Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

p-Cresol, 2,6-di-tert-butyl-

RTECS #

GO7875000

CAS #

128-37-0; 58500-82-6

Updated

December 2016

Molecular Weight

220.39

Molecular Formula

C15H24O

Synonyms

2,6-Bis(1,1-dimethylethyl)-4-methylphenol
2,6-Di-terc.butyl-p-kresol (Czech)
2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene
2,6-Di-tert-butyl-4-methylphenol
2,6-Di-tert-butyl-p-cresol
2,6-Di-tert-butyl-p-cresol (ACGIH)
2,6-Di-tert-butyl-p-methylphenol
3,5-Di-tert-butyl-4-hydroxytoluene
4-Hydroxy-3,5-di-tert-butyltoluene
4-Methyl-2,6-di-terc. butylfenol (Czech)
4-Methyl-2,6-di-tert-butylphenol
Advastab 401
Agidol
Agidol 1
Alkofen BP
Antioxidant 29
Antioxidant 30
Antioxidant 4
Antioxidant 4K
Antioxidant DBPC
Antioxidant KB
Antrancine 8
AO 29
AO 4K
BHT
BHT (food grade)
BUKS
Butylated hydroxytoluene
Butylhydroxytoluene
Butylohydroksytoluenu (Polish)
CAO 1
CAO 3
Catalin cao-3
Chemanox 11
Dalpac
DBMP
DBPC
DBPC (technical grade)
Deenax
Dibunol
Dibutylated hydroxytoluene
Impruvol
Ionol
Ionol (antioxidant)
Ionol 1
Ionol CP
Ionole
Kerabit
Methyldi-tert-butylphenol
NCI-C03598
Nocrac 200
Nonox TBC
P 21
Parabar 441
Paranox 441
Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl- (9CI)
Stavox
Sumilizer BHT
Sustane BHT
Swanox BHT
Tenamene 3
Tenox BHT
Topanol
Topanol O
Topanol OC
Toxolan P
Vanlube PC
Vanlube PCX
Vianol
Vulkanox KB

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg/24H moderate85JCAE -,229,1986
skin /human 500 mg/48H mildAMIHBC 5,311,1952
skin /rabbit 500 mg/48H moderateAMIHBC 5,311,1952

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster100 µg/LMUREAV 345,73,1995
DNA Damageoral/mouse100 mg/kgMUREAV 519,103,2002
DNA Damageoral/rat1400 mg/kg/2DHPV260 -,-,2001
DNA Damageoral/rat1400 mg/kgFCTOD7 25,603,1987
DNA inhibitionHeLa cell/human500 µmol/LCRNGDP 13,2389,1992
DNA inhibitionlymphocyte/human20 µmol/LBBRCA9 80,963,1978
DNA inhibitionintraperitoneal/mouse250 mg/kgCBINA8 19,279,1977
Dominant Lethal Testoral/mouse12 gm/kg/10W-continuousNTIS** PB278-026
Dominant Lethal Testoral/rat5460 mg/kg/10W-continuousENMUDM 8,357,1986
mutation in mammalian somatic cellslymphocyte/mouse6 mg/LEMMUEG 11,91,1988
mutation in microorganismslymphocyte/mouse6 mg/L (+enzymatic activation step)EMMUEG 11,91,1988
other mutation test systemsoral/mouse500 mg/kgMUREAV 343,157,1995
specific locus testother cell types/mouse45 µmol/LMUREAV 608,29,2006
sperm morphologyintraperitoneal/mouse350 mg/kg/5D- intermittentCMMUAO 5,257,1978
Unscheduled DNA Synthesisoral/rat16800 mg/kg/4W-continuousTXAPA9 99,37,1989
Unscheduled DNA Synthesisliver/rat100 pmol/LCRNGDP 5,1547,1984
Unscheduled DNA Synthesisintraperitoneal/rat1200 mg/kg/3D-continuousDANKAS 287,371,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 6 gm/kg (13W male/13W pre-3W after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)FCTOD7 24,1,1986
oral/rat 18 gm/kg (2W male/2W pre-3W after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral
FCTXAV 19,153,1981
oral/rat 9 gm/kg (2W male/2W pre-3W after birth)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)FCTXAV 19,153,1981
oral/rat 35 gm/kg (10W male)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)ENMUDM 8,357,1986
oral/mouse 43800 mg/kg (52D prior to copulation/1-21D pregnant)Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FCTXAV 3,371,1965
oral/mouse 12600 mg/kg (1-21D pregnant)Reproductive: Effects on newborn: BehavioralFEPRA7 31,596,1972
oral/mouse 1200 mg/kg (9D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTRENAF 28(2),45,1977
oral/rat 28000 mg/kg (multigeneration)Reproductive: Other effects on female

Reproductive: Effects on newborn: Biochemical and metabolic
HPV260 -,-,2001
oral/rat 3300 mg/kg (7-17D pregnant)Reproductive: Effects on newborn: PhysicalHPV260 -,-,2001
oral/mouse 1200 mg/kg (9D pregnant)Reproductive: Other effects on femaleHPV260 -,-,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 435 mg/kg/69W- continuousTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Gastrointestinal: Tumors
FCTXAV 12,367,1974
oral/mouse toxic dose: 1423 mg/kg/43W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
TXCYAC 38,151,1986
oral/mouse lowest published toxic dose: 1200 mg/kg/3W- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously
CALEDQ 145,101,1999
oral/rat lowest published toxic dose: 134 gm/kg/32W- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Cells (cultured) transformed
CRNGDP 4,895,1983
oral/rat toxic dose: 247 gm/kgTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
FCTOD7 24,1121,1986
oral/rat toxic dose: 963 gm/kgTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
FCTOD7 24,1071,1986
oral/rat toxic dose: 247 gm/kg/3Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Liver: Tumors
FCTOD7 24,1,1986
oral/rat toxic dose: 247 gm/kg/3Y- continuousTumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors
FCTOD7 24,1,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 10 mg/LBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductasesJOETD7 146,456,2013
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 2.5 mg/L/16HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJOETD7 146,456,2013
In Vitro/Human, lung tumor Inhibitor Concentration (50 percent kill): 0.15 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (dye exclusion): trypan blue assay etc.TIVIEQ 1,85,1987
In Vitro/Rat, lung Inhibitor Concentration (50 percent kill): 4.04 mmol/L/24HIn Vitro Toxicity Studies: Cell countingTIVIEQ 18,79,2004
intraperitoneal/mouse lowest published toxic dose: 150 mg/kgLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other proteins
CRTOEC 21,1631,2008
intraperitoneal/mouse lethal dose (50 percent kill): 138 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
IJTOFN 21,19,2002
intraperitoneal/mouse lethal dose (50 percent kill): 138 mg/kgENTOX* -,365,2005
intraperitoneal/mouse lethal dose (50 percent kill): 138 mg/kgLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
TXAPA9 61,475,1981
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,212,1994
intraperitoneal/rat lethal dose (50 percent kill): 8 gm/kgIJTOFN 21,19,2002
intraperitoneal/rat lowest published toxic dose: 10 mg/kgLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
FATOAO 55,34,1992
intraperitoneal/rat lowest published toxic dose: 1 mg/kgImmunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement)TXAPA9 223,164,2007
intravenous/mouse lethal dose (50 percent kill): 180 mg/kgBehavioral: SleepJMCMAR 23,1350,1980
oral/cat lowest published lethal dose: 940 mg/kgGastrointestinal: Hypermotility, diarrhea

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
AMIHAB 11,93,1955
oral/cat lowest published lethal dose: 940 mg/kgVCVGK* -,212,1994
oral/guinea pig lethal dose (50 percent kill): 10700 mg/kgGastrointestinal: Hypermotility, diarrhea

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
AMIHAB 11,93,1955
oral/guinea pig lethal dose (50 percent kill): 10700 mg/kgENTOX* -,365,2005
oral/mouse lethal dose (50 percent kill): 1040 mg/kgENTOX* -,365,2005
oral/mouse lethal dose (50 percent kill): 650 mg/kgBehavioral: Tremor

Behavioral: Ataxia

Lung, Thorax, or Respiration: Other changes
IJTOFN 21,19,2002
oral/mouse lowest published toxic dose: 50 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationEKFAE9 62,56,1999
oral/mouse lethal dose (50 percent kill): 650 mg/kgBehavioral: Tremor

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
SRTCAC 36(1-4),10,1989
oral/rabbit lowest published lethal dose: 2100 mg/kgGastrointestinal: Hypermotility, diarrhea

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
AMIHAB 11,93,1955
oral/rabbit lethal dose (50 percent kill): 2100 mg/kgVCVGK* -,212,1994
oral/rabbit lowest published lethal dose: 2000 mg/kgVCVGK* -,212,1994
oral/rat lowest published toxic dose: 25 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
EKFAE9 62,56,1999
oral/rat lethal dose (50 percent kill): 890 mg/kgENTOX* -,365,2005
oral/woman lowest published toxic dose: 80 mg/kgBehavioral: Coma

Gastrointestinal: Gastritis

Gastrointestinal: Nausea or vomiting
NEJMAG 314,648,1986
rectal/mouse lowest published toxic dose: 50 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationEKFAE9 62,56,1999
rectal/rat lowest published toxic dose: 25 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
EKFAE9 62,56,1999
skin/rat lethal dose (50 percent kill): >2000 mg/kgHPV260 -,-,2001
subcutaneous/mouse lethal dose (50 percent kill): 650 mg/kgENTOX* -,365,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/guinea pig lowest published toxic dose: 570 mg/kg/3D- intermittentBlood: Change in clotting factorsVCVGK* -,212,1994
intraperitoneal/hamster lowest published toxic dose: 1140 mg/kg/3D- intermittentBrain and Coverings: Changes in circulation

Behavioral: Tremor
VCVGK* -,212,1994
intraperitoneal/mouse lowest published toxic dose: 1750 mg/kg/1W- intermittentGastrointestinal: Tumors

Liver: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
VCVGK* -,213,1994
intraperitoneal/mouse lowest published toxic dose: 600 mg/kg/4W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other proteins
CRTOEC 21,1631,2008
intraperitoneal/mouse lowest published toxic dose: 750 mg/kg/3W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 169,1,2001
intraperitoneal/mouse lowest published toxic dose: 750 mg/kg/3W- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXCYAC 169,1,2001
intraperitoneal/mouse lowest published toxic dose: 735 mg/kg/4W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
JNCIEQ 97,1778,2005
intraperitoneal/rabbit lowest published toxic dose: 480 mg/kg/4D- intermittentCardiac: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
FATOAO 55,19,1992
oral/hamster lowest published toxic dose: 1596 mg/kg/14D- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FCTOD7 34,595,1996
oral/monkey lowest published toxic dose: 14 gm/kg/4W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphatasesFCTXAV 10,769,1972
oral/mouse lowest published toxic dose: 13500 mg/kg/18D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
FCTXAV 3,417,1965
oral/mouse lowest published toxic dose: 48600 mg/kg/30D- continuousLung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
FCTOD7 30,89,1992
oral/mouse lowest published toxic dose: 10.08 mg/kg/1W- continuousBrain and Coverings: Changes in circulation

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,212,1994
oral/mouse lowest published toxic dose: 2000 mg/kg/4D- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,212,1994
oral/rat lowest published toxic dose: 6.3 mg/kg/1W- continuousBrain and Coverings: Changes in circulation

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,212,1994
oral/rat lowest published toxic dose: 547.5 mg/kg/2Y- continuousBrain and Coverings: Changes in brain weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,213,1994
oral/rat lowest published toxic dose: 1200 mg/kg/3D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferasesFATOAO 50,81,1987
oral/rat lowest published toxic dose: 840 mg/kg/14D- intermittentCardiac: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
EKFAE9 56,47,1993
oral/rat lowest published toxic dose: 5185 mg/kg/4W- continuousLiver: Other changes

Liver: Changes in liver weight
TOLED5 87,103,1996
oral/rat lowest published toxic dose: 109 gm/kg/2Y- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
FCTXAV 19,147,1981
oral/rat lowest published toxic dose: 27 gm/kg/90D- continuousLiver: Changes in liver weight

Endocrine: Evidence of thyroid hyperfunction

Endocrine: Changes in thyroid weight
TOLED5 10,239,1982
oral/rat lowest published toxic dose: 37800 mg/kg/6W- continuousLiver: Changes in liver weight

Endocrine: Changes in adrenal weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AJEBAK 39,353,1961
oral/rat lowest published toxic dose: 5600 mg/kg/16W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes in urine composition
FCTXAV 3,433,1965
oral/rat lowest published toxic dose: 275 mg/kg/26W- continuousLiver: Changes in liver weight

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AJEBAK 37,533,1959
oral/rat lowest published toxic dose: 112 gm/kg/80W- continuousLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 7,289,1977
oral/rat lowest published toxic dose: 5040 mg/kg/7D- continuousLiver: Changes in liver weight

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
APTOA6 49,14,1981
oral/rat lowest published toxic dose: 350 mg/kg/7D- intermittentGastrointestinal: Other changes

Liver: Other changes
FATOAO 47,87,1984
oral/rat lowest published toxic dose: 350 mg/kg/7D- intermittentGastrointestinal: Other changesFATOAO 47,87,1984
oral/rat lowest published toxic dose: 500 mg/kg/5D- intermittentGastrointestinal: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
EKFAE9 61,21,1998
oral/rat lowest published toxic dose: 39.7 mg/kg/3D- intermittentBlood: Change in clotting factorsEKFAE9 62,38,1999
oral/rat lowest published toxic dose: 6300 mg/kg/6W- continuousLiver: Tumors

Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent
CALEDQ 143,173,1999
oral/rat lowest published toxic dose: 2.625 mg/kg/1W- continuousLiver: Other changes

Blood: Change in clotting factors

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
VCVGK* -,212,1994
oral/rat lowest published toxic dose: 2000 mg/kg/4D- intermittentLiver: Multiple effects

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,212,1994
oral/rat lowest published toxic dose: 4200 mg/kg/14D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
BIJOAK 300,117,1994
oral/rat lowest published toxic dose: 778.4 mg/kg/28D- continuousLiver: Other changesFCTOD7 46,2616,2008
oral/rat lowest published toxic dose: 2458.4 mg/kg/28D- continuousLiver: Other changes

Liver: Changes in liver weight
FCTOD7 46,2616,2008
oral/rat lowest published toxic dose: 4673.2 mg/kg/28D- continuousLiver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FCTOD7 46,2616,2008
oral/rat lowest published toxic dose: 8999.2 mg/kg/28D- continuousLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTOD7 46,2616,2008
oral/rat lowest published toxic dose: 32446.4 mg/kg/28D- continuousLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 46,2616,2008
oral/rat lowest published toxic dose: 239400 mg/kg/76W- intermittentLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV260 -,-,2001
oral/rat lowest published toxic dose: 119700 mg/kg/76W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainHPV260 -,-,2001
skin/mouse lowest published toxic dose: 5 gm/kg/4W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOLED5 34,99,1986

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 mg/m3 (inhal, vapor)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 40,161,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 40,161,1986
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWFEPRA7 35,89,1976
TOXICOLOGY REVIEWIJTOFN 21,19,2002
TOXICOLOGY REVIEWENTOX* -,365,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 659,15,2008
TOXICOLOGY REVIEWHUTOX* -,259,1996
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWMUREAV 705,184,2010
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 mg/m3, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 mg/m3, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 10 mg/m3, FEB2006
Occupational Exposure Limit-GERMANYMAK 10 mg/m3, C carcinogen, 2011
Occupational Exposure Limit-GERMANYMAK 10 mg/m3, inhal, 2011
Occupational Exposure Limit-ICELANDtime-weighted average 10 mg/m3, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 10 mg/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 mg/m3;short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg/m3, inhal, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3, OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,6-DI-t-BUTYL-p-CRESOL-air10H time-weighted average 10 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 83383; Number of Industries 210; Total Number of Facilities 27242; Number of Occupations 154; Total Number of Employees Exposed 591238; Total Number of Female Employees Exposed 163774
National Occupational Hazard Survey 1974Hazard Code 83383; Number of Industries 32; Total Number of Facilities 1526; Number of Occupations 39; Total Number of Employees Exposed 28860

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Mouse specific locus
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9076
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,ratNCITR* NCI-TR-150,1979
TOP