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Registry of Toxic Effects of Chemical Substances (RTECS)

Barium sulfate

RTECS #

CR0600000

CAS #

7727-43-7; 8054-35-1; 12751-32-5

Updated

March 2014

Molecular Weight

233.40

Molecular Formula

O4S·Ba

Synonyms

A 15 (inorganic compound)
Actybaryte
Artificial barite
Artificial heavy spar
BA147
Bakontal
Baridol
Barite
Baritop
Barium sulfate (1:1)
Barium sulfate (ACGIH:OSHA)
Barium sulphate
Barosperse
Barotrast
Baryta White
Barytes
Barytes 22
Bayrites
Blanc fixe
C.I. 77120
C.I. Pigment White 21
Citobaryum
Colonatrast
Enamel White
Esophotrast
Eweiss
E-Z-Paque
Finemeal
Lactobaryt
Liquibarine
Macropaque
Neobar
Oratrast
Permanent White
Precipitated barium sulphate
Raybar
Redi-Flow
Solbar
Sulfuric acid, barium salt (1:1)
Supramike
Travad
Unibaryt

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testintraperitoneal/mouse12500 µg/kgGWZHEW 12,77,1986

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intrapleural/rat lowest published toxic dose: 200 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
BJCAAI 28,173,1973

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intratracheal/mouse Lethal dose: >600 µL/kgLung, Thorax, or Respiration: Other changesOYYAA2 50,123,1995
intratracheal/rat lowest published lethal dose: 250 mg/kgLung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Other changes
VCVN1* -,137,1988
intravenous/woman lowest published lethal dose: 1.25 mL/kgLung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Pleural effusion

Lung, Thorax, or Respiration: Respiratory depression
JTCTDW 41,673,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 250 mg/m3/1H/24W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchiVCVN1* -,139,1988
inhalation/mammal (species unspecified) lowest published toxic concentration: 40 mg/m3/8W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchiVCVN1* -,139,1988

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 mg/m3DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW31BYAP -,94,1974
TOXICOLOGY REVIEWHBTME* ,407,2007
TOXICOLOGY REVIEWDERCL* 27,289,2009
TOXICOLOGY REVIEWTXAPA9 258,151,2012

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(Ba)/m3DTLVS* 3,21,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg/m3, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.5 mg(Ba)/m3, MAY2011
Occupational Exposure Limit-KOREAtime-weighted average 0.5 mg(Ba)/m3, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.5 mg(Ba)/m3, 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 mg/m3 (inspirable dust), JAN2002
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.5 mg(Ba)/m3, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.5 mg(Ba)/m3, JAN1999
Occupational Exposure Limit-PERUtime-weighted average 10 mg/m3, JUL2005
Occupational Exposure Limit-SWEDENtime-weighted average 0.5 mg(Ba)/m3, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 4 mg/m3 (total dust), 2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 1.5 mg/m3 (respirable dust), 2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.5 mg(Ba)/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 10 mg/m3 (inhal, dust), OCT2007
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 4 mg/m3 (resp. dust), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 15 mg/m3, total dustCFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg/m3, respirable fractionCFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BARIUM SULFATE, respirable fraction-air10H time-weighted average 5 mg/m3NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BARIUM SULFATE, total dust-air10H time-weighted average 10 mg/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 80611; Number of Industries 200; Total Number of Facilities 25446; Number of Occupations 133; Total Number of Employees Exposed 363169; Total Number of Female Employees Exposed 96327
National Occupational Hazard Survey 1974Hazard Code 80611; Number of Industries 173; Total Number of Facilities 18620; Number of Occupations 104; Total Number of Employees Exposed 188781

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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