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Registry of Toxic Effects of Chemical Substances (RTECS)

Acetic acid, vinyl ester

RTECS #

AK0875000

CAS #

108-05-4; 61891-42-7; 82041-23-4

Updated

December 2015

Molecular Weight

86.10

Molecular Formula

C4H6O2

Synonyms

1-Acetoxyethylene
Acetate de vinyle (French)
Acetic acid, ethenyl ester
Acetic acid, ethylene ether
Acetoxyethene
Ethanoic acid, ethenyl ester
Ethenyl acetate
Ethenyl ethanoate
Octan winylu (Polish)
VAC
Vinile (acetato di) (Italian)
Vinyl A monomer
Vinyl acetate
Vinyl acetate (ACGIH)
Vinyl acetate H.Q.
Vinyl ethanoate
Vinylacetaat (Dutch)
Vinylacetat (German)
Vinyle (acetate de) (French)
Vinylester kyseliny octove (Czech)
VYAC
Zeset T

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /human 22 ppmAIHAAP 30,449,1969

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human250 µmol/LMUREAV 159,109,1986
micronucleus testintraperitoneal/mouse1 gm/kgMUREAV 190,41,1987
micronucleus testlymphocyte/human500 µmol/LMUREAV 190,41,1987
morphological transformembryo/hamster62500 µg/LAETODY 1,241,1980
sister chromatid exchangeovary/hamster125 µmol/LCNREA8 45,4816,1985
sister chromatid exchangelymphocyte/human100 µmol/LCNREA8 45,4816,1985
sperm morphologyintraperitoneal/mouse2500 mg/kg/5DMUREAV 202,171,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 1000 ppm/6H (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 24,198,1995
oral/rat 500 mg/kg (multigenerations)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)EPASR* 8EHQ-0185-0543
oral/rat 91 gm/kg (multigeneration)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 24,206,1995
oral/rat 4770 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleNTIS** OTS0535164

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 600 ppm/6H/5D/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
EPASR* 8EHQ-0187-0650
inhalation/rat lowest published toxic concentration: 600 ppm/6H/5D/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors
EPASR* 8EHQ-0187-0650
oral/rat lowest published toxic dose: 100 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors

Reproductive: Tumorigenic effects: Uterine tumors
TXAPA9 68,43,1983

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lethal concentration (50 percent kill): 6200 ppm/4HNTIS** OTS0521596
inhalation/mouse lethal concentration (50 percent kill): 1550 ppm/4HDUPON* ES-3574,1975
inhalation/rabbit lethal concentration (50 percent kill): 2500 ppm/4H85INA8 5,621,1986
inhalation/rat lethal concentration (50 percent kill): 11400 mg/m3/4HGTPZAB 25(11),57,1981
intraperitoneal/guinea pig lowest published lethal dose: 500 mg/kgLiver: Fatty liver degenerationAIHAAP 35,21,1974
oral/mouse lethal dose (50 percent kill): 1600 mg/kgNTIS** OTS0521596
oral/rat lethal dose (50 percent kill): 2900 mg/kgNTIS** OTS0521596
skin/rabbit lethal dose (50 percent kill): 2335 mg/kgDUPON* ES-3574,1975

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 1000 ppm/6H/13W- intermittentLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0521599
inhalation/mouse lowest published toxic concentration: 600 ppm/6H/2Y- intermittentLung, Thorax, or Respiration: Other changesNTIS** OTS0521599
inhalation/rat lowest published toxic concentration: 600 ppm/6H/4W- intermittentOlfaction: Other olfaction effectsINHTE5 9,331,1997
inhalation/rat lowest published toxic concentration: 250 ppm/6H/15D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** OTS0521599
inhalation/rat lowest published toxic concentration: 1000 ppm/6H/13W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0521599
inhalation/rat lowest published toxic concentration: 2500 ppm/4H/1Y- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTIS** OTS0521599
oral/mouse lowest published toxic dose: 6300 mg/kg/20W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldGISAAA 31(8),19,1966
oral/mouse lowest published toxic dose: 18400 mg/kg/92D- continuousBehavioral: Fluid intakeTOXID9 60,439,2001
oral/rat lowest published toxic dose: 21 mg/kg/30W- intermittentBehavioral: Alteration of classical conditioningGISAAA 31(8),19,1966
oral/rat lowest published toxic dose: 46000 mg/kg/92D- continuousBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 60,439,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppm;short term exposure limit 15 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed animal carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 63,443,1995
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate EvidenceIMEMDT 39,113,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 39,113,1986
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 63,443,1995
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 63,443,1995
TOXICOLOGY REVIEWARPTDI 43,485,2003
TOXICOLOGY REVIEWTOLED5 138,9,2003
TOXICOLOGY REVIEWTOLED5 140-141,43,2003
TOXICOLOGY REVIEWTOLED5 140-141,83,2003
TOXICOLOGY REVIEWMUREAV 567,227,2004
TOXICOLOGY REVIEWMUREAV 567,109,2004
TOXICOLOGY REVIEWMUTAEX 20,389,2005
TOXICOLOGY REVIEWENTOX* -,434,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWHUTOX* -,649,1996
TOXICOLOGY REVIEWMUREAV 682,94,2009
TOXICOLOGY REVIEWFCTOD7 49,1877,2011
TOXICOLOGY REVIEWFCTOD7 55,596,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 10 ppm (30 mg/m3)DTLVS* 3,276,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 10 ppm (35 mg/m3), short term exposure limit 20 ppm (70 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 10 ppm (35 mg/m3);KZW 20 ppm (70 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (36 mg/m3), short term exposure limit 15 ppm (54 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 10 ppm (30 mg/m3), carc, MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 5 ppm (18 mg/m3), short term exposure limit 10 ppm (35 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 10 ppm (30 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 10 ppm (30 mg/m3), NOV2011
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 10 ppm (30 mg/m3), short term exposure limit 20 ppm (60 mg/m3), 2006
Occupational Exposure Limit-MEXICOtime-weighted average 10 ppm (30 mg/m3);short term exposure limit 20 ppm (60 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 10 ppm (35 mg/m3), short term exposure limit 20 ppm (70 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 10 ppm (35 mg/m3); short term exposure limit 15 ppm (53 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 10 mg/m3, MAC(short term exposure limit) 30 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 5 ppm (18 mg/m3);short term exposure limit 10 ppm (35 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDceiling concentration 10 ppm (35 mg/m3), carc 3, JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 18 mg/m3, 2003
Occupational Exposure Limit-TURKEYtime-weighted average 10 ppm (30 mg/m3), JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO VINYL ACETATE-airceiling concentration 4 ppm/15MNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code X6624; Number of Industries 79; Total Number of Facilities 6264; Number of Occupations 71; Total Number of Employees Exposed 129024; Total Number of Female Employees Exposed 36642
National Occupational Hazard Survey 1974Hazard Code 76420; Number of Industries 62; Total Number of Facilities 5046; Number of Occupations 59; Total Number of Employees Exposed 50282

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/110898/AS)
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Vinyl acetate, 1453
On EPA IRIS database
OSHA ANALYTICAL METHOD #51
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