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Registry of Toxic Effects of Chemical Substances (RTECS)

Acrylic acid, methyl ester

RTECS #

AT2800000

CAS #

96-33-3

Updated

December 2015

Molecular Weight

86.10

Molecular Formula

C4H6O2

Synonyms

2-Propenoic acid, methyl ester (9CI)
Acrylate de methyle (French)
Acrylsaeuremethylester (German)
Curithane 103
Methoxycarbonylethylene
Methyl acrylate
Methyl acrylate (ACGIH:OSHA)
Methyl propenate
Methyl propenoate
Methyl-2-propenoate
Methylacrylaat (Dutch)
Methyl-acrylat (German)
Methylester kyseliny akrylove (Czech)
Metilacrilato (Italian)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeAJOPAA 29,1363,1946
eye /rabbit 100 mg/24H moderate85JCAE -,368,1986
eye /rat 578 ppm/49H- intermittentJIHTAB 31,317,1949
skin /rabbit 100%/1M immersionJIHTAB 31,317,1949
skin /rabbit 10 mg/24H open irritation testJIHTAB 30,63,1948

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/mouse22 mg/LENMUDM 8(Suppl 6),4,1986
Cytogenetic Analysisfibroblast/hamster189 ppmESKHA5 (102),77,1984
Cytogenetic Analysislung/hamster6500 µg/LGMCRDC 27,95,1981
micronucleus testintraperitoneal/mouse37500 µg/kgMUREAV 135,189,1984
micronucleus testovary/hamster2109 mg/L/3H (+enzymatic activation step)MUREAV 582,116,2005
mutation in mammalian somatic cellslymphocyte/mouse14 mg/LEMMUEG 11,49,1988
mutation in microorganismslymphocyte/mouse22 mg/L (+enzymatic activation step)ENMUDM 8(Suppl 6),4,1986
mutation in microorganisms/Saccharomyes cerevisiae500 mg/L/17H (-enzymatic activation step)MUREAV 582,116,2005
mutation in microorganisms/Saccharomyes cerevisiae1000 mg/L/17H (+enzymatic activation step)MUREAV 582,116,2005

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 100 ppm/6H (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOSCF2 48,240,1999
inhalation/rat 100 ppm (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female
TOSCF2 48,240,1999

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 7.1 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
inhalation/human lowest published toxic concentration: 75 ppmOlfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes
34ZIAG -,75,1969
inhalation/mouse lethal concentration (50 percent kill): 12800 mg/m3GTPZAB 23(9),55,1979
inhalation/rabbit Lowest published lethal concentration: 2522 ppm/1HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
JIHTAB 31,317,1949
inhalation/rat lethal concentration (50 percent kill): 1350 ppm/4HOlfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea
JTEHD6 16,811,1985
inhalation/rat lethal concentration (50 percent kill): 1600 ppm/4HENTOX* -,69,2005
intraperitoneal/mouse lethal dose (50 percent kill): 254 mg/kgJDREAF 51,526,1972
intraperitoneal/rat lethal dose (50 percent kill): 325 mg/kgAMPMAR 36,58,1975
oral/mouse lethal dose (50 percent kill): 827 mg/kgTOLED5 11,125,1982
oral/rabbit lowest published lethal dose: 280 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
JIHTAB 31,317,1949
oral/rat lethal dose (50 percent kill): 277 mg/kgAMPMAR 36,58,1975
skin/rabbit lethal dose (50 percent kill): 1243 mg/kgJIHTAB 30,63,1948

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 100 µg/m3/24H/14W- continuousBehavioral: Muscle contraction or spasticity

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in spleen
GISAAA 32(10),3,1967
inhalation/rat lowest published toxic concentration: 71 mg/m3/3H/17W- intermittentBrain and Coverings: Recordings from specific areas of CNSGISAAA 45(1),34,1980
oral/rat lowest published toxic dose: 109 gm/kg/2Y- continuousBehavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 6,29,1964

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 2 ppm (skin, sen)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 39,99,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1489,1999
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 39,99,1986
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 71,1489,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMEMDT 71,1489,1999
TOXICOLOGY REVIEWEVHPAZ 11,141,1975
TOXICOLOGY REVIEWCMTVAS 10(3),49,1973
TOXICOLOGY REVIEWENTOX* -,69,2005
TOXICOLOGY REVIEWNTAPM* -,727,1995
TOXICOLOGY REVIEWMUREAV 721,27,2011
TOXICOLOGY REVIEWFCTOD7 49,1877,2011
TOXICOLOGY REVIEWFCTOD7 55,596,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 ppm (35 mg/m3) (skin)DTLVS* 3,154,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (35 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 5 ppm (18 mg/m3);KZW 10 ppm (36 mg/m3), skin, sen, 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 2 ppm (7.2 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 2 ppm (7 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 2 ppm (7 mg/m3), short term exposure limit 5 ppm (18 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 10 ppm (35 mg/m3), VLE 15 ppm (50 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 5 ppm (18 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 18 mg/m3, short term exposure limit 18 mg/m3, Skin, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (35 mg/m3), skin, sen, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 2 ppm (7 mg/m3), s2 sen, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (35 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (35 mg/m3) (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (35 mg/m3), skin, sen, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 10 ppm (35 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 2 ppm (7 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 20 mg/m3, MAC(short term exposure limit) 70 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 5 mg/m3, short term exposure limit 15 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 10 ppm (35 mg/m3);short term exposure limit 15 ppm (50 mg/m3), Skin, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 5 ppm (18 mg/m3), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 18 mg/m3, Skin, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 10 ppm (35 mg/m3), Skin, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 10 ppm (35 mg/m3), Skin, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 10 ppm (35 mg/m3) (skin)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 10 ppm (35 mg/m3) (skin)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 10 ppm (35 mg/m3) (skin)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 10 ppm (35 mg/m3) (skin)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ACRYLATE-air10H time-weighted average 10 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 46450; Number of Industries 6; Total Number of Facilities 129; Number of Occupations 16; Total Number of Employees Exposed 9762; Total Number of Female Employees Exposed 3877
National Occupational Hazard Survey 1974Hazard Code 46450; Number of Industries 22; Total Number of Facilities 931; Number of Occupations 14; Total Number of Employees Exposed 11809

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl acrylate, 1459
On EPA IRIS database
OSHA ANALYTICAL METHOD #92
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