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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetophenone, 2-chloro-

RTECS #

AM6300000

CAS #

532-27-4

Updated

December 2014

Molecular Weight

154.60

Molecular Formula

C8H7ClO

Synonyms

1-Chloroacetophenone
2-Chloro-1-phenylethanone
2-Chloroacetophenone
alpha-Chloroacetophenone
alpha-Chloroacetophenone (ACGIH:OSHA)
Chemical mace
Chloromethyl phenyl ketone
CN
Ethanone, 2-chloro-1-phenyl-
Mace (lacrimator)
NCI-C55107
omega-Chloroacetophenone
Phenacyl chloride
Phenylchloromethylketone

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 1 mg mildTXAPA9 17,295,1970
eye /rabbit 3 mg severeTXAPA9 17,295,1970
eye /rabbit 2% rinse mildARTODN 34,183,1975
eye /rabbit 1%VCVGK* -,463,1994
skin /guinea pig 12%/6H open irritation test moderateARTODN 40,75,1978
skin /human 0.5 mg/1H moderateCODEDG 86,150,1972
skin /rabbit 5 mg/24H mildTXAPA9 17,295,1970
skin /rabbit 12%/6H open irritation test moderateARTODN 40,75,1978
skin /rat 12%/6H open irritation test moderateARTODN 40,75,1978

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster3 mg/LNTPTR* NTP-TR-379,1990
DNA Damageliver/rat10 µmol/LMUREAV 368,59,1996

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2 mg/m3/6H/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors

Skin and Appendages: Tumors
NTPTR* NTP-TR-379,1990
skin/mouse lowest published toxic dose: 2400 mg/kg/27W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
BJCAAI 7,482,1953

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
eye/rabbit lowest published toxic dose: 5 pphEye: Corneal damageVCVGK* -,463,1994
inhalation/guinea pig Lowest published lethal concentration: 490 mg/m3/30MOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
ARTODN 40,75,1978
inhalation/human Lowest published lethal concentration: 159 mg/m3/20M34ZIAG -,163,1969
inhalation/human lowest published toxic concentration: 93 mg/m3/3MEye: Lacrimation

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 23,199,1962
inhalation/human lowest published toxic concentration: 20 mg/m3Eye: Other eye effects

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea
BJIMAG 29,298,1972
inhalation/human lowest published toxic concentration: 0.05 mg/m3/10SEye: Conjunctiva irritationVCVGK* -,463,1994
inhalation/mouse lethal concentration (50 percent kill): 59 mg/m3GISAAA 58(10),4,1993
inhalation/rabbit Lowest published lethal concentration: 465 mg/m3/20MOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
ARTODN 40,75,1978
inhalation/rat Lowest published lethal concentration: 417 mg/m3/15MOlfaction: Other olfaction effects

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
ARTODN 40,75,1978
intraperitoneal/guinea pig lethal dose (50 percent kill): 17 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair
ARTODN 40,75,1978
intraperitoneal/mouse lethal dose (50 percent kill): 60 mg/kgNTIS** AD837-111
intraperitoneal/rat lethal dose (50 percent kill): 36 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair
ARTODN 40,75,1978
intravenous/mouse lethal dose (50 percent kill): 81 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes
ARTODN 40,75,1978
intravenous/mouse lethal dose (50 percent kill): 81 mg/kgENTOX* ,706,2005
intravenous/rabbit lethal dose (50 percent kill): 30 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes
ARTODN 40,75,1978
intravenous/rat lethal dose (50 percent kill): 41 mg/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Kidney, Ureter, and Bladder: Other changes
ARTODN 40,75,1978
oral/guinea pig lethal dose (50 percent kill): 158 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair
ARTODN 40,75,1978
oral/mouse lethal dose (50 percent kill): 139 mg/kgNTIS** AD837-111
oral/rabbit lethal dose (50 percent kill): 118 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Other changes

Skin and Appendages: Other: Hair
ARTODN 40,75,1978
oral/rat lethal dose (50 percent kill): 50 mg/kgTXAPA9 17,295,1970
skin/guinea pig lethal dose (50 percent kill): >1 gm/kgNTIS** OTS0556684

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 10 mg/m3/6H/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-379,1990
inhalation/mouse lowest published toxic concentration: 87.6 mg/m3/15M/5D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Lung, Thorax, or Respiration: Other changes

Endocrine: Hyperglycemia
JAPTO* 14,411,1994
inhalation/rat lowest published toxic concentration: 19 mg/m3/6H/14D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-379,1990

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.05 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWCPEMM* 3,239,2002
TOXICOLOGY REVIEWENTOX* -,626,2005
TOXICOLOGY REVIEWENTOX* -,706,2005
TOXICOLOGY REVIEWHTCWA* 2,153,
TOXICOLOGY REVIEWCCACL* 21,719,2005
TOXICOLOGY REVIEWTOLED5 204,148,2011

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.05 ppm (0.3 mg/m3)DTLVS* 3,48,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 ppm (0.32 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 0.04 ppm (0.3 mg/m3);KZW 0.08 ppm (0.6 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 0.05 ppm (0.32 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 0.05 ppm (0.3 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDshort term exposure limit 0.05 ppm (0.32 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 0.05 ppm (0.3 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 0.05 ppm (0.3 mg/m3), NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 0.05 ppm (0.3 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 0.05 ppm (0.3 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.05 ppm (0.32 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 0.05 ppm (0.3 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 0.05 ppm (0.32 mg/m3), JUL2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 ppm (0.3 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.3 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.05 ppm (0.32 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.05 ppm (0.3 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.05 ppm (0.3 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.05 ppm (0.3 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.05 ppm (0.3 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-CHLOROACETOPHENONE-air10H time-weighted average 0.05 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X4754; Number of Industries 1; Total Number of Facilities 35; Number of Occupations 4; Total Number of Employees Exposed 2294; Total Number of Female Employees Exposed 1412

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat
NCI Carcinogenesis Studies (inhal);no evidence:mouse
On EPA IRIS database
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