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Registry of Toxic Effects of Chemical Substances (RTECS)

Acrylic acid, ethyl ester

RTECS #

AT0700000

CAS #

140-88-5

Updated

June 2017

Molecular Weight

100.13

Molecular Formula

C5H8O2

Synonyms

2-Propanoic acid, ethyl ester
2-Propenoic acid, ethyl ester
Acrylate d'ethyle (French)
Acrylsaeureaethylester (German)
Aethylacrylat (German)
Akrylanem etylu (Polish)
Carboset 511
Ethoxycarbonylethylene
Ethyl 2-propenoate
Ethyl acrylate
Ethyl acrylate (ACGIH:OSHA)
Ethyl propenoate
Ethylacrylaat (Dutch)
Ethylakrylat (Czech)
Ethylester kyseliny akrylove (Czech)
Etil acrilato (Italian)
Etilacrilatului (Romanian)
NCI-C50384
RCRA waste number U113

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /guinea pig 1204 ppm/7HJIHTAB 31,317,1949
eye /monkey 1204 ppm/15H- intermittentJIHTAB 31,317,1949
eye /rabbit 45 mg mildUCDS** 12/14/1971
eye /rabbit 1204 ppm/7HJIHTAB 31,317,1949
eye /rat 1204 ppm/14H- intermittentJIHTAB 31,317,1949
skin /rabbit 500 mg open irritation test mildUCDS** 12/14/1971
skin /rabbit 10 mg/24H mildJIHTAB 31,311,1949
skin /woman 0.1%/48HCODEDG 57,21,2007

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/mouse20 mg/LENMUDM 8(Suppl 6),4,1986
Cytogenetic Analysisovary/hamster299 mg/LSCIEAS 236,933,1987
Cytogenetic Analysislung/hamster9800 µg/LGMCRDC 27,95,1981
DNA Damageother cell types/human10 µmol/L/24H (+enzymatic activation step)MUREAV 760,23,2014
DNA Damageother cell types/human100 µmol/L/24HMUTAEX 31,83,2016
micronucleus testlymphocyte/mouse12 mg/L/30HMUREAV 789,7,2015
micronucleus testother cell types/human6 mg/L/24HMUREAV 789,7,2015
micronucleus testintraperitoneal/mouse225 mg/kgMUREAV 135,189,1984
micronucleus testovary/hamster20 mg/L/24H (-enzymatic activation step)MUREAV 742,11,2012
micronucleus testlymphocyte/human38 mg/L/24H (-enzymatic activation step)MUREAV 742,11,2012
micronucleus testlung/hamster1 mg/L/24H (-enzymatic activation step)MUREAV 742,11,2012
micronucleus testother cell types/human10 mg/L/24H (-enzymatic activation step)MUREAV 742,11,2012
micronucleus testliver/human35 mg/L/24H (-enzymatic activation step)MUREAV 742,11,2012
mutation in mammalian somatic cellslymphocyte/mouse20 mg/LENMUDM 8(Suppl 6),4,1986
mutation in microorganismslymphocyte/mouse20 mg/L (+enzymatic activation step)ENMUDM 8(Suppl 6),4,1986
mutation in microorganisms/Salmonella typhimurium100 µg/plate (-enzymatic activation step)ENMUDM 5(Suppl 1),3,1983
sister chromatid exchangeovary/hamster150 mg/LSCIEAS 236,933,1987
specific locus testother cell types/human100 µmol/L/24HEMMUEG 54,737,2013

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 200 ppm/6H (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOSCF2 48,240,1999
inhalation/rat 200 ppm (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female
TOSCF2 48,240,1999
oral/rat 8 gm/kg (0-19D pregnant)Reproductive: Other effects on femaleNTIS** OTS0557583

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 103 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTPTR* NTP-TR-259,1986
oral/mouse lowest published toxic dose: 51500 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB87-204061/AS
oral/rat lowest published toxic dose: 51500 mg/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTPTR* NTP-TR-259,1986
oral/rat lowest published toxic dose: 51500 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB87-204061/AS

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, skin Inhibitor Concentration (20 percent kill): 40.0 mg/L/21HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 27,314,2013
In Vitro/Human, skin Inhibitor Concentration Low: 40.0 mg/L/4HIn Vitro Toxicity Studies: Other assaysTIVIEQ 27,314,2013
inhalation/guinea pig Lowest published lethal concentration: 1204 ppm/7HBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cough
JIHTAB 31,317,1949
inhalation/human lowest published toxic concentration: 50 ppmOlfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes
34ZIAG -,75,1969
inhalation/human lowest published toxic dose: 5 ppm/4HEye: Other eye effectsTOLED5 196S,S3,2010
inhalation/monkey Lethal concentration: >75 ppm/6HOlfaction: Deviated nasal septum

Olfaction: Ulcerated nasal septum
TOXID9 36(1 Pt2),113,1997
inhalation/mouse lowest published toxic concentration: 200 ppm/6MLung, Thorax, or Respiration: Respiratory depressionTOLED5 9,137,1981
inhalation/mouse lethal concentration (50 percent kill): 16200 mg/m3GTPZAB 23(9),55,1979
inhalation/rabbit Lowest published lethal concentration: 1204 ppm/7HBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea
JIHTAB 31,317,1949
inhalation/rat lowest published toxic concentration: 25 ppm/3HOlfaction: Change in olfactory nerve

Biochemical: Metabolism (intermediary): Other proteins
TXAPA9 183,23,2002
inhalation/rat lowest published toxic concentration: 4.2 gm/m3/6HLiver: Other changes

Endocrine: Hyperglycemia

Biochemical: Metabolism (intermediary): Other
TXCYAC 65,209,1990
inhalation/rat lethal concentration (50 percent kill): 1414 ppm/4HOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
NTIS** OTS0520180
inhalation/rat lethal concentration (50 percent kill): 2180 ppm/4HENTOX* -,279,2005
intraperitoneal/mouse lethal dose (50 percent kill): 599 mg/kgJDREAF 51,526,1972
intraperitoneal/rat lethal dose (50 percent kill): 450 mg/kgAMPMAR 36,58,1975
oral/cat Lethal dose: >800 µL/kgGastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting
NTIS** OTS0521003
oral/mouse lethal dose (50 percent kill): 1799 mg/kgTOLED5 11,125,1982
oral/rabbit lethal dose (50 percent kill): 370 mg/kgGastrointestinal: Alteration in gastric secretionNTIS** OTS0521003
oral/rat lethal dose (50 percent kill): 800 mg/kgBCTKAG 12,405,1979
skin/mouse lethal dose (50 percent kill): 2997 mg/kgNTIS** OTS0520999
skin/rabbit lethal dose (50 percent kill): 500 µL/kgLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0520180
skin/rat lethal dose (50 percent kill): 3049 mg/kgENTOX* -,279,2005
skin/rat lowest published lethal dose: 1800 mg/kgPJPPAA 32,223,1980

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 75 ppm/6H/26W- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
APTOD9 19,A53,1980
inhalation/mouse lowest published toxic concentration: 75 ppm/6H/2Y- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 8,1,1985
inhalation/mouse lowest published toxic concentration: 75 ppm/6H/1Y- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0544830
inhalation/mouse lowest published toxic concentration: 300 ppm/6H/30D- intermittentOlfaction: Deviated nasal septum

Olfaction: Ulcerated nasal septum

Olfaction: Other olfaction effects
NTIS** OTS0540690
inhalation/rat lowest published toxic concentration: 75 ppm/6H/2Y- intermittentOlfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DCTODJ 8,1,1985
inhalation/rat lowest published toxic concentration: 300 ppm/7H/30D- intermittentKidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 31(6),311,1949
inhalation/rat lowest published toxic concentration: 75 ppm/6H/26W- intermittentOlfaction: Other olfaction effectsNTIS** OTS0520180
oral/mouse lowest published toxic dose: 2800 mg/kg/14D- intermittentGastrointestinal: Other changesNTPTR* NTP-TR-259,1986
oral/rat lowest published toxic dose: 5600 mg/kg/28D- continuousGastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0533909
oral/rat lowest published toxic dose: 6500 mg/kg/13W- intermittentGastrointestinal: Other changesNTIS** OTS0540988
oral/rat lowest published toxic dose: 183 gm/kg/2Y- continuousBehavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 6,29,1964
oral/rat lowest published toxic dose: 11200 mg/kg/14D- intermittentGastrointestinal: Ulceration or bleeding from stomachNTPTR* NTP-TR-259,1986
oral/rat lowest published toxic dose: 800 mg/kg/4D- intermittentGastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Other changes
TXAPA9 80,323,1985

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 5 ppm;short term exposure limit 15 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 39,81,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,1447,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 39,81,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1447,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,1447,1999
TOXICOLOGY REVIEWEVHPAZ 11,141,1975
TOXICOLOGY REVIEWMUREAV 543,201,2003
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWEMMUEG 39,69,2002
TOXICOLOGY REVIEWENTOX* -,279,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWRTOPDW 53,6,2009
TOXICOLOGY REVIEWMUREAV 723,101,2011
TOXICOLOGY REVIEWMUREAV 653,99,2008
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWMUREAV 795,7,2016
TOXICOLOGY REVIEWMUREAV 802,1,2016

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 25 ppm (100 mg/m3) (skin)DTLVS* 3,102,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAceiling concentration 5 ppm (20 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (20 mg/m3);KZW 10 ppm (40 mg/m3), skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 5 ppm (20 mg/m3), short term exposure limit 15 ppm (62 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 5 ppm (20 mg/m3), skin, carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (21 mg/m3), short term exposure limit 10 ppm (42 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 5 ppm (20 mg/m3), Skin, FEB2006
Occupational Exposure Limit-GERMANYMAK 5 ppm (21 mg/m3), skin, sen, 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 10 mg/m3, short term exposure limit 10 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 5 ppm (20 mg/m3), skin, sen, NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 5 ppm (20 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 5 ppm (20 mg/m3);short term exposure limit 25 ppm (100 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDceiling concentration 5 ppm (20 mg/m3), sen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 5 ppm (20 mg/m3); short term exposure limit 15 ppm (61 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 20 mg/m3, short term exposure limit 80 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 5 mg/m3, short term exposure limit 15 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 5 ppm (20 mg/m3);short term exposure limit 10 ppm (40 mg/m3), Skin, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 5 ppm (20 mg/m3), KZG-week 10 ppm (40 mg/m3), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 20 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 25 ppm (100 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 25 ppm (100 mg/m3), Skin, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 5 ppm (21 mg/m3);short term exposure limit 15 ppm (62 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 25 ppm (100 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 25 ppm (100 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 25 ppm (100 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 25 ppm (100 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL ACRYLATE-airCarcinogen (4.0 ppm LOQ)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 31490; Number of Industries 26; Total Number of Facilities 2898; Number of Occupations 42; Total Number of Employees Exposed 44604; Total Number of Female Employees Exposed 7205
National Occupational Hazard Survey 1974Hazard Code 31490; Number of Industries 42; Total Number of Facilities 3312; Number of Occupations 51; Total Number of Employees Exposed 40491

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NIOSH Analytical Method, 1994: Esters I, 1450
On EPA IRIS database
OSHA ANALYTICAL METHOD #92
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