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Registry of Toxic Effects of Chemical Substances (RTECS)

Diethylenetriamine

RTECS #

IE1225000

CAS #

111-40-0

Updated

October 2017

Molecular Weight

103.20

Molecular Formula

C4H13N3

Synonyms

1,2-Ethanediamine, N-(2-aminoethyl)-
1,4,7-Triazaheptane
2,2'-Diaminodiethylamine
2,2'-Iminobis(ethanamine)
3-Azapentane-1,5-diamine
Aminoethylethandiamine
Bis(2-aminoethyl)amine
Bis(beta-aminoethyl)amine
ChS-P 1
Diethylamine, 2,2'-diamino-
Diethylenetriamine (ACGIH:OSHA)
Ethylamine, 2,2'-iminobis-
Ethylenediamine, N-(2-aminoethyl)-

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 500 mg open irritation test moderateUCDS** 12/30/1971
skin /rabbit 500 mgIYKEDH 6,170,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, leukemia cells Inhibitor Concentration (5 percent kill): 127 mg/L/30MIn Vitro Toxicity Studies: Cell countingTIVIEQ 27,857,2013
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 110 mg/L/30MIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,857,2013
In Vitro/Human, leukemia cells Inhibitor Concentration (25 percent kill): 1221.6 mg/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 26,1150,2012
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): >2000 µmol/L/48HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TXAPA9 245,281,2010
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 1259.4 µmol/L/48HIn Vitro Toxicity Studies: Other assaysTXAPA9 245,281,2010
inhalation/rat Lowest published lethal concentration: 70 mg/m3/4HNTIS** OTS0556409
intraperitoneal/mouse lethal dose (50 percent kill): 71 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Peritonitis
AMIHAB 17,129,1958
intraperitoneal/rat lethal dose (50 percent kill): 74 mg/kgBehavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Peritonitis
AMIHAB 17,129,1958
oral/rat lethal dose (50 percent kill): 1080 mg/kgBehavioral: Convulsions or effect on seizure thresholdAMIHAB 17,129,1958
skin/guinea pig lethal dose (50 percent kill): 170 µL/kgJIHTAB 26,269,1944
skin/rabbit lethal dose (50 percent kill): 1090 mg/kgJIHTAB 31,60,1949
unreported route/guinea pig lethal dose (50 percent kill): 600 mg/kgGISAAA 37(7),103,1972
unreported route/mouse lethal dose (50 percent kill): 970 mg/kgGISAAA 37(7),103,1972
unreported route/rabbit lethal dose (50 percent kill): 970 mg/kgGISAAA 37(7),103,1972
unreported route/rat lethal dose (50 percent kill): 970 mg/kgGISAAA 37(7),103,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 1820 mg/kg/26W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesGISAAA 37(7),103,1972

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 1 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWJJOMDZ 15,808,1973
TOXICOLOGY REVIEWFCTOD7 55,596,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 ppm (4 mg/m3) (skin)DTLWS* 3,85,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 ppm (4.2 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1 ppm (4 mg/m3), sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1 ppm (4.3 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1 ppm (4 mg/m3), skin, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.46 ppm (2 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 1 ppm (4 mg/m3), FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 4 mg/m3, short term exposure limit 4 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 1 ppm (4 mg/m3), skin, sen, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 1 ppm (4 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 1 ppm (4.2 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 1 ppm (4.2 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 1 ppm (4 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 1 ppm (4.2 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 ppm (4.5 mg/m3);short term exposure limit 2 ppm (10 mg/m3), Skin, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1 ppm (4 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 4 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 1 ppm (4.3 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 10 ppm (42 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 10 ppm (42 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIETHYLENE TRIAMINE-air10H time-weighted average 1 ppm (Sk)NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code 25210; Number of Industries 78; Total Number of Facilities 2978; Number of Occupations 74; Total Number of Employees Exposed 94517; Total Number of Female Employees Exposed 15589
National Occupational Hazard Survey 1974Hazard Code 25210; Number of Industries 66; Total Number of Facilities 2804; Number of Occupations 56; Total Number of Employees Exposed 38557

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Diethylenetriamine, 2540
OSHA ANALYTICAL METHOD #ID-60
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