 ppm (60 mg/m3);short term exposure limit 150 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 100 ppm (606 mg/m3); short term exposure limit 150 ppm (909 mg/m3), skin, JAN2002
Occupational Exposure Limit-PERUtime-weighted average 100 ppm (606 mg/m3); short term exposure limit 150 ppm (909 mg/m3), JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 50 ppm (300 mg/m3);short term exposure limit 75 ppm (450 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 50 ppm (300 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 300 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 100 ppm (600 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 300 ppm (600 mg/m3), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 50 ppm (308 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 100 ppm (600 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 100 ppm (600 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 100 ppm (600 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 100 ppm (600 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air10H time-weighted average 100 ppm (Sk);short term exposure limit 150 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84537; Number of Industries 123; Total Number of Facilities 15846; Number of Occupations 89; Total Number of Employees Exposed 210740; Total Number of Female Employees Exposed 21792
National Occupational Hazard Survey 1974Hazard Code 84537; Number of Industries 66; Total Number of Facilities 5594; Number of Occupations 55; Total Number of Employees Exposed 52536

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #101
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