Acrylic acid, methyl ester

RTECS #

AT2800000

CAS #

96-33-3
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

86.10

Molecular Formula

C₄H₆O₂

Synonyms

2-Propenoic acid, methyl ester (9CI)
Acrylate de methyle (French)
Acrylsaeuremethylester (German)
Curithane 103
Methoxycarbonylethylene
Methyl acrylate
Methyl acrylate (ACGIH:OSHA)
Methyl propenate
Methyl propenoate
Methyl-2-propenoate
Methylacrylaat (Dutch)
Methyl-acrylat (German)
Methylester kyseliny akrylove (Czech)
Metilacrilato (Italian)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	100 mg	severe	AJOPAA 29,1363,1946
eye /rabbit	100 mg/24H	moderate	85JCAE -,368,1986
eye /rat	578 ppm/49H- intermittent		JIHTAB 31,317,1949
skin /rabbit	100%/1M immersion		JIHTAB 31,317,1949
skin /rabbit	10 mg/24H open irritation test		JIHTAB 30,63,1948

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	lymphocyte/mouse	22 mg/L	ENMUDM 8(Suppl 6),4,1986
Cytogenetic Analysis	fibroblast/hamster	189 ppm	ESKHA5 (102),77,1984
Cytogenetic Analysis	lung/hamster	6500 µg/L	GMCRDC 27,95,1981
micronucleus test	intraperitoneal/mouse	37500 µg/kg	MUREAV 135,189,1984
micronucleus test	ovary/hamster	2109 mg/L/3H (+enzymatic activation step)	MUREAV 582,116,2005
mutation in mammalian somatic cells	lymphocyte/mouse	14 mg/L	EMMUEG 11,49,1988
mutation in microorganisms	lymphocyte/mouse	22 mg/L (+enzymatic activation step)	ENMUDM 8(Suppl 6),4,1986
mutation in microorganisms	/Saccharomyes cerevisiae	500 mg/L/17H (-enzymatic activation step)	MUREAV 582,116,2005
mutation in microorganisms	/Saccharomyes cerevisiae	1000 mg/L/17H (+enzymatic activation step)	MUREAV 582,116,2005

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	100 ppm/6H (6-20D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	TOSCF2 48,240,1999
inhalation/rat	100 ppm (6-20D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other effects on female	TOSCF2 48,240,1999

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
In Vitro/Human, liver tumor	Inhibitor Concentration (50 percent kill): 7.1 mmol/L/24H	In Vitro Toxicity Studies: Cell protein synthesis	TIVIEQ 3,189,1989
inhalation/human	lowest published toxic concentration: 75 ppm	Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Other changes	34ZIAG -,75,1969
inhalation/mouse	lethal concentration (50 percent kill): 12800 mg/m³		GTPZAB 23(9),55,1979
inhalation/rabbit	Lowest published lethal concentration: 2522 ppm/1H	Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands	JIHTAB 31,317,1949
inhalation/rat	lethal concentration (50 percent kill): 1350 ppm/4H	Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Dyspnea	JTEHD6 16,811,1985
inhalation/rat	lethal concentration (50 percent kill): 1600 ppm/4H		ENTOX* -,69,2005
intraperitoneal/mouse	lethal dose (50 percent kill): 254 mg/kg		JDREAF 51,526,1972
intraperitoneal/rat	lethal dose (50 percent kill): 325 mg/kg		AMPMAR 36,58,1975
oral/mouse	lethal dose (50 percent kill): 827 mg/kg		TOLED5 11,125,1982
oral/rabbit	lowest published lethal dose: 280 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea	JIHTAB 31,317,1949
oral/rat	lethal dose (50 percent kill): 277 mg/kg		AMPMAR 36,58,1975
skin/rabbit	lethal dose (50 percent kill): 1243 mg/kg		JIHTAB 30,63,1948

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lowest published toxic concentration: 100 µg/m³/24H/14W- continuous	Behavioral: Muscle contraction or spasticity Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in spleen	GISAAA 32(10),3,1967
inhalation/rat	lowest published toxic concentration: 71 mg/m³/3H/17W- intermittent	Brain and Coverings: Recordings from specific areas of CNS	GISAAA 45(1),34,1980
oral/rat	lowest published toxic dose: 109 gm/kg/2Y- continuous	Behavioral: Fluid intake Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXAPA9 6,29,1964

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 2 ppm (skin, sen)	DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-Not classifiable as a human carcinogen	DTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 39,99,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Human No Adequate Data	IMEMDT 71,1489,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 39,99,1986
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Inadequate Evidence	IMEMDT 71,1489,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 3	IMEMDT 71,1489,1999
TOXICOLOGY REVIEW		EVHPAZ 11,141,1975
TOXICOLOGY REVIEW		CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW		ENTOX* -,69,2005
TOXICOLOGY REVIEW		NTAPM* -,727,1995
TOXICOLOGY REVIEW		MUREAV 721,27,2011
TOXICOLOGY REVIEW		FCTOD7 49,1877,2011
TOXICOLOGY REVIEW		FCTOD7 55,596,2013
TOXICOLOGY REVIEW		RTOPDW 55,43,2009

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 10 ppm (35 mg/m³) (skin)	DTLVS* 3,154,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 10 ppm (35 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 5 ppm (18 mg/m³);KZW 10 ppm (36 mg/m³), skin, sen, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 2 ppm (7.2 mg/m³), Skin, MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 2 ppm (7 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 2 ppm (7 mg/m³), short term exposure limit 5 ppm (18 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 10 ppm (35 mg/m³), VLE 15 ppm (50 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 5 ppm (18 mg/m³), 2011
Occupational Exposure Limit-HUNGARY	time-weighted average 18 mg/m³, short term exposure limit 18 mg/m³, Skin, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 10 ppm (35 mg/m³), skin, sen, NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 2 ppm (7 mg/m³), s2 sen, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 10 ppm (35 mg/m³), skin, 2006
Occupational Exposure Limit-MEXICO	time-weighted average 10 ppm (35 mg/m³) (skin), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 10 ppm (35 mg/m³), skin, sen, JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 10 ppm (35 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 2 ppm (7 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 20 mg/m³, MAC(short term exposure limit) 70 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	time-weighted average 5 mg/m³, short term exposure limit 15 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 10 ppm (35 mg/m³);short term exposure limit 15 ppm (50 mg/m³), Skin, Sen, JUN2005
Occupational Exposure Limit-SWITZERLAND	ceiling concentration 5 ppm (18 mg/m³), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 18 mg/m³, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINES	time-weighted average 10 ppm (35 mg/m³), Skin, JAN1993
Occupational Exposure Limit-TURKEY	time-weighted average 10 ppm (35 mg/m³), Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 10 ppm (35 mg/m³) (skin)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 10 ppm (35 mg/m³) (skin)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 10 ppm (35 mg/m³) (skin)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 10 ppm (35 mg/m³) (skin)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ACRYLATE-air	10H time-weighted average 10 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 46450; Number of Industries 6; Total Number of Facilities 129; Number of Occupations 16; Total Number of Employees Exposed 9762; Total Number of Female Employees Exposed 3877
National Occupational Hazard Survey 1974	Hazard Code 46450; Number of Industries 22; Total Number of Facilities 931; Number of Occupations 14; Total Number of Employees Exposed 11809

Status in Federal Agencies

Organization	Reference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl acrylate, 1459
On EPA IRIS database
OSHA ANALYTICAL METHOD #92

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health