n-Butanethiol

RTECS #

EK6300000

CAS #

109-79-5
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

90.20

Molecular Formula

C₄H₁₀S

Synonyms

Butanethiol (OSHA)
Butyl mercaptan
Butyl mercaptan (DOT:OSHA)
n-Butyl mercaptan
n-Butyl mercaptan (ACGIH)
NCI-C60866

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	83 mg		AIHAAP 19,171,1958

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	68 ppm/6H (6-16D pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Musculoskeletal system	FAATDF 8,170,1987

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/Dog	lethal concentration (50 percent kill): 770 ppm/30M		85JCAE -,982,1986
inhalation/mouse	lethal concentration (50 percent kill): 2500 ppm/4H	Lung, Thorax, or Respiration: Respiratory stimulation Behavioral: Somnolence (general depressed activity) Eye: Lacrimation	AIHAAP 19,171,1958
inhalation/rat	lethal concentration (50 percent kill): 4020 ppm/4H	Lung, Thorax, or Respiration: Respiratory stimulation Behavioral: Somnolence (general depressed activity) Eye: Lacrimation	AIHAAP 19,171,1958
intraperitoneal/rat	lethal dose (50 percent kill): 399 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression Behavioral: Coma	AIHAAP 19,171,1958
oral/mouse	lethal dose (50 percent kill): 3 gm/kg		85JCAE -,982,1986
oral/rat	lethal dose (50 percent kill): 1500 mg/kg	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression Behavioral: Coma	AIHAAP 19,171,1958

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 1114 ppm/6H/2W- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTIS** OTS0555470

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.5 ppm	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES	Active registration	RBREV* -,357,1998
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 0.5 ppm (1.5 mg/m³)	DTLWS* 3,12,1973
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.5 ppm (1.8 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.5 ppm (1.5 mg/m³);KZW 0.5 ppm (1.5 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.5 ppm (1.8 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.5 ppm (1.5 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.5 ppm (1.9 mg/m³), short term exposure limit 1.5 ppm (5.6 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 0.5 ppm (1.5 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 0.5 ppm (1.9 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 0.5 ppm (1.5 mg/m³), NOV2011
Occupational Exposure Limit-INDIA	time-weighted average 0.5 ppm (1.5 mg/m³), JAN1993
Occupational Exposure Limit-KOREA	time-weighted average 0.5 ppm (1.5 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.5 ppm (1.5 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.5 ppm (1.8 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 0.5 ppm (1.8 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	time-weighted average 1 mg/m³, short term exposure limit 2 mg/m³, JAN1999
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.5 ppm (1.9 mg/m³), KZG-week 1 ppm (3.8 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 1.5 mg/m³, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 10 ppm (35 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 0.5 ppm (1.5 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 10 ppm (35 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 10 ppm (35 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 0.5 ppm (1.5 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1-BUTANETHIOL-air	ceiling concentration 0.5 ppm/15M	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 13785; Number of Industries 1; Total Number of Facilities 3; Number of Occupations 8; Total Number of Employees Exposed 106; Total Number of Female Employees Exposed 3
National Occupational Hazard Survey 1974	Hazard Code 13785; Number of Industries 2; Total Number of Facilities 71; Number of Occupations 7; Total Number of Employees Exposed 2764

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Mercaptans, 2542
NIOSH Analytical Method, 1996: n-Butyl mercaptan, 2525

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health