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Registry of Toxic Effects of Chemical Substances (RTECS)

Camphor

RTECS #

EX1225000

CAS #

76-22-2

Updated

October 2017

Molecular Weight

152.26

Molecular Formula

C10H16O

Synonyms

1,7,7-Trimethylbicyclo(2.2.1)-2-heptanone
2-Bornanone
2-Camphanone
2-Kamfanon (Czech)
2-Keto-1,7,7-trimethylnorcamphane
Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-
Bornane, 2-oxo-
Camphor, natural
Camphor, synthetic
Camphor, synthetic (ACGIH:OSHA)
Formosa camphor
Gum camphor
Huile de camphre (French)
Japan camphor
Kampfer (German)
Laurel camphor
Matricaria camphor
Norcamphor, 1,7,7-trimethyl-

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damagekidney/monkey500 µmol/L/20HFCTOD7 49,2035,2011
sister chromatid exchangeintraperitoneal/mouse80 mg/kgMUREAV 224,157,1989

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 400 mg/m3/3HBehavioral: Muscle contraction or spasticityGISAAA 22(11),83,1957
inhalation/mouse lethal concentration (50 percent kill): 450 mg/m3Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Gastrointestinal: Nausea or vomiting
VCVPS* -,296,1998
inhalation/rat lethal concentration (50 percent kill): 500 mg/m3VCVPS* -,296,1998
intraperitoneal/cat lowest published lethal dose: 400 mg/kgHBAMAK 4,1289,1935
intraperitoneal/mouse lethal dose (50 percent kill): 3 gm/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Behavioral: Rigidity (includes catalepsy)
AJPAA4 30,857,1954
intraperitoneal/rat lowest published lethal dose: 900 mg/kgBehavioral: Convulsions or effect on seizure thresholdJPETAB 65,275,1939
oral/child lowest published toxic dose: 51 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
AJEMEN 7,41,1989
oral/Dog lowest published lethal dose: 800 mg/kgHBAMAK 4,1289,1935
oral/infant lowest published lethal dose: 70 mg/kgEye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
AJPAA4 30,857,1954
oral/mouse lethal dose (50 percent kill): 1310 mg/kgSHGKA3 75,934,1975
oral/mouse lowest published toxic dose: 15 mg/kg/5HLung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
PYTOEY 21,1298,2014
oral/rabbit lowest published lethal dose: 2 gm/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Behavioral: Rigidity (includes catalepsy)
AJPAA4 30,857,1954
subcutaneous/frog lowest published lethal dose: 240 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory changeAEXPBL 50,199,1903
subcutaneous/mouse lowest published toxic dose: 7.6 mg/kgBehavioral: AnalgesiaPYTOEY 23,429,2016
subcutaneous/mouse lowest published lethal dose: 200 mg/kgBehavioral: ExcitementHDTU** -,-,1933
subcutaneous/rat lethal dose (50 percent kill): 70 mg/kgCDGU** -,-,1934
unreported route/child lowest published lethal dose: 100 mg/kgYKYUA6 31,1499,1980
unreported route/human lowest published toxic dose: 0.01 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tetany

Lung, Thorax, or Respiration: Respiratory depression
VCVPS* -,296,1998
unreported route/man lowest published lethal dose: 29 mg/kg85DCAI 2,73,1970

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 210 mg/m3/3H/7W- intermittentLung, Thorax, or Respiration: EmphysemaGISAAA 22(11),83,1957
inhalation/rabbit lowest published toxic concentration: 33 mg/m3/3H/7W- intermittentBrain and Coverings: Other degenerative changes

Cardiac: Other changes

Lung, Thorax, or Respiration: Emphysema
GISAAA 22(11),83,1957

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppm;short term exposure limit 3 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWJRPMAP 12,27,1974
TOXICOLOGY REVIEWNTIS** PB293-503
TOXICOLOGY REVIEWHUTOX* -,247,1996
TOXICOLOGY REVIEWCLLID* 13,277,2009
TOXICOLOGY REVIEWFCTOD7 81,9,2015

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,267,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 2 ppm (12 mg/m3)DTLVS* 3,37,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (12 mg/m3), short term exposure limit 3 ppm (19 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 ppm (13 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (12 mg/m3), short term exposure limit 3 ppm (19 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (12 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 0.3 ppm (1.9 mg/m3), short term exposure limit 0.9 ppm (5.7 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 2 ppm (12 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 2 ppm (13 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (12 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (12 mg/m3), short term exposure limit 3 ppm (18 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 2 ppm (12 mg/m3);short term exposure limit 3 ppm (19 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (12 mg/m3); short term exposure limit 3 ppm (19 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (12.4 mg/m3); short term exposure limit 3 ppm (18.7 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAshort term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (13 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 12 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 2 ppm, JAN1999
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2 ppm (13 mg/m3);short term exposure limit 3 ppm (19 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 2 mg/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 2 mg/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 2 mg/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 2 mg/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CAMPHOR, synthetic-air10H time-weighted average 2 mg/m3NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983Hazard Code X1190; Number of Industries 1; Total Number of Facilities 25; Number of Occupations 1; Total Number of Employees Exposed 427; Total Number of Female Employees Exposed 176
National Occupational Exposure Survey 1983Hazard Code 15800; Number of Industries 101; Total Number of Facilities 9166; Number of Occupations 87; Total Number of Employees Exposed 153554; Total Number of Female Employees Exposed 53187
National Occupational Hazard Survey 1974Hazard Code 15800; Number of Industries 68; Total Number of Facilities 8356; Number of Occupations 63; Total Number of Employees Exposed 95578

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301
NTP Carcinogenesis studies; test completed (peer review), October 2000
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