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Registry of Toxic Effects of Chemical Substances (RTECS)

Allyl alcohol

RTECS #

BA5075000

CAS #

107-18-6

Updated

April 2017

Molecular Weight

58.09

Molecular Formula

C3H6O

Synonyms

1-Propen-3-ol
1-Propenol-3
2-Propen-1-ol
2-Propene-1-ol
2-Propenyl alcohol
3-Hydroxypropene
AA
Alcool allilco (Italian)
Alcool allylique (French)
Allilowy alkohol (Polish)
Allyl alcohol (ACGIH:OSHA)
Allylalkohol (German)
Allylic alcohol
Orvinylcarbinol
Propen-1-ol-3
Propenol
Propenyl alcohol
RCRA waste number P005
Shell unkrautted A
Vinylcarbinol
Weed drench

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 25 ppm severeAMIHAB 18,303,1958
eye /rabbit 20 mg severeAJOPAA 29,1363,1946
eye /rabbit 0.1 mLHPV111 -,-,2003
skin /rabbit 0.5 mL mildHPV111 -,-,2003
skin /rabbit 10 mg/24H open irritation testJIHTAB 30,63,1948

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in mammalian somatic cellslung/hamster1 µmol/LCRNGDP 11,497,1990
mutation in mammalian somatic cellsfibroblast/hamster58000 ng/L/2HHPV111 -,-,2003
mutation in microorganisms/Salmonella typhimurium50 µg/plate/45M (+enzymatic activation step)HPV111 -,-,2003
mutation in microorganisms/Salmonella typhimurium20 µmol/L/90M (+enzymatic activation step)HPV111 -,-,2003
mutation in microorganisms/Salmonella typhimurium100 µmol/L (+enzymatic activation step)MUREAV 93,305,1982
mutation in microorganisms/Salmonella typhimurium50 µg/plate (-enzymatic activation step)TCMUD8 1,259,1980

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 2100 mg/kg (84D male)Reproductive: Other effects on male

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV111 -,-,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, kidney Inhibitor Concentration Low: 100 µmol/L/6HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)TXCYAC 290,82,2011
In Vitro/Human, kidney Inhibitor Concentration Low: 100 µmol/L/48HIn Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.)

In Vitro Toxicity Studies: Other assays
TXCYAC 290,82,2011
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 3.7 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/mammal (species unspecified) lethal concentration (50 percent kill): 1 gm/m3GTPZAB 32(10),25,1988
inhalation/monkey Lowest published lethal concentration: 1000 ppm/4HGastrointestinal: Hypermotility, diarrhea

Blood: Hemorrhage

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
JAMAAP 98,2269,1932
inhalation/mouse lethal concentration (50 percent kill): 500 mg/m3/2H85GMAT -,17,1982
inhalation/mouse lethal concentration (50 percent kill): 500 mg/m3/2HCardiac: Other changes

Liver: Hepatitis (hepatocellular necrosis), diffuse
VCVGK* -,121,1984
inhalation/rabbit Lowest published lethal concentration: 1000 ppm/3.5HEye: Iritis

Lung, Thorax, or Respiration: Dyspnea

Blood: Hemorrhage
JAMAAP 98,2269,1932
inhalation/rat lowest published toxic concentration: 140 mg/m3Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VCVGK* -,121,1984
inhalation/rat lowest published toxic concentration: 200 mg/m3Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)VCVGK* -,121,1984
inhalation/rat lethal concentration (50 percent kill): 76 ppm/8HLung, Thorax, or Respiration: Acute pulmonary edemaAMIHAB 18,303,1958
inhalation/rat lethal concentration (50 percent kill): 165 ppm/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Hepatitis (hepatocellular necrosis), zonal
HPV111 -,-,2003
inhalation/rat lethal concentration (50 percent kill): 250 ppm/4HHPV111 -,-,2003
intraperitoneal/mouse lowest published toxic dose: 64 mg/kgLiver: Liver function tests impairedETOPFR 3,129,1997
intraperitoneal/mouse lethal dose (50 percent kill): 60 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Ataxia
AMIHAB 18,303,1958
intraperitoneal/mouse lowest published toxic dose: 64 mg/kgETOPFR 3,129,1997
intraperitoneal/mouse lowest published toxic dose: 60 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesTXCYAC 325,85,2014
intraperitoneal/rat lowest published toxic dose: 0.62 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonal

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 196,155,2004
intraperitoneal/rat lethal dose (50 percent kill): 37 mg/kgTXAPA9 83,108,1986
intraperitoneal/rat lowest published toxic dose: 5 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ETOPFR 18,149,2004
intravenous/mouse lethal dose (50 percent kill): 78 mg/kgAIPTAK 135,330,1962
intravenous/rat lowest published toxic dose: 125 mg/kgLiver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BCPCA6 67,2141,2004
oral/human lowest published lethal dose: 0.43 mL/kgLung, Thorax, or Respiration: Emphysema

Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,121,1984
oral/mammal (species unspecified) lethal dose (50 percent kill): 70 mg/kgGTPZAB 32(10),25,1988
oral/mouse lethal dose (50 percent kill): 75 mg/kgVCVGK* -,121,1984
oral/mouse lethal dose (50 percent kill): 96 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Behavioral: Ataxia
AMIHAB 18,303,1958
oral/mouse lethal dose (50 percent kill): 96 mg/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Acute pulmonary edema
HPV111 -,-,2003
oral/rabbit lethal dose (50 percent kill): 52 mg/kgNTIS** OTS0571508
oral/rat lowest published toxic dose: 50 mg/kgLiver: Multiple effectsFATOAO 50,100,1987
oral/rat lowest published toxic dose: 50 mg/kgLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Liver function tests impaired
FATOAO 50,100,1987
oral/rat lowest published toxic dose: 0.05 mg/kgLiver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VCVGK* -,121,1984
oral/rat lowest published toxic dose: 60 mg/kgGastrointestinal: Ulceration or bleeding from stomach

Liver: Hepatitis (hepatocellular necrosis), zonal

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 66,199,2002
oral/rat lowest published toxic dose: 0.1 mL/kgLiver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
JTPAE7 15,95,2002
oral/rat lethal dose (50 percent kill): 70 mg/kgBehavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea
HPV111 -,-,2003
oral/rat lethal dose (50 percent kill): 99 mg/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Other changes
HPV111 -,-,2003
oral/rat lethal dose (50 percent kill): 64 mg/kgHPV111 -,-,2003
parenteral/frog lowest published lethal dose: 51 mg/kgBehavioral: Excitement

Gastrointestinal: Nausea or vomiting
AIPTAK 50,296,1935
skin/rabbit lethal dose (50 percent kill): 89 mg/kgLung, Thorax, or Respiration: Respiratory depression

Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Other changes
HPV111 -,-,2003
skin/rabbit lethal dose (50 percent kill): 45 mg/kgHPV111 -,-,2003
subcutaneous/rabbit lowest published lethal dose: 100 mg/kgBDBU** -,-,1930
unreported route/Dog lowest published lethal dose: 4270 µg/kgBehavioral: Coma

Gastrointestinal: Nausea or vomiting

Blood: Other changes
JPETAB 25,144,1925
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 66 mg/kgGISAAA 51(5),61,1986
unreported route/rat lowest published toxic dose: 120 mg/kgKidney, Ureter, and Bladder: Other changes in urine compositionTOXID9 44,104,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 60 ppm/7H/13W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AMIHAB 18,303,1958
inhalation/rat lowest published toxic concentration: 40 ppm/12W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV111 -,-,2003
inhalation/rat lowest published toxic concentration: 100 ppm/12W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Liver: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV111 -,-,2003
oral/mouse lowest published toxic dose: 812.5 mg/kg/90D- intermittentGastrointestinal: GastritisTXCYAC 253,79,2008
oral/mouse lowest published toxic dose: 3250 mg/kg/90D- intermittentGastrointestinal: Gastritis

Liver: Hepatitis (hepatocellular necrosis), diffuse
TXCYAC 253,79,2008
oral/rat lowest published toxic dose: 90 mg/kg/3D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)HETOEA 28,231,2009
oral/rat lowest published toxic dose: 610 mg/kg/244D- intermittentLiver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
VCVGK* -,121,1994
oral/rat lowest published toxic dose: 390 mg/kg/90D- intermittentLiver: Changes in liver weightTXCYAC 253,79,2008
oral/rat lowest published toxic dose: 1625 mg/kg/90D- intermittentGastrointestinal: Gastritis

Liver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TXCYAC 253,79,2008
oral/rat lowest published toxic dose: 871.5 mg/kg/15W- intermittentKidney, Ureter, and Bladder: Renal function tests depressedHPV111 -,-,2003
oral/rat lowest published toxic dose: 1470 mg/kg/15W- intermittentKidney, Ureter, and Bladder: Renal function tests depressed

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HPV111 -,-,2003
oral/rat lowest published toxic dose: 724.5 mg/kg/15W- intermittentKidney, Ureter, and Bladder: Changes in kidney weightHPV111 -,-,2003
oral/rat lowest published toxic dose: 4200 mg/kg/15W- continuousBehavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 9,29,1978

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCHHSA* 9,6,2002
TOXICOLOGY REVIEWENTOX* -,80,2005
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWFCTOD7 49,1877,2011
TOXICOLOGY REVIEWFCTOD7 55,596,2013
TOXICOLOGY REVIEWMUREAV 786-788,14,2015

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 2 ppm (5 mg/m3) (skin)DTLVS* 3,7,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 2 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 2 ppm (4.8 mg/m3), short term exposure limit 4 ppm (9.5 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 2 ppm (4.8 mg/m3);KZW 5 ppm (12 mg/m3), skin, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (4.8 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 4 ppm (9.6 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (5 mg/m3), skin, MAY2011
Occupational Exposure Limit-ECtime-weighted average 4.8 mg/m3 (2 ppm);short term exposure limit 12.1 mg/m3 (5 ppm), skin, JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 0.5 ppm (1.2 mg/m3), short term exposure limit 2 ppm (4.8 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 0.2 ppm (0.48 mg/m3), VLE 2 ppm (4.8 mg/m3), Skin, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 4.8 mg/m3, short term exposure limit 12.1 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 2 ppm (4.8 mg/m3), short term exposure limit 5 ppm (12.1 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 1 ppm (2.4 mg/m3), skin, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 2 ppm (5 mg/m3), short term exposure limit 4 ppm (10 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 2 ppm (5 mg/m3);short term exposure limit 4 ppm (10 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 2 ppm (4.8 mg/m3); short term exposure limit 4 ppm (9.5 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 2 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.5 ppm (1.2 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 2 mg/m3, MAC(short term exposure limit) 10 mg/m3, Skin, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 1 ppm, JUN2003
Occupational Exposure Limit-RUSSIAshort term exposure limit 2 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 2 ppm (5 mg/m3);short term exposure limit 6 ppm (14 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 2 ppm (5 mg/m3), KZG-week 4 ppm (10 mg/m3), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 5 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 2 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 2 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 2 ppm (4.8 mg/m3);short term exposure limit 4 ppm, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 2 ppm (5 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 2 ppm (5 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 2 ppm (5 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 2 ppm (5 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ALLYL ALCOHOL-air10H time-weighted average 2 ppm (Sk);short term exposure limit 4 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 04370; Number of Industries 3; Total Number of Facilities 60; Number of Occupations 4; Total Number of Employees Exposed 3246; Total Number of Female Employees Exposed 157
National Occupational Hazard Survey 1974Hazard Code 04370; Number of Industries 3; Total Number of Facilities 69; Number of Occupations 7; Total Number of Employees Exposed 780

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402
NTP Carcinogenesis studies; test completed (peer review), October 2000
On EPA IRIS database
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