Acetic anhydride
RTECS #
AK1925000
CAS #
Updated
June 2018
Molecular Weight
102.10
Molecular Formula
C4H6O3
Synonyms
Acetanhydride
Acetic acid, anhydride (9CI)
Acetic anhydride (ACGIH:OSHA)
Acetic oxide
Acetyl anhydride
Acetyl ether
Acetyl oxide
Anhydrid kyseliny octove (Czech)
Anhydride acetique (French)
Anidride acetica (Italian)
Azijnzuuranhydride (Dutch)
Essigsaeureanhydrid (German)
Ethanoic anhydrate
Octowy bezwodnik (Polish)
Acetic acid, anhydride (9CI)
Acetic anhydride (ACGIH:OSHA)
Acetic oxide
Acetyl anhydride
Acetyl ether
Acetyl oxide
Anhydrid kyseliny octove (Czech)
Anhydride acetique (French)
Anidride acetica (Italian)
Azijnzuuranhydride (Dutch)
Essigsaeureanhydrid (German)
Ethanoic anhydrate
Octowy bezwodnik (Polish)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| skin /rabbit | 540 mg open irritation test | mild | UCDS** 8/7/1963 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| In Vitro/Human, lung | Inhibitor Concentration (50 percent kill): 6.3 gm/L/3H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,174,2013 |
| In Vitro/Human, lung | Inhibitor Concentration (50 percent kill): 20 gm/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 27,174,2013 |
| In Vitro/Human, lung | Inhibitor Concentration (50 percent kill): 6.2 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,174,2013 |
| In Vitro/Human, lung | Inhibitor Concentration (50 percent kill): 4.0 gm/L/24H | In Vitro Toxicity Studies: Other assays | TIVIEQ 27,174,2013 |
| In Vitro/Human, lung tumor | Inhibitor Concentration (50 percent kill): 1.8 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,174,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 2.0 gm/L/24H | In Vitro Toxicity Studies: Cell membrane integrity: Cytoplasmic enzymes leakage (lactate dehydrogenase, ATP enzymes etc.) | TIVIEQ 27,174,2013 |
| In Vitro/Mouse, fibroblast | Inhibitor Concentration (50 percent kill): 1.5 gm/L/24H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 27,174,2013 |
| In Vitro/Rat, lung | Inhibitor Concentration (50 percent kill): 15.5 mmol/L/1H | In Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc. | TIVIEQ 32,347,2016 |
| In Vitro/Rat, lung | Inhibitor Concentration (50 percent kill): 21.4 mmol/L/1H | In Vitro Toxicity Studies: Cell protein synthesis | TIVIEQ 32,347,2016 |
| In Vitro/Rat, lung | Inhibitor Concentration (50 percent kill): 17 mmol/L/1H | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation | TIVIEQ 32,347,2016 |
| inhalation/rat | lethal concentration (50 percent kill): 1000 ppm/4H | 34ZIAG -,607,1969 | |
| oral/rat | lethal dose (50 percent kill): 1780 mg/kg | AMIHBC 4,119,1951 | |
| skin/rabbit | lethal dose (50 percent kill): 4 mL/kg | UCDS** 8/7/1963 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | lowest published toxic concentration: 2470 µg/m3/24H/95D- continuous | Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in leukocyte (WBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | GISAAA 34(4),103,1969 |
| inhalation/rat | lowest published toxic concentration: 400 ppm/6H/2W- intermittent | Eye: Lacrimation Lung, Thorax, or Respiration: Dyspnea Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTIS** OTS0556144 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 ppm;short term exposure limit 3 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Not classifiable as a human carcinogen | DTLVS* TLV/BEI,2013 |
| TOXICOLOGY REVIEW | FCTOD7 47,1287,2009 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD | air-ceiling concentration 5 ppm (20 mg/m3) | DTLWS* 3,2,1971 |
| Occupational Exposure Limit-AUSTRALIA | ceiling concentration 5 ppm (21 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 5 ppm (20 mg/m3);KZW 10 ppm (40 mg/m3), 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 5 ppm (21 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | ceiling concentration 5 ppm (20 mg/m3), MAY2011 | |
| Occupational Exposure Limit-FINLAND | short term exposure limit 5 ppm (21 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VLE 5 ppm (20 mg/m3), FEB2006 | |
| Occupational Exposure Limit-GERMANY | MAK 5 ppm (21 mg/m3), 2011 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 20 mg/m3, short term exposure limit 20 mg/m3, SEP2000 | |
| Occupational Exposure Limit-ICELAND | short term exposure limit 5 ppm (20 mg/m3), NOV2011 | |
| Occupational Exposure Limit-JAPAN | ceiling concentration 5 ppm (21 mg/m3), MAY2012 | |
| Occupational Exposure Limit-KOREA | ceiling concentration 5 ppm (20 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 5 ppm (20 mg/m3), 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | ceiling concentration 5ppm (21 mg/m3), JAN2002 | |
| Occupational Exposure Limit-PERU | time-weighted average 5 ppm (21 mg/m3), JUL2005 | |
| Occupational Exposure Limit-POLAND | time-weighted average 10 mg/m3, JAN1999 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 3 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | ceiling concentration 5 ppm (20 mg/m3), JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 5 ppm (20 mg/m3), JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 0.1 mg/m3, 2003 | |
| Occupational Exposure Limit-UNITED KINGDOM | time-weighted average 0.5 ppm (2.5 mg/m3);short term exposure limit 2 ppm, OCT2007 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 5 ppm (20 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 5 ppm (20 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 5 ppm (20 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 5 ppm (20 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETIC ANHYDRIDE-air | ceiling concentration 5 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code 02740; Number of Industries 73; Total Number of Facilities 7514; Number of Occupations 59; Total Number of Employees Exposed 92428; Total Number of Female Employees Exposed 11630 | |
| National Occupational Hazard Survey 1974 | Hazard Code 02740; Number of Industries 23; Total Number of Facilities 3012; Number of Occupations 16; Total Number of Employees Exposed 19365 |
Status in Federal Agencies
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health